2024-11-01 12:30:44, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS XM_005158665 9747 bp mRNA linear VRT 08-SEP-2024 DEFINITION PREDICTED: Danio rerio dicer 1, ribonuclease type III (dicer1), transcript variant X1, mRNA. ACCESSION XM_005158665 VERSION XM_005158665.5 DBLINK BioProject: PRJNA13922 KEYWORDS RefSeq. SOURCE Danio rerio (zebrafish) ORGANISM Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007128.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XM_005158665.4. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_000002035.6-RS_2024_08 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 08/15/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..9747 /organism="Danio rerio" /mol_type="mRNA" /strain="Tuebingen" /db_xref="taxon:7955" /chromosome="17" gene 1..9747 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="dicer 1, ribonuclease type III; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 mRNAs, 10 ESTs, 690 long SRA reads, 21 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 68 samples with support for all annotated introns" /db_xref="GeneID:324724" /db_xref="ZFIN:ZDB-GENE-030131-3445" misc_feature 1 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /experiment="COORDINATES: cap analysis [ECO:0007248]" /note="transcription start site" CDS 335..5932 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /codon_start=1 /product="endoribonuclease Dicer isoform X1" /protein_id="XP_005158722.1" /db_xref="GeneID:324724" /db_xref="ZFIN:ZDB-GENE-030131-3445" /translation="
MAGLQLVTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALEHNTIVCLNTGSGKTFIAVLLIKELSHQIRGENGKRTVFLVNAASSVAQQASTVRTHSDLQVGDYMSEDMTSWPEEMWNREMIENQVLVMTCHIFLHVLKNGVLPLSKINLLVFDECHLAITGHPYREIMKICEGCPSCPRILGLTASILNGKCDPCDLEEKIQNLEKILQSNAETATDLVVLDRYASQPREEVLDCGQYQDQSGLSERLLNELDEALNFLNDCNLSVHREDRDPTFISKQVLNDCRAVLTVLGPWCADKAAGIMVRELQKYIKHEQEELNRKFLLFTDTILRKIHALCEEHFSPASLDLKFVTPKVIRLLEILHEYKPFERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEAEAKEKTEANFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHSIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPVSNYIMLADSERTKTFQEDLKTYKAIEKILRNKCSKSAECNDFELEPVTDDDNVLPPYVLRSEDGGPRVTMNTAIGHVNRYCARLPSDPFTHLAPKCKTVEMNTGGYRSTLFLPINSPLRVPVTGPVMNCARLAEKAVALLCCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCSPKAIPECLRGCYPVPEQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPRIPHFPVYTRSGEVTISIELQKSGFSLSAEQLELITRLHQYIFSHILRLEKPALEFKPVEADSAYCVLPLNIVEDSNTLDLDFKFMEDIEKSEARIGIPNTQYTKQNPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLSNVNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRSQTAIDAGVGAQTLPPDFRYPNLDFGWKKSIDSKSFISCPSACMEEDDDHCKLGTSSDSNHTAPESCSMEVSQPPEGAPNTPDEKLETLTLPVTDLNKDCFPNLPNGTQADSDDLPHRSDVCQCSQLGPLERDLSTQTTTSVSVRPSPAGEPQPWPSDECTGRSSDLCDPHVKKPTSKHCPKSETATSTPAPSETSSEDCRSACAGPAWDSPKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSSTDKWDSDENKDLANGKASDDEDEDDDDEPEEAEVEPSKEDVNVEDDLEYYYEHIRFIDSMLIGSGAFGKKISLQPTDPGYEWKAPKKAHNSHFSPDGGADEFDYSSWDAMCYLDPSKAGEEDDFVVGFWNPSEENCGTDIGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPPEKQSSGGSAELQYGWLKIPPRCMFEHPDAERTLNHLISGFLNFESKINYTFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVQNN"
misc_feature 428..1009 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="DEXH-box helicase domain of endoribonuclease Dicer; Region: DEXHc_dicer; cd18034" /db_xref="CDD:350792" misc_feature order(428..439,446..448,497..520,632..634,818..820, 911..913) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:350792" misc_feature order(596..601,668..673,743..745,749..754,761..763, 836..844) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="nucleic acid binding site [nucleotide binding]; other site" /db_xref="CDD:350792" misc_feature 1103..1387 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="Partner-binding domain of the endoribonuclease Dicer; Region: Dicer_PBD; cd15903" /db_xref="CDD:277191" misc_feature order(1118..1123,1130..1132,1136..1141,1316..1321, 1328..1333,1340..1342,1349..1354,1361..1363) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="Trbp binding interface [polypeptide binding]; other site" /db_xref="CDD:277191" misc_feature 1406..1984 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="C-terminal helicase domain of the endoribonuclease Dicer; Region: SF2_C_dicer; cd18802" /db_xref="CDD:350189" misc_feature order(1637..1645,1853..1855,1910..1912,1916..1918) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:350189" misc_feature order(1865..1867,1871..1873,1946..1948,1952..1954) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:350189" misc_feature 2180..2446 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="Dicer dimerization domain; Region: Dicer_dimer; pfam03368" /db_xref="CDD:460900" misc_feature 2948..3316 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named...; Region: PAZ_dicer_like; cd02843" /db_xref="CDD:239209" misc_feature order(3137..3139,3176..3178,3194..3196,3206..3208, 3260..3262,3284..3286,3290..3292) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239209" misc_feature 4166..>4441 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="Ribonuclease III family; Region: RIBOc; smart00535" /db_xref="CDD:197778" misc_feature order(4217..4222,4229..4234,4241..4243,4250..4255, 4262..4267,4271..4279,4307..4309) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:238333" misc_feature 5207..5701 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional...; Region: RIBOc; cd00593" /db_xref="CDD:238333" misc_feature order(5267..5272,5279..5284,5291..5293,5300..5305, 5312..5317,5321..5329,5357..5359,5621..5623,5654..5656) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:238333" misc_feature order(5267..5269,5276..5278,5288..5290,5591..5593, 5600..5602) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="active site" /db_xref="CDD:238333" misc_feature order(5276..5278,5591..5593,5600..5602) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="metal binding site [ion binding]; metal-binding site" /db_xref="CDD:238333" misc_feature 5714..5902 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="double-stranded RNA binding motif of endoribonuclease Dicer and similar proteins; Region: DSRM_DICER; cd10843" /db_xref="CDD:380680" misc_feature order(5714..5719,5723..5728,5735..5740,5747..5752, 5762..5764,5777..5785,5789..5791,5795..5797,5846..5857, 5864..5866) /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /note="putative RNA binding site [nucleotide binding]; other site" /db_xref="CDD:380680" polyA_site 9747 /gene="dicer1" /gene_synonym="fc39d11; fc74b05; wu:fc39d11; wu:fc74b05" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN
aacagcagcagcagcagcaggagggaatgggtagagaggggctccgcaccgtttaacaagacactcttcagcacaacacgaccattaaaacaattcaccatcgaacatcgaaggaatactgtctcaggccccctcccccatctgcagctttgagagtaactcaaggggagaaaagaatgagctgattttaagagctcagataatgatgcccagaataagtgcggcctggtcacagagcaaagtggggaacgcacacgcttgagcattagatggccatgatgcaatgagataaacactggatgactggaggtctcctgcttatcagtctctaagcatggctggcctacagctggtgacccctgcctcctcacccatggggcccttctttggtctcccgtggcaacaggaagctatccatgacaacatatacacaccaaggaaatatcaggttgaacttcttgaagcagctcttgaacataatactatagtctgcttaaatactggctcagggaagacctttatcgcagtgctcctaatcaaagaactctcccaccaaattcgtggcgagaatgggaagaggacagttttcctggtgaatgcagcgtcatctgtggctcagcaagcatctactgtaagaacacactctgatctccaagtaggcgactatatgtcagaggacatgacatcatggcccgaggagatgtggaacagagagatgatagagaatcaggtgctggtgatgacgtgccacatcttcctgcatgttttaaagaatggagtcttgccactatcaaagatcaacctgctggtttttgacgaatgccaccttgcaatcactggccatccttatcgggaaataatgaagatttgtgaaggttgccccagctgtcctcgcattttgggtctcactgcttccattttaaatggcaaatgtgacccttgtgatttggaggagaaaattcagaacctggagaagattcttcagagcaatgcagaaactgccactgatcttgtggtgctggataggtatgcgtcgcagccgcgtgaggaggtgctggattgtggacagtaccaagatcagagtgggctctcggagaggcttttaaatgagctggacgaagccctcaattttctaaacgattgcaacttgtctgtacatagagaagatagagaccccacgtttatctccaaacaggtgctgaatgactgtcgtgctgtgttgactgtgctgggcccttggtgtgcggataaagctgcaggaatcatggttcgggagctgcagaaatatattaaacatgaacaggaagagctaaaccgcaagttcctgttgttcaccgacaccatcctgaggaaaatccatgccttatgtgaggagcatttttccccagcttccctcgacctgaagtttgtcactcccaaggtcatcagacttttggagattctccacgagtacaagcctttcgaacggcagcagtttgagagtgtggagtggtacaacaatcgcaatcaggacaattatgtttcttggagtgattctgaagatgatgatgaggacgaagaggcggaggcaaaggagaaaaccgaagcaaattttccctcgccgttcacaaatatcctctgtggaatcatctttgtggaaaggcgatatacagcggttgttttaaacagacttattaaggaggcaggaaagcaagacccagagctggcttacatcagtagcaacttcatcacagggcacagcatcggcaagaaccagcctcgcaacaagcagatggaggtggagttcagaaaacaagaggaagtcttgaggaaattcagagcccatgaaaccaacttgctcattgcaaccagcattgtggaggaaggcgtcgatatcccaaagtgcaatttggtcgttcggtttgacctgccgacagagtaccggtcgtacgtgcaatccaaaggtcgagcccgtgctccagtctccaactacatcatgctagcagacagcgaacggactaaaaccttccaagaagacctcaagacctacaaggccatagagaagatcctccgaaataagtgctcgaagtcggctgaatgcaatgattttgagctggagcctgtgaccgatgacgacaatgttctcccaccgtacgtcctgcgctcagaggacggcgggcctcgtgtcaccatgaacactgccattgggcacgtcaaccgatattgtgcgcgcttgcccagtgatccgttcactcatctcgctccgaagtgtaaaactgtagagatgaacaccggagggtatcgatccacactcttcctacctatcaactcaccactcagagttcctgtcaccgggccagtaatgaattgtgcaagactggctgagaaagctgtcgctcttctctgttgtgaaaaactccacaaaattggtgaactggatgatcatctgatgcctgtgggaaaggaaactgtgaagtatgaggaggagctggacctgcatgatgaagaggagacaagcgtgccaggaagaccaggctccactaaacggagacagtgctccccaaaagccataccagagtgtctgcggggttgttaccctgtgccagagcagccttgctacctttacgttattgggatggtcctcaccacccctctacctgacgaactcaacttccggcggaggaagctgtatccaccagaggacacaacccgatgttttggcattctgacagctaaaccaataccccggatccctcatttccctgtgtacactcgttctggtgaggtgaccatctccattgagctgcagaagtcgggctttagtctaagtgcggagcagctggagctgatcacacgtctgcatcagtacatcttctcccacatcctccgtctggaaaagccagcactagagtttaagcctgtagaggcagattctgcctactgtgttctacctctcaacatcgttgaggattccaatactttggatctggatttcaagttcatggaggatattgaaaagtctgaagcacgcattggcattccaaacactcagtacaccaagcaaaacccattcatcttcaaattggaggactaccaggatgctgtcatcattccaaggtatcgtaattttgaccagccgcatcggttctacgtggctgacgtttacacagacctcaccccgctcagtaaattcccctctccagagtacgagacttttgccgaatactataaaaccaagtacaacctggacctgtcaaatgttaatcagcccctactggatgtggaccacacatcttcaagattgaatcttttaactccccggcaccttaatcaaaaggggaaagcccttcctctcagcagtgcggagaagagaaaggccaagtgggaaagcctacaaaacaaacagattttagttccggagctctgtgccattcaccccatcccagcctctttgtggaggaaagccgtctgccttcccagcattctctatagacttcactgccttctgacggccgaagagctgcggtctcagacagccatcgatgctggcgtaggggctcagaccttgcctcctgatttcaggtatcctaatttggatttcggatggaagaaatccatcgacagcaagtctttcatctcctgccccagtgcatgtatggaagaagacgacgatcactgtaaactcggcacaagctccgattcaaaccacactgcccccgagagctgcagtatggaggtctcccagcctccagaaggcgctcccaacacaccagatgaaaagctagaaaccctcactctccctgtgactgatctaaacaaagactgtttcccaaacctcccaaacggcactcaggccgacagcgacgacctccctcacagaagtgacgtttgccaatgctctcagctgggccctctggagagagacctatcaacacaaaccactacctcagtttcagtgcggccctctccagctggagaaccacagccatggcccagcgatgaatgtacaggcaggagctcggatctctgcgacccacatgtgaagaaacctacctcaaagcattgccctaaatcggagacggcgactagcaccccagcaccttcagaaacgtcatcagaggactgtagatcagcctgcgctggtccagcctgggattcgcccaaaaccctgggcccgaaccccgggctcatcctgcaggccctgactctctccaacgccagtgacggcttcaatctggaacgcctggagatgctgggcgactccttcctgaaacacgccatcaccacatacctgttctgcacttaccctgacgcccacgagggcagactgtcctacatgagaagcaagaaggtcagcaactgtaacctgtatcggctggggaagaagaagggtcttccgagtcgaatggtggtgtccatctttgacccgccggtaaactggcttcctccaggctacgtcgtgaatcaggacaaaagcagcacagacaagtgggactcagatgagaataaagatttagcgaatggaaaagccagcgatgacgaagacgaggatgacgatgatgagccggaagaagcagaggtcgagccatctaaagaagatgtaaatgttgaagacgacctggagtattattacgaacacatccgcttcatcgacagcatgttaatcggctctggcgctttcggcaagaagatctccctccagcccacagaccccggctacgaatggaaagctcctaaaaaagcccacaactcccacttctcgccagacgggggtgctgacgagttcgattacagctcctgggacgccatgtgttacctggaccccagtaaagcaggtgaggaggacgatttcgtggtgggcttctggaatccctctgaggaaaactgcggcacggacatcgggaaacagtccatctcttatgaccttcacacggagcagtgcatcgcagataagagcatagcggactgtgtggaggctctgctgggctgctatctgaccagctgtggtgagcgagcggctc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//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]