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Previous release (v1)
2024-11-01 10:28:57, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001105587 3210 bp mRNA linear VRT 02-APR-2024
DEFINITION Danio rerio myosin light chain kinase 3 (mylk3), mRNA.
ACCESSION NM_001105587 XM_685048
VERSION NM_001105587.2
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (bases 1 to 3210)
AUTHORS Hesaraki,M., Bora,U., Pahlavan,S., Salehi,N., Mousavi,S.A.,
Barekat,M., Rasouli,S.J., Baharvand,H., Ozhan,G. and Totonchi,M.
TITLE A Novel Missense Variant in Actin Binding Domain of MYH7 Is
Associated With Left Ventricular Noncompaction
JOURNAL Front Cardiovasc Med 9, 839862 (2022)
PUBMED 35463789
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3210)
AUTHORS Fang,Y., Lai,K.S., She,P., Sun,J., Tao,W. and Zhong,T.P.
TITLE Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing
Cardiomyocyte Dedifferentiation and Endocardial Expansion
JOURNAL Front Cell Dev Biol 8, 738 (2020)
PUBMED 32850848
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3210)
AUTHORS Kossack,M., Hein,S., Juergensen,L., Siragusa,M., Benz,A.,
Katus,H.A., Most,P. and Hassel,D.
TITLE Induction of cardiac dysfunction in developing and adult zebrafish
by chronic isoproterenol stimulation
JOURNAL J Mol Cell Cardiol 108, 95-105 (2017)
PUBMED 28554511
REFERENCE 4 (bases 1 to 3210)
AUTHORS Munch,J., Grivas,D., Gonzalez-Rajal,A., Torregrosa-Carrion,R. and
de la Pompa,J.L.
TITLE Notch signalling restricts inflammation and serpine1 expression in
the dynamic endocardium of the regenerating zebrafish heart
JOURNAL Development 144 (8), 1425-1440 (2017)
PUBMED 28242613
REFERENCE 5 (bases 1 to 3210)
AUTHORS Xie,H., Fan,X., Tang,X., Wan,Y., Chen,F., Wang,X., Wang,Y., Li,Y.,
Tang,M., Liu,D., Jiang,Z., Liu,X., Yuan,W., Li,G., Ye,X., Zhou,J.,
Mo,X., Deng,Y. and Wu,X.
TITLE The LIM protein fhlA is essential for heart chamber development in
zebrafish embryos
JOURNAL Curr Mol Med 13 (6), 979-992 (2013)
PUBMED 23438903
REMARK GeneRIF: fhlA regulates the size of the heart chamber by reducing
the number of cardiac cells.
REFERENCE 6 (bases 1 to 3210)
AUTHORS Tournoij,E., Weber,G.J., Akkerman,J.W., de Groot,P.G., Zon,L.I.,
Moll,F.L. and Schulte-Merker,S.
TITLE Mlck1a is expressed in zebrafish thrombocytes and is an essential
component of thrombus formation
JOURNAL J Thromb Haemost 8 (3), 588-595 (2010)
PUBMED 20002541
REFERENCE 7 (bases 1 to 3210)
AUTHORS Webb,K.J., Norton,W.H., Trumbach,D., Meijer,A.H., Ninkovic,J.,
Topp,S., Heck,D., Marr,C., Wurst,W., Theis,F.J., Spaink,H.P. and
Bally-Cuif,L.
TITLE Zebrafish reward mutants reveal novel transcripts mediating the
behavioral effects of amphetamine
JOURNAL Genome Biol 10 (7), R81 (2009)
PUBMED 19646228
REFERENCE 8 (bases 1 to 3210)
AUTHORS Seguchi,O., Takashima,S., Yamazaki,S., Asakura,M., Asano,Y.,
Shintani,Y., Wakeno,M., Minamino,T., Kondo,H., Furukawa,H.,
Nakamaru,K., Naito,A., Takahashi,T., Ohtsuka,T., Kawakami,K.,
Isomura,T., Kitamura,S., Tomoike,H., Mochizuki,N. and Kitakaze,M.
TITLE A cardiac myosin light chain kinase regulates sarcomere assembly in
the vertebrate heart
JOURNAL J Clin Invest 117 (10), 2812-2824 (2007)
PUBMED 17885681
REMARK GeneRIF: These results suggest a significant role for cardiac-MLCK
in cardiogenesis.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL928906.4.
On Aug 9, 2023 this sequence version replaced NM_001105587.1.
##Evidence-Data-START##
Transcript exon combination :: AB267907.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA2168446,
SAMEA2168447 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
is not conserved
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-302 AL928906.4 10469-10770
303-396 AL928906.4 20256-20349
397-730 AL928906.4 20503-20836
731-1353 AL928906.4 21794-22416
1354-1459 AL928906.4 23954-24059
1460-1553 AL928906.4 28065-28158
1554-1663 AL928906.4 32858-32967
1664-1805 AL928906.4 33652-33793
1806-1876 AL928906.4 36288-36358
1877-2005 AL928906.4 39806-39934
2006-2158 AL928906.4 43211-43363
2159-2294 AL928906.4 46519-46654
2295-3210 AL928906.4 46751-47666
FEATURES Location/Qualifiers
source 1..3210
/organism="Danio rerio"
/mol_type="mRNA"
/strain="Tuebingen"
/db_xref="taxon:7955"
/chromosome="7"
/map="7"
gene 1..3210
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="myosin light chain kinase 3"
/db_xref="GeneID:561635"
/db_xref="ZFIN:ZDB-GENE-030131-3497"
exon 1..302
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
misc_feature 183..185
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="upstream in-frame stop codon"
misc_feature 222..224
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="upstream_AUG_codon; putative N-terminal extension:
M"
CDS 225..2372
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/EC_number="2.7.11.18"
/note="z-cardiac MLCK; cardiac myosin light chain kinase;
cardiac-MLCK; myosin light chain kinase, cardiac;
cardiac-MyBP-C-associated Ca/CaM kinase"
/codon_start=1
/product="myosin light chain kinase 3"
/protein_id="NP_001099057.1"
/db_xref="GeneID:561635"
/db_xref="ZFIN:ZDB-GENE-030131-3497"
/translation="
MGTSLYRSTLLSTGGFSVSDYIRKFTKNKPDVNNIQPNVGFCHQSTQTSQQVKEVISAELELQQPEVTLPNDPSSQHSPEAHTGASEPLKPVSAGESSKALQKAKEISVKSSEPTHVQTFAPAVHLEQIDVHNVPKQETNSLVAAPADAKCVIETMTKVEKDIALQQERALERADDSHVANKVFLKSIIPGQQLEKIEDPQQQAEVSLFVDEDSLEKSVPGQHLDKKMEVLQKQAKDLPVVDEDSLNLSAPGQRQLEEKVDVPEKAEKKIDEAHKKMEEVPRKDELCIEKPVIRHAGIKTQHEETMGMETTVPKHDESKCPTETYVEKTENKNADVTLESDKIMICAVSPQNTSLDEDEKSKAAPLRKVESTLLIIDDSPPLPAPFDHRIVSAKQVPINSYYAVNPVEVLGGGRFGQVHKCAELSSGLTLAAKIIKVRGMKERDEVKNEIGVMNQLNHVNLIQLYDAFESRTNLTLIMEYVEGGELFERIIDESYQLTELDAIVFTRQICEGVQYLHQQYILHLDLKPENILCVNSTGNQIKIIDFGLARKYRPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVITYMLLSGLSPFMGDNDAETMNNILHAKWEFDTEAFENVSEEAKDFISSLLVSAKCSRLSASGCMKHSWLNNLEDKAKMYKVRLKSQMMLQRYLVAHRQWKKHFYAVAAANRLKRFQQSRSISTPN"
misc_feature 423..566
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="propagated from UniProtKB/Swiss-Prot (A8C984.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1419..2201
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="Catalytic domain of the Serine/Threonine Kinase,
Myosin Light Chain Kinase 3; Region: STKc_MLCK3; cd14192"
/db_xref="CDD:271094"
misc_feature order(1452..1466,1470..1472,1476..1478,1515..1517,
1521..1523,1608..1610,1656..1661,1665..1667,1677..1679,
1683..1685,1797..1799,1803..1805,1809..1814,1818..1820,
1854..1859,1866..1868,1911..1922)
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="active site"
/db_xref="CDD:271094"
misc_feature order(1452..1466,1470..1472,1476..1478,1515..1517,
1521..1523,1608..1610,1656..1661,1665..1667,1677..1679,
1809..1814,1818..1820,1854..1859)
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:271094"
misc_feature order(1464..1466,1677..1679,1683..1685,1797..1799,
1803..1805,1809..1811,1866..1868,1911..1922)
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:271094"
misc_feature 1854..1922
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/note="activation loop (A-loop); other site"
/db_xref="CDD:271094"
exon 303..396
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 397..730
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 731..1353
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 1354..1459
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 1460..1553
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 1554..1663
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 1664..1805
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 1806..1876
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 1877..2005
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 2006..2158
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 2159..2294
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
exon 2295..3210
/gene="mylk3"
/gene_synonym="bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1;
wu:fc41h03"
/inference="alignment:Splign:2.1.0"
ORIGIN
tgtgcaggaagtgctttctgggcctctgccgagaggatgggggggcgcaaaccctgtaaatgggctgaaagtgataagataggtagtgtttgaggggggatatgtccactacagaatgttagagatccctaagagcgcagctctgtggagtattatttgcttttgatggcccactttgggaatagagcacactgagtcccattaacctaggacagcagggcatgatggggacctcgctgtacagatcaacgcttctcagcacaggagggttcagtgtgtcggactacattcgcaaattcacgaaaaacaagccagatgtcaacaacattcaaccaaacgtcggtttctgccaccagagcacacagacttcacagcaggttaaagaagttatttcagctgagcttgagctccagcagcccgaggtcactcttcctaatgaccccagcagccaacattctcctgaagcccatacaggggcaagtgaacctctgaaacctgttagtgcaggggaaagctcaaaagccttacaaaaggccaaagagatctctgtgaaaagcagcgagcccacacatgtccagacatttgctcctgcagtccatcttgagcagatcgacgtgcataatgtccctaagcaagagacgaacagcttggtcgcagctccggctgatgctaaatgtgtcattgagacaatgactaaggtggaaaaagatatagcgcttcagcaagagagagctcttgaacgggcagatgattcacatgttgctaataaggtttttctcaaatcaataattccgggacaacaattggagaagattgaggatcctcaacaacaggcagaggtttcactgtttgttgatgaggattcgttagaaaaatcagttcctggacaacacctagataagaagatggaggttcttcaaaaacaggcaaaggatttaccggttgtagatgaagactcattaaatctgtcagctcctggacaaagacaactagaagagaaggtggatgttcctgaaaaagctgagaagaagattgatgaagctcataaaaagatggaggaggttcctcgaaaagatgagctctgcatagaaaagcctgttattagacatgcaggaattaaaacacaacacgaagagacaatggggatggaaacaacagtgccaaaacatgatgagagcaagtgtccaactgaaacatatgttgagaaaactgaaaataaaaatgcagatgtcactttagagtctgataaaataatgatctgtgctgttagtccacaaaacacaagccttgatgaggatgagaaaagtaaagcagcacctctaagaaaagttgagtcgacactgctgatcattgatgacagcccacctctgccagccccattcgaccatcgcattgtcagtgccaagcaggttcccattaactcatattatgctgtcaaccctgtcgaggttctaggcggaggccgatttggacaggtacacaagtgcgcagagctatcgtcaggtcttacgctggccgctaagataataaaagtccgcggaatgaaagaaagggatgaagtgaagaatgagattggagtcatgaaccagctaaatcacgtgaacttgattcaattatatgatgcttttgagtctcgaacaaacctcacactcattatggaatacgtggagggcggcgaattgtttgaacgaatcattgatgagagttaccagctgacggagctggatgccatcgtgtttaccaggcagatttgcgaaggggttcagtaccttcaccagcagtacattctccatttagatcttaagccggaaaatatcttatgtgtgaacagcacaggcaatcaaatcaagatcattgactttggactcgccagaaagtacaggcccagggaaaagctgaaggtcaactttggtaccccagagtttctggcaccagaagttgtcaactatgactttgtgtcatttcctacagacatgtggagtgttggtgtcatcacttacatgcttttgagtggcctttctccattcatgggtgacaacgacgcagaaacaatgaacaacattctgcacgccaagtgggaatttgacacggaggcattcgagaatgtgtcagaggaagccaaagacttcatatccagccttcttgtgtccgccaaatgcagccgattgagtgcatcaggatgcatgaagcacagctggctaaataacctggaggacaaggccaagatgtacaaagttcggctgaagtctcaaatgatgcttcagcgttaccttgttgcacaccgtcagtggaagaaacacttctatgcagtggctgcagcaaacaggctgaagaggtttcagcaaagcagatcaattagtacaccaaattagctattaacctggaggacagtggacatcacaacatcgcacattgaacttgtctgaatggttttgaaatggcttcacagtacgtgttcaatatgttcttgcctttcatcttgttaaaaaggtcgcatttcccttaatgttttaccttgcaacaccattacatttcatttacacgtcttcatcatgctttttgtagagcatggatggcagggtgtgcttttgaaccacatgaaaaagctgttgtcccttctgtgaaggtgttttccttgggcacttctgccttatactagtatctgaatgttgcttttgtcctcatggattggtattttatatttagtcaaaatagcatgaagatttgatgtagaaacacattggtcatcttatgttttcgttatttttagcatgttgattagagccgcaaacaaattgttaacttgatacattttcaatttaaatcttcatagttgaaacctttttatttgttgttcagaatttcctgaatgttaatccatactgtgacttgaaactgcttcctaggacttgactgcaatagcggatatacacattcatatggtaaaagcatgagaacaaaaacatccactacggtggttttgctcatggcttggcaaccagcaatcaagagcacagaatcatagggtagtcctgttttgctattttgtagagtgtgcttgcgtagacagcatctaacaggagtttttttttcagtgtaatactgattgtcaccagttttctgggtagaaaatgtctaattaagtcaaaaaatgagaagttaaattgtgtcaagaacacccattttattcacattaaaatccaaatggaa
//
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@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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