LOCUS       XM_043080959            2796 bp    mRNA    linear   INV 17-AUG-2021
DEFINITION  Brugia malayi PAZ domain containing protein (Bm4557), partial mRNA.
ACCESSION   XM_043080959
VERSION     XM_043080959.1
DBLINK      BioProject: PRJNA27801
            BioSample: SAMEA3146321
KEYWORDS    RefSeq.
SOURCE      Brugia malayi
  ORGANISM  Brugia malayi
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
REFERENCE   1  (bases 1 to 2796)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   2
  AUTHORS   Howe,K., Paulini,M. and Williams,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-2019) EBI, Wormbase, EMBL-EBI, Wellcome Trust
            Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK, United
            Kingdom
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NW_025062477).
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Brugia malayi"
                     /mol_type="mRNA"
                     /strain="FR3"
                     /db_xref="taxon:6279"
                     /chromosome="Unknown"
                     /note="contig: Bm_v4_Chr3_scaffold_001"
     gene            <1..>2796
                     /gene="Bm4557"
                     /locus_tag="BM_BM4557"
                     /old_locus_tag="Bm1_18705"
                     /db_xref="GeneID:6098650"
     CDS             1..2796
                     /gene="Bm4557"
                     /locus_tag="BM_BM4557"
                     /old_locus_tag="Bm1_18705"
                     /standard_name="Bm4557"
                     /note="Partially confirmed by transcript evidence"
                     /codon_start=1
                     /product="PAZ domain containing protein"
                     /protein_id="XP_042936893.1"
                     /db_xref="GeneID:6098650"
                     /translation="

MAGSSAVEKVRMQMEQASVSRLPVRLADKIAPGIRKSELLDVVTNVWGLISHENIPIYRYDFRVLEEYPPKKDSKEPSFKEVTKQVRNDYVAVDRRAKCFAVYQALLRREKQFFGAADTLIYDRASILYSLRKLSFPRASGDEVRKTFFLNKNELPANIVSDDCVKVHVNIKPCKEDFQLAMHDLKNCVSNNPDEINSSLQQFLEILAMQEVFFMQGRFVSYGTGECYLMDPSQFGFGDRDMPELQEGKYVAIGAAKGVRIIEGLGNFKRGINAGLVLDAKKAAFHIDNQHLLEKVESIFRRTRAEIGHGIDQQSILILSKALKGLYVRCSYGKNREFAIAGISKENAHTSKLALKTGEMSVEKYFMTKYSIKLKYPKLPLIMERCQPKNNLYPIEVLVVCENQRVSKGQQTSSQVQTMIRACATEPSVRLMQTNRLSQAMKLDNSNQHKWIGKCNMTITDNFMFPARVLPQPVIEYHTNGWINPNEKTVWMDGKKYYLIPAVCEKWYAVALMGPREERFHENQFCTYIKMFLERCRKHGMQIRDPIGYEYIRRSKEQDIESLIIKAKKSGATFIHFVTADELNYHARMKYIESQEQILTQDLKASTALGIVMKRQYQTLDNIVNKTNIKMGGLNYSVHLEENCDRWLGRPGFLIVGLDIAHPSYSRVPNKDRNTVLSVVGYSANIKKHPLDFIGGYRFAKAQMEELMDDAIQQIFSDLLRYFNANRGTPPTHLFVIRDGISVGQYKYVMNTEVEQIKHACQLVGGQNYRPHITFIVLTKMHNLRIYKKNIHKQERAAQQNIKPGTVIDKHVVNPVLSEFYLNSHSTFQGTAKTPRYTLLFDTSKMEADEMQGIVHALAYNFQIVNMAVSLPSPVMIASRMAKRGRCNYVAMFGDGSESSDNGKNNEKDAVELNKQLSYINKPLEVVRFNA"

     misc_feature    961..1254
                     /gene="Bm4557"
                     /locus_tag="BM_BM4557"
                     /old_locus_tag="Bm1_18705"
                     /note="PAZ domain; Region: PAZ; pfam02170"
                     /db_xref="CDD:460472"
     misc_feature    1402..2658
                     /gene="Bm4557"
                     /locus_tag="BM_BM4557"
                     /old_locus_tag="Bm1_18705"
                     /note="PIWI domain. Domain found in proteins involved in
                     RNA silencing. RNA silencing refers to a group of related
                     gene-silencing mechanisms mediated by short RNA molecules,
                     including siRNAs, miRNAs, and heterochromatin-related
                     guide RNAs. The central component...; Region: Piwi-like;
                     cd02826"
                     /db_xref="CDD:239208"
     misc_feature    order(1756..1758,1768..1770,1801..1812,1819..1821,
                     1855..1857,1864..1866,1876..1878,1888..1890)
                     /gene="Bm4557"
                     /locus_tag="BM_BM4557"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:239208"
     misc_feature    order(1975..1977,1981..1983,2215..2217,2635..2637)
                     /gene="Bm4557"
                     /locus_tag="BM_BM4557"
                     /note="active site"
                     /db_xref="CDD:239208"
ORIGIN      

atggcaggtagtagtgcagtcgaaaaagtgaggatgcagatggaacaggcaagcgttagtagattgcctgttcgtttggcagataaaatagctccaggaattcgtaagtcagaattattggatgtagtaacaaatgtttggggattaatttcacatgaaaatataccaatttatcgttatgatttccgtgttttggaagaatatccgcctaaaaaagatagcaaagaaccttcatttaaagaagtgacgaaacaagtgcgaaatgattatgttgctgtggatcgaagagcaaaatgttttgcggtttatcaagctttattaagacgtgagaagcagtttttcggtgccgcagatacactcatttatgatcgtgcttccattttatattcattgcgaaagttatcttttccaagagctagtggcgacgaggtacgaaaaacattttttctgaataaaaatgagcttccagcgaatatagttagcgatgattgtgttaaagtccatgtaaatatcaaaccttgtaaagaggattttcaattagcaatgcatgatctgaagaattgtgtcagtaataatccagatgaaatcaacagcagtttgcagcagtttttagaaattttggctatgcaagaagtattttttatgcagggccgctttgttagttacggaacaggagaatgttatcttatggatccgagtcagtttggttttggcgatagagatatgcctgaacttcaggaaggaaaatatgttgctattggtgccgcaaaaggtgtacgaattattgaaggactgggtaattttaaaagaggcatcaatgcaggactagtgctcgacgcaaaaaaagcagcatttcatatcgataatcagcatttgcttgaaaaagtagaatccatatttcgaaggactagagctgaaattggccatggtattgatcaacaatcaatacttattttaagtaaagctctcaaaggtttgtacgttcgttgttcttatggtaaaaaccgtgagttcgctattgcaggcatttcgaaagaaaatgcgcatacatcaaaattggcgcttaaaacgggtgaaatgtcggttgagaagtatttcatgacgaaatattcgattaaactaaaatatccaaaattgccattgattatggagcgatgtcaaccaaaaaataacctttatccgatagaagtactagttgtatgtgaaaatcaacgggtatccaaaggacaacagacatcatctcaagtacaaacaatgattcgagcatgtgctacagaaccatctgttcgattaatgcagacgaatagattgagtcaagcaatgaagcttgacaattctaatcagcataaatggatagggaaatgtaatatgaccattacagataatttcatgtttccagcaagagtgcttcctcagccagttatcgaatatcacactaatggatggataaacccaaatgaaaagactgtatggatggatggaaaaaaatattacctaattccggctgtttgcgaaaagtggtatgcggtggcattaatgggtccacgagaagaaagatttcatgaaaatcaattctgcacttatataaaaatgtttttggaacgttgtcgtaaacatggcatgcaaataagagatccaattggttatgagtatattcgtcgttcaaaagagcaagatattgaatcgttaataataaaagccaaaaaatcgggtgcaacattcattcattttgtgactgctgatgaattgaattatcatgcacgtatgaaatacatcgaatcacaggaacaaattcttacacaagatttaaaagcgtcaactgcattaggaatagtcatgaaacggcaatatcaaacacttgacaatatcgttaataaaacaaacataaaaatgggtggattaaattattcggttcatcttgaagaaaactgtgacagatggctaggaaggccgggatttcttattgtgggtttggatattgcgcatccttcttattctagggtacctaataaagatcgaaatactgtgctatcagttgttggttattcggcaaacataaaaaaacatccgttagatttcattggtggatatcgctttgctaaagctcagatggaagagctaatggatgatgcgatacaacaaatattctcagatttattgcgttattttaatgcaaatcgtgggacgccgcccacccacttattcgttattcgagatggcatatctgttgggcaatataaatatgttatgaacaccgaagtagaacagatcaaacatgcatgccagttagttggtggtcaaaactatcgtccacatatcacattcattgtacttacaaagatgcataatttgcgcatttataaaaagaatattcataagcaagaacgagcagcacaacagaatattaagccgggtacagttattgataagcatgtggtaaatcctgtcttaagtgaattttatttgaattcgcattctacatttcagggtactgcaaagacgccacgatatacgttgttatttgatacttcgaaaatggaagccgatgaaatgcaaggtattgtgcatgcacttgcatataattttcaaattgttaatatggcagtatcacttccatctccagtaatgatagcttcacgtatggcaaaacgtggtcgctgtaattatgtggctatgttcggggatggatcggaaagttctgataatggtaaaaataatgagaaggatgcagtcgagttaaacaaacaactaagctatattaataaaccattggaagtagtacgatttaatgcatga

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