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Previous release (v1)
2024-11-01 12:40:29, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001079986 7263 bp mRNA linear VRT 08-JUN-2024
DEFINITION Danio rerio G protein-coupled receptor kinase 4 (grk4), transcript
variant 2, mRNA.
ACCESSION NM_001079986 XM_009306444 XM_684159
VERSION NM_001079986.2
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (bases 1 to 7263)
AUTHORS Gerhards,J., Maerz,L.D., Matthees,E.S.F., Donow,C., Moepps,B.,
Premont,R.T., Burkhalter,M.D., Hoffmann,C. and Philipp,M.
TITLE Kinase Activity Is Not Required for G Protein-Coupled Receptor
Kinase 4 Restraining mTOR Signaling during Cilia and Kidney
Development
JOURNAL J Am Soc Nephrol 34 (4), 590-606 (2023)
PUBMED 36810260
REFERENCE 2 (bases 1 to 7263)
AUTHORS Guo,H., Du,X., Zhang,Y., Wu,J., Wang,C., Li,M., Hua,X., Zhang,X.A.
and Yan,J.
TITLE Specific miRNA-G Protein-Coupled Receptor Networks Regulate
Sox9a/Sox9b Activities to Promote Gonadal Rejuvenation in Zebrafish
JOURNAL Stem Cells 37 (9), 1189-1199 (2019)
PUBMED 31116894
REFERENCE 3 (bases 1 to 7263)
AUTHORS Bayes,A., Collins,M.O., Reig-Viader,R., Gou,G., Goulding,D.,
Izquierdo,A., Choudhary,J.S., Emes,R.D. and Grant,S.G.
TITLE Evolution of complexity in the zebrafish synapse proteome
JOURNAL Nat Commun 8, 14613 (2017)
PUBMED 28252024
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 7263)
AUTHORS Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
Guiguen,Y. and Bobe,J.
TITLE Gene evolution and gene expression after whole genome duplication
in fish: the PhyloFish database
JOURNAL BMC Genomics 17, 368 (2016)
PUBMED 27189481
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 7263)
AUTHORS Zhao,Z., Lee,R.T., Pusapati,G.V., Iyu,A., Rohatgi,R. and
Ingham,P.W.
TITLE An essential role for Grk2 in Hedgehog signalling downstream of
Smoothened
JOURNAL EMBO Rep 17 (5), 739-752 (2016)
PUBMED 27113758
REFERENCE 6 (bases 1 to 7263)
AUTHORS Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
TITLE RFX transcription factors are essential for hearing in mice
JOURNAL Nat Commun 6, 8549 (2015)
PUBMED 26469318
REMARK Publication Status: Online-Only
REFERENCE 7 (bases 1 to 7263)
AUTHORS Valanne,S., Myllymaki,H., Kallio,J., Schmid,M.R., Kleino,A.,
Murumagi,A., Airaksinen,L., Kotipelto,T., Kaustio,M., Ulvila,J.,
Esfahani,S.S., Engstrom,Y., Silvennoinen,O., Hultmark,D.,
Parikka,M. and Ramet,M.
TITLE Genome-wide RNA interference in Drosophila cells identifies G
protein-coupled receptor kinase 2 as a conserved regulator of
NF-kappaB signaling
JOURNAL J Immunol 184 (11), 6188-6198 (2010)
PUBMED 20421637
REFERENCE 8 (bases 1 to 7263)
AUTHORS Miranda,C.L., Collodi,P., Zhao,X., Barnes,D.W. and Buhler,D.R.
TITLE Regulation of cytochrome P450 expression in a novel liver cell line
from zebrafish (Brachydanio rerio)
JOURNAL Arch Biochem Biophys 305 (2), 320-327 (1993)
PUBMED 8373170
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BX908747.25.
On or before Apr 21, 2018 this sequence version replaced
XM_009306444.2, NM_001079986.1.
Transcript Variant: This variant (2) uses an alternate splice
junction in the 3' end compared to variant 1, that causes a
frameshift. The resulting isoform (2) has a shorter and distinct
C-terminus compared to isoform 1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: BC124213.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMEA2168446, SAMEA2168447
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-358 BX908747.25 139048-139405
359-454 BX908747.25 157223-157318
455-567 BX908747.25 164550-164662
568-645 BX908747.25 165128-165205
646-746 BX908747.25 165360-165460
747-839 BX908747.25 171634-171726
840-903 BX908747.25 176701-176764
904-1044 BX908747.25 177588-177728
1045-1235 BX908747.25 187067-187257
1236-1273 BX908747.25 190542-190579
1274-1363 BX908747.25 194116-194205
1364-1572 BX908747.25 194291-194499
1573-1710 BX908747.25 199203-199340
1711-1848 BX908747.25 199445-199582
1849-2029 BX908747.25 200549-200729
2030-7263 BX908747.25 204613-209846
FEATURES Location/Qualifiers
source 1..7263
/organism="Danio rerio"
/mol_type="mRNA"
/strain="Tuebingen"
/db_xref="taxon:7955"
/chromosome="1"
/map="1"
gene 1..7263
/gene="grk4"
/gene_synonym="zgc:153020"
/note="G protein-coupled receptor kinase 4"
/db_xref="GeneID:560761"
/db_xref="ZFIN:ZDB-GENE-060929-1198"
exon 1..358
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
misc_feature 268..270
/gene="grk4"
/gene_synonym="zgc:153020"
/note="upstream in-frame stop codon"
CDS 307..2028
/gene="grk4"
/gene_synonym="zgc:153020"
/EC_number="2.7.1.-"
/note="isoform 2 is encoded by transcript variant 2; GRK5"
/codon_start=1
/product="G protein-coupled receptor kinase 4 isoform 2"
/protein_id="NP_001073455.1"
/db_xref="GeneID:560761"
/db_xref="ZFIN:ZDB-GENE-060929-1198"
/translation="
MEIENIVANTVLLKAREGGGGKRNGRSKKWKEMLKLPHISQCEELRRTIERDYTSLCEKQPIGRQLFRQFCDTQPKLRRCIEFLDSVAMYQVAPDEKRRDAGLNILDTYFNNGSAAHLPEMAQDVVGECRQKLEQSPCKELFQECTRIVREYLSGAPFSAYQETMYFSRFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRVKKRKGEAMALNEKRILEKVNSSFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNSGFDEQRAIFYAAEICCGLEDLHRERIVYRDLKPENILLDDRGHIRISDLGLAVQIPEGETIRGRVGTVGYMAPEVIQNESYTFSPDWWGLGCLIYEMIQGQSPFRRRKERVKREEVDRRVCEDQEEYTEKFSEDAKDICRQLLCKDPKERLGCRGSGAAEVKLHPIFRNINFKRLEANMLDPPFCPDPRAVYCKDVLDIEQFSTVKGVNLDPTDDDFYHKFVTGSVSIPWQNEMIEMECFKEINVFEMDGALCADLDVNRPNPAPKRGFFYRLFHREASGSASPAVLRGGGA"
misc_feature 460..855
/gene="grk4"
/gene_synonym="zgc:153020"
/note="Regulator of G protein signaling domain (RGS) found
in G protein-coupled receptor kinase 4 (GRK4); Region:
RGS_GRK4; cd08750"
/db_xref="CDD:188704"
misc_feature order(511..513,520..522,793..795,799..804,808..813)
/gene="grk4"
/gene_synonym="zgc:153020"
/note="putative dimer interface [polypeptide binding];
other site"
/db_xref="CDD:188704"
misc_feature 859..1713
/gene="grk4"
/gene_synonym="zgc:153020"
/note="Catalytic domain of the Serine/Threonine Kinase, G
protein-coupled Receptor Kinase 4; Region: STKc_GRK4;
cd05631"
/db_xref="CDD:173720"
misc_feature order(880..894,904..906,943..945,949..951,1045..1047,
1093..1098,1102..1104,1114..1116,1120..1122,1237..1239,
1243..1245,1249..1254,1258..1260,1288..1293,1300..1302,
1339..1356,1435..1437,1453..1455,1462..1464)
/gene="grk4"
/gene_synonym="zgc:153020"
/note="active site"
/db_xref="CDD:173720"
misc_feature order(880..894,904..906,943..945,949..951,1096..1104,
1258..1260,1291..1293)
/gene="grk4"
/gene_synonym="zgc:153020"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173720"
misc_feature order(892..894,1114..1116,1120..1122,1237..1239,
1243..1245,1249..1251,1300..1302,1339..1356,1435..1437,
1453..1455,1462..1464)
/gene="grk4"
/gene_synonym="zgc:153020"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:173720"
misc_feature 1288..1356
/gene="grk4"
/gene_synonym="zgc:153020"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173720"
exon 359..454
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 455..567
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 568..645
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 646..746
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 747..839
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 840..903
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 904..1044
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 1045..1235
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 1236..1273
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 1274..1363
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 1364..1572
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 1573..1710
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 1711..1848
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 1849..2029
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
exon 2030..7263
/gene="grk4"
/gene_synonym="zgc:153020"
/inference="alignment:Splign:2.1.0"
ORIGIN
gtaagcgagagctcgagacaggaaggactgctgagcactgaatgctaacaagggggagagagagtacatgtccacggcgagcggaaaggtggggggttcaacagcgagatatggagaaatacaattaacctgcaatgtgccaacgccaaactcacgccgatcataaccatcctcaccaccgatcatcatcatcatcatcatcctcaccctcatcaccaccaccagcagcaacggcgcgaccgacctcgtcttttttctcctaagaagtgaaatgtatcgggactgcatgggatctttcttctgacaatggagattgagaatatcgtggccaacaccgtgctgctgaaggcgagggaaggaggcggagggaagcgtaatggacggagcaagaaatggaaggagatgctgaaattgcctcatatcagtcagtgtgaggaactgagacgcacaattgagagggattatacaagcctttgtgaaaagcagccaattggacgtcagttgtttcgtcaattctgtgacactcagcccaaattacggcgctgtatagagttcctggattctgtggcaatgtatcaggtggctccggatgagaagaggagagacgccggtttaaatattttagacacatattttaataacgggtcagccgctcatctaccagagatggctcaggatgtggtcggggaatgcaggcagaaactggaacagagtccatgtaaagagctgttccaggagtgtaccaggatagttcgtgaatatttaagtggagcgccattctcggcttatcaggagactatgtacttttcccgttttcttcagtggaagtggttggagaggcaaccagtaaccaaaaacacattcagacattacagggtattgggcaagggcggatttggtgaggtttgtgcctgccaggttcgtgccactggtaagatgtacgcctgtaaaaagctggagaagaaacgtgtgaagaaaagaaaaggtgaagcaatggcattaaatgaaaaacgcattttagaaaaagttaacagtagttttgtagttagtttggcatatgcgtatgagactaaggacgctctatgtttggtgttgaccataatgaacggtggtgatctgaagtttcatatctataacatgggaaactcaggtttcgatgagcagcgggccatcttttacgcggcagagatctgttgcggattagaggatctgcatcgagagcggatcgtctacagagacttgaaaccagaaaatattctgctagatgatcgcgggcacatccgtatttctgatctgggactggccgtgcaaattccagagggcgagacgatacgagggcgtgttggcacagtggggtacatggcaccagaggtcatccagaacgagagctacaccttcagtcctgactggtggggtttgggctgtctaatatacgaaatgattcagggtcagtctcctttccgtcgccgtaaagagcgagtgaagagagaggaagtggaccggcgagtttgtgaggaccaggaggaatatactgagaagttctcagaagacgctaaagacatctgccgtcagttgttatgtaaagatccaaaggagcgcttgggctgtcggggcagtggagcggccgaagtcaaactgcatcccattttccgcaacatcaacttcaagcggctggaggccaacatgctggacccgccgttctgtccagacccgcgagcagtttactgtaaggacgtcctggacatagagcagttttcgacagtcaaaggtgtaaacctggacccaacagatgacgatttctaccacaagtttgtaacagggagtgtctccatcccatggcaaaatgagatgattgagatggagtgttttaaggagatcaacgtgttcgagatggacggagcgctgtgtgctgatctggatgtgaacagacccaatccagcaccgaagcgaggattcttctaccgtttatttcaccgagaggcaagtggtagtgcatcgcccgccgtgctcagagggggaggggcttgaggtttgttttgggagtgccaacagtgaggaggaggagaaagaggagaaggaggaggagccatcttgacttaaaaccactcccacttcccatcagctgccaatcagaatgctaaacgtatgaatgttcaactgtatttatgaactgtatcaaactgtatcataattaaagaaaagggtatgagtttaaagaattttgtacatttgtacttgaattatgtgtagatgtatattttcactaaaggttgtattgtacaaaaagccatagaaataccacttgaatgcatatataatgtttttattgttattatttttcatctgtactgaatatgaaatgtgtatttctttttaagcacaatataaacactcaccttttgtttccaatgctaacgctctgttagcactgcctttgtttgtatgttaacttagatcgtttggctggacagatccaccgcgcttcttttgtacagcagggtaagatcaatcacacataaagagggagcagtacaaatgatctattcatatcatatcatttacagtggtcaaccagaatgctaatatcaaaagcaggggtggctgtggtcaaataaaaacaaaaaaacaaactgtatatagcctagatatataaaaacgaggttcaaaagtctgagaataccaagtaaaatgctttagaatatatattcagaaaaatctggactgaaaatgaattgcgtgcaataataacacctttgttaagcaatatgtggctaattttgagattcgaactgttaggaaatatactcataatttcaaaattagcctaatgttgatgtattaaaatatattaatgctttattgccaccttcactcattccccccccccccccccccccccccccaatttttgtcaaatttgacatgcctttttcttcaacccaggctcattctgaaaatgtacccccgtatacatttctggagagcactaaatacatccctggagctacgtcattgcttttttttttttcgaattccccagaggccgctgtgtatgctttttaaaatctcaattttttctagcaagtaccatttaaacctgctgttcttgcgtaaatccaccagaggctgctgtaaactgtccttccctaaacccaaccaatagtgtttccaatagcaccgattgacccgccttcgctaaccccaaccgacagtttaaaaagcaatccaaaaaaagaaaagcccttgcctgatttttaccatgttttcagatttttccacattctcaccctgttatttacttcattttattttttggcttctgtttttgtcttacccgctttctggaaccattcgaaccctgtcgttggggtcaactcctctctgcgtctcaagtcatacatgactcgacatacatggcgagctgctggacaaactgataacagtagaaacgctgtttacatggaagtcagcggtcagctggaaagcgagaaaagaccaccctgtagccttcattttaaagacgaaatgctgccatatgtacctctggctacataattcatgatcttcttaaatgtatatagggctatgtttttagagtgagcctatgttgttgttgttgttttgtaaatgtttatttttagggctaaattgaatatataactccagattttcagtgtgtcctcagacttctgaaccccacctgtgtgttgacctcattgacaagctgtctggattttgtacaaaaggaaagtgttcatacatatgttaatgataatgggtgtgccaatagctagtgccaatagcctcaaaacaaccagatgattaataggtccaatccaatgactaataacaatgtgtaacttgcgggttgtggaagtgtaacgtcattcattttctccatagggaatttttttttttaaactgataactgcagtcttgttgtgagctctgaggttcttgattgtatatgctgttgctgaacttgtctattcacattaaatcactttattatttcaacagtcatttttgattgtagaatttggccataacaacgacattacccatgatgctgtgcagaaaaccaaccaatcagacagttgcagcgtttctgattgtagaatctggcaaaagcaaccaatttacccatgatactgtgcagaaaactcaccaatcagactgttgcagtgtttttgatcatagaattgggccataacaaccacattaaacattatgctgtgcagaaaacccaccaatcagagagttgtagcattttacattttagaatttggccataacaacaacattacccatgatgctatgcagaaaacccaccaatcagacagttgcagctgacaaagcaactttacattatatcactttattatagtcaattttgatcgtagaattgggccataacaacaacattacccgtgatgctgtgcagaaatgccaccaatcagacagttgcagcttttttgattgtagaattggtccataacaactacattacccatgatgctgtgcattaaagccaccaatcagacagttgcagcgattttaattgtagaatttcgccataactacaatacccatgatgctgtgcagaaaacctatcaatcagaccgttgcagcgtttttgattgtagaatttggccaaaacaactacattacccatgatgctgtgcagaaaagttaccaatcggacagttgctgctaacaaagcaacttcagattaaatcaccttttttattttaacgatcatttttgattgtagaatctggccataacaactacattacccaacatgctgtgtgcataaaacccaccaatcagacagttgcagcattttttattatagaatttggctataacaactacattacccatgatgctgtgcacaaaacccaccaatcaggcacttacagcatttttgatagtagaatttggccataacaactacattacccatgatgctgtgcagaaaatccatcaatcagacagttgctgcatttttgattgtagaatttggccataacagccacattacccatgatgctttgcagaaaacccaccaatcagacagttgtagcgttttaatggtagaattgggacacaacaaccacattacccatgatgctgtgcagaaaacccaccaattagacagttgcagctaacatagcacgtcaagagatctttaactccaaaaacttccatgaagcaccccaaaatattttccaaaaaagcttaaaatatggataaaacaaacacctttaattgaacaattttttatttcttaatcgttttaatctgattatgttttgtgcaatgctttatgggattgtagttctttttctcatttaacctgttcagtatgtcttgtacttcttctcagatttgtaaggttgtgattcacctcagatgattagacagttttattactcaaaaaaataaatattttttaatccctatggtaaaatgaacaggcaaatactttctgaaaaagtgaacgtcagcactagtcgtaaaattgttctttcattaaattcatgcagctttaacgaaatgcatgaaaccaataatctctgtgcatcgggtgactaatcccagttttggttacgcattaacaagacacatatgtatgttaattaacgtagtcaccgtagctttcagatgcatcaacgacagggaaccaggcatgttgttcaacgatagactaatatgagttttttttttcagtggcagataatcgatatctagtacctagtaatatggacatgtacgtaaataagtgactgaatgatggcatattacactatatttactcaaaacccacatacgattgaacatataaaatgtttactatccattaacatggctgttgttcggtttttggagttgatacaaggaaatgttaattactctagctatgtgtcagtagttttcaggccgctaatctgaaatgatttattttttccgttttgttgactgtttgctaatatccactctcatggttacatttagtgccatcaggaatctttaaaccaacgaaataagcttcatctttgaatttgctcttgaacgagctgtcgattttgccttaggtgtcatgtgttcggtcgacattccaaacggagtatcgatcgatcccttaacgataatcatatgatgtaattaatgactgtgcagtttgttcgttatacacttgcacattttacattttgctttgtatgtatttgtgtggcatattttaatcgcaatgaaggcttccatttagtgatgggaattagcatctcgatcttacgagaaactattttacatgtcatcagaaaagtggctaacttgtacaaattcgtacggtttcatttgcatgaaaacataagatttttttttaagtaggagtggccccaaaccccacccaaaacttattcctcattgggtggaattagtgaatcttattaaaatgtacatatgagatcgtacaaattaatatgaattagccactacatcaaaaagttacgaattgagaattgcgttggaattagtctcaaatgtattgttcataaattgggtaatattacatttgatttaaatggaggaagtgaaaattagttttgcttccattcagtggtgagaattagcagctcgatctcacgaggaactattttacatgtcagaaaagaggctaattcgtataaatgcatacaatttaatttgtatgaaaacgtacaattttaaaagagtaggtgtggcctcaaaccccacccctaaccctacccgtcattgggtggaattatcgaatcttattaaaatttacgaattagatcgtacaattaatacaaaatagccactacatcaaaaagttacgaatttagaattgcgttggaattcaaatgtcaaatgtatctttcggaaattgcataatattacatttgatttaaatggaggaagtggaaattagttttgatctaaaaaatgcttttgtctaacgcaccttcgaaatcagagtcccaaccaatggcgtgagtcgggggcggggctataacatgcttcagcactgacagtaaagctcaaataggaaccattattttacctccatcacccatttttctctttatgaggatctttatggtcccgtttgcaaagctgtgaactgaaaacaactcctcttctgttattcccatatgtgtgcatgttctactgtgtccatggttttacaagaggatgagcactcactttagttgacaataaagttatgagttgaca
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]