LOCUS       NM_131762               1882 bp    mRNA    linear   VRT 30-APR-2023
DEFINITION  Danio rerio claudin a (cldna), mRNA.
ACCESSION   NM_131762
VERSION     NM_131762.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Rostam N, Goloborodko A, Riemer S, Hertel A, Riedel D, Vorbruggen G
            and Dosch R.
  TITLE     The germ plasm is anchored at the cleavage furrows through
            interaction with tight junctions in the early zebrafish embryo
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35735123
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Hou Y, Lee HJ, Chen Y, Ge J, Osman FOI, McAdow AR, Mokalled MH,
            Johnson SL, Zhao G and Wang T.
  TITLE     Cellular diversity of the regenerating caudal fin
  JOURNAL   Sci Adv 6 (33), eaba2084 (2020)
   PUBMED   32851162
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Conant GC.
  TITLE     The lasting after-effects of an ancient polyploidy on the genomes
            of teleosts
  JOURNAL   PLoS One 15 (4), e0231356 (2020)
   PUBMED   32298330
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Mathiyalagan N, Miles LB, Anderson PJ, Wilanowski T, Grills BL,
            McDonald SJ, Keightley MC, Charzynska A, Dabrowski M and Dworkin S.
  TITLE     Meta-Analysis of Grainyhead-Like Dependent Transcriptional
            Networks: A Roadmap for Identifying Novel Conserved Genetic
            Pathways
  JOURNAL   Genes (Basel) 10 (11), 876 (2019)
   PUBMED   31683705
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Kim SS, Lee JA and Yeo MK.
  TITLE     Reduction in Toxicity of Nano-Ag-Polyvinyl-pyrrolidone Using Hydra
            Proteins and Peptides during Zebrafish Embryogenesis
  JOURNAL   Nanomaterials (Basel) 9 (9), 1210 (2019)
   PUBMED   31462001
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1882)
  AUTHORS   Schlueter PJ, Royer T, Farah MH, Laser B, Chan SJ, Steiner DF and
            Duan C.
  TITLE     Gene duplication and functional divergence of the zebrafish
            insulin-like growth factor 1 receptors
  JOURNAL   FASEB J 20 (8), 1230-1232 (2006)
   PUBMED   16705083
REFERENCE   7  (bases 1 to 1882)
  AUTHORS   Li Y, Xiang J and Duan C.
  TITLE     Insulin-like growth factor-binding protein-3 plays an important
            role in regulating pharyngeal skeleton and inner ear formation and
            differentiation
  JOURNAL   J Biol Chem 280 (5), 3613-3620 (2005)
   PUBMED   15550380
REFERENCE   8  (bases 1 to 1882)
  AUTHORS   Mackereth MD, Kwak SJ, Fritz A and Riley BB.
  TITLE     Zebrafish pax8 is required for otic placode induction and plays a
            redundant role with Pax2 genes in the maintenance of the otic
            placode
  JOURNAL   Development 132 (2), 371-382 (2005)
   PUBMED   15604103
REFERENCE   9  (bases 1 to 1882)
  AUTHORS   Hans S, Liu D and Westerfield M.
  TITLE     Pax8 and Pax2a function synergistically in otic specification,
            downstream of the Foxi1 and Dlx3b transcription factors
  JOURNAL   Development 131 (20), 5091-5102 (2004)
   PUBMED   15459102
REFERENCE   10 (bases 1 to 1882)
  AUTHORS   Loh YH, Christoffels A, Brenner S, Hunziker W and Venkatesh B.
  TITLE     Extensive expansion of the claudin gene family in the teleost fish,
            Fugu rubripes
  JOURNAL   Genome Res 14 (7), 1248-1257 (2004)
   PUBMED   15197168
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF359423.1.
            
            On Oct 7, 2002 this sequence version replaced NM_131762.1.
            
            Summary: This gene encodes a member of the claudin family. As the
            major transmembrane proteins of tight junctions, claudins mediate
            cellular adhesion and migration. Claudins are also thought to play
            a role in morphogenesis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF359423.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="15"
                     /map="15"
     gene            1..1882
                     /gene="cldna"
                     /gene_synonym="cldn30a; fb99d09; wu:fb99d09"
                     /note="claudin a"
                     /db_xref="GeneID:81580"
                     /db_xref="ZFIN:ZDB-GENE-010328-1"
     exon            1..1851
                     /gene="cldna"
                     /gene_synonym="cldn30a; fb99d09; wu:fb99d09"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    31..33
                     /gene="cldna"
                     /gene_synonym="cldn30a; fb99d09; wu:fb99d09"
                     /note="upstream in-frame stop codon"
     CDS             55..675
                     /gene="cldna"
                     /gene_synonym="cldn30a; fb99d09; wu:fb99d09"
                     /codon_start=1
                     /product="claudin a"
                     /protein_id="NP_571837.2"
                     /db_xref="GeneID:81580"
                     /db_xref="ZFIN:ZDB-GENE-010328-1"
                     /translation="

MVSAGLQMVGIALAVIGWIGVIVVCILPMWQVTAFIGQNIVTAQVTWEGIWMSCVVQSTGQMQCKVYDSMLALSSDLQAARALCIISILVGVVGILLAAAGGKCTTCIKEERAKAKVCVISGAIFIVAGVLCLIPVCWTANNIIRDFYNPMTNSAQKRELGASLFIGWGASALLIIGGSLLCANCPPQDQYKATYTARSGGTKGYV"

     misc_feature    67..597
                     /gene="cldna"
                     /gene_synonym="cldn30a; fb99d09; wu:fb99d09"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="cldna"
                     /gene_synonym="cldn30a; fb99d09; wu:fb99d09"
     polyA_site      1850
                     /gene="cldna"
                     /gene_synonym="cldn30a; fb99d09; wu:fb99d09"
ORIGIN      

ctctacagaccaacgaatatttttgctgtctaatacacctgcaattgttccaccatggtatcagcagggctgcagatggtgggtatagccctggcagtgattggctggattggggttatagtggtttgcattctccccatgtggcaagtcactgcttttatcggacagaatatcgtcacggcgcaggttacctgggaaggaatttggatgagttgcgtggtgcagagcaccggacagatgcagtgtaaagtctacgactccatgttggctctgagctcagatcttcaagccgctcgagctttgtgtatcatctccatcctagtcggtgttgttggaatcctcctcgcggcggcgggaggaaaatgcaccacctgcattaaagaagaacgtgccaaggctaaagtctgcgttatttctggagccatcttcatcgtggctggagttctgtgcttgattcctgtttgctggactgccaataatattatacgcgatttctacaaccctatgaccaacagcgcgcaaaagagggaactgggagcgtcgttgtttattggctggggggcttcggcgctgttgattattggcgggtcgttgctttgtgctaattgccctccacaagaccagtacaaggcaacgtacaccgctcgatctggaggaaccaaggggtatgtctgaggaaccaaaagtactacattcaaggaggatattgggttttttatgtgtattggatgctggacagcttttgaggtggtgttgttgttgactatgatcgtgaccgttattttatttaaaataacggtcgacatattcaaaaactgacggttgttgtttgttcatgctacttaaaatgagctaaaacaagtggagccaacttaattgtttgatgttcaatccacttaaatgtgtaaaaactattaagtgatcttaattcattcattcaacttgttaaaatcaaatctaatcgttttttttttacagtgtatgaggcattgtgaaatacaatgaacatgtcagggtgcctgctttgaatggaataagtgttcaataagtgttttaaattgtaaatatagtttgttttacttggtatttactgttcttcaagtggtcttgtgagtttcttttttctcctcatctcaatattttgtggaatgttttaaaacgcaactaggcatgggacgataaaggttttcaaggtataccgcggtttggaaaagtcaaggttttaaaacaattttttaaacaataaattaaatacatttttaataatttttaataatgttttttatttaccttttttaggacaacagcagaaaagatatccaaagatgccatttttaattgtaaaaaaaatcatttttttaaataaatcaagacagcagatgtaaacaatcatttattttaaggatttatcctgaaatgtttactatttcaaaatatttcaaatgtttcttaaactaaaatatattgtgttgaaaagtgaaaaatgtgttttttacccaggcatttaaaaagaatatttttagagcagtaatcacaataagctttagtccaaggttatcatattgccagaatcttataccagcccatgcctacctgtaaccactgacatccacagtaggaaaaacaaatactatggaagtcaatggttactagtttccagcattctttaaaatatcttcctttgtgttcaactgaaggaagaaactcatgttaagtgatcaagtaggctacatgatgacaggattttcatttttgagtgaattgtttcttcaatttttcttgtttttactgagaatctcttcagaagtgctgaaactgtacatgattttttattaaagttatctttgatcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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