LOCUS       NM_001410774            3579 bp    mRNA    linear   PRI 01-JAN-2023
DEFINITION  Homo sapiens actin related protein 8 (ACTR8), transcript variant 2,
            mRNA.
ACCESSION   NM_001410774 XM_011534249
VERSION     NM_001410774.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Zhang S, Zhou B, Wang L, Li P, Bennett BD, Snyder R, Garantziotis
            S, Fargo DC, Cox AD, Chen L and Hu G.
  TITLE     INO80 is required for oncogenic transcription and tumor growth in
            non-small cell lung cancer
  JOURNAL   Oncogene 36 (10), 1430-1439 (2017)
   PUBMED   27641337
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA,
            Weisswange I, Mansfeld J, Buchholz F, Hyman AA and Mann M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   3  (bases 1 to 3579)
  AUTHORS   Cao L, Ding J, Dong L, Zhao J, Su J, Wang L, Sui Y, Zhao T, Wang F,
            Jin J and Cai Y.
  TITLE     Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin
            Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest
            and Abnormal Chromosome Stability
  JOURNAL   PLoS One 10 (9), e0137411 (2015)
   PUBMED   26340092
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3579)
  AUTHORS   Osakabe A, Takahashi Y, Murakami H, Otawa K, Tachiwana H, Oma Y,
            Nishijima H, Shibahara KI, Kurumizaka H and Harata M.
  TITLE     DNA binding properties of the actin-related protein Arp8 and its
            role in DNA repair
  JOURNAL   PLoS One 9 (10), e108354 (2014)
   PUBMED   25299602
  REMARK    GeneRIF: Plays a regulatory role in the binding of Arp8 to DNA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3579)
  AUTHORS   Vassileva I, Yanakieva I, Peycheva M, Gospodinov A and Anachkova B.
  TITLE     The mammalian INO80 chromatin remodeling complex is required for
            replication stress recovery
  JOURNAL   Nucleic Acids Res 42 (14), 9074-9086 (2014)
   PUBMED   25016522
REFERENCE   6  (bases 1 to 3579)
  AUTHORS   Yao T, Song L, Jin J, Cai Y, Takahashi H, Swanson SK, Washburn MP,
            Florens L, Conaway RC, Cohen RE and Conaway JW.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
REFERENCE   7  (bases 1 to 3579)
  AUTHORS   Aoyama N, Oka A, Kitayama K, Kurumizaka H and Harata M.
  TITLE     The actin-related protein hArp8 accumulates on the mitotic
            chromosomes and functions in chromosome alignment
  JOURNAL   Exp Cell Res 314 (4), 859-868 (2008)
   PUBMED   18163988
  REMARK    GeneRIF: Expression of truncated hArp8 proteins and depletion of
            endogenous hArp8 by RNA interference caused misalignment of mitotic
            chromosomes, suggesting that chromosome-associated hArp8 has a role
            in chromosome behavior.
REFERENCE   8  (bases 1 to 3579)
  AUTHORS   Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, Lu J, Qi HH, Wang
            W, Nickoloff JA, Wu C and Shi Y.
  TITLE     A YY1-INO80 complex regulates genomic stability through homologous
            recombination-based repair
  JOURNAL   Nat Struct Mol Biol 14 (12), 1165-1172 (2007)
   PUBMED   18026119
REFERENCE   9  (bases 1 to 3579)
  AUTHORS   Jin J, Cai Y, Yao T, Gottschalk AJ, Florens L, Swanson SK,
            Gutierrez JL, Coleman MK, Workman JL, Mushegian A, Washburn MP,
            Conaway RC and Conaway JW.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   10 (bases 1 to 3579)
  AUTHORS   Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P and
            Souchelnytskyi S.
  TITLE     Proteins associated with type II bone morphogenetic protein
            receptor (BMPR-II) and identified by two-dimensional gel
            electrophoresis and mass spectrometry
  JOURNAL   Proteomics 4 (5), 1346-1358 (2004)
   PUBMED   15188402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012467.9.
            
            On Aug 15, 2022 this sequence version replaced XM_011534249.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14243140.4961166.1,
                                           SRR14038194.1901467.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC012467.9         34257-34430
            175-345             AC012467.9         35987-36157
            346-456             AC012467.9         37629-37739
            457-561             AC012467.9         38345-38449
            562-735             AC012467.9         38709-38882
            736-829             AC012467.9         39383-39476
            830-962             AC012467.9         40016-40148
            963-1116            AC012467.9         41732-41885
            1117-1212           AC012467.9         42969-43064
            1213-1353           AC012467.9         43572-43712
            1354-1618           AC012467.9         44600-44864
            1619-1782           AC012467.9         45951-46114
            1783-3579           AC012467.9         47234-49030
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..3579
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="actin related protein 8"
                     /db_xref="GeneID:93973"
                     /db_xref="HGNC:HGNC:14672"
                     /db_xref="MIM:619716"
     exon            1..174
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            175..345
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            346..456
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1926
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="isoform 2 is encoded by transcript variant 2; INO80
                     complex subunit N; ARP8 actin related protein 8 homolog"
                     /codon_start=1
                     /product="actin-related protein 8 isoform 2"
                     /protein_id="NP_001397703.1"
                     /db_xref="CCDS:CCDS93290.1"
                     /db_xref="GeneID:93973"
                     /db_xref="HGNC:HGNC:14672"
                     /db_xref="MIM:619716"
                     /translation="

MVDQAIWSKKMSNGTRRIPVSPEQARSYNKQMRPAILDHCSGNKWTNTSHHPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLGSAQGDGLMAGNDSEEALTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW"

     misc_feature    535..1908
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="Nucleotide-Binding Domain of the sugar
                     kinase/HSP70/actin superfamily; Region:
                     NBD_sugar-kinase_HSP70_actin; cl17037"
                     /db_xref="CDD:450142"
     exon            457..561
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            562..735
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            736..829
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            830..962
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1116
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1212
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1353
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1618
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1782
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..3579
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1973..1978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="hexamer: TATAAA"
     polyA_site      1992
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="major polyA site"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="hexamer: AATGAA"
     polyA_site      2059
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
     regulatory      2127..2132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="hexamer: AATAAA"
     polyA_site      2149
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="major polyA site"
     regulatory      3559..3564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="hexamer: AGTAAA"
     polyA_site      3579
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
ORIGIN      

cttttccgggtggtggcgcgccgggacgccgagggctgggaggtgcggagcgccaggagccaggcggagcccccgcagggacaccgctccgatctcccgcacgccccaccgtctggttgtgtgcgctcctgcccgggctctggcctcagcttccccgaccataaaacgaccacgcaaatccagagcaacttcatcattgtcatacatccaggttcaacaactttaaggattggtcgagccacagacactcttcctgccagcattcctcacgtcattgcccgaagacacaaacaacaagggcagcccctatacaaggacagttggctcctaagggagggactaaataaaccagaaagtaatgaacaaagacaaaatggccttaaaatggtggatcaagcaatatggtctaaaaagatgtccaatggtacaagacgcattcctgtgtcccctgaacaggcacgctcctacaataagcagatgcgacctgcaattttagatcactgttcgggaaataagtggacaaacacatctcatcaccctgagtatttagtaggagaagaggccttgtatgttaatccactggactgttacaatattcactggcctatcagaagaggtcagttaaatattcacccaggccctgggggctctcttacagctgttctggcagatattgaagtaatatggtctcatgcgatacaaaaatacttggaaatcccactgaaagatttaaagtattatagatgtatcttgttaattcctgatatctataataagcagcatgtgaaagaactagtgaatatgatactaatgaagatgggtttttcagggattgtggtccatcaggagtctgtgtgtgccacctatggaagtggcttaagcagcacgtgtattgtagacgttggggaccagaagacaagtgtatgctgtgtggaggatggggtgtctcatcggaatactcggctttgtctggcatacggaggatctgatgtgtcaagatgtttttactggctaatgcagcgagctgggttcccttacagagaatgccagttaacaaataaaatggattgtcttcttctgcaacaccttaaagaaactttttgtcatttagatcaggacatctctgggcttcaggaccatgagtttcagattcgacatcctgattctcctgccctgctttaccagtttcgattaggagatgaaaaactgcaggctccaatggctttgttttaccccgcaacttttggaatcgttggacagaaaatgacgactttgcagcacagatctcagggcgatcctgaggatcctcacgatgaacattacctgctggccacacagagcaaacaagaacagtctgcaaaagctactgctgaccgaaagtctgcatccaaacctattggatttgaaggggatcttcgtggccagtcctctgatcttccagaaagactccattcccaggaggtagatttggggtctgcacagggagatggcctgatggccggcaacgattccgaggaggccctcactgcactgatgtccaggaagactgccatctcgctgtttgaaggaaaagccctgggcctggataaagccatcctccatagcatagactgctgttcatctgacgacaccaaaaagaagatgtacagctccatcctagtggtgggaggtggtttgatgtttcataaagctcaagaatttctgcagcacagaattctcaacaaaatgccaccatccttcaggcgaattattgaaaatgtggatgtgatcacaaggcctaaggacatggacccccggctgattgcatggaaaggaggggcagtgttggcttgtttggatacaacacaggaactgtggatttatcagcgagagtggcagcgctttggtgtccgcatgttacgagagcgggctgcgtttgtgtggtgaatggggaggaaatgtcactgccgaagaccaaaaacaagcttcttggtataaaagactcttacagaatatgtgtattgtaatttattgatctggatgcttaagtgtcatggacagtaaatgaatttgaactttatgttgaggacatgacattggtttgaaaatataaactgcttttgagcagtttagtcagggcatttgagaataaataggaactttctcttcagttgtaaactctcttgccctctctcagggtctcataaactccccagtgatgtaaacgttgctattgaaggttctcatgtggtgaagcccttcatttaagttggcttgaatctcatcagcaggcagcctcatgcaaccatgagggatagtatgtgacgagggagaactgtccactcatgccattttctctcttgtctagtatttcattaggatctaaagttgtctgagttaaatgcacttatgtgactcatgtgtcctcttagaatcccaaatagggggaaaaagttttggtggtttttgttttttttttcattttctgttggattacagaaaaagaatgggacccattcaggtctcgatttccaaaggtaaagatggaaggctgggcagactggcttttgttacctgacatgccgtagggtgagcttagaggaagaaagaaaacaatttttatttggccaaaacagaacaaatgctgaaaaggaaatcttgtttttttcctaaagccaaatagaaatgatttgggtataatttaagagtccttgtgttgtacagatatggtgactgatgtagttattaatactaccaacttagtcatcaagcctcaattttcctttacctgaaggattaagtgaaagcttttggagttcatgatgttcagtatgatcagttaaccttaacctctgagcatcctgaagcaaaatctaaataatgcagctattaccactggtggtccaggctctggtgaagccctctgagcccaggaggaagagaaagcattgtccagaggtaggaacacagtctgggagcccagagctctgggaggagtgggaaaatgctgcttcctgctgcttgcttctaggcacctgcttccgccatctcacttaccatggctagagatgggggtgagactggggaaggacaaaagcagggaacagataagtgatggaaatcagaagggaatatagaaagaactctggatgtggagaaatgccggtacctgagcattttgtatcaatgggagtaccctctgtaactgctcagtaggttacaaatgaagagtccaccagtattagaaacaatttaaacttgccagtaccaactgggatgtgtgccttcaatttgaaaattgtatgttttattttttaaatttgttaacagcattaatttatagagtattgatgtcatttatgtttctgaggtgtttcaacacaattttggatcagctgcctgtttgcaaaaacataatatatttctgttaaacagttcttcacctaacagcatattgctcttataactggtagagctgtttcaaaggaagttggtttctggtccaagttttgacctaaaccatgtccatcttctattaccagcacttacaagcactgtgaaaactgatcatgacaaataagtaaaatttgctacattaaa

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