2024-11-01 14:30:39, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001423197 3683 bp mRNA linear VRT 06-JUL-2023 DEFINITION Danio rerio argonaute RISC catalytic component 3a (ago3a), mRNA. ACCESSION NM_001423197 VERSION NM_001423197.1 KEYWORDS RefSeq. SOURCE Danio rerio (zebrafish) ORGANISM Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio. REFERENCE 1 (bases 1 to 3683) AUTHORS Raman R, Ryon M and Jagadeeswaran P. TITLE RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish JOURNAL Sci Rep 10 (1), 20187 (2020) PUBMED 33214638 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 3683) AUTHORS Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD and Grant SG. TITLE Evolution of complexity in the zebrafish synapse proteome JOURNAL Nat Commun 8, 14613 (2017) PUBMED 28252024 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 3683) AUTHORS Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and Hertzano R. TITLE RFX transcription factors are essential for hearing in mice JOURNAL Nat Commun 6, 8549 (2015) PUBMED 26469318 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 3683) AUTHORS McFarlane L, Svingen T, Braasch I, Koopman P, Schartl M and Wilhelm D. TITLE Expansion of the Ago gene family in the teleost clade JOURNAL Dev Genes Evol 221 (2), 95-104 (2011) PUBMED 21556854 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR762469.15, CABZ01034603.1, CABZ01034602.1, CABZ01034601.1 and CABZ01034600.1. ##Evidence-Data-START## Transcript exon combination :: JX448393.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA2168446, SAMEA2168447 [ECO:0006172] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-708 CR762469.15 14797-15504 c 709-880 CABZ01034603.1 3865-4036 c 881-1001 CABZ01034603.1 1321-1441 c 1002-1210 CABZ01034603.1 283-491 c 1211-1347 CABZ01034602.1 13900-14036 c 1348-1482 CABZ01034602.1 11070-11204 c 1483-1570 CABZ01034602.1 8445-8532 c 1571-1718 CABZ01034602.1 6277-6424 c 1719-1838 CABZ01034602.1 4551-4670 c 1839-1982 CABZ01034602.1 1862-2005 c 1983-2116 CABZ01034601.1 1048-1181 c 2117-2301 CABZ01034600.1 10659-10843 c 2302-2461 CABZ01034600.1 7143-7302 c 2462-2552 CABZ01034600.1 5560-5650 c 2553-2747 CABZ01034600.1 5137-5331 c 2748-2882 CABZ01034600.1 4924-5058 c 2883-2984 CABZ01034600.1 3348-3449 c 2985-3184 CABZ01034600.1 1466-1665 c 3185-3683 CABZ01034600.1 647-1145 c FEATURES Location/Qualifiers source 1..3683 /organism="Danio rerio" /mol_type="mRNA" /strain="Tuebingen" /db_xref="taxon:7955" /chromosome="16" /map="16" gene 1..3683 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="argonaute RISC catalytic component 3a" /db_xref="GeneID:567622" /db_xref="ZFIN:ZDB-GENE-051107-16" exon 1..708 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" misc_feature 687..689 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="upstream in-frame stop codon" CDS 690..3293 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /EC_number="3.1.26.n2" /note="eukaryotic translation initiation factor 2C, 1; argonaute 3a; eukaryotic translation initiation factor 2C, 3a" /codon_start=1 /product="protein argonaute-3" /protein_id="NP_001410126.1" /db_xref="GeneID:567622" /db_xref="ZFIN:ZDB-GENE-051107-16" /translation="
MEIGTTGAVGAQSLFSMPRRPGYGTMGKPIKLLANCFQVEIPKMDVYLYEVDIKPEKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKKSLYTANPLPVAPAGVDLDVTLPGEGGKDRPFKVSIKFVSLVSWHLLHEVLTGRSMPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYEADPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRVSTEHFMNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEVIQDLSSMVRELLIQFYKSTRYKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKEYQPGITYIVVQKRHHTRLFCADRNERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADEFQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTLRTMYFA"
misc_feature 906..1190 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:465134" misc_feature 1218..1370 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 1371..1733 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1527..1529,1572..1574,1614..1616,1626..1628, 1680..1682,1701..1703,1707..1709) /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_feature 1866..3164 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the...; Region: Piwi_ago-like; cd04657" /db_xref="CDD:240015" misc_feature order(2298..2300,2310..2312,2346..2357,2364..2366, 2388..2390,2397..2399,2409..2411,2421..2423) /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="5' RNA guide strand anchoring site [active]" /db_xref="CDD:240015" misc_feature order(2502..2504,2508..2510,2718..2720,3132..3134) /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /note="active site" /db_xref="CDD:240015" exon 709..880 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 881..1001 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 1002..1210 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 1211..1347 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 1348..1482 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 1483..1570 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 1571..1718 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 1719..1838 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 1839..1982 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 1983..2116 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 2117..2301 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 2302..2461 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 2462..2552 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 2553..2747 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 2748..2882 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 2883..2984 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 2985..3184 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" exon 3185..3683 /gene="ago3a" /gene_synonym="eif2c1; eif2c3a; sb:eu275; sb:eu416" /inference="alignment:Splign:2.1.0" ORIGIN
ccatatttagctgcagcgagtctcgcagaggctctgagtgtttgagaaagcgggcagagagagagttctgcttccaacttactttatgtgaccactggcggaaaaccacgggaatacgcgcttataaaaagccactagagccgagagcgaaattcatggcagaccggggactttaagcgaagacacgactggatttttgtttcctctcagatgggaatgtagcttagctggttagcctggccactagcagtagcaagttagctctgtcgaagagcggaggcgacataagtggacttttacttgctataacgtcataacacctctacaaaccgccctagtctttccaaagacgtgtttctgaaggcgtcgccgtcacagaaacagagactcgggactgaatttgggctgactgagaggaacttaccgttaccgttttagctagctggctagctggccgtcacgtcaatctgtcaaccgtacccgaaatcccgaccggatagtttgagtcacataccgggcaaccaaacattatctccggtgacacacgagcctcagggaaggtggactaataccgagaggaatcgcttgcggtgggttaacgcaaccggtttgtgcggccataggacagtcagagtttctgaagttcatcaactgcgagccggggacggaaccggacagagacctcatgaatggaaatcggaactacaggagccgttggggcccagtccctgttctccatgccacggaggcccggctatggcaccatggggaaacctatcaaactgctggccaactgcttccaggtggagatcccaaagatggacgtctacctgtacgaggtggacatcaagcccgagaagtgtccacggagagtaaatagggaggtggtggactccatggtgcagcactttaaagtcaccatctttggggatcgaaggccagtttatgatgggaagaaaagtctctacaccgccaacccacttcctgtggcacctgcaggggtggatctggatgtcacgctgccaggtgaagggggcaaagaccggccctttaaagtctcaattaagtttgtgtctctggtgagctggcacctgctgcacgaggtgctaaccgggcgcagtatgccagagccgctggaactggacaagccaatcagcaccaacccagtgcacgctgtggatgtggtgctccgccatctgccctccatgaagtacacacccgtgggccgctcatttttctccgccccggagggttatgatcatcctctaggtggaggcagagaggtgtggttcggtttccatcagtctgttcggcccgccatgtggaaaatgatgctcaacattgatgtgtcagccacggctttctacaaagcacagccagtcattcagttcatgtgtgaagtcctggacatccacaacatcgacgagcagccgcgacccctcacagactcccacagagtcaaattcaccaaagaaatcaaaggtctgaaggtggaggtgacccactgcgggaccatgcggaggaagtaccgcgtctgcaatgtgacccgccggcctgccagccaccaaacgttccctttgcagttggagaacggccaaactgtagaacggacagtagctcagtatttcagagagaagtacaacctgcagctcaagtaccctcacctgccctgtctacaggtgggacaggagcagaaacacacatacctgcctctggaggtttgcaatattgtagcagggcagcggtgcatcaagaaactgacagataatcagacgtccaccatgatcaaagccacggcgcgctccgcaccagaccgacaggaggagatcagcagactggtgcgcagcgctaactatgaagccgacccgttcgtgcaggagtttcagtttaaggtccgggatgagatggcccacgtgacggggcgcgtgttgcccgcgcccatgctgcagtacgggggcagggtgagcacagagcactttatgaaccgcactgtcgccacaccgagtcacggcgtttgggacatgagaggaaagcagtttcacaccggcgtggagatcaagatgtgggccatcgcctgcttcgccacacagaggcagtgcagagaggagatcctcaagggttttaccgaccagctgcgcaaaatctcgaaggatgctgggatgccgattcagggtcagccgtgtttctgtaagtacgctcagggggccgacagcgtggagcccatgttcagacacctgaagaacacttactctggactgcagctcatcatcgtcatcctgcctggaaaaacccccgtctacgcggaagtgaagcgtgttggagacactcttctaggaatggccactcagtgtgtgcaggtgaagaacgtggtaaaaacctccccgcagacgctctccaacctctgcctgaaaatcaacgtcaaactcggcggcatcaacaacatcctcgtgccgcatcaacggccatcagttttccagcagccagtcatctttctgggggcggacgttacacatccccctgcaggagatgggaagaaaccgtccatcgcagcggtggtgggcagtatggacgctcatcccagcaggtattgtgccactgtgcgcgtccagagaccccgtcaggaggtcattcaggatttgtcctcaatggtgcgagagttactcatccagttctacaaatccactcgctacaagcccaccagaatcatcttctacagggacggtgtttctgagggccagttcagacaggtgttgtattatgagctgctggccattcgagaggcctgtatcagtctggagaaggagtaccagcccggcatcacgtatatagtggtgcagaaacgccaccacacacgcctcttctgtgccgaccgcaacgagagggtgggtcgcagtggaaacattcctgctggtacgacggtggatacagatatcacacacccttatgagtttgacttttacctctgcagtcatgctggaatacagggcaccagcaggccctcccactatcatgtcctgtgggacgacaactgcttcactgctgatgagttccagctgctcacctaccagctgtgccacacgtatgtgcgctgcacccgctccgtctccatccccgcgccagcctactacgcccacctggtggccttccgcgcccgataccacttggtggacaaagaacacgacagtgccgagggaagccatgtctccggacagagcaacggccgggacccccaagcgctggccaaagctgtgcagattcaccacgacaccctgaggaccatgtactttgcctaagccagctcacgttcatctagtcatgcacacaaacccgacaaccacacacacacacacatgctgacaaacacacacacctcccagaatcctgtgcgtcctgaagggtcgatctctgtggcgattgaagcacggcccacccgacactgtgcagcaggacgaggaaggcctttaaggaagccgacctgctttaaaaccacacatggacctcggcgctattatgcaatattaaaccagccaactgaggccgttctgtcagatccccctccaaaaccaaaagggaagtccgtctgtatatccctcccgctccttttcctgtctatagacgtcacgttttaatcacttccccccccctgcctgtcacgccttgtacctcaacgtcttttctaacag
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@meso_cacase at
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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