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2024-04-20 04:51:14, GGRNA : RefSeq release 222 (Jan, 2024)
Summary:
Results:
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misc_feature <1410..1628 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1422..1424,1467..1469,1509..1511,1521..1523, 1575..1577,1596..1598,1602..1604) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="...
misc_feature 191..553 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(347..349,392..394,434..436,446..448,500..502, 521..523,527..529) /gene="AGO4" /gene_synonym="EIF2C4" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_...
misc_feature 100..441 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(235..237,280..282,322..324,334..336,388..390, 409..411,415..417) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_...
misc_feature 1055..1396 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1190..1192,1235..1237,1277..1279,1289..1291, 1343..1345,1364..1366,1370..1372) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD...
misc_feature 1050..1391 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1185..1187,1230..1232,1272..1274,1284..1286, 1338..1340,1359..1361,1365..1367) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD...
misc_feature 175..327 /gene="AGO4" /gene_synonym="EIF2C4" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 328..690 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order...
note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 382..534 /gene="AGO4" /gene_synonym="EIF2C4" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 535..897 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 565..717 /gene="AGO4" /gene_synonym="EIF2C4" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 718..1080 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 1756..1908 /gene="AGO3" /gene_synonym="EIF2C3" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1909..2271 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 821..973 /gene="AGO3" /gene_synonym="EIF2C3" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 974..1336 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 987..1139 /gene="AGO3" /gene_synonym="EIF2C3" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1140..1502 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
CDD:435368" misc_feature 625..777 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 778..1140 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
misc_feature 6085..6237 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 6238..6600 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212"...
misc_feature 8280..8432 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 8433..8795 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212"...
CDD:435368" misc_feature 771..923 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 924..1286 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
CDD:435368" misc_feature 733..885 /gene="AGO1" /gene_synonym="EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 886..1248 /gene="AGO1" /gene_synonym="EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
misc_feature <213..317 /gene="PIWIL1" /gene_synonym="CT80.1; HIWI; MIWI; PIWI" /note="PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301" /db_xref="CDD:444818" misc_feature 273..1604 /gene="PIWIL1" /gene_synonym="CT80.1; HIWI; MIWI; PIWI" /note="PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is...
misc_feature 1524..1667 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1668..2021 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order...
misc_feature 1142..1285 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1286..1639 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order...
misc_feature 1524..1667 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1668..2021 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order...
gene="TOPAZ1" /gene_synonym="C3orf77" /replace="a" /replace="c" /db_xref="dbSNP:1303803668" variation 168 /gene="TOPAZ1" /gene_synonym="C3orf77" /replace="c" /replace="t" /db_xref="dbSNP:1699483170" CDS 169..5247 /gene="TOPAZ1" /gene_synonym="C3orf77" /note="testis and ovary-specific PAZ domain gene 1; topaz 1; testis- and ovary-specific PAZ domain-containing protein 1; testis and ovary specific PAZ domain containing 1" /codon_start=1 /product="protein TOPAZ1" /protein_id="NP_001138502.1" /db_xref="CCDS:CCDS46809.1" /db_xref="GeneID:375337" /db_xref="HGNC:HGNC:24746" /db_xref="MIM:614412" /...
COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK302409.1, AP000359.1 and AP000358.1. Summary: This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript...
validation or preliminary review. The reference sequence was derived from AP000359.1 and AB079368.1. On Dec 20, 2011 this sequence version replaced NM_001008496.2. Summary: This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript...
misc_feature 191..553 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(347..349,392..394,434..436,446..448,500..502, 521..523,527..529) /gene="AGO4" /gene_synonym="EIF2C4" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_...
N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 897..1049 /gene="AGO4" /gene_synonym="EIF2C4" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1050..1412 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
misc_feature 175..327 /gene="AGO4" /gene_synonym="EIF2C4" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 328..690 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order...
note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 382..534 /gene="AGO4" /gene_synonym="EIF2C4" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 535..897 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 565..717 /gene="AGO4" /gene_synonym="EIF2C4" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 718..1080 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
misc_feature <213..317 /gene="PIWIL1" /gene_synonym="CT80.1; HIWI; MIWI; PIWI" /note="PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301" /db_xref="CDD:444818" misc_feature 273..1604 /gene="PIWIL1" /gene_synonym="CT80.1; HIWI; MIWI; PIWI" /note="PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is...
misc_feature 152..295 /gene="PIWIL4" /gene_synonym="HIWI2; MIWI2" /note="propagated from UniProtKB/Swiss-Prot (Q7Z3Z4.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 959..1309 /gene="PIWIL4" /gene_synonym="HIWI2; MIWI2" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order...
misc_feature 1144..1287 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1288..1641 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order...
misc_feature 1524..1667 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1668..2021 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order...
RNA loading. This highlights the pleiotropic role of the Ago N domain & emphasizes the unique position of human Ago4 within the Ago protein family. REFERENCE 5 (bases 1 to 5087) AUTHORS Gu S, Jin L, Huang Y, Zhang F and Kay MA. TITLE Slicing-independent RISC activation requires the argonaute PAZ domain JOURNAL Curr Biol 22 (16), 1536-1542 (2012) PUBMED 22795694 REFERENCE 6 (bases 1 to 5087) AUTHORS Pillai RS, Artus CG and Filipowicz W. TITLE Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis JOURNAL RNA 10 (10), 1518-1525 (2004) PUBMED 15337849...
validation or preliminary review. The reference sequence was derived from AP000359.1 and AP000358.1. On Aug 14, 2020 this sequence version replaced NR_045649.1. Summary: This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript...
or preliminary review. The reference sequence was derived from AP000359.1, BC144696.1 and AP000358.1. On Aug 31, 2013 this sequence version replaced XM_005261612.1. Summary: This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript...
from BF979526.1, BC025769.1, BX104163.1, AA251146.1 and AL138787.11. On May 31, 2019 this sequence version replaced NM_177422.2. Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct...
misc_feature 1144..1287 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1288..1641 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order...
AL139286.13, AL138787.11, AK303929.1, BX104163.1 and AA251146.1. On Nov 23, 2018 this sequence version replaced NM_024852.3. Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms...
Swiss-Prot (Q8TC59.1); methylation site" misc_feature 1144..1287 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1288..1641 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD...
misc_feature 1524..1667 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1668..2021 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order...
Swiss-Prot (Q8TC59.1); methylation site" misc_feature 1524..1667 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1668..2021 /gene="PIWIL2" /gene_synonym="CT80; HILI; mili; PIWIL1L" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD...
misc_feature 100..441 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(235..237,280..282,322..324,334..336,388..390, 409..411,415..417) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_...
CDD:435368" misc_feature 733..885 /gene="AGO1" /gene_synonym="EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 886..1248 /gene="AGO1" /gene_synonym="EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
CDD:435368" misc_feature 733..885 /gene="AGO1" /gene_synonym="EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 886..1248 /gene="AGO1" /gene_synonym="EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
misc_feature 1050..1391 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1185..1187,1230..1232,1272..1274,1284..1286, 1338..1340,1359..1361,1365..1367) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD...
misc_feature 1055..1396 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1190..1192,1235..1237,1277..1279,1289..1291, 1343..1345,1364..1366,1370..1372) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD...
note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 808..960 /gene="AGO3" /gene_synonym="EIF2C3" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 961..1323 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 824..976 /gene="AGO3" /gene_synonym="EIF2C3" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 977..1339 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
misc_feature <1410..1628 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1422..1424,1467..1469,1509..1511,1521..1523, 1575..1577,1596..1598,1602..1604) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="...
CDD:435368" misc_feature 625..777 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 778..1140 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD...
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Redirect URI : http://ggrna.dbcls.jp/ja/hs/%22PAZ+domain%22
lang : ja |
div : |
spe : hs |
query_string : "PAZ domain" |
format : html |
download :
0.000 | 0.000 | search_start;
0.077 | 0.077 | count_done; http://172.18.8.71:7700/v1/refsub/query?q=((full_search:*:PAZ+domain)%7C(nt:PAZ+domain)%7C(aa:PAZ+domain))?source=Homo sapiens (human)?to=0&format=json
0.907 | 0.830 | search_done; http://172.18.8.71:7700/v1/refsub/query?q=((full_search:*:PAZ+domain)%7C(nt:PAZ+domain)%7C(aa:PAZ+domain))?source=Homo sapiens (human)?to=49?from=0?snippet=full_search?drilldown=source?get=accession,version,gi,length,symbol,synonym,geneid,division,source,definition&format=json
0.913 | 0.006 | cgi_end;
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