LOCUS       NM_198813               3252 bp    mRNA    linear   VRT 02-OCT-2022
DEFINITION  Danio rerio zinc fingers and homeoboxes 3b (zhx3b), mRNA.
ACCESSION   NM_198813
VERSION     NM_198813.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Diotel N, Rodriguez Viales R, Armant O, Marz M, Ferg M, Rastegar S
            and Strahle U.
  TITLE     Comprehensive expression map of transcription regulators in the
            adult zebrafish telencephalon reveals distinct neurogenic niches
  JOURNAL   J Comp Neurol 523 (8), 1202-1221 (2015)
   PUBMED   25556858
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Nachtigall,P.G., Dias,M.C. and Pinhal,D.
  TITLE     Evolution and genomic organization of muscle microRNAs in fish
            genomes
  JOURNAL   BMC Evol Biol 14, 196 (2014)
   PUBMED   25253178
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Huang HT, Kathrein KL, Barton A, Gitlin Z, Huang YH, Ward TP,
            Hofmann O, Dibiase A, Song A, Tyekucheva S, Hide W, Zhou Y and Zon
            LI.
  TITLE     A network of epigenetic regulators guides developmental
            haematopoiesis in vivo
  JOURNAL   Nat Cell Biol 15 (12), 1516-1525 (2013)
   PUBMED   24240475
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Zheng W, Wang Z, Collins JE, Andrews RM, Stemple D and Gong Z.
  TITLE     Comparative transcriptome analyses indicate molecular homology of
            zebrafish swimbladder and mammalian lung
  JOURNAL   PLoS One 6 (8), e24019 (2011)
   PUBMED   21887364
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Bayarsaihan D, Enkhmandakh B, Makeyev A, Greally JM, Leckman JF and
            Ruddle FH.
  TITLE     Homez, a homeobox leucine zipper gene specific to the vertebrate
            lineage
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10358-10363 (2003)
   PUBMED   12925734
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY311506.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY311506.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="23"
                     /map="23"
     gene            1..3252
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="zinc fingers and homeoboxes 3b"
                     /db_xref="GeneID:386659"
                     /db_xref="ZFIN:ZDB-GENE-031107-1"
     CDS             1..3252
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="triple homeobox 1; zinc fingers and homeoboxes 3"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 3"
                     /protein_id="NP_942108.1"
                     /db_xref="GeneID:386659"
                     /db_xref="ZFIN:ZDB-GENE-031107-1"
                     /translation="

MASKRKSTVPCMIPVKAIHLQDDFDREIMSPQTKDIGITFTEEASAKSSQSLDQSSGQEDILKDAGFYTCRPCNFETQDLNLFLDHVYSGHTDFRMDPCFLCVSCGKSSAKFEGLALHNARVHPSTITTTLQLKKKDNRVIVEQSLCVEPCESTSSRDTEISITKTPIMKMLKSKSESKRIVVSHPATDEPSPSISKVVEKKDPPAVTVTHVPTIVHNGAATKVSLPSAIQIVNGSGALPMLKTAMTQVVSVVQNRSLSQQSAPITLSSSHSSSGSLTSTKNLPKVMIPLSSIPTYNASMDNSSFLKTSFSKFPYPTKAELCYLTVVTKYPEEQIKIWFTAQRLKQGISWSPEEIEEARRKMFNTIIQAAPSNGQQQRQAHHTPAQSTITVLGTTGIPHILQGSLVGQGGVIVTQPMMANGIQVSSAPVTLAVTPKPQAAAKPLMQARPAAALVADKGISMVLGSVGSSSSGNCSSSSSSSNASTSSSLSSVSSTSNLCNQTSVISIGESSTAKSNGNSNVRVSATGTNGTCVQSSGNVVKSEDKVSSESKSTSKSSVPAASTTPPTTLASTTSTDTPVPCKSDSPSPASTNSRVVSNSNFLDPGFNKTKKSQEQLSALKESFLISQFPNQEEVDRLINLTGLSVREVRKWFSDRRYHFRNLKGSRSSGGGQTVTTSGSISQLDTVAAVDLSENGSPPERPKTPQQSPLSPTQTSSPPTPTRRPPRPPSPDFTAIRYKEREPHQVRALEASFTQEPDPTSEEVDRLRAETKMTRREIHGWFAERRRRVAAEKKKEEAEKAEREDDDYVGEEEETGVKKEGISNEETHEAEDSSVETQGEDEKLKDETGNEPKVNPIKINLKMLKVTESSGKGEPEGSQPVEASKVPQTPVPQTSQYRGKKTPEQLHLLKQVFARTHWPSSPQYNELITKTGLPRPEVVRWFGDCRYVLKNGQLKWLESYQTMVDEEDFQKANISVLQEHLDTHGKLDETKLEEIAKSSGFGEESIRRWFAKTPLLSEKRNSENTASEATGSSATPTEAASGSQHAEHEDVKVEESGSSTVSKDHTVDISNAEGDYISAIFTFK"

     misc_feature    286..444
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="Zinc-fingers and homeoboxes C2H2 finger domain;
                     Region: zf_C2H2_ZHX; pfam18387"
                     /db_xref="CDD:465737"
     misc_feature    895..1038
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    1819..1980
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    order(1822..1827,1831..1833,1882..1884,1900..1902,
                     1939..1941,1945..1950,1957..1962,1966..1974,1978..1983)
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1828..1830,1948..1950,1957..1962,1969..1971)
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    2224..2361
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    2683..2856
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(2683..2694,2698..2700,2749..2751,2767..2769,
                     2806..2808,2812..2817,2824..2829,2833..2841,2845..2850)
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(2686..2688,2695..2697,2815..2817,2824..2829,
                     2836..2838)
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            1..3252
                     /gene="zhx3b"
                     /gene_synonym="tix1; zgc:110489; zhx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atggctagcaagaggaagtccactgttccatgcatgatacctgtaaaagcaattcatctgcaggatgactttgatcgtgaaatcatgtcccctcagactaaggacatagggattaccttcacagaggaagcaagtgcaaaaagcagtcaaagtttggaccagtcctctgggcaagaagatatccttaaagatgctggattttacacttgtagaccatgtaactttgagacccaggatcttaatcttttccttgatcatgtctacagtgggcacacagatttccgtatggacccctgttttctttgtgtgagctgtggaaaaagttctgcaaaatttgagggcttggcactgcacaatgcccgtgtccatcccagtacaataactaccacacttcaacttaaaaagaaggacaacagggtcattgtggagcagagtctttgtgttgaaccttgtgaaagcactagctcaagagatactgaaatttccatcacgaagacaccaatcatgaaaatgctgaagagtaaatccgaatccaaaaggattgtggtttctcatcctgctactgatgagccttccccctctatttctaaagtcgtggagaaaaaggaccctcctgctgtaacagtcacccatgtgcccactattgtacacaatggggcagccaccaaagtttccctgccatcagccatacagattgttaatggctctggggctttacccatgctgaagacagcaatgacacaagttgtatctgttgtgcagaacagaagtctcagccagcaatctgctccaatcactctctcttcatcccactcctcttcaggctccctcacaagtactaaaaatcttcccaaagtgatgatccccctaagcagcattcctacctacaatgcatccatggacaacagcagtttcttaaagacatcttttagcaagttcccttatccaaccaaggctgaactttgctaccttactgtagttaccaagtacccagaggagcagatcaagatctggttcacagcacaaaggctgaaacaaggaatcagctggtctccagaggaaatagaagaggcccgaagaaaaatgttcaacacaattatacaggcagcaccttccaatggccagcagcaacggcaggcccaccatactcctgctcagtctactatcacagttcttggcacgactggcatcccacacatcttacaaggtagcctggttgggcaaggaggagtcatagtcacccagcccatgatggcaaatggtattcaggtcagcagtgccccagttaccctagcggttacacccaaaccccaggctgctgcaaagcctttaatgcaggccagacctgctgcagccctggtagctgataaaggaatcagcatggttttgggctctgttggtagcagtagtagtggaaattgcagcagcagcagtagcagcagcaatgctagtactagcagcagtttaagcagtgttagtagtactagcaacctgtgcaaccagactagtgtaatcagtattggtgaaagcagcactgctaagtcaaatggcaacagcaatgtaagggtcagtgcaacgggtaccaatggcacttgtgttcaaagcagtggtaatgttgtgaaaagtgaagataaagtcagttctgagtctaaaagcaccagcaagagcagtgttccagctgccagtaccactccacccacaaccttagcatctacaacctcaacagacaccccagtaccatgtaaatcagactccccaagtcctgcctctacgaactctcgtgttgtctctaacagtaactttttggaccccggctttaacaaaaccaaaaagtcccaggaacaactgtcagccttaaaggagagcttccttataagccaatttcccaaccaagaggaagtggacagacttataaacctaactggtctatctgtgcgtgaagtacggaagtggttcagtgaccgccgctaccacttcaggaatctgaaaggttcaaggtcgagtggtggcggtcagactgttacaacaagtggtagcatctcccaacttgatacggttgctgctgtagacctatcagaaaacggttcacccccagagcggcccaaaactccacagcagtcacctcttagtcccacacagacatcatcaccgccaactccaacacgtcgtcctccacgacccccttcaccagattttacggctatacgctacaaagagcgagagcctcaccaggttcgagctttagaggcaagctttacacaagagccagatccaactagtgaagaagttgaccggttaagagcagaaacaaagatgacccgacgtgagatccatggttggtttgctgagcggcgaaggagggtagcagcagagaagaagaaagaggaagctgagaaggcggaaagagaagatgatgattatgtgggagaggaagaggagactggggtaaaaaaggaaggaataagcaatgaggaaacacatgaagctgaagattcctcagtagagacacaaggtgaagacgagaaactgaaggatgaaaccggtaatgagccaaaggttaatcctatcaaaatcaatctcaaaatgcttaaggttactgaatccagtggaaaaggtgaaccagagggaagtcaaccggttgaggctagcaaggtgccacagacacctgttccacagacctctcaataccgaggtaagaaaacaccagaacagctccacctgctgaaacaagtctttgcacgcacccactggcctagtagtccacagtacaacgaactgataactaaaacaggtctacctaggccagaggtagtacgttggtttggagattgccgctatgtcctgaagaatggtcaactgaagtggcttgagagttaccagaccatggtagacgaggaagactttcagaaagctaacataagtgtcctacaggagcacctagacacgcatgggaaactcgatgagactaagttggaagagatagccaagtcaagtggattcggtgaggaatctatacggcgatggtttgcgaagacaccacttttatcggagaaaagaaactctgagaacacggcaagtgaagcgacggggtcatctgcaactccaactgaagctgcttcaggatcacagcatgcagagcatgaagatgtaaaggtggaggagtcggggagcagcacagtctcaaaggatcacacagttgacatatcaaatgctgaaggtgattacatttctgccatttttaccttcaaataa

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