LOCUS       NM_183074               1044 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio ventrally expressed dharma/bozozok antagonist (ved),
            mRNA.
ACCESSION   NM_183074
VERSION     NM_183074.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1044)
  AUTHORS   Greenfeld H, Lin J and Mullins MC.
  TITLE     The BMP signaling gradient is interpreted through concentration
            thresholds in dorsal-ventral axial patterning
  JOURNAL   PLoS Biol 19 (1), e3001059 (2021)
   PUBMED   33481775
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1044)
  AUTHORS   Rogers KW, ElGamacy M, Jordan BM and Muller P.
  TITLE     Optogenetic investigation of BMP target gene expression diversity
  JOURNAL   Elife 9, e58641 (2020)
   PUBMED   33174840
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1044)
  AUTHORS   Ye D, Wang X, Wei C, He M, Wang H, Wang Y, Zhu Z and Sun Y.
  TITLE     Marcksb plays a key role in the secretory pathway of zebrafish
            Bmp2b
  JOURNAL   PLoS Genet 15 (9), e1008306 (2019)
   PUBMED   31545789
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1044)
  AUTHORS   Prummel KD, Hess C, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova
            I, Racioppi C, Brombacher EC, Czarkwiani A, Knapp D, Burger S,
            Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L,
            Kozmik Z, Muller P, Bronner M, Krumlauf R and Mosimann C.
  TITLE     A conserved regulatory program initiates lateral plate mesoderm
            emergence across chordates
  JOURNAL   Nat Commun 10 (1), 3857 (2019)
   PUBMED   31451684
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1044)
  AUTHORS   Dasgupta,S., Cheng,V., Vliet,S.M.F., Mitchell,C.A. and Volz,D.C.
  TITLE     Tris(1,3-dichloro-2-propyl) Phosphate Exposure During the
            Early-Blastula Stage Alters the Normal Trajectory of Zebrafish
            Embryogenesis
  JOURNAL   Environ Sci Technol 52 (18), 10820-10828 (2018)
   PUBMED   30157643
REFERENCE   6  (bases 1 to 1044)
  AUTHORS   Ramel MC, Buckles GR, Baker KD and Lekven AC.
  TITLE     WNT8 and BMP2B co-regulate non-axial mesoderm patterning during
            zebrafish gastrulation
  JOURNAL   Dev Biol 287 (2), 237-248 (2005)
   PUBMED   16216234
REFERENCE   7  (bases 1 to 1044)
  AUTHORS   Shimizu T, Bae YK, Muraoka O and Hibi M.
  TITLE     Interaction of Wnt and caudal-related genes in zebrafish posterior
            body formation
  JOURNAL   Dev Biol 279 (1), 125-141 (2005)
   PUBMED   15708563
REFERENCE   8  (bases 1 to 1044)
  AUTHORS   Gilardelli CN, Pozzoli O, Sordino P, Matassi G and Cotelli F.
  TITLE     Functional and hierarchical interactions among zebrafish vox/vent
            homeobox genes
  JOURNAL   Dev Dyn 230 (3), 494-508 (2004)
   PUBMED   15188434
REFERENCE   9  (bases 1 to 1044)
  AUTHORS   Furthauer M, Van Celst J, Thisse C and Thisse B.
  TITLE     Fgf signalling controls the dorsoventral patterning of the
            zebrafish embryo
  JOURNAL   Development 131 (12), 2853-2864 (2004)
   PUBMED   15151985
REFERENCE   10 (bases 1 to 1044)
  AUTHORS   Shimizu T, Yamanaka Y, Nojima H, Yabe T, Hibi M and Hirano T.
  TITLE     A novel repressor-type homeobox gene, ved, is involved in
            dharma/bozozok-mediated dorsal organizer formation in zebrafish
  JOURNAL   Mech Dev 118 (1-2), 125-138 (2002)
   PUBMED   12351176
  REMARK    GeneRIF: ved functions redundantly with vox/vega1 and vent/vega2 to
            restrict the organizer domain in zebrafish
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB082517.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB082517.1, CF269265.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA4476734,
                                           SAMEA4476747 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1044
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..1044
                     /gene="ved"
                     /gene_synonym="cb675"
                     /note="ventrally expressed dharma/bozozok antagonist"
                     /db_xref="GeneID:368201"
                     /db_xref="ZFIN:ZDB-GENE-030813-1"
     CDS             30..866
                     /gene="ved"
                     /gene_synonym="cb675"
                     /codon_start=1
                     /product="ventrally expressed dharma/bozozok antagonist"
                     /protein_id="NP_898897.1"
                     /db_xref="GeneID:368201"
                     /db_xref="ZFIN:ZDB-GENE-030813-1"
                     /translation="

MKGQFSIEWLSQSSSSVRDEQQTSSTSTDSLPGSYSRWTSPHMEKHMEEKYTEEKYLQEKSMEKFMHEKYTEEKHMPEKYTEGKRIQKHTHESGFSSSTEDEELSGCESEGSRSEGSGSRSPAAPGSVAPASGSGSPSSGRRPRTAFSSEQISSLERVFKRNAYLGAQDKAELCRTLKLTDKQIRNWFQNRRMKLKRTVQDSLAQACQVKVASHMMHYSDLHSFRAAPYPSFYPETPAAFAPPYPISPAAESLYYSSYQNLQGVPSIPVHPYQYYSTH"

     misc_feature    462..620
                     /gene="ved"
                     /gene_synonym="cb675"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
ORIGIN      

gacacacacacacacaggacagctccagcatgaagggtcagttctccatcgagtggctttctcagagcagctcatcggtcagagacgaacagcagacatccagcaccagcacagacagcctgccaggctcctacagccgctggaccagcccgcacatggagaaacatatggaggagaaatatacagaggagaaatacctgcaggagaaaagcatggagaaattcatgcatgaaaaatatacagaggagaaacacatgccggagaaatacacggaggggaaacgcatccagaaacacacacacgagtctggcttcagcagcagcacagaagatgaggagttgtcaggctgtgagagtgaaggctcccgcagtgaaggctccggctctcggtcccctgcagctcctggatctgtggctccggcttcaggctccgggtctccctctagtggccggcggccgcgcaccgctttcagcagcgagcagatcagcagtctggagcgagtctttaagaggaacgcgtatctgggggcgcaggacaaggcggagctctgcagaacactcaaactcaccgacaaacagatcagaaactggttccagaaccggcgcatgaagctaaagcggacggttcaggacagtctggctcaggcctgtcaggtgaaggtggcgtctcacatgatgcattattcagatctgcacagtttcagagccgctccgtatcccagtttctacccggagactccagcagcgttcgcacccccgtatcccatcagccccgcagcagagagcctgtattacagcagctaccagaacctccagggcgtcccgagcatccctgtacatccctaccagtattacagcacacactgacggatgacacacagcgggacggtgtgcaatattgatagtaacagcacaggactggctttattgtgctgaggaattatttaaagatgtaaatctggagggaacagaagctctattttcctgcaggagtggattaataaagtgctttctattttgactacaaaaaaaaaaaaaaaaaaaa

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