LOCUS       XM_071607569            2507 bp    mRNA    linear   ROD 01-MAR-2025
DEFINITION  PREDICTED: Marmota flaviventris dicer 1, ribonuclease III (Dicer1),
            transcript variant X6, mRNA.
ACCESSION   XM_071607569
VERSION     XM_071607569.1
DBLINK      BioProject: PRJNA1228026
KEYWORDS    RefSeq.
SOURCE      Marmota flaviventris (yellow-bellied marmot)
  ORGANISM  Marmota flaviventris
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciuromorpha; Sciuridae; Xerinae; Marmotini; Marmota.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_092499) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_047511675.1-RS_2025_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/25/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Marmota flaviventris"
                     /mol_type="mRNA"
                     /isolate="mMarFla1"
                     /db_xref="taxon:93162"
                     /chromosome="2"
                     /sex="male"
                     /tissue_type="brown fat"
                     /dev_stage="adult"
                     /geo_loc_name="USA: Gunnison County, Colorado"
                     /lat_lon="38.718100 N 107.199200 W"
                     /collection_date="2017-07-11"
                     /collected_by="Gregory Florant"
     gene            1..2507
                     /gene="Dicer1"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     Protein"
                     /db_xref="GeneID:114104724"
     CDS             130..2418
                     /gene="Dicer1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X5"
                     /protein_id="XP_071463670.1"
                     /db_xref="GeneID:114104724"
                     /translation="

MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGFLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFIDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLRFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDEDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKRKSFEEDLKTYKAIEKILRNKCSKSVDTGEADVDPVVDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDEHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAVSIDSRVFKG"

     misc_feature    253..846
                     /gene="Dicer1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(253..264,271..273,322..345,466..468,655..657,
                     748..750)
                     /gene="Dicer1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(430..435,502..507,580..582,586..591,598..600,
                     673..681)
                     /gene="Dicer1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    940..1224
                     /gene="Dicer1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(955..960,967..969,973..978,1153..1158,1165..1170,
                     1177..1179,1186..1191,1198..1200)
                     /gene="Dicer1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1243..1821
                     /gene="Dicer1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1474..1482,1690..1692,1747..1749,1753..1755)
                     /gene="Dicer1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1702..1704,1708..1710,1783..1785,1789..1791)
                     /gene="Dicer1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2017..2283
                     /gene="Dicer1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
ORIGIN      

gctgtgattttccaataaactgctatcacaatgtcaaaatgcagttcagacagcagcaacacagagatctcaaacattaaaacgtaagctgtgctaggacaaaaatgcaatgaaagaaacactggatgaatgaaaagccctgctttgcaacccctcagcatggcaggcctgcagctcatgacccctgcttcctcaccaatgggtcctttctttggactgccatggcaacaagaagcaattcatgataacatttatacgccaagaaaatatcaggttgaactgcttgaagcagctctggatcataataccatcgtctgtttgaacactggctcagggaagacatttattgcagtactactcactaaagagctgtcctatcagatcaggggagacttcaacagaaatggaaaaaggaccgtattcttggtcaactctgcaaaccaggttgctcaacaagtatcagctgtcagaactcattccgatctcaaggttggggaatactcaaacctagaagtaaatgcgtcttggacaaaagagagatggaaccaagagtttactaagcaccaggttctcattatgacttgctatgtcgccttgaatgttttgaaaaatggcttcttatcactgtcggacattaacttgttggtgtttgatgagtgtcatcttgccattctggatcacccctatcgagaaattatgaagctctgtgaaaattgtccatcatgtcctcgaattttgggactaactgcttccattttaaatgggaaatgtgatccagaggaattagaagaaaagattcagaaactggagaaaatccttaagagtaatgctgaaactgccactgacctggtggtcttagacaggtatacttctcagccatgtgagattgtggtagattgtggaccatttattgacagaagtgggctttatgaaagactgctgatggaattagaggaagcacttaattttatcaatgactgtaatatatctgtacattcaaaagaaagagattctactttaatttctaaacagattctgtcagactgtcgtgcagtattggtagttctgggaccctggtgtgcagataaagtagctggcatgatggtgagggaacttcagaagtacatcaaacatgagcaagaggagctgcacaggaagttcctattgtttacagacacttttctgaggaaaatccatgcactgtgtgaagagcacttctcacctgcctcgcttgacctgagatttgtgactcctaaagtaataaaactgctcgaaatcttgcgcaaatataaaccatatgagcggcagcagtttgaaagtgtcgagtggtacaacaacaggaaccaggacaattatgtgtcttggagtgattctgaggatgaggatgaggatgaagaaattgaagaaaaagagaagccagagacaaattttccttctccatttaccaatattttatgtggaattatttttgtggaaagaagatacacagcagttgtcctaaacagattgataaaggaagctggcaaacaggatccagagctggcttatatcagcagcaactttataactggacatggcattggaaagaatcagcctcgaaacaaacagatggaagcagagttcagaaaacaggaagaggtacttaggaaatttcgagcacatgagacaaacctgcttattgcaacaagtattgtagaagagggtgttgatattccaaaatgcaacttggtggttcgttttgatttgcccacagagtatcgatcctatgttcaatctaaaggaagagcaagggcaccgatctctaattacattatgttagcagatacagacaaaagaaaaagttttgaagaagacctgaaaacctacaaagcaattgaaaagattttgagaaacaaatgttccaagtctgttgatactggtgaggctgacgttgatcctgttgtggatgatgacgacgttttcccaccgtatgtgttgaggcctgatgatgggggtccccgggtaacaatcaacacagccattggacacatcaatagatactgtgctagattaccaagtgatccgtttactcatctagctcccaaatgtagaacccgagagttgcctgatggtacattttattcaactctttacctgccaatcaactcacctcttcgagcctccattgttggcccaccaatgagctgtgtgcgattggctgaaagagtcgtagctctcatttgctgtgaaaaactgcacaaaattggtgaactggatgaacatttgatgccagttggaaaagaaactgttaaatatgaggaagagcttgatttacacgatgaagaagaaaccagtgttccaggaagaccaggttccacaaaacgaaggcagtgctacccaaaagcagttagtattgattccagagtgtttaagggatagttatcccaaacccgagcagccctgttacctgtatgtgataggaatggtcttaactactccgttacctgatgaacttaacttcagaaggc

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