LOCUS       XM_053804999            2868 bp    mRNA    linear   INV 24-FEB-2023
DEFINITION  PREDICTED: Anopheles marshallii protein argonaute-2 (LOC128709962),
            transcript variant X1, mRNA.
ACCESSION   XM_053804999
VERSION     XM_053804999.1
DBLINK      BioProject: PRJNA935337
KEYWORDS    RefSeq.
SOURCE      Anopheles marshallii
  ORGANISM  Anopheles marshallii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Nematocera;
            Culicoidea; Culicidae; Anophelinae; Anopheles.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_071326) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_943734725.1-RS_2023_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/15/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2868
                     /organism="Anopheles marshallii"
                     /mol_type="mRNA"
                     /db_xref="taxon:1521116"
                     /chromosome="2"
     gene            1..2868
                     /gene="LOC128709962"
                     /note="protein argonaute-2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 78
                     Proteins"
                     /db_xref="GeneID:128709962"
     CDS             1..2868
                     /gene="LOC128709962"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X1"
                     /protein_id="XP_053660974.1"
                     /db_xref="GeneID:128709962"
                     /translation="

MSTERELTPGSTQQLHPLSYSDMATHIQLNGVIMGKSFNESPWTSSPPRPPSPSQSQTSFDTLSPPPAGATVNPTTVATTTGTQGAQALGVVPATPPAPPDLPVFTCPRRPNLGREGRPIVLRANHFQITMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKMFGALKPVFDGRNNLYTRDLLPIGNDRVELEVTLPGEGKDRVFRVTIKWVAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPDGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGTMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYKMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVRRADFNNDAYVQEFGLTISNNMMEVRGRVLPPPKLQYGGRVSSMSGQLLSGPQNKVSLALPNQGVWDMRGKQFFTGVEIRVWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKSTFSHLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFDEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGFKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEADYKPGITFIVVQKRHHTRLFCADKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFESDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA"

     misc_feature    352..741
                     /gene="LOC128709962"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    769..921
                     /gene="LOC128709962"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    922..1284
                     /gene="LOC128709962"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1078..1080,1123..1125,1165..1167,1177..1179,
                     1231..1233,1252..1254,1258..1260)
                     /gene="LOC128709962"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1420..2739
                     /gene="LOC128709962"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1870..1872,1882..1884,1918..1929,1936..1938,
                     1960..1962,1969..1971,1981..1983,1993..1995)
                     /gene="LOC128709962"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2074..2076,2080..2082,2293..2295,2707..2709)
                     /gene="LOC128709962"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

atgtccacggaaagggaactaactcccggatcaacgcagcaattgcacccgctgtcctactcggatatggccacacacattcaactgaacggagtaataatgggcaaatcatttaatgaatcaccatggacttcttcgccgccaaggcctccaagtccgtctcagtcgcagaccagcttcgatacactctcaccaccgccagcaggcgcgacggtcaacccgacaacggtggcgacgacgaccggaacgcaaggtgcccaggcactcggtgtcgtaccggccacaccaccggccccaccagacctaccggtgttcacatgtccgcgccggccaaatttgggccgcgaaggccgaccgattgtgctgcgggcgaaccacttccagatcacgatgccccggggctatgtgcatcactacgacatcaacatccagcccgacaagtgtccacggaaggtgaaccgcgaaatcatcgaaacgatggtgcacgcgtacagcaaaatgttcggcgcactcaagccggtgttcgacgggcgtaacaatctgtacacgcgcgatctgctaccgatcggtaacgatcgcgtcgagctagaggtgacgttgcccggcgagggcaaggatcgtgtgttccgcgtcacaatcaagtgggtggcacaggtgtctctgttcaatctggaggaagcgctcgagggtcgcacacggcagataccgtacgacgctatactggcgctggatgtggtaatgcgccatctgccgagcatgacgtacacaccggtcggaagaagtttcttcagctctccggatggatactatcacccactgggtggaggccgtgaggtatggtttggtttccaccagagcgtcaggccatcgcagtggaagatgatgctaaacattgacgtgtcggctaccgccttctacaaagcgcaaccggtgatcgagttcatgtgcgaagtgttggacatcagagacatcaacgagcagcgcaaaccgttgaccgactcgcagcgcgtcaagttcacgaaggaaatcaaggggctcaagatcgaaattacccactgtggtacgatgcgacgaaagtatcgcgtctgcaatgtgactcgacgacccgcacaaatgcaatcgttcccgttgcagctagagaacggccaaacggtagagtgtacggtggcgaaatacttcctcgacaagtataagatgaagctgcgctatccgcatctgccctgtctgcaggtgggccaggagcacaaacacacttacctcccgctggaggtatgcaacattgtggccggtcagcgttgcatcaagaagctgacggatatgcaaacgtctaccatgatcaaggcaactgcccgttcggctccggatcgagagcgagaaatcaataatctggtgcgacgggccgatttcaacaacgacgcgtacgtgcaggagtttggtttgaccatctcgaacaacatgatggaggtgcgaggacgtgtgcttccgccaccgaagctacagtacggtggtcgtgtttccagcatgagcggacaattactctccggtccacagaataaggtgagcttagcattaccaaaccaaggggtttgggatatgcgaggcaaacaatttttcactggcgtcgagattcgcgtatgggctatcgcctgtttcgcaccgcagcgcaccgtgcgggaggatgcactacggaacttcacccagcagttgcagaagatttccaacgatgctggtatgccgatcattggtcagccatgcttctgcaagtacgccactggaccggatcaggtggagccgatgttcagatatctgaagagcaccttcagtcacctgcagctcgtcgtcgtggtgctgcccggcaaaacacccgtttatgcggaagtgaagcgagttggtgacacggttctcggtatggcgacacaatgtgttcaggctaaaaatgtcaacaagacgtcaccacagacactgtccaatctctgcttgaagatcaacgtgaagctgggcggtatcaactcgatcctggtgccatcgatcagaccaaaggtattcgacgagcctgtcattttccttggcgccgatgtaacacatccaccggccggtgataacaaaaaaccctcgatagcagcagtggtcggttcgatggatgcgcatccgtcgcggtacgcggccaccgttcgtgtacagcagcaccgtcaggaaattattcaggagttgagtagtatggtgcgggagctgctaattatgttctacaaatcgaccggtggtttcaagccacaccgcattatactgtaccgggacggtgtatcggagggccagttcccgcacgtgcttcagcacgagctgaccgcgattcgtgaggcgtgcataaagctggaggcagattacaagccaggcatcacgttcatcgtggttcagaaacgtcaccacacgaggctattctgtgcggacaagaaggagcaaagtggtaaatcgggcaacattccagccggtacgaccgtcgatgtaggcattactcatccgaccgagttcgacttttacctgtgcagtcaccagggcattcagggcacgagtcgtccgtcccattaccacgtactctgggatgacaatcacttcgagtcggacgagctgcagtgcctaacgtatcaactgtgtcacacatacgtgcggtgtactcgatccgtgtccattccagctcctgcctactacgcacatctggtggcatttagggcgaggtaccacttggttgagaaggagcacgattctggcgaaggatcgcatcagagcggctgctccgaggacagaacgcctggtgcgatggcacgtgccattaccgtacacgccgacaccaaaaaggttatgtactttgcttaa

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