LOCUS       NM_201319               2862 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio PMS1 homolog 1, mismatch repair system component
            (pms1), mRNA.
ACCESSION   NM_201319
VERSION     NM_201319.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Meng ZZ, Liu W, Xia Y, Yin HM, Zhang CY, Su D, Yan LF, Gu AH and
            Zhou Y.
  TITLE     The pro-inflammatory signalling regulator Stat4 promotes
            vasculogenesis of great vessels derived from endothelial precursors
  JOURNAL   Nat Commun 8, 14640 (2017)
   PUBMED   28256502
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL672217.6.
            
            On Dec 31, 2004 this sequence version replaced NM_201319.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="9"
                     /map="9"
     gene            1..2862
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /note="PMS1 homolog 1, mismatch repair system component"
                     /db_xref="GeneID:368631"
                     /db_xref="ZFIN:ZDB-GENE-030616-528"
     exon            1..66
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            67..208
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2767
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /note="PMS1 postmeiotic segregation increased 1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1"
                     /protein_id="NP_958476.2"
                     /db_xref="GeneID:368631"
                     /db_xref="ZFIN:ZDB-GENE-030616-528"
                     /translation="

MKALPPETVRLLCSSQVITSVLNVVKELIENSLDAGSSSLEVKLENYGLDRIEVRDNGSGIKATDVSVMAVKHYTSKISCHEDLEQLETYGFRGEALASICAISEVIITTKTADDDFSIQYSVDHNGQIVSQKPSHLGQGTTVCAANLFKNLPVRRQYYSNTKKCKDELKRVQNLLMAYAVIKPELRVTLSHNKAVVWQKSRVSDHRTALMAVLGAASVANMLPVQHHQEQPEITIDGFFPKPGSDLNSTSSSTTDKSFIFVNSRPVHHKEILKLIKQYYTSAQSNSESVSRRYPTFMMNITIPASTVDVNLTPDKTEVMLQNKDEVLLSVETMLISLYGYSNGEENLKTAGNPPDVTSLDEPKRTSPDISLKHPELPEDSSSNAEKQDGELSLSNTANTSSSSISEDWVINRSDLDSINCSVPVDDVVMNSTADLNSNSPKASESDSGPESQISAENWSAGRVFSNQITGEYLEPVKLHIPKAIEDLGGTEAKSVKSSPSKKPSNVIVEKMAKLTAYELISNRSVRQPSSAFSLFEQDTRSQVLQENPKASPQDVTAAAKERWESLGEEDRKKYEGKAEKSLNAYNLQRKRAAEGGVQCGEGKKQMSAESPLNKAQGVKRKAPLANQQALDKLFSSQPSSKRSPAKISKPLPFTIATLKQSLNLLSEQSSSSVQGLRLVNRLASHGAWVVLCGRKLMLLNPFRVEEALLFKRLLEDNILPTVRLQTPVLLTDGVLGGPEYMDVLLNMKKDGPEFNGDISLTDPRLVANGFEIRMISGPQSSERHVEVMGMADCMPFFGIGDLREILQAIKARGAKTVAQCRPRKVSHYLESEAVRLARQLPLSLSRADVTNTLCRMQQELQDESQVCIHRLPFFHNLVTLPETELEALQIMSGSQ"

     misc_feature    77..1036
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /note="DNA mismatch repair protein MutL; Region: mutl;
                     TIGR00585"
                     /db_xref="CDD:273155"
     misc_feature    1649..1867
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /note="high mobility group (HMG)-box found in PMS1 protein
                     homolog 1 (PMS1) and similar proteins; Region:
                     HMG-box_PMS1; cd21985"
                     /db_xref="CDD:438801"
     misc_feature    order(1655..1660,1664..1678,1685..1690,1709..1711,
                     1745..1750,1757..1759,1766..1771,1790..1792,1802..1804,
                     1811..1813,1823..1825,1832..1834)
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438801"
     exon            209..391
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..494
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..658
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..775
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..898
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1048
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1797
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..2277
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2408
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2569
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2862
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2862
                     /gene="pms1"
                     /gene_synonym="PMSL1; si:dz164h20.2; si:dz72b14.2"
ORIGIN      

ttcggaaacatgtgaagtacacttgtgtgatgaagttactggatattttttaacattctacctgaaaaagagaaccatgaaggcgcttccccccgagactgtgcgtctgctgtgcagctctcaggttattacatctgtcctgaatgttgtcaaggaactgatcgagaattcacttgatgctggttcctcaagccttgaagtcaaactggagaattatggactggatcgcattgaagtgcgagacaatggctctggtattaaagctactgatgtttctgtgatggctgtaaaacactatacgtctaaaatctcttgccatgaagacctggaacagctagagacttacggcttcagaggagaagctctggcatccatatgtgccatctcagaggtgattattactaccaaaactgcagatgacgattttagcattcagtattcagtggatcacaatggacagatcgtctctcagaagccatctcatcttggccagggcaccacggtgtgtgcggcaaatctgttcaagaacctcccagttagacggcagtattattccaacactaaaaaatgtaaagatgagcttaagagggttcagaacttactcatggcttatgctgtaataaagcctgagttacgggtcacgctgagccacaacaaggctgtggtctggcagaagtccagggtgtcggatcaccgaactgccctcatggccgtgctcggagcagcgtccgtagccaacatgctccccgtccagcatcaccaggagcaaccagagatcaccatcgatggattctttcccaaaccgggctcagatttgaattccaccagctcctctacgaccgataagtcattcatctttgtaaacagtcgacctgtgcatcataaagagatacttaagcttatcaagcagtattacaccagtgctcagtctaacagtgaatccgtaagccgccgatatcccacttttatgatgaacatcaccataccggcctcaactgtggacgttaacctgacacctgataaaactgaagtgatgctacagaataaggatgaagttctgttgtcagtggaaactatgctaatctccttgtatggatactctaatggtgaagagaatctcaaaactgcaggaaatccccctgatgttacttcattggatgagcctaaacggacttccccagatattagtttaaagcacccagaactgcccgaggattcttcctcgaatgcagaaaaacaggacggtgagctctccttgagcaacaccgcaaacaccagctcttcttcgatttcggaggattgggtgatcaacagaagtgatttggacagtattaattgctcagtacctgttgacgatgtggtaatgaactctacagctgatctgaactccaactctccaaaggcgtctgagagtgacagcggtccagagagccagatatctgccgagaactggagtgcgggcagggtcttctccaatcaaatcactggggaatacctagaacctgtcaaactgcacatcccaaaggcaattgaagaccttggaggaaccgaggccaagagcgtgaagtctagcccatctaaaaagccctctaatgtgattgtggagaaaatggccaagctgacagcctatgagcttatcagcaaccgctccgtgcgtcagccctcgtctgccttttcgctgtttgagcaagacaccagatcgcaggtcctccaggagaacccaaaagccagtcctcaggatgtcacagctgctgcgaaagagagatgggaaagcctcggggaggaagaccgcaaaaagtatgaaggcaaggccgaaaagtctctgaacgcctacaaccttcaaaggaagagggcagcggagggaggcgtccagtgcggagagggcaagaagcagatgagcgccgagtctccattgaacaaagctcaaggcgtgaagcgcaaagcccccctcgccaaccagcaggccctggacaaactcttctcctctcagccctccagtaaaaggagccctgccaaaatctccaaacccctcccgttcactatcgcaaccctcaagcagagtcttaacctcctctccgagcagagcagctcaagtgtgcagggcctcaggcttgtaaaccgcttggcttctcacggtgcctgggtcgttttatgcggcagaaagctcatgttgttgaacccgtttcgagtggaggaggccttgctgtttaaaagacttctggaggataatatacttccaaccgtgaggctgcagacccccgtactgctgacagatggggtgctcggtgggccagagtacatggatgtccttctgaacatgaagaaagatggtcctgaatttaatggagacatcagcttaactgatcccaggcttgtggcaaacggttttgagattaggatgatttcaggtccgcagtcttcggagaggcatgttgaggtgatgggcatggccgactgcatgccgttcttcgggataggagacctgagggagattctgcaggctataaaggcccgcggagcaaaaaccgtggcgcaatgtagacctcgcaaagtctcacactacctcgagagcgaggcagtgagactagcaagacagttacctctcagtctctcaagagccgatgttacaaacacactttgcagaatgcaacaggaacttcaagacgaaagtcaggtctgcattcacaggctgccattttttcacaatctggtgacccttcctgaaaccgagctggaggctctacagatcatgtccggttctcagtaaaaaggacttcaatacaaggacccgtcatttcatacactattaataattgatcaatatccaggccatttgaaataataaatgtttttctagatgaa

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