LOCUS       NM_001282153            3990 bp    mRNA    linear   VRT 15-OCT-2021
DEFINITION  Danio rerio transient receptor potential cation channel, subfamily
            M, member 4b, transient receptor potential cation channel,
            subfamily M, member 4b, tandem duplicate 2 (trpm4b.2), mRNA.
ACCESSION   NM_001282153 XM_001339945
VERSION     NM_001282153.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3990)
  AUTHORS   Jeronimo R, Moraes MN, de Assis LVM, Ramos BC, Rocha T and
            Castrucci AML.
  TITLE     Thermal stress in Danio rerio: a link between temperature, light,
            thermo-TRP channels, and clock genes
  JOURNAL   J Therm Biol 68 (Pt A), 128-138 (2017)
   PUBMED   28689714
REFERENCE   2  (bases 1 to 3990)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3990)
  AUTHORS   Han B, Li W, Chen Z, Xu Q, Luo J, Shi Y, Li X, Yan X and Zhang J.
  TITLE     Variation of DNA Methylome of Zebrafish Cells under Cold Pressure
  JOURNAL   PLoS One 11 (8), e0160358 (2016)
   PUBMED   27494266
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3990)
  AUTHORS   Cheng H, Ellis J and Kleinow KM.
  TITLE     Expression and functionality of transient receptor potential
            melastatin 4 (TRPM4)-like channels during development of the
            zebrafish
  JOURNAL   Comp Biochem Physiol C Toxicol Pharmacol 178, 33-44 (2015)
   PUBMED   26432160
REFERENCE   5  (bases 1 to 3990)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3990)
  AUTHORS   Kastenhuber E, Gesemann M, Mickoleit M and Neuhauss SC.
  TITLE     Phylogenetic analysis and expression of zebrafish transient
            receptor potential melastatin family genes
  JOURNAL   Dev Dyn 242 (11), 1236-1249 (2013)
   PUBMED   23908157
REFERENCE   7  (bases 1 to 3990)
  AUTHORS   Saito S and Shingai R.
  TITLE     Evolution of thermoTRP ion channel homologs in vertebrates
  JOURNAL   Physiol Genomics 27 (3), 219-230 (2006)
   PUBMED   16926268
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from KF305310.1.
            
            On Aug 20, 2013 this sequence version replaced XM_001339945.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KF305310.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3990
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="WIK"
                     /db_xref="taxon:7955"
                     /chromosome="12"
                     /map="12"
     gene            1..3990
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 4b, transient receptor potential
                     cation channel, subfamily M, member 4b, tandem duplicate
                     2"
                     /db_xref="GeneID:799647"
                     /db_xref="ZFIN:ZDB-GENE-061214-2"
     exon            1..100
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    26..28
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /note="upstream in-frame stop codon"
     CDS             47..3715
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /note="transient receptor potential melastatin 4b1;
                     transient receptor potential cation channel, subfamily M,
                     member 4c"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 4b.2"
                     /protein_id="NP_001269082.1"
                     /db_xref="GeneID:799647"
                     /db_xref="ZFIN:ZDB-GENE-061214-2"
                     /translation="

MNEKDIEEGGVAVMPKDLSWIPTFFKKRLCTTFVEDSFSNGGLCQCGAARDHHPSVALGDNFSTAVVSQWFSTQHSSEQPTDAYGELDFNNSRKRDSYFLRLSSTTDPAKVFDLMKEHWKLQQPNLVVSVVGGEGRSEVKSWVLDILRQGLVKTAQSTGAWIITGGLRQGISRCIGEAVKDNATAVSSITLNKVLPIGIAPWGLVENRQHLVNSEGSFPAKVTTQDSCNLDNNHKAFLLVDDGTTGRKGGELAFRARLEDYISRQRPGNASIDIPVLNMLIAGDTSMLEFLEMSLKNSTPCLVLAGSGGLANLVSDIVENVQSAAMPGASEKEDASPIMELREQLAAKVKKYFPAEKKTDKLVDKVLSIYQNKDIISIYNAEQEGAEDFDIVMLKVLVQASKRNVSENTNSYADELRLAVTWNRVDIAKSELFNGHIDWKYEELKDSMTDALENNKPQFVRLLIDNGLNISTYLTYNRLEILYNSISDTCLAKTLLLHHLNERIHQSIKQIYKISLYEVSQLLTDLFGEVCLPFYKAELKLEATTKRKALKNACDVLNGSCTYRDEKCKHPWLCLFIWAVLQNRREMAIFFWEMCGESVLTALAGCKLLLELSKQEIETEAKLSMKELALKFEQMAHDVFGTCYQTKASHSYKLLIRKSKLWGDATCLKMAIAADARIFFSHDGVQSLLSQIWWGDIERGTAFWRLLLVMICPPLCYTNCIEFRKTDPAKEEKSMTAPPSSPTDSHYEKTVYSFKDIKHQNEGENEDSNHIRQNTKGEPAFIESMKSSFVVSRWKQFWYAPVTSFIGNLLMYFLFLFLYAYVLLVDFKPPPPDGPAVSEYVLYFWVFTLVCEEIREASIAGNKKFPQMLFVYAQDMWNKFDVLAISLFITGLCCRMFSWSFNMGRGILCVDYMVFTLRLIHIFAIHRQLGPKIIILGKMIKDAFFFLFFLLVWLSAYGVANQALLYQYDPSPARTFRRVLYRPYLHIFGQIPVEEIDTGRHWERDCTDNLTLINEGIEPCRDTSHNWLVVVLLVIFLLVTNILLVNLLIATFSYTFSKVQERSDTYWKFQRYNLIVEYHSRPTLAPPFIILSHINLLIKRKIRKVQSAKVQRFALKIKGQEKKELVKWENLQKENYLALEIKKQRGTDSERLKRITSKVDSVIKQVAEIRDVDRRLRAVESEMEFCTSSLQWIMETLSQSSMVKTTKAHPTRKAVTSASIEK"

     misc_feature    335..1147
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /note="SLOG in TRPM; Region: LSDAT_euk; cl39032"
                     /db_xref="CDD:476852"
     misc_feature    <2651..3598
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); Region: TRPV; cl40437"
                     /db_xref="CDD:454755"
     exon            101..162
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            163..340
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            341..521
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            522..691
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            692..848
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            849..913
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1141
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1244
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1366
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1600
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1699
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1828
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1958
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2104
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2217
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2325
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2375
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2614
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2730
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2863
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..3038
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3204
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3386
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3519
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3592
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3686
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3990
                     /gene="trpm4b.2"
                     /gene_synonym="TRPM4b1; trpm4c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aaactcacaacaaacagggaattgataagatcctaaaaccaccaccatgaacgagaaggacattgaggagggcggagtggccgtgatgccgaaagatctaagctggattccaactttcttcaagaagagattgtgcacaacgtttgtggaggactccttcagtaacggaggtctgtgtcagtgcggggcggcacgagaccatcacccatcagtggcactgggcgataacttcagcacagcagtggtcagtcagtggttcagcactcagcactcctctgaacagcccactgacgcttatggagaattggacttcaataacagtaggaaaagagacagctactttctgcgtctgtccagcaccacagatcctgccaaagtgtttgacctgatgaaggagcactggaagctgcaacagcctaacctggtggtgtcagtggtgggcggcgagggtaggtcagaggtcaagagctgggtgctggacatcctgagacaggggctggtcaaaacggcacagagtacaggagcgtggatcatcactggtggactgaggcagggtatcagccggtgtattggagaggctgtgaaagataacgccactgctgtttcctccatcacacttaataaagtgcttcctataggcatcgctccctgggggctggtggagaacagacagcacctcgtcaactcagagggaagttttcctgcaaaggtcacaacccaagactcctgcaatctggataacaaccataaggcttttcttctggtggacgacgggaccactggccgtaaaggtggagagctggcgttcagagcccgtctggaggattacatttcacgccagcgcccaggcaatgcaagcattgacattcctgttctgaacatgctgatagctggagacacgtccatgctggagtttttagagatgtctttgaagaattcaacaccgtgtttggttctggctggttcgggtggtcttgccaatctagtgagcgacattgtggagaatgttcagtctgcggcgatgcctggagcatcagagaaggaggacgccagccccatcatggagctccgagaacaactggcggcaaaagtcaagaaatattttcctgctgagaaaaaaactgacaaacttgttgacaaggttttaagcatctaccaaaacaaagacatcatctccatttataatgcagaacaggaaggagcagaagattttgacattgtgatgcttaaagtgcttgttcaagcgagtaagcgaaatgtatcagagaatactaactcctatgctgatgagttgagactggccgtaacctggaacagagtggacatcgccaagagtgaactcttcaatggacacatcgactggaagtatgaggagctgaaggattccatgactgacgccttggagaacaacaaaccccagtttgtgcgtctcctcatcgataacggcctgaatatttcgacctacttgacttacaaccgactggagatactgtacaactccatctctgacacctgcctggccaaaacactcctgctccatcatctgaatgagcgcatacaccagtccatcaagcagatctacaagatcagcctttatgaggtgtctcagctactgacagatctgtttggcgaggtctgtcttcctttctacaaggctgaactcaaactggaagcaacgaccaaaagaaaagctttaaaaaatgcatgcgatgtcttgaatgggagttgcacatatcgagatgagaagtgtaagcacccatggttgtgtctcttcatctgggcagtgctgcagaaccgcagagagatggccatcttcttctgggaaatgtgtggcgagtcggttctgacggctctggctggatgtaaactgttgttggagctctctaaacaggagatcgagaccgaggccaagctctccatgaaggagctggcgctgaagtttgagcagatggctcatgatgtgtttggcacatgctaccaaaccaaagcaagtcattcctacaagctgttgatccgcaagtcaaaactgtggggtgacgccacctgtctgaagatggccatagctgcggatgcccggatcttcttcagccatgatggagtgcagtctctgctgtctcagatctggtggggggatatagaaagaggaactgcgttctggagactcctgctggtgatgatctgtcctcctctctgctacaccaactgcattgaattcaggaaaacagatccagcaaaagaagagaaatcgatgacggcacctccatcttcaccgacagacagccattacgaaaagaccgtctactccttcaaagacatcaaacaccaaaatgaaggcgagaatgaggactcaaatcatatcagacagaacacaaaaggagaacctgcattcatcgaatcaatgaagagtagctttgtggtctcccgctggaagcagttctggtacgctcctgtcacctcattcatcggcaaccttctgatgtacttcctcttcctgtttctgtatgcctacgtgctattggtggacttcaagccgcctccccctgatggcccggcggtttcggagtatgtgctgtatttctgggtcttcactttagtgtgcgaggagattcgagaggcgtccattgcaggcaataagaagtttcctcagatgttgttcgtgtatgctcaggatatgtggaataagtttgatgttcttgccatttccctcttcattactggtttgtgctgcaggatgttcagctggtcattcaacatgggtcgtggtatactgtgtgtggactacatggtcttcactctcagactcatacacattttcgccattcacagacagctgggtcccaaaatcatcatactcggcaaaatgatcaaggatgcgttcttcttcctgttcttcctgctggtgtggttgagtgcatatggagtagccaatcaagctctactataccagtacgatccgagccctgcaagaacgtttcgacgagtgttgtacaggccatatctgcacatattcggacagataccagttgaagaaatagacactggcagacactgggaaagagactgcacagataatctgacgttgatcaatgaagggatagagccgtgcagagacaccagccacaactggcttgtggtcgttttgttggtcatcttcttactagtcacaaacattttacttgtcaacctgctcatcgccacattcagctatacgttttccaaggttcaggagcgcagtgacacatactggaaatttcagcggtataatctgatcgtggagtatcattcacgtccgacgctcgctccaccattcatcatcctgtctcacatcaacctcctgatcaaaagaaaaatacgcaaagtgcagtccgccaaagtccaacgatttgccctgaagataaagggtcaagagaagaaggagctggtgaaatgggagaacctgcagaaggagaactatctggcccttgagatcaaaaaacagagaggaactgactctgagaggctcaaacgcataacttctaaagtggatagtgtgatcaaacaggttgcagagatcagagatgtagaccgcagactgagagcggtcgagtcagagatggagttctgtacctcttctctacagtggattatggagactctttctcagagcagcatggtgaagaccactaaagcacatcctactcgcaaagccgtcacttcagccagcattgagaaatgagaaagagccgtttcctgtgttggtcttctgtcctcattgatggatactctaaacaagaagccgcagagagccagtgaaaggagggatgatgccaaaaactcttcccatgttctgctttccatctttaaactggtcatcctggccttttcatgcttcatcctgctcctacaggtttactcggtgtgagattcagcttttgttcagtggttttgcgtaatacagagtaaccttcctgaaccaaattcatacatttaattcagtatatctcatttatt

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