LOCUS       NM_001433944            2088 bp    mRNA    linear   PRI 27-OCT-2024
DEFINITION  Homo sapiens HOXA10-HOXA9 readthrough (HOXA10-HOXA9), mRNA.
ACCESSION   NM_001433944
VERSION     NM_001433944.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Chen,Y., Li,Q., Yu,X., Lu,L., Zhou,Z., Li,M., Xia,R., Gan,X.,
            Hu,Y., Guo,G., Guo,J., Li,H., Li,Q., Liu,Y., Liu,X. and Sun,M.
  TITLE     The microprotein HDSP promotes gastric cancer progression through
            activating the MECOM-SPINK1-EGFR signaling axis
  JOURNAL   Nat Commun 15 (1), 8381 (2024)
   PUBMED   39333095
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004080.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring HOXA10 (homeobox A10) and
            HOXA9 (full description written out) genes on chromosome 7. The
            read-through transcript is a candidate for nonsense-mediated mRNA
            decay (NMD), and is unlikely to produce a protein product.
            [provided by RefSeq, Mar 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1466788.1,
                                           SRR14038195.2541903.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 3205, 3206
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-594               AC004080.2         53016-53609         c
            595-684             AC004080.2         38248-38337         c
            685-2088            AC004080.2         35808-37211         c
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2088
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /note="HOXA10-HOXA9 readthrough"
                     /db_xref="GeneID:100534589"
                     /db_xref="HGNC:HGNC:51908"
     exon            1..594
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    525..527
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /note="upstream in-frame stop codon"
     CDS             585..923
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /note="HOXA10-HOXA9-derived small protein"
                     /codon_start=1
                     /product="HOXA10-HOXA9 readthrough"
                     /protein_id="NP_001420873.1"
                     /db_xref="GeneID:100534589"
                     /db_xref="HGNC:HGNC:51908"
                     /translation="

MCQVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE"

     misc_feature    723..893
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            595..684
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            685..2088
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /note="major polyA site"
     regulatory      2064..2069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /note="hexamer: AATAAA"
     polyA_site      2088
                     /gene="HOXA10-HOXA9"
                     /gene_synonym="HDSP"
                     /note="major polyA site"
ORIGIN      

agagagagtctagccaggaggactgctcgcgggcgggcggcgggcgggcgcgggtttgatttctgagccctataaaagcccatcctccgatggctgtgacaatgtggtcgtaaacccgtccggggccggccaatttgcatatttggaatgcgccgctataaacccggctggggttttgcagcgatttcttagatgtaaaaatgagatctcaatagcagcgggctgggcacatcctctcctctctccttctctctctgcccggagctggtttccgtctctcggctcggggctggaactccggcccaacctaggcgcgcagccgccacgagatggcgcacttccgatcaatgtcaaagccgccggggagccgggaaccccagcatgattcttggcctttgttcgcttctgatactaagagcagcacggtacattatttcacttgtcccgctccccttcataacagaaaaaggggactcaccctcaagaagtgattggtatggtaatttaaagcaacgcgcattcgctaggcctcgcgagcgtcgccgcgcggagaagccagctgtcccttggcagtgatttcggaaatgtgtcaagttgatagagaaaaacaacccagcgaaggcgccttctctgaaaacaatgctgagaatgagagcggcggagacaagccccccatcgatcccaataacccagcagccaactggcttcatgcgcgctccactcggaaaaagcggtgcccctatacaaaacaccagaccctggaactggagaaagagtttctgttcaacatgtacctcaccagggaccgcaggtacgaggtggctcgactgctcaacctcaccgagaggcaggtcaagatctggttccagaaccgcaggatgaaaatgaagaaaatcaacaaagaccgagcaaaagacgagtgatgccatttgggcttatttagaaaaaagggtaagctagagagaaaaagaaagaactgtccgtcccccttccgccttctcccttctctcacccccaccctagcctccaccatccccgcacaaagcggctctaaacctcaggccacatcttttccaaggcaaaccctgttcaggctggctcgtaggcctgccgctttgatggaggaggtattgtaagctttccattttctataagaaaaaggaaaagttgaggggggggcattagtgctgatagctgtgtgtgttagcttgtatatatatttttaaaaatctacctgttcctgacttaaaacaaaaggaaagaaactacctttttataatgcacaactgttgatggtaggctgtatagtttttagtctgtgtagttaatttaatttgcagtttgtgcggcagattgctctgccaagatacttgaacactgtgttttattgtggtaattatgttttgtgattcaaacttctgtgtactgggtgatgcacccattgtgattgtggaagatagaattcaatttgaactcaggttgtttatgaggggaaaaaaacagttgcatagagtatagctctgtagtggaatatgtcttctgtataactaggctgttaacctatgattgtaaagtagctgtaagaatttcccagtgaaataaaaaaaaattttaagtgttctcggggatgcatagattcatcattttctccaccttaaaaatgcgggcatttaagtctgtccattatctatatagtcctgtcttgtctattgtatatataatctatatgattaaagaaaatatgcataatcagacaagcttgaatattgtttttgcaccagacgaacagtgaggaaattcggagctatacatatgtgcagaaggttactacctagggtttatgcttaattttaattggaggaaatgaatgctgattgtaacggagttaattttattgataataaattatacactatgaaaccgccattgggctactgtagatttgtatccttgatgaatctggggtttccatcagactgaacttacactgtatattttgcaatagttacctcaaggcctactgaccaaattgttgtgttgagatgatatttaactttttgccaaataaaatatattgattcttttcta

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