LOCUS       NM_001039628            2553 bp    mRNA    linear   VRT 15-JUN-2024
DEFINITION  Danio rerio taste receptor, type 1, member 3 (tas1r3), mRNA.
ACCESSION   NM_001039628 XM_685707
VERSION     NM_001039628.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Gong,Y., Yang,B., Zhang,D., Zhang,Y., Tang,Z., Yang,L., Coate,K.C.,
            Yin,L., Covington,B.A., Patel,R.S., Siv,W.A., Sellick,K., Shou,M.,
            Chang,W., Danielle Dean,E., Powers,A.C. and Chen,W.
  TITLE     Hyperaminoacidemia induces pancreatic alpha cell proliferation via
            synergism between the mTORC1 and CaSR-Gq signaling pathways
  JOURNAL   Nat Commun 14 (1), 235 (2023)
   PUBMED   36646689
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Del Vecchio,G., Murashita,K., Verri,T., Gomes,A.S. and Ronnestad,I.
  TITLE     Leptin receptor-deficient (knockout) zebrafish: Effects on nutrient
            acquisition
  JOURNAL   Gen Comp Endocrinol 310, 113832 (2021)
   PUBMED   34089707
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Kossack,M.E., High,S.K., Hopton,R.E., Yan,Y.L., Postlethwait,J.H.
            and Draper,B.W.
  TITLE     Female Sex Development and Reproductive Duct Formation Depend on
            Wnt4a in Zebrafish
  JOURNAL   Genetics 211 (1), 219-233 (2019)
   PUBMED   30446521
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Cai,W., He,S., Liang,X.F. and Yuan,X.
  TITLE     DNA Methylation of T1R1 Gene in the Vegetarian Adaptation of Grass
            Carp Ctenopharyngodon idella
  JOURNAL   Sci Rep 8 (1), 6934 (2018)
   PUBMED   29720695
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2553)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2553)
  AUTHORS   Ohmoto,M., Okada,S., Nakamura,S., Abe,K. and Matsumoto,I.
  TITLE     Mutually exclusive expression of Galphaia and Galpha14 reveals
            diversification of taste receptor cells in zebrafish
  JOURNAL   J Comp Neurol 519 (8), 1616-1629 (2011)
   PUBMED   21452212
REFERENCE   7  (bases 1 to 2553)
  AUTHORS   Wang,H.
  TITLE     Comparative analysis of period genes in teleost fish genomes
  JOURNAL   J Mol Evol 67 (1), 29-40 (2008)
   PUBMED   18535754
REFERENCE   8  (bases 1 to 2553)
  AUTHORS   Oike,H., Nagai,T., Furuyama,A., Okada,S., Aihara,Y., Ishimaru,Y.,
            Marui,T., Matsumoto,I., Misaka,T. and Abe,K.
  TITLE     Characterization of ligands for fish taste receptors
  JOURNAL   J Neurosci 27 (21), 5584-5592 (2007)
   PUBMED   17522303
REFERENCE   9  (bases 1 to 2553)
  AUTHORS   Ishimaru,Y., Okada,S., Naito,H., Nagai,T., Yasuoka,A., Matsumoto,I.
            and Abe,K.
  TITLE     Two families of candidate taste receptors in fishes
  JOURNAL   Mech Dev 122 (12), 1310-1321 (2005)
   PUBMED   16274966
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB200902.1.
            
            On Mar 1, 2006 this sequence version replaced XM_685707.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB200902.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Wako-Riken"
                     /db_xref="taxon:7955"
                     /chromosome="11"
                     /map="11"
     gene            1..2553
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="taste receptor, type 1, member 3"
                     /db_xref="GeneID:562318"
                     /db_xref="ZFIN:ZDB-GENE-070917-3"
     CDS             1..2553
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="zfT1R3; T1R taste receptor"
                     /codon_start=1
                     /product="taste receptor type 1 member 3 precursor"
                     /protein_id="NP_001034717.1"
                     /db_xref="GeneID:562318"
                     /db_xref="ZFIN:ZDB-GENE-070917-3"
                     /translation="

MLLLRMKNKWTFLVLCGILGSGLGDNPSWFNNITTNFFKSPGDILIGGLFPINQLTSELSQRVKPDDLQCDSISTYGLSLSLVMKFTVDEINSKKHILPGITLGFESYDTCMQPAVIMKPVLQLLTQESTDELDIYCNYTNYKPRVMAIIGPDSSDVVPDAGKLIGFFLMPMISYGATSDEFSNKQTYPSFMRTVASDQWQVVAMIQLLKQFGWNWVSVIGSDEEYGQMGQQQFSSMANDESICVAYQGLIPVYSDPGPTIQDMLNRIVDAKVGVVVVFSIPIPAKAFFTEVIKRNITAVWVASTAWSLNDGVSTLPGISSIGTVLAFADITRPLDLFTPYIRELFTKIEGMAIPQQPDADISPLDNPCPRCSYVSQANVSMVEVDLVQRSAFSVYAAVYCAAYALHDLLGCNATSCTRNPKRDNVYPWQLLRKLQKLSLDLEGVNIQFDDEGNPNFGYDFMQWIFNDTTVTFDVIGYFYQNLTIESNAIKWHTKNGEVPMSTCSSDCGIGQVRRVKGFHSCCFDCIDCLEGTFLNNTDDIQCKSCPNGQWSTLRSTSCVYPIYTYLDWTNYESIGVILGGIVVLASHVWVGALFFKHRGTPLVKTAGGSLCGLTLLSLAGGCMSLVLFLGQPGDTVCRLQEPLNAFFPTVALSVILSSSLQIVCVTEFPEQSSEHLENLRGRGSWFVILGCCGLQAGLCGWYGLEGPSLTQYVASLDVTYVKTFLRCPVEPMLNFGLMLGFNVILALMSFMSTFMALKPPGQYNLARDITISTLSYCVMWVMFIPIYTSLDDKNKSLAQVGVSLLSNMGLVAAYFFPKCHLLVKQPELNTDDHFRTFLEGVPPTPPEES"

     sig_peptide     1..72
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    112..1500
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="ligand-binding domain of the T1R taste receptor;
                     Region: PBP1_taste_receptor; cd06363"
                     /db_xref="CDD:380586"
     misc_feature    order(343..348,352..357,364..369,376..378,409..411,
                     478..480,487..489,499..504,694..696)
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:380586"
     misc_feature    order(457..459,526..534,676..678,916..918)
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:380586"
     misc_feature    1498..1656
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1714..2475
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="type 1 taste receptor subtype 3, member of the
                     class C of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmC_TAS1R3; cd15290"
                     /db_xref="CDD:320417"
     misc_feature    1714..1791
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320417"
     misc_feature    order(1723..1725,1732..1737,1744..1749,1753..1758,
                     1858..1860,1870..1872,1879..1884,1906..1908,1918..1920)
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320417"
     misc_feature    1825..1890
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320417"
     misc_feature    order(1885..1887,1921..1926,1933..1938,1945..1947,
                     2191..2193,2206..2208,2215..2220,2227..2229,2329..2331,
                     2338..2343,2350..2352,2362..2364,2386..2391,2398..2400,
                     2407..2409,2419..2421)
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320417"
     misc_feature    1915..1989
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320417"
     misc_feature    2053..2115
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320417"
     misc_feature    2194..2274
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320417"
     misc_feature    2296..2367
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320417"
     misc_feature    2380..2457
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320417"
     exon            1..14
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
     exon            15..215
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..516
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..873
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1290
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1494
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1615
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1986
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2553
                     /gene="tas1r3"
                     /gene_synonym="t1rc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgcttctactgaggatgaagaacaagtggacttttctggtgctctgtggcattctggggtctggactcggcgacaacccatcatggttcaacaacatcactacaaattttttcaaatctcctggagatattctcattggaggacttttccccatcaaccaactcacaagtgaactgagccaacgggtgaaacctgatgatcttcagtgtgacagcataagcacatatggtctgtctctttcgctggtgatgaagttcactgtggacgagatcaactctaaaaagcatattctcccagggatcactcttggatttgagagttatgacacctgcatgcagccagccgttatcatgaagcccgtcctgcagcttctcacacaggaatcaacagatgaactggacatttattgtaactacaccaactacaagcctcgggttatggctatcataggaccagacagctcagacgtggtcccagatgctggcaagctgattggttttttcttgatgccaatgattagttacggtgccaccagcgatgagttcagtaacaaacagacctacccgtctttcatgcgaaccgtcgccagcgatcagtggcaggttgtggccatgatacagctgctgaaacagtttgggtggaactgggtgtcagtaataggtagtgacgaagaatacggccagatgggtcagcagcagttctccagcatggccaatgatgagtccatctgcgtggcctaccagggtttaattcccgtatacagtgatccaggacctacaatacaagatatgctgaatcggatcgtggatgctaaagttggagtggtggtggtcttctctattcccatcccagctaaagccttctttacagaggtaatcaaaagaaacattacagctgtttgggtggcgagcacagcatggagtctgaatgatggtgtatccaccctgcctggcatcagttcaataggcaccgtgctggcatttgcagacatcaccagacctcttgacctctttactccctacatccgtgagcttttcaccaaaatagaggggatggcgatcccacaacagccagatgcagacatctcgcctctggacaacccatgcccaagatgcagctatgtgagccaagccaacgtgagcatggtagaggtagacctagtgcagcgctcagctttcagtgtctatgctgccgtctactgtgccgcatatgctctgcatgacttgcttggatgcaatgcaaccagctgcactcgaaatcctaaaagagacaatgtctatccatggcagctgttgcggaaactccaaaaactgtctttagaccttgagggggtcaatattcagtttgatgatgagggcaatccaaactttggctacgattttatgcagtggatcttcaatgacaccactgtgacctttgatgtaattggatacttttatcagaaccttaccattgaaagcaatgctataaaatggcacacaaaaaacggagaggtgccaatgtccacctgctcctcagactgtgggataggacaggtgcgcagagtcaaaggtttccattcctgctgttttgactgtattgactgcttggagggaacattcctaaacaacacagatgacattcagtgtaaatcatgtcccaatggccagtggtcaactctaagaagcacaagctgtgtctatccaatctacacctacctggactggaccaactatgagtcaattggagtcattctgggaggaattgtagtgctagcatcacatgtatgggtgggggctctgtttttcaagcacagaggaactccactggtgaaaactgcaggtggatcgctgtgtggccttaccttgctgagccttgctggaggatgtatgagtctggtgctgttcctgggtcagccgggagacactgtctgccgcctgcaggagccacttaatgccttttttcccaccgtggccctctcagtcattctgtccagttcccttcagattgtgtgtgtcacagagtttcctgaacagtcttccgaacacctagaaaacctacgaggacgaggaagctggtttgtgattctgggatgttgcgggctgcaagcgggactatgcggctggtatggcctagaaggtccctccctgacccaatacgtcgccagtttggatgtgacttatgtgaaaacttttctacgctgcccagtggagccgatgttaaacttcggcctgatgctcggttttaatgtcatcctggctctgatgtcattcatgtccaccttcatggctctaaagccacctggacagtacaacttagccagagacatcaccatctccaccttgagttactgcgtcatgtgggtgatgttcatccctatttacaccagtctagatgataaaaataagtccctcgctcaagtaggagttagtttactcagtaatatggggttggttgcggcctacttcttccctaaatgccacctgctggtcaaacaaccagaactcaacacagatgatcactttcgtacatttttggaaggcgtcccacctacaccacctgaagaaagctaa

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