LOCUS       NM_201306               2075 bp    mRNA    linear   VRT 24-JUN-2024
DEFINITION  Danio rerio low density lipoprotein receptor-related protein
            associated protein 1 (lrpap1), mRNA.
ACCESSION   NM_201306
VERSION     NM_201306.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Liu,S., Chen,T., Chen,B., Liu,Y., Lu,X. and Li,J.
  TITLE     Lrpap1 deficiency leads to myopia through TGF-beta-induced
            apoptosis in zebrafish
  JOURNAL   Cell Commun Signal 20 (1), 162 (2022)
   PUBMED   36261846
  REMARK    GeneRIF: Lrpap1 deficiency leads to myopia through TGF-beta-induced
            apoptosis in zebrafish.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Bayes,A., Collins,M.O., Reig-Viader,R., Gou,G., Goulding,D.,
            Izquierdo,A., Choudhary,J.S., Emes,R.D. and Grant,S.G.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Tseng,L.C., Zhang,C., Cheng,C.M., Xu,H., Hsu,C.H. and Jiang,Y.J.
  TITLE     New classes of mind bomb-interacting proteins identified from yeast
            two-hybrid screens
  JOURNAL   PLoS One 9 (4), e93394 (2014)
   PUBMED   24714733
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2075)
  AUTHORS   Aanes,H., Winata,C.L., Lin,C.H., Chen,J.P., Srinivasan,K.G.,
            Lee,S.G., Lim,A.Y., Hajan,H.S., Collas,P., Bourque,G., Gong,Z.,
            Korzh,V., Alestrom,P. and Mathavan,S.
  TITLE     Zebrafish mRNA sequencing deciphers novelties in transcriptome
            dynamics during maternal to zygotic transition
  JOURNAL   Genome Res 21 (8), 1328-1338 (2011)
   PUBMED   21555364
REFERENCE   6  (bases 1 to 2075)
  AUTHORS   Knoll-Gellida,A., Andre,M., Gattegno,T., Forgue,J., Admon,A. and
            Babin,P.J.
  TITLE     Molecular phenotype of zebrafish ovarian follicle by serial
            analysis of gene expression and proteomic profiling, and comparison
            with the transcriptomes of other animals
  JOURNAL   BMC Genomics 7, 46 (2006)
   PUBMED   16526958
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2075)
  AUTHORS   Whitehead,G.G., Makino,S., Lien,C.L. and Keating,M.T.
  TITLE     fgf20 is essential for initiating zebrafish fin regeneration
  JOURNAL   Science 310 (5756), 1957-1960 (2005)
   PUBMED   16373575
REFERENCE   8  (bases 1 to 2075)
  AUTHORS   Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
            Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   9  (bases 1 to 2075)
  AUTHORS   Sharma,M.K., Denovan-Wright,E.M., Degrave,A., Thisse,C., Thisse,B.
            and Wright,J.M.
  TITLE     Sequence, linkage mapping and early developmental expression of the
            intestinal-type fatty acid-binding protein gene (fabp2) from
            zebrafish (Danio rerio)
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 138 (4), 391-398 (2004)
   PUBMED   15325340
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX511116.4.
            
            On Jun 24, 2024 this sequence version replaced NM_201306.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               BX511116.4         19505-19775
            272-416             BX511116.4         20204-20348
            417-547             BX511116.4         21859-21989
            548-668             BX511116.4         22094-22214
            669-824             BX511116.4         23903-24058
            825-907             BX511116.4         24145-24227
            908-1084            BX511116.4         26612-26788
            1085-2075           BX511116.4         28432-29422
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     gene            1..2075
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="low density lipoprotein receptor-related protein
                     associated protein 1"
                     /db_xref="GeneID:333939"
                     /db_xref="ZFIN:ZDB-GENE-030131-5871"
     exon            1..271
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    89..91
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="upstream in-frame stop codon"
     CDS             116..1153
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /codon_start=1
                     /product="alpha-2-macroglobulin receptor-associated
                     protein precursor"
                     /protein_id="NP_958463.2"
                     /db_xref="GeneID:333939"
                     /db_xref="ZFIN:ZDB-GENE-030131-5871"
                     /translation="

MQLLILVSLFAVGAMAGKYSKEMNEKNASDKSNSQVEFRIAKLNQVWEKAIRMQLAPVRLSELHSDLKIQEKDELQWKKLKAEGMDEDGEREAKLRRNFNIILAKYGMDGKKDTRTLDSNRLKDHEVKVGDTFDDPKLDKLWNKARTSGKFSDEELQTLHREFQHHKDKIHEYNIVMDTVSRTEEIHKNVISPLEGDVKENVLHQKHTDLKQRMRDLNQGFERLRKITHEGYTDDSEFREPRVIELWEMAKRSNLSKDELDSLKEELRHFETKVEKHQHYQEQLELSHQKLKHVEALGDEDHIMRNKEKYNTLAEKAREMGYKMKKHLQDLTNKLSKNGLQHNEL"

     sig_peptide     116..163
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    116..118
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MQLIILVSLFAVGA"
     exon            272..416
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            417..547
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            548..668
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            669..824
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            825..907
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1084
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..2075
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aggcatgtgaacgccgtatgattccagtagcgcttcctggatagcgctgcagatgctctacgaaacggtttatttaggttttcataactaatttgcttctgttgccacaattaaaatgcagcttctaattttggtttcgttgttcgctgtcggtgcaatggcgggaaagtactcaaaagaaatgaatgaaaaaaatgcgtctgataaaagcaacagccaggtggaatttaggattgccaaactaaatcaggtttgggaaaaggcgataaggatgcagcttgcaccggtccgtctgtcagaactacacagtgacttgaaaatccaagaaaaagatgaacttcaatggaaaaaactcaaagcagaagggatggacgaagatggagagagagaagccaagctcaggcgaaattttaatattattcttgcaaagtatggaatggatgggaaaaaagacacccgaacattggacagcaacagactgaaagatcatgaagttaaagttggagacacatttgatgacccaaagttggacaagctgtggaataaggccagaacttctggaaaattctctgatgaggaactccagaccttacatagagaattccagcatcacaaagacaagatccatgagtataacattgtcatggacactgtcagccggactgaagagatccataagaacgtgatcagtcctctggagggggatgtgaaggagaacgttcttcatcagaaacacacagatctgaagcagagaatgagggatctaaaccagggctttgagcgtctccgcaagatcacccacgagggctacactgatgacagcgaatttagggagccacgagtcattgagctgtgggagatggcaaaaagatccaacctcagcaaagatgaacttgattctcttaaagaggaactccgacactttgaaacaaaggtggagaagcaccagcactatcaggagcagctggaactgtctcatcagaaactgaagcatgtggaggctctgggagatgaggatcacattatgagaaacaaagagaaatacaacactctggctgagaaagcacgggagatgggatacaagatgaagaagcacttgcaggatttaacgaacaagctttccaaaaatggattacaacacaatgaactctgagcactcttttcctcagcatggcagcactacagttagttatgatcacatatggagtgttattccacactgattggctggggttatgaaggtaaggtgcacagcatttccactggaaagtcaaaccaattattaaataatgagatttttttttacggtacggagcagtgaacagttctgtgcattctgttcattatccatgttctatttgttgtggccaaatttgtatgaatttcatgatacttgctaaaaaatgaactgaaacacgtgtagcttcccacaaacatgtgggtgcaatagaacttcacaacaaaaccacacaagaaggctcgcaaagttttcaatgtaaacttttaagcttccatttgagcaatctcctaaagctgagcatcttaacatttaaagaaaggctcaattgaactctgccatgaaaaacggtgccatcccaatgcaggtttgatgttatatccagataacctctgttacgagctaaacctggcagattgaggacaatagatgtgctttaatggaaaaagctgcagtgaaatggagaaccagaagctaaggccaggcacaaaagtaaagcaggtcttgaatcagccgttatatttaccaaacagcattgagtgcagatattatcaacatgattgacagctttgtccagagttagacttgaatcatcctgacttttagatatttaaagatttgttacaaaaattcaaactacaaactgattctattatatgacaatgtaattactcaatcgacagaattttgtgattttgtgtagaacacatgctataatccagtattgtaattcatgatcaggaatgtgttgtctgttaataataggatctcttttgtataagtctgttttgtatatgtcagtcgcacatttcataataaaacaaactaaccatttttt

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