LOCUS       NM_131560               1867 bp    mRNA    linear   VRT 16-OCT-2021
DEFINITION  Danio rerio mix-type homeobox gene 1 (mxtx1), mRNA.
ACCESSION   NM_131560 XM_001923892
VERSION     NM_131560.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Dogra D, Ahuja S, Kim HT, Rasouli SJ, Stainier DYR and Reischauer
            S.
  TITLE     Opposite effects of Activin type 2 receptor ligands on
            cardiomyocyte proliferation during development and repair
  JOURNAL   Nat Commun 8 (1), 1902 (2017)
   PUBMED   29196619
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1867)
  AUTHORS   Nakayama Y, Inomata C, Yuikawa T, Tsuda S and Yamasu K.
  TITLE     Comprehensive analysis of target genes in zebrafish embryos reveals
            gbx2 involvement in neurogenesis
  JOURNAL   Dev Biol 430 (1), 237-248 (2017)
   PUBMED   28756106
REFERENCE   3  (bases 1 to 1867)
  AUTHORS   Lee MT, Bonneau AR, Takacs CM, Bazzini AA, DiVito KR, Fleming ES
            and Giraldez AJ.
  TITLE     Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the
            maternal-to-zygotic transition
  JOURNAL   Nature 503 (7476), 360-364 (2013)
   PUBMED   24056933
REFERENCE   4  (bases 1 to 1867)
  AUTHORS   Chu LT, Fong SH, Kondrychyn I, Loh SL, Ye Z and Korzh V.
  TITLE     Yolk syncytial layer formation is a failure of cytokinesis mediated
            by Rock1 function in the early zebrafish embryo
  JOURNAL   Biol Open 1 (8), 747-753 (2012)
   PUBMED   23213468
REFERENCE   5  (bases 1 to 1867)
  AUTHORS   Pereira LA, Wong MS, Mei Lim S, Stanley EG and Elefanty AG.
  TITLE     The Mix family of homeobox genes--key regulators of mesendoderm
            formation during vertebrate development
  JOURNAL   Dev Biol 367 (2), 163-177 (2012)
   PUBMED   22580160
  REMARK    Review article
REFERENCE   6  (bases 1 to 1867)
  AUTHORS   Hong SK, Levin CS, Brown JL, Wan H, Sherman BT, Huang da W,
            Lempicki RA and Feldman B.
  TITLE     Pre-gastrula expression of zebrafish extraembryonic genes
  JOURNAL   BMC Dev Biol 10, 42 (2010)
   PUBMED   20423468
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1867)
  AUTHORS   Arrington CB and Yost HJ.
  TITLE     Extra-embryonic syndecan 2 regulates organ primordia migration and
            fibrillogenesis throughout the zebrafish embryo
  JOURNAL   Development 136 (18), 3143-3152 (2009)
   PUBMED   19700618
REFERENCE   8  (bases 1 to 1867)
  AUTHORS   Sakaguchi T, Kikuchi Y, Kuroiwa A, Takeda H and Stainier DY.
  TITLE     The yolk syncytial layer regulates myocardial migration by
            influencing extracellular matrix assembly in zebrafish
  JOURNAL   Development 133 (20), 4063-4072 (2006)
   PUBMED   17008449
  REMARK    GeneRIF: Mtx1 in the extra-embryonic yolk syncytial layer appears
            to regulate the embryonic expression of fibronectin, a gene
            previously implicated in myocardial migration.
REFERENCE   9  (bases 1 to 1867)
  AUTHORS   Hirata T, Yamanaka Y, Ryu SL, Shimizu T, Yabe T, Hibi M and Hirano
            T.
  TITLE     Novel mix-family homeobox genes in zebrafish and their differential
            regulation
  JOURNAL   Biochem Biophys Res Commun 271 (3), 603-609 (2000)
   PUBMED   10814508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT573233.10.
            
            On or before Jun 5, 2009 this sequence version replaced
            XM_001923892.1, NM_131560.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127384.1, DV590845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA898399, SAMN02418766
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                CT573233.10        144373-144465
            94-278              CT573233.10        144601-144785
            279-1867            CT573233.10        146275-147863
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="13"
                     /map="13"
     gene            1..1867
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /note="mix-type homeobox gene 1"
                     /db_xref="GeneID:100149566"
                     /db_xref="ZFIN:ZDB-GENE-000710-7"
     exon            1..93
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    60..62
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /note="upstream in-frame stop codon"
     CDS             72..1001
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /codon_start=1
                     /product="mix-type homeobox gene 1"
                     /protein_id="NP_571635.2"
                     /db_xref="GeneID:100149566"
                     /db_xref="ZFIN:ZDB-GENE-000710-7"
                     /translation="

MWKDSTIDATAKTSGSGAVSRSASRRKRTSFSKEHVELLRATFETDPYPGISLRESLSQTTGLPESRIQVWFQNRRARTLKCKGGKKPLWQTDLPAYNNMQTSPMQIHRKNNESSGATGTLCSPPPAYPDRIKEEMEKDAVCGCDTPSSMSISDDSGYCTPSYHQSRAIQSHMSPSPLLSPEHQMPPNWGVRYGRRSPMSSMWSPYHLEAYACNPGFFYSHSEKHNTLQPLTPVTPDSGCWEAGLDRTSPVDNPDVPRTEGQLESGVHHGPLPELPTLSLQEILGELQGDWWQGEGLNNHSTEDNHVYG"

     misc_feature    141..305
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    order(144..158,162..164,213..215,231..233,270..272,
                     276..281,288..293,297..305)
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(150..152,159..161,279..281,288..293,300..302)
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            94..278
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /inference="alignment:Splign:2.1.0"
     exon            279..1867
                     /gene="mxtx1"
                     /gene_synonym="mtx1; sb:cb779"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aaatccctgaggagcaccaagaggacagaccttcactgtcacctccaggattccaccagtgaagacgcaacatgtggaaagacagcactattgatgctactgctaaaacatctggaagtggagctgtatccagaagcgcaagtcgcaggaaaaggacaagtttctccaaggaacacgttgagcttctgcgagctacatttgaaacagacccttaccctggaatcagtctcagagagagtctttcccaaaccacaggactgccagagtctcgcatacaggtctggttccagaataggagagctcgcacgttgaaatgcaagggtggaaaaaagccattgtggcaaaccgacttgccagcctacaacaatatgcagacttcaccaatgcaaatacatcggaaaaacaatgaatccagtggagccactggaactttatgttcaccaccgcctgcatatccagatcgtataaaggaagaaatggaaaaagatgcagtatgcggatgtgacactccgtcttccatgtcaatcagcgacgattctggctattgcacaccttcataccatcaaagcagagccattcaatcccatatgagcccttctcctcttttaagcccagagcatcagatgcctcctaactggggtgtgaggtacggcaggaggtctcctatgagctccatgtggagtccatatcatctggaagcatatgcctgcaatccgggatttttttactcgcattctgaaaaacacaacactcttcaacccctgacccctgttactcctgactcgggctgctgggaggccggtttggacaggacttctcctgttgacaacccagatgttccgagaacggaaggccagctggaaagcggggtccaccatggaccgctgcctgagcttccaaccttgtcgctgcaggagatcctgggagagcttcaaggagactggtggcagggtgaaggactaaataaccactccactgaggataaccatgtgtatggctgaattttgaagggttggatttatttatgactatttattatttactgtatttaatgactaaaatcaataatgtaatatttatttgattcaaaacaacatgagagttttcaaatgttttcagactgatcaagtgtatttattctaattaatattcggtattttttaaatgttttgttggggggtaaagtgttatcatgcagctgtgtgtatatagtttatatagattttaaataaagatgccttttctcctaatgttcctttaaatgattttatacaattgttctgagtaggtatacgtttacttcatgcatggatgaggtcagtgctggaaacattgataagaatcagtctgtaggttgcgaggaatttgttgcataacacattctgtcatctacggggtgaaatgtactgtatgtgcatgatacttttattgggaatgaaaaaaaaaaataacagaactattccaaccctttgtaattttgcttttaaaaggtagtttatttctgtggtgtgtgagagcaacagtgttgaggaaagttacttctaaaagctactaaagtttcttcctctttttcttcttcttctttttcttttcttttcagattttttataaacatcacactgcagaacctttatgtaccttttgaaaaacacataaaaactattgttggataatgttatcttctgagaactttctgaccccaaagctatacatgccatatatacagattaataaaagtttaaagcaatgcaattgctacttttgtactttttgctcttattaaacagtaaaatcagtgtccattcagataatcctcttctcctttttttatgtgttcaaaataaagacaatatttctattgcaaaaa

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