LOCUS       NM_170766               2281 bp    mRNA    linear   VRT 13-MAR-2024
DEFINITION  Danio rerio T cell leukemia homeobox 3b (tlx3b), mRNA.
ACCESSION   NM_170766
VERSION     NM_170766.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2281)
  AUTHORS   England,S.J., Rusnock,A.K., Mujcic,A., Kowalchuk,A., de Jager,S.,
            Hilinski,W.C., Juarez-Morales,J.L., Smith,M.E., Grieb,G.,
            Banerjee,S. and Lewis,K.E.
  TITLE     Molecular analyses of zebrafish V0v spinal interneurons and
            identification of transcriptional regulators downstream of Evx1 and
            Evx2 in these cells
  JOURNAL   Neural Dev 18 (1), 8 (2023)
   PUBMED   38017520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2281)
  AUTHORS   Schwarzer,S., Spiess,S., Brand,M. and Hans,S.
  TITLE     Dlx3b/4b is required for early-born but not later-forming sensory
            hair cells during zebrafish inner ear development
  JOURNAL   Biol Open 6 (9), 1270-1278 (2017)
   PUBMED   28751305
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2281)
  AUTHORS   Takeuchi,M., Yamaguchi,S., Sakakibara,Y., Hayashi,T., Matsuda,K.,
            Hara,Y., Tanegashima,C., Shimizu,T., Kuraku,S. and Hibi,M.
  TITLE     Gene expression profiling of granule cells and Purkinje cells in
            the zebrafish cerebellum
  JOURNAL   J Comp Neurol 525 (7), 1558-1585 (2017)
   PUBMED   27615194
  REMARK    Erratum:[J Comp Neurol. 2021 Aug 1;529(11):3127. PMID: 34050936]
REFERENCE   4  (bases 1 to 2281)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2281)
  AUTHORS   Aoki,M., Segawa,H., Naito,M. and Okamoto,H.
  TITLE     Identification of possible downstream genes required for the
            extension of peripheral axons in primary sensory neurons
  JOURNAL   Biochem Biophys Res Commun 445 (2), 357-362 (2014)
   PUBMED   24513284
REFERENCE   6  (bases 1 to 2281)
  AUTHORS   Wotton,K.R., Weierud,F.K., Dietrich,S. and Lewis,K.E.
  TITLE     Comparative genomics of Lbx loci reveals conservation of identical
            Lbx ohnologs in bony vertebrates
  JOURNAL   BMC Evol Biol 8, 171 (2008)
   PUBMED   18541024
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2281)
  AUTHORS   Chen,J., Jette,C., Kanki,J.P., Aster,J.C., Look,A.T. and
            Griffin,J.D.
  TITLE     NOTCH1-induced T-cell leukemia in transgenic zebrafish
  JOURNAL   Leukemia 21 (3), 462-471 (2007)
   PUBMED   17252014
REFERENCE   8  (bases 1 to 2281)
  AUTHORS   Takamiya,M. and Campos-Ortega,J.A.
  TITLE     Hedgehog signalling controls zebrafish neural keel morphogenesis
            via its level-dependent effects on neurogenesis
  JOURNAL   Dev Dyn 235 (4), 978-997 (2006)
   PUBMED   16502420
REFERENCE   9  (bases 1 to 2281)
  AUTHORS   Langenau,D.M., Feng,H., Berghmans,S., Kanki,J.P., Kutok,J.L. and
            Look,A.T.
  TITLE     Cre/lox-regulated transgenic zebrafish model with conditional
            myc-induced T cell acute lymphoblastic leukemia
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 6068-6073 (2005)
   PUBMED   15827121
REFERENCE   10 (bases 1 to 2281)
  AUTHORS   Nguyen,V.H., Trout,J., Connors,S.A., Andermann,P., Weinberg,E. and
            Mullins,M.C.
  TITLE     Dorsal and intermediate neuronal cell types of the spinal cord are
            established by a BMP signaling pathway
  JOURNAL   Development 127 (6), 1209-1220 (2000)
   PUBMED   10683174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005027.13.
            
            On Aug 2, 2023 this sequence version replaced NM_170766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF398519.1, BC162334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA898401, SAMEA898403
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               BX005027.13        145148-145663
            517-754             BX005027.13        147763-148000
            755-2281            BX005027.13        149468-150994
FEATURES             Location/Qualifiers
     source          1..2281
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..2281
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /note="T cell leukemia homeobox 3b"
                     /db_xref="GeneID:266965"
                     /db_xref="ZFIN:ZDB-GENE-021021-1"
     exon            1..516
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..968
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /note="tlx3"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 3b"
                     /protein_id="NP_739572.2"
                     /db_xref="GeneID:266965"
                     /db_xref="ZFIN:ZDB-GENE-021021-1"
                     /translation="

MDRAPSSSPSGTSQTSQPTQHEPISFGIDQILSGTDQESQQNSTRNSSESSSGSSSASGGCYHLGSPTGASATPYTTLTGTFHGIAAPYEESSPYGMNLTLAPGGVIRVPAHRPLAAAVPPPMASAVPGLGSLSFPWMESSQRFAKDRFAAALTPFTVARRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKTLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMIQLQHDAFQKSLTDSVPTDPLCIHNSSLFALQNLQPWASEESSKLGGVTALV"

     misc_feature    588..758
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            517..754
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /inference="alignment:Splign:2.1.0"
     exon            755..2281
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcaaatccaggactgttcgaaattgtctgtggaataaaaccgctggaaaggttcgggtggtgaggatggaccgagctccaagctccagcccaagtggcaccagtcaaacatcacaaccaacccaacatgaacccatcagcttcggcattgaccagattctcagcggaaccgatcaagaatcacagcagaactcgaccaggaatagttcggagagcagcagtggcagtagcagtgcgagcggaggctgttaccatctcggcagcccaacgggagcgagcgcaacgccgtacacgacgcttaccggcacatttcatggtatcgcggctccttatgaggagtccagtccatacggaatgaacttgacccttgcgcccggaggagtgattagggtcccggcgcacaggccccttgccgcggccgttcctccacctatggccagcgcggtacccggacttgggagcctcagttttccctggatggagagcagccagcgctttgcaaaagacaggtttgcagcagccttgacgccttttactgtggctcgacgtattggtcacccgtaccagaaccgcacaccaccaaagagaaagaagcctcgcacgtccttctccagagtgcagatctgtgagctggagaagcgctttcacagacaaaaatacctggccagcgctgaacgggcagctttggccaaaactctaaagatgacagacgcacaggtcaaaacatggtttcagaaccgcaggactaaatggagacggcaaacggcggaggaaagggaagcagagcgtcagcaggccaaccggctaatgattcagcttcagcatgatgccttccagaaatctttgactgattcagttccaacagatccgctctgcatccacaactcatccctgtttgccctgcagaacctacagccttgggctagtgaagagagcagcaagcttggaggagtgacggcgctcgtatgagtatcgcaactcaaaggaaaagacattctttgttttgatggactaggatgttggttgactttatccccatcccaaatgactatttcattcaaccacaaaaaaggcgaggaactaatttcggcagtctacaaatgagcaaacccatataaataaaaaggcctttccaaaataaatgaaggccgttttctgtggtgtgtctgtgagtacagagacttttatccccatcagggtcaatttcattgacaaactgacccaaaggaaggacagggcatctcagctgacccttttacagagctactaatctcctcttccatcctttcatttgcccttctgccctaaacccccccctcccccctgtgtaatttctccaccactcagagctgtgcaatacaggattaatgcagaagagggaagtaacaatgaattaattatttataatgcaagttgcacgacctaaaatgcccccaatatgtccatgtaagaaaaaaaggacaaaaaagtatttttaaagagtagtacagtcttcaacacatataatttcatttctttctcaagttgggtataatagcaaaatgtatcatttcagattttaacccacacaaaaataattcagagttggtttaaatccaatttgcattaaatatggacaaactttacatttgaattattattaatatttatttaatcattattttaagtttttttttttttttaccttttattgggataggatagtggaggacagacaggaaaacattgggagcagagagaagggaagggtcggcataggacctcgagccaggaatcgaacttgggtcgccatgagccctatggtgctatatgtcatcgctcttaaccactaggctattggcgcagaccattttaattatttttcaattaacgttttaattcagtggttaggtttgtcaatattttcacccaaattcttgagtgaaggaacaataacactctcctatttgtgtttttatttatatttatgaaacggcatcccaacaatttgaggaataggatgaagtgtcctgaagaaaggggtaattttgtattttgcagtggttgcaattttcatcacccgcgtttcattcagtagtatcttcaaatgcagctcaaaaactttttcgaaacagtccagtggctgagcgttgtgtgtcagtgggaaatgaacaatttaaagggtttgtgagatgaccctgtgatgtaggtgtgctgttgcatcccaaaatctgtattatactttgtatttgataaatatgtaaatagcaaacaaaaaggaataaacattgttttggcattaa

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