LOCUS       XM_048969220            3443 bp    mRNA    linear   VRT 07-JUL-2022
DEFINITION  PREDICTED: Lagopus muta argonaute RISC component 4 (AGO4),
            transcript variant X2, mRNA.
ACCESSION   XM_048969220
VERSION     XM_048969220.1
DBLINK      BioProject: PRJNA853367
KEYWORDS    RefSeq.
SOURCE      Lagopus muta (rock ptarmigan)
  ORGANISM  Lagopus muta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Tetraoninae; Lagopus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_064455) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: Lagopus muta Annotation Release 100
            Annotation Version          :: 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3443
                     /organism="Lagopus muta"
                     /mol_type="mRNA"
                     /isolate="bLagMut1"
                     /db_xref="taxon:64668"
                     /chromosome="23"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
                     /geo_loc_name="Iceland: Husavik, NE"
                     /lat_lon="66.088900 N 17.264700 W"
                     /collected_by="Kristinn P. Magnusson"
     gene            1..3443
                     /gene="AGO4"
                     /note="argonaute RISC component 4; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 36
                     Proteins"
                     /db_xref="GeneID:125703987"
     CDS             300..2684
                     /gene="AGO4"
                     /codon_start=1
                     /product="protein argonaute-4 isoform X2"
                     /protein_id="XP_048825177.1"
                     /db_xref="GeneID:125703987"
                     /translation="

MVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSIQWVSVVSLQMLLEALAGHLNEVPEDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKLTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQETSQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA"

     misc_feature    309..563
                     /gene="AGO4"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    594..746
                     /gene="AGO4"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    747..1109
                     /gene="AGO4"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(903..905,948..950,990..992,1002..1004,1056..1058,
                     1077..1079,1083..1085)
                     /gene="AGO4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1248..2555
                     /gene="AGO4"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1659..1661,1671..1673,1707..1718,1725..1727,
                     1749..1751,1758..1760,1770..1772,1782..1784)
                     /gene="AGO4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1863..1865,1869..1871,2109..2111,2523..2525)
                     /gene="AGO4"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gtccttcggctgtccacagccgcggggcacgtgtgggagccccggtgctgggcctgcggaggtcgcagccacaccgttacccgaacccgcgcggtgtgggatccggctcacaaatagggcccccaacaagccttttccagcccccccgtcgcccaggcctgggaactgttgggaagcccatccgcctcctggccaaccatttccaggtgcagatccctaagatcgacgtttatcactatgatgtggatatcaaaccagaaaaacgaccccgaagagtcaacagggaggtggtggatactatggtgaggcacttcaagatgcagatatttggtgaccggcagcctggatacgatgggaagaggaacatgtacactgcacacccgttacccatcggcagggacagagtggatatggaggtgacgcttccaggagaggggaaggaccagacttttaaagtgtccattcagtgggtgtcagtcgtcagccttcagatgctgttggaagctctggcagggcatctgaacgaagttcctgaggattctgtgcaggccctggatgtaattacccggcaccttccctccatgaggtatactcctgtgggtcgctccttcttctccccccctgaaggctattaccaccctctggggggtggcagggaggtctggtttggtttccaccagtctgtcagacctgccatgtggaacatgatgctcaacattgatgtatcagcaactgctttctatcgtgctcagcctatcattgagttcatgtgtgaggtcttggacattcagaacatcaatgaacaaaccaagcctctgacagactcccagcgtgtcaagtttaccaaagaaatcagaggtctgaaagtagaggttactcactgtggccagatgaagagaaaataccgagtttgcaatgttactcgtcgaccagccagtcatcagacgtttcccctgcagttggaaaacgggcaggctatggagtgcacagtagctcagtattttaagcagaagtacagtctgcagctaaaatatcctcatcttccctgtctgcaagtaggacaggagcagaaacacacgtacctaccgcttgaggtgtgtaacatcgtggcaggccagaggtgcatcaagaagctgacagacaatcagacatcaaccatgataaaagcgactgcgagatcggcgccggaccggcaggaagaaatcagcagactcgtgaaaagtaacagtatggttggtggacctgatccatatctgaaggagtttggtattgttgtccataatgaaatgactgagttgacaggcagagttttgccagcgccaatgctgcaatatggaggcaggaacaagactgtggccacaccaaaccaaggtgtgtgggacatgagagggaaacagttctatgctggcattgagattaaagtttgggctgttgcctgttttgctcctcaaaaacaatgcagggaagacttactaaagagttttacagaccagctgcgtaagatctccaaggacgcagggatgccgatccagggccagccctgcttctgtaaatatgcccagggtgcagacagtgtggagcccatgtttaaacatctaaaactgacttatgttggcctgcagctgatcgtggtgattctacccggcaagacacccgtgtatgctgaagtaaagcgggttggtgacactcttcttggcatggccactcagtgcgttcaggtaaagaacgtggtgaaaacctcaccacaaacgctgtccaacctgtgtctgaaaataaatgcaaagctcggaggaatcaacaatgtgctcgtacctcatcaaaggccctcagtgttccagcagcccgtgatctttctgggagcagatgtcactcaccctcctgctggggatggaaagaagccttccatagctgctgtggtgggcagcatggacggccatcccagccggtactgcgccacggtgcgggtgcagacctcccgtcaggagacctcacaggagctgctgtacagccaggaggtgatccaggatctgacaaacatggtgcgggagctgctgatacagttctacaagtccacgcgtttcaagccgaccagaatcatttactacagaggaggagtgtcagaagggcagatgaagcaggtagcttggccagaacttatagcaatccgaaaggcctgtattagtttggaagaagactacagaccaggaataacctacattgttgtgcagaaaaggcatcacaccaggctgttctgtgctgacaaaactgaaagggtgggtaagagtggcaacgtaccagcgggcaccactgtggacagcaccatcacgcatccctctgaatttgacttttacctctgcagccacgcgggaattcagggaaccagccggccctcgcactaccaggtcctgtgggatgacaactgtttcactgcagatgagctacagctgctgacctatcagctgtgtcacacgtacgtgcgctgtacgcgatcagtctctattccagcacctgcatactatgccagactggtggcatttagggctaggtaccatcttgtggacaaggatcacgacagtgctgaaggcagccacgtgtcaggacagagcaatggccgtgatcctcaggctctggcaaaggcagtgcagatccaccacgatactcaacataccatgtattttgcttgagagcgtttgggaagatgaggcaaagccaacaactcgttcagtcctgacgtgttttcaatgcctactgctctagctagggccctttctttcagactgcccactaccagcagctctgaacggtcgcactgaatctggactgcaaacaatgtctgatgcaccgacacaattgagccatttgttccgttcttttacgtaatagaaattcatagactgtcttttctgatgcattggactgaatttttacctcaaagtgcaaaaggccgatcaccccgacgtttttcaaggacttggcacgaaaggtttctatggaatattttgctagcgatggtctttaggttcccttctcaccccatgcgttgatggtgacgactgattctccgtcctcacgcgctgctcagtgactgcgtagtatggcgaaactcctccacttcgatgtcattgttctcttgtgtggggccatagatttttttaatggagattttagacttcactactgtaaatgccttttaacagacgtaactttcacaggtcttgcagttttcgtcggttttactaatgacctttttaacctgcagactcgggctgcaaagcaattgcactattctgccagtccagaccggtggttcctgctctgtgaatgtgtgacgtgcccaggtggtgatgcctgtcagcaggtttgcattggaacggctaccagtaacactgccctggtctcataacaaacactgaaccatcgttttctcccccctcttaaaaaaa

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