LOCUS       XM_028963480            3736 bp    mRNA    linear   VRT 02-JUL-2025
DEFINITION  PREDICTED: Denticeps clupeoides argonaute RISC catalytic component
            2 (ago2), mRNA.
ACCESSION   XM_028963480
VERSION     XM_028963480.1
DBLINK      BioProject: PRJNA533386
KEYWORDS    RefSeq.
SOURCE      Denticeps clupeoides (denticle herring)
  ORGANISM  Denticeps clupeoides
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes;
            Denticipitoidei; Denticipitidae; Denticeps.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_041726.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_900700375.1-RS_2025_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/27/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3736
                     /organism="Denticeps clupeoides"
                     /mol_type="mRNA"
                     /db_xref="taxon:299321"
                     /chromosome="20"
     gene            1..3736
                     /gene="ago2"
                     /note="argonaute RISC catalytic component 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 34 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 1 sample
                     with support for all annotated introns"
                     /db_xref="GeneID:114769985"
     CDS             165..2735
                     /gene="ago2"
                     /codon_start=1
                     /product="protein argonaute-2"
                     /protein_id="XP_028819313.1"
                     /db_xref="GeneID:114769985"
                     /translation="

MYSSGAAGTPPSPPATEYAFKPPQRPDFGTMGRTIKLQANFFEMEIPKLDVYHYDIDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVYDGRKNLYTAMPLPIGRDKVELEVTIPGEGKDRSFKVAIKWMSCVSLQGLHEALSGHLPNIPFETIQALDVVMRHLPSMRYTPVGRSFFTPSEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFMCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQENGQTIECTVAQYFKDKYKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCVKKLTDNQTSTMIRATARSAPDRQDEISKLMRSANFNSDPYVREFGVMVRDDMTEVNGRVLQAPSILYGGRNKAIATPIQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTELLLKAFTDQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFKHLKYTYQGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQVKNVQKTTPQTLSNLCLKINVKLGGVNNILLPQGRPLVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQQHRQDIIQDLATMVRELLIQFYKSTRFKPTRIIYYRDGISEGQFNQVLQHELLAIREACIKLEKDYQPGITFVVVQKRHHTRLFCTDRNERVGKSGNIPAGTTVDTKITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNHFTSDELQVLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDQQALAKAVQVHQDTLRTMYFA"

     misc_feature    429..653
                     /gene="ago2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    681..833
                     /gene="ago2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    834..1196
                     /gene="ago2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(990..992,1035..1037,1077..1079,1089..1091,
                     1143..1145,1164..1166,1170..1172)
                     /gene="ago2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1329..2606
                     /gene="ago2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1740..1742,1752..1754,1788..1799,1806..1808,
                     1830..1832,1839..1841,1851..1853,1863..1865)
                     /gene="ago2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1944..1946,1950..1952,2160..2162,2574..2576)
                     /gene="ago2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gatcagcagccactcatgttggtgtattttaaatcttcttatcattaattttaatagcgcttttaaaacaagcgtccgccgccacatgtgtgcgcgcctctgtcggtttttaatacattaaagggagcacgtccttggacccgtgagaagacgtctaaattaaaatgtattcaagtggagcagctgggactcctccatctcctccagcaaccgaatatgcgttcaaacccccccagcggccagattttggcactatgggtcggacaatcaagcttcaagccaatttttttgagatggagattcccaaactggatgtgtaccattacgacatcgatatcaagcccgagaaatgcccgcgaagagtcaaccgtgaaatagtggagcacatggtccagcactttaaaacgcagatctttggtgaccgaaaaccagtgtatgatggaagaaagaacctctatacggcaatgcccttacctataggaagggacaaagttgagttggaggtgaccatcccaggtgagggaaaagacagaagcttcaaggtggccatcaagtggatgtcctgtgtcagcttgcaaggtcttcatgaagccctgtctggccacctccccaacatcccctttgagacaatccaggctctggatgtggttatgagacatttgccgtcaatgagatacactcccgttggccgatcattcttcaccccatcagaaggctgttccaacccccttggaggaggacgtgaggtttggtttggtttccaccagtctgtcagaccttccctttggaagatgatgcttaacattgatgtgtcagccactgctttctacaaagcccagcctgtgattgagtttatgtgtgaggttttggatttcaagagcattgaagagcaacagaagcccttaacagactcccagagagtgaaattcaccaaggaaataaaaggcttgaaggtggagattactcattgtgggcaaatgaagagaaaatatcgtgtctgcaacgtaactagaagaccagccagtcaccagacgtttcccttgcagcaggagaatggacagacaattgaatgcacagttgcacagtacttcaaagacaaatacaaactggtgctgcggtatcctcatctgccatgtttacaggttggccaggaacagaagcacacctatctgcccttggaggtgtgtaacatagttgctggccagaggtgcgtgaagaaactgactgacaatcagacctccactatgatccgtgccactgccaggtctgcccctgaccgccaagatgagatcagcaaactgatgagaagtgccaactttaactctgatccatatgtgcgagagtttggggttatggtaagagatgacatgactgaagtgaatggtcgggttctacaggcaccttccattctgtacgggggccggaataaagctatagctaccccaattcagggtgtatgggacatgaggaacaagcagtttcacactggaattgagatcaaagtgtgggccattgcttgctttgctcctcagaggcagtgcaccgagctcctgctcaaggcgtttacagaccagctccgaaagatctcccgcgatgcaggaatgccaattcaaggacagccatgcttctgtaaatacgcccaaggagccgacagcgttgagcccatgttcaagcaccttaagtacacttaccagggcctacagctggtggtggtcattctcccagggaaaacacccgtctatgccgaggtgaagcgtgttggtgatacagtgctgggcatggcaacgcagtgtgttcaggtgaagaatgttcaaaagacaacacctcagacactgtccaacctctgtctgaagattaacgtcaagctgggtggtgtgaacaacatccttctgccgcagggccggcccttggtgttccagcagccagtcatcttcttgggtgctgatgtgacccaccccccagcaggagatgggaagaagccctccattgctgctgttgtgggcagtatggatgcccaccccagccgttattgtgccacagtacgtgttcagcaacaccgtcaggacatcatccaggacttggccaccatggtgcgtgaactgctcatccagttctacaagtccactcgcttcaagcccacgcgtatcatatactaccgtgatggcatctctgagggacagttcaaccaggtgctgcaacacgagctcctggcaatccgtgaagcctgcattaagcttgaaaaggactaccagccaggcatcacttttgtagtagtgcagaagcgccatcacacccgcctgttctgtacggacaggaatgagagggtgggaaagagtggcaatatccctgctggtaccacagtggacaccaaaatcacccacccgtcagagtttgacttctacctttgtagccatgctggcatacagggcaccagcagaccgtcacactaccacgtgctgtgggacgataaccatttcacttctgacgagctgcaggtcctcacttaccagctgtgccacacctatgtccgctgcacacgctccgtctcgatcccggctccagcttactatgcccacctggtggcgttccgtgctcgataccacctggttgacaaggagcacgacagtgctgaagggagccacacatctgggcagagcaatggaagggaccagcaggccctggccaaggcggtgcaggtgcaccaggacacgcttcgcaccatgtactttgcctaggcgctggccggggcccaggagccatgggccagccacccagcatgatgattgagtcatggactgcaccagcggggctcttggcaaatcagcacagatccaacgggatcgccacattgttctcctgtgcactgctgaacatcacaacagccatgggtgaggcctcaagtggacaaaactcattcccaaccttctgtcacaactccacattagtccatgtccaaatctgtaaactgcttgcccccccccacccctgctgcccttagtgtgtgatattcgtctgtacaaaaattgcagggtggggggtcactgttttaatttgctgtgtgtttttatatgttgttcatgttttatatttgttaattaggggctaaatcgtttacataggagagcaatcctattcggagtacattttacccactgaccattcgtaatcagacaacatggggacagtattagattgatctggccaaagagggttaaagctctacatgctaacctttgtaagctggcaattgtatgaagtattgaattgacaaggttcttggtatagcggctatgggcatgttctaaagagacaatgcactgactggagcagacttggctgaagtacttagcatgcttagatatctttgtctatccttccctaaacgtggcagggagagggggatcttccctcaacccaactgtatttgttcttgaacgtccatcacaaatttgggcagaaggttagtgtgagagatttgaaaactgtaagacaattcaaatttaggggtaggctacacatcaagctcctcccctctaatgtcgctaagagatttgtttttgacaatcatttgccccaagactcctttaaagttccaaaattcctcatctattttgggaccggttcccagcagcgacaccatctgtgctctctgagccaagtttcattagcccttaattctttttaagagccttcgtttccagtttcaatgcgtaagcacacttgtcttagctctgta

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