LOCUS       XM_031684022            6912 bp    mRNA    linear   MAM 07-APR-2025
DEFINITION  PREDICTED: Vicugna pacos argonaute RISC component 1 (AGO1),
            transcript variant X3, mRNA.
ACCESSION   XM_031684022
VERSION     XM_031684022.2
DBLINK      BioProject: PRJNA1244907
KEYWORDS    RefSeq.
SOURCE      Vicugna pacos (alpaca)
  ORGANISM  Vicugna pacos
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda;
            Camelidae; Vicugna.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_132999) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 7, 2025 this sequence version replaced XM_031684022.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_048564905.1-RS_2025_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/02/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6912
                     /organism="Vicugna pacos"
                     /mol_type="mRNA"
                     /db_xref="taxon:30538"
                     /chromosome="13"
     gene            1..6912
                     /gene="AGO1"
                     /note="argonaute RISC component 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 4 long SRA reads, 4 Proteins"
                     /db_xref="GeneID:102541909"
     CDS             91..2220
                     /gene="AGO1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X3"
                     /protein_id="XP_031539882.1"
                     /db_xref="GeneID:102541909"
                     /translation="

MPHRVGACARGTSSLPVPARYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRVSRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    157..309
                     /gene="AGO1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    310..672
                     /gene="AGO1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(466..468,511..513,553..555,565..567,619..621,
                     640..642,646..648)
                     /gene="AGO1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    805..2091
                     /gene="AGO1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1225..1227,1237..1239,1273..1284,1291..1293,
                     1315..1317,1324..1326,1336..1338,1348..1350)
                     /gene="AGO1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1429..1431,1435..1437,1645..1647,2059..2061)
                     /gene="AGO1"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      6912
                     /gene="AGO1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

aaatccctgttcccctggagtctgtgcaagccctggatgtggccatgaggcacctggcatccatgaggccagggctcctccgtgcccaggatgcctcacagggtgggggcctgtgcccgagggaccagttctctgcctgtccctgccaggtacacccctgtgggccgctccttcttctcaccgcctgagggctactaccacccgctggggggtgggcgcgaggtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtctcagccaccgccttctacaaggcgcagccagtgattgagttcatgtgtgaggtgctggacatcaggaacatagatgagcagcctaagcctctcacggactctcagcgtgtgcgcttcaccaaggagatcaagggcctaaaggtggaagtgacccactgtggacagatgaagaggaaatatcgcgtgtgtaatgttactcgccgccctgccagccatcagacgtttcccttgcagctggagagtggacagactgtggaatgtacagtggcacagtatttcaagcagaaatacaaccttcagctcaagtatccccacctgccctgcctgcaggttggccaggaacaaaagcatacctacctgcctctagaggtctgtaacattgtggctgggcagcgctgcattaagaagctgaccgacaaccagacttcgaccatgataaaggctacagctaggtcggccccagacagacaggaggagatcagccgtctgatgaagaatgctagctacaacctagatccctacatccaggaatttgggatcaaggtgaaggatgacatgacggaggtgacagggcgagtgctgccggcgcccatcttgcagtacggcggccgggtgagcaggaaccgggccattgccacacccaatcagggtgtctgggacatgcgggggaaacagttctacaatgggattgagatcaaagtctgggccatcgcctgcttcgcaccccaaaaacagtgtcgagaagaggtgctcaagaacttcaccgaccagctgcggaagatttccaaggatgcaggaatgcctatccagggccaaccttgcttctgcaaatacgcgcagggggcagacagcgtggagcccatgttccggcatctcaagaacacctactcagggctgcagctcattatcgtcatcctgccagggaagacgccagtgtatgctgaagtgaaacgtgttggagatacactgttgggaatggctacacagtgtgtgcaagtgaagaatgtggtcaagacctcacctcagactctgtccaacctctgcctgaagatcaatgtcaaacttggtggcattaacaacatcctagtcccacaccagcgctctgccgtctttcaacagccagtgatattcctgggagcggatgttacacaccccccggcaggggatgggaaaaagccttcgatcacagcagtggtaggcagtatggatgcccatcccagccgttactgtgctactgtgcgagtgcagcgaccacggcaggagatcattgaagacttatcctacatggtacgtgagctgcttatccagttctacaagtccacccgcttcaagcctacccgcatcattttctaccgagatggtgttcctgaaggccagctcccccagatcctccactatgagctgctggccattcgtgatgcctgcatcaaactggaaaaggactaccagcctgggatcacttatattgtggttcagaaacgccatcacacccgccttttttgtgctgacaagaatgagcgaattgggaagagtggtaacatcccagctgggaccactgtggacaccaacatcacccacccatttgagtttgacttctatctgtgcagccacgcaggcatccagggcaccagccgaccatcccattactatgtcctttgggatgacaaccgtttcacagcggatgagctccagatcttgacgtaccagctgtgccacacttacgtgcgatgcacacgctccgtctcaatcccagcacctgcctactatgctcgcttggtggctttccgggcacgataccacctagtggacaaggagcatgacagtggagaagggagccacatatcggggcagagcaatgggcgggatccccaggccctggccaaagccgtgcaggttcaccaggatactctgcgcaccatgtacttcgcttgaaggcagaacgctgttacctcactggatagaagaaagctttccaagccccaagagctgtgctgcccaaatccagaggaagcagggaggagggaggtggggtaggaagaaatgcagaaggccttgtttccttctacagagtggatgaaagagtggggaacagggccagtaagccagaccaccagccagaaatctctgatattcacctcatgtcctccacccctcaccccatcttgtcacatctggccctgaccccactggaccaagacgggcagcatcggtgcccaccatacacacaggtgtctcatgtgactcacagtgctaaagactcatgcctgacagcttggtaaggtcggctctgcagccctgcggacaaaagctggtaggtttgggtttgatactttagatgggaaagtgaggggcttgagaaagtgggtgggaggagggaagaatattttaggagccttaatcagaaaaggtctagatttgtttaagaagaaaaacgaaaccagacccagatcaatattttaggatactagatgttttaattggttgataatccagtttgtaggaagatttttaatgctaatggttttggttgctcctcccccagctgtcactcccctttccctattcctctctttccaccttttctaccccgccttacacctcctccctgtcagacaaccagcccctagtaagacttaaggcactatggcacttagctccgaagtgacatgaccctgtcttccttccgcctgctggtgggtaaccagtgccttccctgtaacggtaatgctgcagaactgcaaccttttgtaccttttgggtgggggacggggaggggtgggagaggaggtaggtggggatgaaatacccctaacccaacaagcctccagccagagcgccagctattttgcatttgaaggaattgacttccatattcattgagctttttaaaagatcatgacctcaagatggttaaaatccattgacatttgcactttcagacctgacaagtctcagagctgctgagatgactggcccctggcctttccacttatgtctcctttcttcctgtctcccattcctgggtctggagttactttcatagcatttctcactcttggtttctttttttccctgatggtcaagtctctttacgtttcaatatttcttaactggggtgtcttataacaaacgatccttaggtctaaaataagaaaaaagcaaaaactaaatgttatttttataccataacttgagtctattgccaaaatctggaaatccctcccatgcccaatgagtttacatcccagaaacattgagccatcagaaggaactatatacctgacttgttctttggcctggctagttagggggtggttatctccccagggtggggctcaggctccacccttcctctgtgcagataatatctttttcttgctacaggctccctcttctgcactgccctgcactctttcctgcaaatgcatcttcccttcctctggactgttttctgacactttggctcatcccagatttcagcgtgtcctgtggataggctggggattttgctgctccctattgcttctgtttacacaaatgaatttttcctggtttcccactagggcatgtgagtgggtagcatgggcttttttttttttttttttttttccatctccctgggtagagatggggtttggctgtcttgcagaactggaaaagtagggggttctagcttggtgcctgtgaccttgaagcaaggctccctctttccttgactgttcatttttttcctgtcccactgtttgggatgcggagttcagcttcagtgtggaaattcctctttttgaggaacctgggcttggatttgccctaatctggtgatgaagccatgacactttagacctagcttgtgctcagaggccagccagaggaaggtcggtctgaatacgggcctgtgcagttagagctaccatttcccctccccagcagcccttgtacagacccagatttgctatgcaaaacagtctatcccaggttcttttctggttggctacttcattcagcaacttcacaaaacgtagcacaaacattgattatggagaaggcatcaggactgttgagtaactcctcctttacttcttttgtactggtatgggatgccccatgggcacagcccagctgaagaacagaatggagggctctgggaggaggcagctcactggagagcctacattccttacacaagtgcctaaagagagtgatgccaacactccatctgccctgtccatcgccttcatacactgtctacttcgtgttcagtcaccctttggggaggggagctctcttgggacagtgggctctgcatgttctcttcttgggtgtgttttggggctgggatcagggcagcattcctggaggatccagtcattcaccagcatttgcaaatatccattgggagctggtggtagccacctactctcagcaacgagtttgtgttctctcttttttctctctttgcctcactctctccagttgggttttgaactggggcttgaaatgtgtattttagccctttggcattgtatatgccatttaggaaataaaagcaagaaaaacagcttgggcaatggcaagaaaatgacttcttgctgtgattttctttcttttcttttcttcttttttttaatctttgaaacttgaaaaatgaccttgaggattattcttgtttgaaaggtggtgcatgcagattgagcagtggtgttggcagcaagctttggctttctgggatttggttaaagtggtgcttcttacttaagctttgaggaattgctggggggaccccagcctcatcctcttaaacaggtctcttctccctttctttcacttttttgccttccttttccccttctctcttcctctgatctcttttaattttttattttatttattttttgttgttgttcactcagcttgctggctggcctgtctgcctatgtgataatgaattctctgcatggctacaatgatcccaccgttagctggcaaggtcaggcttagctccttggctgtaggagaccaagaatctgtttcccaggcccagtgatgtccaccctgggctgtactgccctccaacttacatgagggcattagcagaaggcctgtccaactagcatgataccaggagggcttctggcaacttccacacttgtccactctttggagttggtttctctcattgctttttctagatctggtttcatttctctcttcttggggcctcccttttctgaggatgtcctagagttgagctacttggtcatccggagttggagggttaggagatggacataggggaagaagagagtgataggaagaaaatggagagagtgtggcttaaatgtgggaaaggagggcattgatcttattgatcacttttccagtctagcctgactcattgggggttgaggtgctactgctagccactggggataatcctggggctgttgttcctgcgaacttaggcttagaataatgctgaagaagaaggtacctaaaagtatgacacctcccttaaaagttccggttctttcctattcagtagatcctctctggcctcctctttggctaagcaatgatgttgttggatagttttctttttcttgtccagaattctgtaaatgaggctagcaagatggacagccacggagacactttgacttcttagctggcccaggggatatctgcaaggctgactggacaatgtttttagacttggcatcatgtgtaataaagaaggatgaaagttccttccccttcagggtagaaagtcatctcaaactaactaaaatgttgttttggaaactacattggggaagttatttttatttatatttactgggcctaggccaatccaggatggtagctgggatgccttccttcttaaagtctgatcatggcagggttttgcagggcactgtttcctctttggccttctaagcagactggggagaagggattctctggttttctctccctccctccccccaccatttattaggacttaccttctccctgggcagggagagaggctaggttggtgctctccccttactctactccttagaacctctagctgctgtttgggagcccaagaaaggggatggagggaatgagctcaaaagaaaagaaaagaaaacaaaacaaaaaacagaataatgtggggaaggcagatttccttctttaaaaaggaaaataggaaaccctccaaggattgtgcaagtaaagacaatgtgtcgaatgcactgagtcccctggtgtagtagcaataaggaaaaatgaaatgactttcctgtgcacacagtccagcctgattggtgtgtgatgttgcacttagcagccatctggtgggcatgtgtgactactctgggtttcactttagtttctaaactttttatctctctcaagtccagcatggatggggaaatgttccttgaaccccacagctgtgtacttgtttgcatttgtttccccttgagacttgtgtttgtgtcctgctttgagctgtaccttgtccagtccattgtaaaattatcccagcagctgtaatgtacagttccttctgaagcaagcagcagcagcacaattctgtgttttataaagacaacagtggcttctatttctaaa

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