LOCUS       NM_212575               1435 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio metaxin 2 (mtx2), mRNA.
ACCESSION   NM_212575
VERSION     NM_212575.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1435)
  AUTHORS   Newman M, Hin N, Pederson S and Lardelli M.
  TITLE     Brain transcriptome analysis of a familial Alzheimer's disease-like
            mutation in the zebrafish presenilin 1 gene implies effects on
            energy production
  JOURNAL   Mol Brain 12 (1), 43 (2019)
   PUBMED   31053140
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1435)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1435)
  AUTHORS   Garcia-Reyero N, Escalon L, Prats E, Faria M, Soares AM and Raldua
            D.
  TITLE     Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon
            Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes
  JOURNAL   Bull Environ Contam Toxicol 96 (6), 707-713 (2016)
   PUBMED   27086301
REFERENCE   4  (bases 1 to 1435)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1435)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1435)
  AUTHORS   Woltering,J.M. and Durston,A.J.
  TITLE     The zebrafish hoxDb cluster has been reduced to a single microRNA
  JOURNAL   Nat Genet 38 (6), 601-602 (2006)
   PUBMED   16736008
REFERENCE   7  (bases 1 to 1435)
  AUTHORS   Muto A, Arai K and Watanabe S.
  TITLE     Rab11-FIP4 is predominantly expressed in neural tissues and
            involved in proliferation as well as in differentiation during
            zebrafish retinal development
  JOURNAL   Dev Biol 292 (1), 90-102 (2006)
   PUBMED   16457799
REFERENCE   8  (bases 1 to 1435)
  AUTHORS   Phillips RB, Amores A, Morasch MR, Wilson C and Postlethwait JH.
  TITLE     Assignment of zebrafish genetic linkage groups to chromosomes
  JOURNAL   Cytogenet Genome Res 114 (2), 155-162 (2006)
   PUBMED   16825768
REFERENCE   9  (bases 1 to 1435)
  AUTHORS   Bruce AE, Howley C, Dixon Fox M and Ho RK.
  TITLE     T-box gene eomesodermin and the homeobox-containing Mix/Bix gene
            mtx2 regulate epiboly movements in the zebrafish
  JOURNAL   Dev Dyn 233 (1), 105-114 (2005)
   PUBMED   15765511
  REMARK    GeneRIF: knockdown leads to an inhibition of epiboly in
            gastrulation
REFERENCE   10 (bases 1 to 1435)
  AUTHORS   Adolph KW.
  TITLE     The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure,
            and comparison to zebrafish metaxins 1 and 2
  JOURNAL   Gene 330, 67-73 (2004)
   PUBMED   15087125
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY289938.1.
            
            On Aug 30, 2012 this sequence version replaced NM_212575.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY289938.1, EH497931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1435              AY289938.1         5-1439
FEATURES             Location/Qualifiers
     source          1..1435
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="6"
                     /map="6"
     gene            1..1435
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /note="metaxin 2"
                     /db_xref="GeneID:286741"
                     /db_xref="ZFIN:ZDB-GENE-021210-2"
     exon            1..382
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    226..228
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /note="upstream in-frame stop codon"
     CDS             343..1167
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /codon_start=1
                     /product="metaxin-2"
                     /protein_id="NP_997740.1"
                     /db_xref="GeneID:286741"
                     /db_xref="ZFIN:ZDB-GENE-021210-2"
                     /translation="

MSLAAEAFVSQIAAAEPWPENAALYQPLKEDQILLSDSASSLAVQTFLRMCGLPVQVSCRANAEYMSPSGKVPFIQVGNQVVSELGPIVQFTKAKGHSLSDGLDDVQRAEMKAYMELVNNMLLTAELYIQWCDDFTATEISRPRYSSPYSWPLNHILAYQKQWEVRRKMNAIGWSGKSLEQVYEDVSQCCQALSQRLGTQPYFFNKQPTELDALVFGHLFTILTTQLTSDELVEKVKSYSNLLSFCHRIEQAYFKEQEREGQSGSSRHSKGSLP"

     misc_feature    406..627
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /note="GST_N family, Metaxin subfamily, Metaxin 2; a
                     metaxin 1 binding protein identified through a yeast
                     two-hybrid system using metaxin 1 as the bait. Metaxin 2
                     shares sequence similarity with metaxin 1 but does not
                     contain a C-terminal mitochondrial outer...; Region:
                     GST_N_Metaxin2; cd03079"
                     /db_xref="CDD:239377"
     misc_feature    order(460..462,466..471,475..480,487..492,598..600,
                     607..612)
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /note="putative C-terminal domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239377"
     misc_feature    order(460..462,553..561,592..597)
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /note="putative GSH binding site (G-site) [chemical
                     binding]; other site"
                     /db_xref="CDD:239377"
     misc_feature    order(553..555,589..594,598..603,610..612)
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239377"
     misc_feature    715..1092
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /note="C-terminal, alpha helical domain of Metaxin 2;
                     Region: GST_C_Metaxin2; cd03211"
                     /db_xref="CDD:198320"
     misc_feature    order(730..732,751..753,970..972,979..984,991..993,
                     1003..1005)
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /note="putative N-terminal domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198320"
     exon            383..430
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     exon            431..477
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     exon            478..550
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     exon            551..627
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     exon            628..720
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     exon            721..759
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     exon            760..885
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     exon            886..962
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1416
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1399..1404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
     polyA_site      1415
                     /gene="mtx2"
                     /gene_synonym="fc02d09; wu:fc02d09"
ORIGIN      

agagcgaggcgaaggcaaggcggacacatttctaaccggcatgcatcttgcggtgatcaccggtgatcgattctgcgcagattttggccaagtcaaacgagcctagtatctgttacgcttttttacttaatggtttgcaggcttgcctttcctttagctttgttcatattgcgtcatcagaagtggaggaaggtgattggacaggaaccaggaaaaacctcggtttgacgtcactacactgggacaggagcttgctttgcccttgcgtgtaaaattgatgtctgtctgagtttttggatcagttgttgtgcttacattacagtagatttcctctgcgctgtcatgtctctcgctgcagaggctttcgtctctcagattgcagctgctgagccatggcctgaaaacgctgctttataccaacctctcaaagaggatcaaatcttgctgtcagattctgcgtcctctctagctgttcagacattcctgaggatgtgcggtctgccagtgcaggtgtcatgccgtgccaatgctgaatacatgtcaccatcagggaaggttcctttcatccaagttggaaatcaggtcgtgtccgaattggggccgattgttcagttcacaaaggcaaagggtcattctctgagtgacgggctggatgatgtccagagggcagagatgaaggcttacatggagttggtcaataacatgcttctgaccgcggagttatacatccagtggtgtgacgactttactgctacagagatctccaggcctcgatacagcagcccctactcttggcccctcaatcacattctggcctatcagaagcagtgggaggtgcgcaggaagatgaacgccattggatggtctggaaagagcctggagcaggtgtatgaagatgtgagccagtgttgtcaggccttgtcacagcgattaggaacacagccctactttttcaacaaacagccaactgaactagatgctctggtgtttggtcatcttttcaccatactcaccacacagctgaccagcgacgagcttgtcgaaaaggtgaaatcctactccaacctgctctctttctgccatcgtatcgaacaggcttactttaaggagcaggagcgagaaggtcagtcaggctcctcacgccattccaaaggctctctaccctgagcagctctcgcggagttctcacatttaataaagatttgtgaatatttacagtgttcccgtcgtgtttccaaactactccttcgcctgttcataatgccataatgggaacttgcctgtcacagcagtagaataaggtttctggtgtaaaattgtagttgatgtaatttttttttttgccactgtgtgatgcctttgtctgatatgtgtgaatggcaagtgcctatgaagtataataaacttcaagatggaaaaaaaaaaaaaaaaaaaa

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