LOCUS       XM_044766391            3779 bp    mRNA    linear   MAM 18-DEC-2024
DEFINITION  PREDICTED: Equus asinus nuclear factor kappa B subunit 1 (NFKB1),
            transcript variant X2, mRNA.
ACCESSION   XM_044766391
VERSION     XM_044766391.2
DBLINK      BioProject: PRJNA1198117
KEYWORDS    RefSeq.
SOURCE      Equus asinus (donkey)
  ORGANISM  Equus asinus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091792) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 18, 2024 this sequence version replaced XM_044766391.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_041296235.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/16/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3779
                     /organism="Equus asinus"
                     /mol_type="mRNA"
                     /isolate="D_3611"
                     /db_xref="taxon:9793"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="Whole blood in anticoagulant"
                     /geo_loc_name="USA: Ithaca, New York"
                     /collection_date="2018-03-01"
                     /breed="Donkey"
     gene            1..3779
                     /gene="NFKB1"
                     /note="nuclear factor kappa B subunit 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 420 long SRA reads, 7 Proteins"
                     /db_xref="GeneID:106825951"
     CDS             192..3104
                     /gene="NFKB1"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     X2"
                     /protein_id="XP_044622326.1"
                     /db_xref="GeneID:106825951"
                     /translation="

MAEDDPYLGGHEQMFHLESLNHTMFNPELFPQEVSLPTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKHTHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACVRGYNPEILVHPDLRYLQAEGGGDRQLTDREKEVIHQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGIWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGGGGGGGGAGSTGPGYGFPHYGFPTYGGITFHPGAAKSNAGMKHGTIDTSCKNDPEGCDASDDREAVNLSGKGTETTARKESGGRADAIAPAPPAGAEEGRSCCQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLVSDDIINMRNDLYQTPLHLAVITKQEAVVEDLLRAGADLSLLDRFGNSALHLAAKEGHDKILGILLKHKKAALLINHPNADGLNAIHIAMMSNSMPCLRLLVTAGADVNAQERKSGRTALHLAVERDNISLAGCLLLEGEAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEEDGEDEGVVPGTTPLDMAASWQVFDILNGKPYEPEFTSDDLLAQGDMKQLTEDAKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIKELVDALRQMGYTEAVEVIQAAFCTSGTAAPSPVTTTSQAPSLPLAPASTRQQIDELREDSVCDSGVETSFRRLSFTESLTSGSSLLTLNKMPHDYMQEGPIEGKI"

     misc_feature    312..917
                     /gene="NFKB1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Region:
                     RHD-n_NFkB1; cd07935"
                     /db_xref="CDD:143651"
     misc_feature    order(354..356,360..365,369..374,381..392,615..617,
                     621..626,915..917)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     misc_feature    936..1241
                     /gene="NFKB1"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; Region:
                     IPT_NFkappaB; cd01177"
                     /db_xref="CDD:238582"
     misc_feature    order(939..941,945..953,957..965,1083..1091,1128..1130,
                     1164..1166,1221..1223,1230..1232,1236..1238)
                     /gene="NFKB1"
                     /note="ankyrin protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238582"
     misc_feature    order(945..950,954..956,993..995,999..1001,1005..1007,
                     1104..1109,1116..1118,1122..1124)
                     /gene="NFKB1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238582"
     misc_feature    order(1008..1010,1014..1016,1107..1112)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     misc_feature    1668..2483
                     /gene="NFKB1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    1800..1913
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(1923..1925,1935..1940,1947..1955,1959..1964,
                     1974..1976,1983..1985,2010..2012,2016..2018,2022..2024,
                     2034..2039,2046..2054,2058..2063,2073..2075,2082..2084,
                     2118..2120,2124..2126,2130..2132,2142..2147,2154..2162,
                     2166..2171,2181..2183,2190..2192)
                     /gene="NFKB1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1923..2012
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2016..2120
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2124..2216
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2226..2324
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2622..2846
                     /gene="NFKB1"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; Region: Death_NFkB1_p105; cd08797"
                     /db_xref="CDD:260063"
     polyA_site      3779
                     /gene="NFKB1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

gcgcccgcgcccctcgccagcgccgggccatggcgcgccgctgaccccggccggcgacaccgcgcccgcccgccccggcgccggctccggttccgcggccgctccctcctgctccgcacgcccaggcccgcgcccgcggagggagccccagcgcagggaggccgcgcgcggacgcgccaccaggctccagaatggcagaagacgatccatatttgggaggtcatgaacaaatgtttcatttggagtctttgaatcatacaatgtttaatccagaattatttccacaagaggtgtcactacccacagatggcccataccttcaaatattagagcaacctaaacagagaggatttcgtttccgttatgtgtgtgaaggcccatcccacggtggactgcccggtgcgtctagtgaaaagaacaagaagtcctaccctcaggtcaaaatctgcaactacgtgggacctgcaaaggttattgttcagttggtcacaaatggaaaacacacccacctgcatgcacacagtttagtgggaaaacactgtgaggacgggatctgcacggtgactgctggacccaaggacatggtggtcggttttgcaaacctgggtatacttcatgtgacaaagaaaaaagtatttgaaacactggaagcccgaatgacagaggcctgtgtcaggggctataaccccgaaattttggtgcatcctgatcttcgttatttgcaggcagaaggcggaggagaccggcagctcacggatcgggaaaaggaggtcatccaccaggcagctcttcagcagacgaaggagatggacctcagcgtggtgcgactcatgttcacggcgtttcttccggacagcaccggcagcttcacacggcgcctggaacccgtggtgtcggacgccatctacgacagcaaagcccccaatgcctccaacttgaagattgtcaggatggacaggacagctggatgcgtgactggaggggaagagatttatcttctctgtgacaaggttcagaaagatgacatccagatccgattttatgaagaggaagaaaatggtggaatctgggaaggatttggagatttctcccccacagacgttcatagacaatttgccatcgtcttcaagactccgaagtataaagatgtcaacattacaaaaccagcctccgtgttcgtccagcttcggaggaaatctgacttggaaaccagcgaaccaaaaccttttctctactatcctgaaatcaaagataaagaggaagtacagaggaagcggcagaagctcatgcccaacttctcggatagtttcggcggcggcagtggggccggcgctggaggtggtggcatgtttggcggtggtggtggaggagggggtgctggaagcacaggtccagggtacggctttccgcactatggattccctacgtatggtggcattaccttccaccctggagctgcgaaatccaatgctgggatgaagcatggaaccatagacacctcgtgtaaaaatgatcctgaaggttgtgacgcaagtgatgacagagaggctgtaaatctctctgggaaaggaaccgagaccacagcacgaaaggagtctggcggcagggctgatgccattgctccagcgcccccagcgggagcagaggaagggcgctcctgctgtcaggataacctgtttctagagaaggctatgcagcttgccaagcggcacgccaatgcccttttcgactacgcggtgacaggagatgtgaagatgctactggctgtccagcgccatctcactgcagtgcaggatgagaatggggacagtgtcttacacttagcgatcatccaccttcacgcccagcttgtgagggatctgctagaagtcacgtctggtttggtttctgatgacattatcaacatgagaaatgacctctaccagacgcccttgcatttggcagtgatcaccaagcaggaagctgtggtggaggacttgctgcgggccggggccgacctgagccttctggaccgcttcggtaactctgctttgcacctagctgccaaagaaggacatgataaaattctcggtattttactcaagcacaaaaaggcagcactacttatcaaccaccccaatgcggacggtctgaatgccattcacatagccatgatgagcaacagcatgccgtgtctgcggctgctggtgactgccggggcggacgtcaacgcccaggagcggaagtcggggcgcacggcgctgcacctggctgtggagcgggacaacatctccctggccggctgcctgctcctggagggtgaagcccatgttgacagtaccacctacgatggaactacacccctgcacatagcggccgggagagggtctacccggctggccgctctcctcaaagcagcaggagcagaccccttggtggagaacttcgagcctctctacgacctggatgactcttgggaagaggatggagaggacgaaggagtcgtgcctggaaccacacccctagacatggccgccagctggcaggtatttgacatattaaatgggaaaccctatgagcccgagtttacatcagatgatttactggcacaaggagacatgaaacagctgactgaagatgcaaagttgcagctctacaagttgctagaaatccctgatccagacaaaaactgggccactctggcacagaaattaggtctggggatactaaataatgccttccggctgagtcctgccccgtctaagactcttatggacaactacgaggtctctggggggacgataaaagagctggtggacgccctgagacagatgggctacacagaagcagttgaagtgatccaggcagcattctgcacctcaggaaccgcagcccccagcccagtgacgaccacctcccaggccccctcgctgcctctcgcacctgcctccacaaggcagcaaatagacgagctccgggaggacagcgtctgtgacagtggcgtggagacctccttccgcagactcagcttcacggagtctctgaccagcggcagctcactgctaactcttaacaaaatgccccacgattacatgcaggaaggacctatagaagggaaaatttagcctgctggcaatttccaacaacatgtaaaccaaagctctgaaattccaccacgctgtccaagagaaggaaggccaagtgcagccaaaggtgctccaaggaaaccacctgcttggatcgttctggactccattcaaggccttggagagttggcttccttccctggctcttagctgagtttaattgggctcgtttacagatagtctcttgcaatcacggcacctggctgggttgaggcctcgctggggtgcggtggcttattgagctttaccagctgctttctgtggtcatcgctgctgtccctctgctgcattcccactgtcactaaaaggtgtcgcagtccgcacctggtgttctctctggccgtccaaggcacacttgtgcattcagattaaggattaagaaaagggatattttaaaatgagtcacttagtatataataaaaaaaggccccctgctttttctgatcgggttatctctgtgatttgaaaaagaacatgtacatgtcaatatttaaacatggttacaatcagtgctggaaatggtattttcccctttttctgcattttgctattgtaaatatgtttttttagatcaaatactttaaaggaaaaaatattggatttataaatgctattttttattttacttttataataaaaggaaaagcaaattga

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