LOCUS       NM_001030111            1442 bp    mRNA    linear   VRT 19-MAY-2024
DEFINITION  Danio rerio follistatin-like 3 (secreted glycoprotein) (fstl3),
            mRNA.
ACCESSION   NM_001030111
VERSION     NM_001030111.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Vocking,O. and Famulski,J.K.
  TITLE     A temporal single cell transcriptome atlas of zebrafish anterior
            segment development
  JOURNAL   Sci Rep 13 (1), 5656 (2023)
   PUBMED   37024546
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Gu,L., Tian,L., Gao,G., Peng,S., Zhang,J., Wu,D., Huang,J., Hua,Q.,
            Lu,T., Zhong,L., Fu,Z., Pan,X., Qian,H. and Sun,L.
  TITLE     Inhibitory effects of polystyrene microplastics on caudal fin
            regeneration in zebrafish larvae
  JOURNAL   Environ Pollut 266 (Pt 3), 114664 (2020)
   PUBMED   32768670
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Giffen,K.P., Liu,H., Kramer,K.L. and He,D.Z.
  TITLE     Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse
            Inner Ear Non-sensory Supporting Cells
  JOURNAL   Front Neurosci 13, 1117 (2019)
   PUBMED   31680844
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   Saunders,L.M., Mishra,A.K., Aman,A.J., Lewis,V.M., Toomey,M.B.,
            Packer,J.S., Qiu,X., McFaline-Figueroa,J.L., Corbo,J.C.,
            Trapnell,C. and Parichy,D.M.
  TITLE     Thyroid hormone regulates distinct paths to maturation in pigment
            cell lineages
  JOURNAL   Elife 8, e45181 (2019)
   PUBMED   31140974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Wagner,D.E., Weinreb,C., Collins,Z.M., Briggs,J.A., Megason,S.G.
            and Klein,A.M.
  TITLE     Single-cell mapping of gene expression landscapes and lineage in
            the zebrafish embryo
  JOURNAL   Science 360 (6392), 981-987 (2018)
   PUBMED   29700229
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1442)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC134879.1.
            
            On Apr 1, 2007 this sequence version replaced NM_001030111.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC134879.1, BC097220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="22"
                     /map="22"
     gene            1..1442
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /note="follistatin-like 3 (secreted glycoprotein)"
                     /db_xref="GeneID:557352"
                     /db_xref="ZFIN:ZDB-GENE-050913-111"
     exon            1..175
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..840
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /codon_start=1
                     /product="follistatin-related protein 3 precursor"
                     /protein_id="NP_001025282.2"
                     /db_xref="GeneID:557352"
                     /db_xref="ZFIN:ZDB-GENE-050913-111"
                     /translation="

MNVLAVLHCVILISVCEILGEHRTSAGMCWLQQGPEHRCDMVLMRGVSREECCAAGRLDTAWSNASLPINEVSLLGFLGIVSCKPCKENCEGVNCGLGKVCRMKSGRPQCVCSPDCSNISTKHAVCGSDGNSYKDECALLMARCKGHPDLEIMYQGECKKSCSNVVCPGTHTCVTDQTNSAHCVMCRTAPCPMPMITEQTICGNDNITYQSACHLRRATCFLGRSIGVRHYGHCRSNEASEENSLF"

     sig_peptide     100..159
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    430..573
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /note="Kazal type serine protease inhibitors; Region:
                     KAZAL; smart00280"
                     /db_xref="CDD:197624"
     misc_feature    700..801
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /note="Kazal type serine protease inhibitors and
                     follistatin-like domains. Kazal inhibitors inhibit serine
                     proteases, such as, trypsin, chyomotrypsin, avian
                     ovomucoids, and elastases. The inhibitory domain has one
                     reactive site peptide bond, which serves the...; Region:
                     KAZAL_FS; cd00104"
                     /db_xref="CDD:238052"
     exon            176..361
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
     exon            362..577
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
     exon            578..805
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1417
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccacgtcccagtctgcagacttcttatcagtacaagtacttcagaggaaagccgctggttccttcaaacatctgtgttaaagaagctttcggcagcatcatgaacgttttggctgtcctgcactgtgtgatacttatttcagtttgtgaaatacttggagaacatcgaacgagcgctggcatgtgctggttgcagcagggtccggagcaccgctgtgacatggtgctcatgaggggtgtgagcagggaagagtgctgtgctgctggccgtctggacactgcctggtccaatgctagtctgcccatcaatgaagtcagcctgctgggattcctgggaatagtttcctgtaagccgtgtaaagagaactgtgaaggagtgaactgtggccttggaaaggtgtgtagaatgaagtcaggacgcccacagtgcgtttgctctccagactgttccaacatctccactaaacacgcagtgtgtgggagcgatgggaattcctacaaagacgagtgcgcgctcctgatggctcgctgcaaaggtcatcctgacctggagataatgtaccagggggaatgcaaaaagtcctgctcaaatgtggtatgtcctggtactcatacctgtgtgacggaccagactaacagtgcccactgtgtcatgtgccgcactgcaccttgtccgatgcccatgatcaccgagcaaaccatctgcggcaatgataacatcacttaccaaagtgcttgccacctgcgtagggcaacctgctttttgggtcgatccataggagttcgccactatggacactgcagaagtaatgaagcaagtgaggaaaattcactcttctgaggatgtcaagacagatcctctccttgtatatattatgatggcacataagacgtgagagaacctgtttgaaaccatatcacaacacggtcctctgtaccaaagaaccactagtattttataggcatgcaattcaatacttaaaggaaacgtgtggtttttaacaggagaattgaactgatgaattgacagtgtgcatattgtaaatatactacaagctactatttattggagaaaagttaggaagtcggtgttatttatgtgttaacacgtttgagacaccatatattcgtacatcagctgcctttctctatgtatttattgtgggttttgcttcagttttcatgtatttgtcagaactgaataatgtaaacgtgcacgacagggtttccgtacctttgaatcctcataattactgaacagaaatgactaaaacattttttttgttttcacaaagagctatttcttgccaaataaatgtttttttacattacattttatggtatttatattatttttgtactaaatgtattatattattttatgtttttatttaaatgataataaataataattcacaaaaaaaaaaaaaaaaaaaaaaaaaa

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