LOCUS       NM_001128692            1974 bp    mRNA    linear   VRT 23-JAN-2022
DEFINITION  Danio rerio serpin peptidase inhibitor, clade I (neuroserpin),
            member 1 (serpini1), mRNA.
ACCESSION   NM_001128692 XM_680719
VERSION     NM_001128692.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1974)
  AUTHORS   Han S, Zhang D, Dong Q, Wang X and Wang L.
  TITLE     Overexpression of neuroserpin in larval and adult zebrafish shows
            different behavioral phenotypes
  JOURNAL   Neurosci Lett 762, 136175 (2021)
   PUBMED   34400286
  REMARK    GeneRIF: Overexpression of neuroserpin in larval and adult
            zebrafish shows different behavioral phenotypes.
REFERENCE   2  (bases 1 to 1974)
  AUTHORS   Han S, Zhang D, Dong Q, Wang X and Wang L.
  TITLE     Deficiency in Neuroserpin Exacerbates CoCl2 Induced Hypoxic Injury
            in the Zebrafish Model by Increased Oxidative Stress
  JOURNAL   Front Pharmacol 12, 632662 (2021)
   PUBMED   33737878
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1974)
  AUTHORS   Han S, Fei F, Sun S, Zhang D, Dong Q, Wang X and Wang L.
  TITLE     Increased anxiety was found in serpini1 knockout zebrafish larval
  JOURNAL   Biochem Biophys Res Commun 534, 1013-1019 (2021)
   PUBMED   33168193
  REMARK    GeneRIF: Increased anxiety was found in serpini1 knockout zebrafish
            larval.
REFERENCE   4  (bases 1 to 1974)
  AUTHORS   Kalka M, Markiewicz N, Ptak M, Sone ED, Ozyhar A, Dobryszycki P and
            Wojtas M.
  TITLE     In vivo and in vitro analysis of starmaker activity in zebrafish
            otolith biomineralization
  JOURNAL   FASEB J 33 (6), 6877-6886 (2019)
   PUBMED   30840836
REFERENCE   5  (bases 1 to 1974)
  AUTHORS   Aoki M, Segawa H, Naito M and Okamoto H.
  TITLE     Identification of possible downstream genes required for the
            extension of peripheral axons in primary sensory neurons
  JOURNAL   Biochem Biophys Res Commun 445 (2), 357-362 (2014)
   PUBMED   24513284
REFERENCE   6  (bases 1 to 1974)
  AUTHORS   Toro S, Wegner J, Muller M, Westerfield M and Varga ZM.
  TITLE     Identification of differentially expressed genes in the zebrafish
            hypothalamic-pituitary axis
  JOURNAL   Gene Expr Patterns 9 (4), 200-208 (2009)
   PUBMED   19166982
REFERENCE   7  (bases 1 to 1974)
  AUTHORS   Kang YJ, Stevenson AK, Yau PM and Kollmar R.
  TITLE     Sparc protein is required for normal growth of zebrafish otoliths
  JOURNAL   J Assoc Res Otolaryngol 9 (4), 436-451 (2008)
   PUBMED   18784957
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC163525.1.
            
            On Jul 31, 2008 this sequence version replaced XM_680719.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC163525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476766, SAMEA4476812
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1974
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="18"
                     /map="18"
     gene            1..1974
                     /gene="serpini1"
                     /gene_synonym="serpini1l; si:ch211-167c22.4"
                     /note="serpin peptidase inhibitor, clade I (neuroserpin),
                     member 1"
                     /db_xref="GeneID:557627"
                     /db_xref="ZFIN:ZDB-GENE-060503-390"
     CDS             21..1268
                     /gene="serpini1"
                     /gene_synonym="serpini1l; si:ch211-167c22.4"
                     /codon_start=1
                     /product="neuroserpin precursor"
                     /protein_id="NP_001122164.1"
                     /db_xref="GeneID:557627"
                     /db_xref="ZFIN:ZDB-GENE-060503-390"
                     /translation="

MLLLVVLPPLLLLRGCFCQASDVPEDVTAEFSVRLYHQLQISSGEENIIFSPLSVALALGMVELGARGSSLQEIRQAVGYSHFREDEEFSLLRNLSQALSTDEEQYVVRLANSLFLQSGVHFNEDFLQLMKKYFRAEVETVDFSQSTAVAERINSWVLNHTESKIQNLVSAEDFSSSTMIMLVNAVYFRGSWKNQFRPENTRTFSFTRDDGSEVQTLMMYQQGDFYYGEFSDGTTEAGGVYQVLEMLYEGEDMSMMIVLPRQEVPLASLEPIIKAPLLEEWANNVKRQKVEVYLPRFKVEQKIDLRESLQQLGIRSIFSKDADLSAMTAQMTDGQDLFIGKAVQKAYLEVTEEGAEGAAGSGMIALTRTLVLYPQVMADHPFFFIIRNRKTGSILFMGRVMNPELIDPFDNNFDM"

     sig_peptide     21..74
                     /gene="serpini1"
                     /gene_synonym="serpini1l; si:ch211-167c22.4"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    93..1220
                     /gene="serpini1"
                     /gene_synonym="serpini1l; si:ch211-167c22.4"
                     /note="serpin family I member 1, neuroserpin; Region:
                     serpinI1_NSP; cd02048"
                     /db_xref="CDD:381005"
     misc_feature    1080..1163
                     /gene="serpini1"
                     /gene_synonym="serpini1l; si:ch211-167c22.4"
                     /note="reactive center loop (RCL); other site"
                     /db_xref="CDD:381005"
ORIGIN      

tctcacgctggtcctccatcatgctgctgctggttgtgttgccaccgctgctgctcctgcgtggatgcttttgtcaggcgtcagacgttcccgaagacgtgacggcagagttctccgtccgcctctaccaccagctccagatcagcagcggggaggagaacatcatcttctctccgctcagcgtggctctggctctgggcatggtggagctgggcgcccgcggctcctctttacaggagatcagacaggccgtgggctacagtcacttcagagaagatgaagagttctcattgctgagaaacctgagccaggcactgtccacagatgaggagcagtacgtggtccgtctggccaactcgctgttcctgcagtcgggggtccacttcaatgaagacttcctgcagctcatgaagaagtactttagagccgaggtggagacggtggatttcagccagtccacagccgtcgctgaacgcatcaactcctgggtgctcaaccacaccgagagcaaaatccagaatctggtgtcagcggaggacttcagcagctccaccatgatcatgctggtgaatgcggtctatttcaggggcagctggaagaaccagttcaggccagaaaacaccagaactttctccttcaccagagatgacggcagtgaagtgcagaccctgatgatgtaccagcagggggacttttactacggtgagttcagcgacggcaccacagaggctggtggagtttaccaggtgctggagatgctctatgagggcgaagacatgagcatgatgatcgtcctgccccgtcaggaggttcctcttgcctcgctggagcccatcattaaagcgccgctgctggaggaatgggccaacaacgtcaagaggcagaaggtggaggtttacctgcccagattcaaggtggagcagaagattgatctgagagagtctctgcagcagctgggcatcaggagcatcttcagcaaagatgccgatctgtcggccatgacggctcagatgacagacggacaagatctgttcatcgggaaagctgttcagaaggcctatctggaggtgacggaggaaggggcagaaggggccgcaggatcaggtatgatcgcattgaccaggacgctggtgttgtacccacaggtcatggctgatcatcccttcttcttcatcatcagaaacagaaaaacaggatccatcctcttcatgggcagagttatgaaccctgaactcatcgaccccttcgacaacaactttgacatgtaaaaaccaagcgtacgcaacgtgacactgaattcatgcttctcatccacgagccgcatcttcactgaaacaagctcatcacagcgccatggttttataaacgcaccagaaaatattatacgaacgggatatttatattacgaaaaagtgattgtgttttgatacttgtaagctttaagcgcagcaggaaacccagagctgtaaatatctgaagtctccatcacgtcttactccacaccagcgtcattcagtcctgtaactcctctaatgtatatttgctattgtgttccgtagagaaaccttgatatttattgcaagaacgtgtgcacttttctatatatagactcacttaaaggcagaattcatccaaaagataaaccaatttactcatcctcaactcaaacttgagtttctcatcatgttgaacacaaaagaagatattttgaagaatgttggaaaccactggtagtatttgtttcttgtatggatgtcaatggatttacacattctacaagatagtttccatttgtgttcaacagaagaaagaaactcttgagtttggaataggggtgtaaagatgaaccaaagatctgaatcacttcaaatatgaaaaaatactatattgaatatgctgtcaaactgcacttttcactacattgatgtccattcagatgcatctgaatatgccagagcggagaagttcggcatt

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