LOCUS       NM_001039525            2466 bp    mRNA    linear   VRT 11-AUG-2023
DEFINITION  Danio rerio taste receptor, type 1, member 1 (tas1r1), mRNA.
ACCESSION   NM_001039525
VERSION     NM_001039525.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2466)
  AUTHORS   Del Vecchio G, Murashita K, Verri T, Gomes AS and Ronnestad I.
  TITLE     Leptin receptor-deficient (knockout) zebrafish: Effects on nutrient
            acquisition
  JOURNAL   Gen Comp Endocrinol 310, 113832 (2021)
   PUBMED   34089707
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Cai W, He S, Liang XF and Yuan X.
  TITLE     DNA Methylation of T1R1 Gene in the Vegetarian Adaptation of Grass
            Carp Ctenopharyngodon idella
  JOURNAL   Sci Rep 8 (1), 6934 (2018)
   PUBMED   29720695
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2466)
  AUTHORS   Oike H, Nagai T, Furuyama A, Okada S, Aihara Y, Ishimaru Y, Marui
            T, Matsumoto I, Misaka T and Abe K.
  TITLE     Characterization of ligands for fish taste receptors
  JOURNAL   J Neurosci 27 (21), 5584-5592 (2007)
   PUBMED   17522303
REFERENCE   4  (bases 1 to 2466)
  AUTHORS   Bjarnadottir TK, Fredriksson R and Schioth HB.
  TITLE     The gene repertoire and the common evolutionary history of
            glutamate, pheromone (V2R), taste(1) and other related G
            protein-coupled receptors
  JOURNAL   Gene 362, 70-84 (2005)
   PUBMED   16229975
REFERENCE   5  (bases 1 to 2466)
  AUTHORS   Ishimaru Y, Okada S, Naito H, Nagai T, Yasuoka A, Matsumoto I and
            Abe K.
  TITLE     Two families of candidate taste receptors in fishes
  JOURNAL   Mech Dev 122 (12), 1310-1321 (2005)
   PUBMED   16274966
  REMARK    GeneRIF: Two families of candidate taste receptors in zebrafish,
            T1Rs and T2Rs, show significant identity to mammalian T1Rs and
            T2Rs, respectively.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB200899.2.
            
            On Feb 2, 2007 this sequence version replaced NM_001039525.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB200899.2, BC162412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Wako-Riken"
                     /db_xref="taxon:7955"
                     /chromosome="23"
                     /map="23"
     gene            1..2466
                     /gene="tas1r1"
                     /note="taste receptor, type 1, member 1"
                     /db_xref="GeneID:654781"
                     /db_xref="ZFIN:ZDB-GENE-060208-2"
     CDS             1..2466
                     /gene="tas1r1"
                     /note="zfT1R1"
                     /codon_start=1
                     /product="taste receptor type 1 member 1 precursor"
                     /protein_id="NP_001034614.2"
                     /db_xref="GeneID:654781"
                     /db_xref="ZFIN:ZDB-GENE-060208-2"
                     /translation="

MGTMLSNFVFLCLLRFSDSTGLHLQGDYILSGWFALHNSDSTIPPTPYLNDCKKGLTNKHGYHLVQAFRYAVDEINNGTQDKQLLPGVTLGYRTYDICSLPASNLATLDLLAQQLHPSAVDSRAVAIIGPDSSSYAFTPAAALGVFLVPQISYEATNELLSNKLLYPSFFRTIPSDKNQVNAMIQVLVKFNWTWIALLGSDNSYGIQGMQSLSEQAPLNNICIAYQAQIPAVTDSTKKYMQDMVKNILKTKVNTIVVFANKRRAAGFFPFVIAQNVTGKVWIGTEDWSVASTVSSIPGISMIGTVIGVAVKYTEFDGFDNYERLSVPGLKNPGQFNLSVPCMQNTNLYDIAINGFSLSQYDITSSFNVYKAVYAVAHALHNVLDCDSGLCQKYDVQPWQVYEQLRQVRFSIRNASFYFDKNGDPPTGYDIVTWEWTNGLWSFKVVGNYSPGANDLHLDDSQIDWSGQVSPVTNVPESICSPECPYGFRKLMTGQHKCCFDCMACPAATFLNKTGYTSCQPCPIDDWSEAESEVCLPRAELYLSWGAPLTTALIIYLAVTLFVTLGTTLVFLLNLSTPVVKSAGGKTCLLMLVSMIVACCSTLCHFSRPSRVGCLLKQPLFVISCTVCLACVTVRSFQVVCIFKWSSKLPRSYETWAKNRGPEMFILITTVVETFISVLRMLLVPPFPSRDYDFYHDSIVLECSKTLSLSAFAELFFVCALSLVCFCLSYMGKDLPANYNEAKCITFSLMIYMISWITFFTAYCISRGSFVMALNVGAILLSVLGILGGYFLPKVYIILIKPQLNTTAHFQNCIQMYTMAKQ"

     sig_peptide     1..57
                     /gene="tas1r1"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    64..1416
                     /gene="tas1r1"
                     /note="ligand-binding domain of the T1R taste receptor;
                     Region: PBP1_taste_receptor; cd06363"
                     /db_xref="CDD:380586"
     misc_feature    order(301..306,310..315,322..327,334..336,343..345,
                     412..414,421..423,433..438,628..630)
                     /gene="tas1r1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:380586"
     misc_feature    order(391..393,460..468,610..612,856..858)
                     /gene="tas1r1"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:380586"
     misc_feature    1423..1581
                     /gene="tas1r1"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1639..2397
                     /gene="tas1r1"
                     /note="type 1 taste receptor subtype 1, member of the
                     class C of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmC_TAS1R1; cd15289"
                     /db_xref="CDD:320416"
     misc_feature    1639..1716
                     /gene="tas1r1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320416"
     misc_feature    order(1648..1650,1657..1662,1669..1674,1678..1683,
                     1783..1785,1795..1797,1804..1809,1831..1833,1843..1845)
                     /gene="tas1r1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320416"
     misc_feature    1750..1815
                     /gene="tas1r1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320416"
     misc_feature    order(1810..1812,1846..1851,1858..1863,1870..1872,
                     2113..2115,2128..2130,2137..2142,2149..2151,2251..2253,
                     2260..2265,2272..2274,2284..2286,2308..2313,2320..2322,
                     2329..2331,2341..2343)
                     /gene="tas1r1"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320416"
     misc_feature    1840..1914
                     /gene="tas1r1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320416"
     misc_feature    1981..2043
                     /gene="tas1r1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320416"
     misc_feature    2116..2196
                     /gene="tas1r1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320416"
     misc_feature    2218..2289
                     /gene="tas1r1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320416"
     misc_feature    2302..2379
                     /gene="tas1r1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320416"
     exon            1..161
                     /gene="tas1r1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..450
                     /gene="tas1r1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..1197
                     /gene="tas1r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1419
                     /gene="tas1r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1540
                     /gene="tas1r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1911
                     /gene="tas1r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2466
                     /gene="tas1r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgggaacgatgttgagcaattttgtgtttctctgtctcttgagattcagtgacagcacaggtctccaccttcaaggagattatatcctctctggctggtttgctctgcataattcagattccaccatcccaccaactccttacctgaatgactgcaagaaaggtttgaccaacaagcatggctatcatctggtgcaggccttcagatatgctgtggacgaaattaacaacggcacccaggacaagcagctccttcctggggtcacactgggctaccggacatatgacatatgctctctcccagccagcaatctggccaccttggatctgctggcccagcagctgcacccctcagctgtggacagccgtgcggtggccatcattggccctgacagtagttcctatgctttcacaccagcagctgcactaggggtgttcctggttcctcagatctcttacgaggctacaaatgaactgcttagcaacaagctcctctatccatctttcttccgcaccattccaagcgacaaaaaccaagtcaacgcaatgatccaggttctcgtcaagtttaactggacctggatcgcccttctcggtagtgacaattcatatggtatacagggaatgcaaagcctatcagagcaagctccacttaacaatatatgcatcgcataccaagcccagatccctgcggtaacagacagcacaaagaaatacatgcaagacatggtcaaaaacatcctcaaaactaaagtcaacactatagttgtctttgccaataagagacgggctgcaggtttctttccttttgttattgcccaaaacgtgacgggtaaagtgtggattgggacagaggactggtcagtggcgtcgacggttagtagtattccaggaatcagtatgatagggacagtcattggtgttgctgttaaatatactgaatttgatggttttgacaattacgaaaggctttctgtgcccgggctaaaaaaccctggtcaatttaacctcagtgtcccgtgtatgcaaaacacaaacctttacgatatagcaattaatggcttttctttgtcgcagtacgacattacctcctcatttaatgtgtataaggctgtttacgcagtggctcatgcgctgcacaatgtactggattgtgactctggactgtgtcagaaatatgacgtgcagccatggcaggtttatgagcagctgagacaagtgcgcttttccatccgaaatgcatcattttactttgataagaatggagaccctcccacgggttatgacatagtgacttgggaatggacgaatgggttgtggtcatttaaggtggtgggaaattacagtcctggtgccaatgatcttcatttagacgactctcagattgactggtcaggacaagtgtctcctgtaaccaatgttcctgagtctatatgttctccggaatgtccttatggattcagaaagctgatgacaggacagcataagtgttgctttgactgcatggcatgccctgcggccacctttctcaacaaaacaggctacaccagctgccagccgtgtccaatagatgactggtctgaagcagagagcgaggtgtgtttgccgagggcagagctgtacctgtcctggggtgctcctctcaccacagccctgatcatttatctagccgtgaccctgtttgtgaccctgggcacaacgctggtctttctgctgaatctcagcactcctgtggtgaagtcggctggaggaaaaacctgtctgctgatgctggtgtctatgatcgtggcctgctgcagcaccttgtgtcacttcagcaggccgtcccgtgtcggctgccttctcaaacagcccctctttgtcatcagctgcactgtgtgcctggcctgtgtcactgtgcgctcttttcaggttgtttgtatattcaagtggtcctccaagctgccaagatcctatgaaacctgggcgaagaatcgagggcctgagatgttcatcctcatcacgacggtggtggagaccttcatctctgttctccgcatgctcctcgtccccccgtttccatctcgagactacgacttctaccatgacagcattgtcctggagtgcagtaagactctgtctctcagtgcctttgctgagctcttttttgtctgtgcgctgagcttagtttgcttctgcctgagttacatgggcaaagatctgccggccaattacaacgaggccaagtgcatcacattcagccttatgatttacatgatttcttggatcacgttctttacagcttactgtatttccagagggagcttcgtcatggcactaaatgtaggggcgattcttcttagcgtgttggggatactcggcggatacttcttgccaaaggtgtacataatcttgattaaaccccaactcaatacaacggctcactttcaaaactgcattcaaatgtataccatggccaagcagtga

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