LOCUS       XM_025165013            4610 bp    mRNA    linear   VRT 24-MAY-2018
DEFINITION  PREDICTED: Python bivittatus argonaute 2, RISC catalytic component
            (AGO2), transcript variant X2, mRNA.
ACCESSION   XM_025165013
VERSION     XM_025165013.1
DBLINK      BioProject: PRJNA238085
KEYWORDS    RefSeq.
SOURCE      Python bivittatus (Burmese python)
  ORGANISM  Python bivittatus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
            Toxicofera; Serpentes; Henophidia; Pythonidae; Python.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_006532583.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Python bivittatus Annotation Release
                                           102
            Annotation Version          :: 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4610
                     /organism="Python bivittatus"
                     /mol_type="mRNA"
                     /db_xref="taxon:176946"
                     /chromosome="Unknown"
                     /sex="female"
                     /tissue_type="liver"
                     /country="USA: Texas"
     gene            1..4610
                     /gene="AGO2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 10 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 9 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:103061429"
     CDS             345..2876
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X2"
                     /protein_id="XP_025020781.1"
                     /db_xref="GeneID:103061429"
                     /translation="

MQAYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKMDIYHYELDIKPEKCPRRVNREIVEHMVQHFKAQIFGDRKPVFDGRKNLYTAMPLPIGRDKQVELEVTLPGEGKDRIFKVAIKWMSVVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPFVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKTFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"

     misc_feature    534..794
                     /gene="AGO2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    822..974
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    975..1337
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1131..1133,1176..1178,1218..1220,1230..1232,
                     1284..1286,1305..1307,1311..1313)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1470..2747
                     /gene="AGO2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1881..1883,1893..1895,1929..1940,1947..1949,
                     1971..1973,1980..1982,1992..1994,2004..2006)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2085..2087,2091..2093,2301..2303,2715..2717)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

cgttgtgtagcttttcctagacgagcattgaagtctctcctttcagggcaactagtctggtttgcattgtggctgctgctgttgctgtgatgtcagagtgattatggttgcctctgtagatgattttgatcaaacatgtcctctcttttgatatctagcctagtgtattggtactgttctattgttagtcgtggcaaaaggtggatgccggttttaaagaacaagagatacctttccttctttaaagatggaggattagttggaaagaatgacagaacttgcatcacttgttgtgatttccctctcttgtagtccttacaacgcctccatcactgccacctccaatgcaggcgtatgcatttaaacctccccctcgacctgatttcggtacttcaggaagaacaatcaaactgcaagccaatttctttgaaatggacattcccaaaatggacatctaccattatgaattggatataaagcccgagaagtgtcctagaagagttaacagagaaatagttgaacacatggtccagcactttaaagcgcagatatttggagatcgcaagccagtatttgatgggagaaaaaatctctatacagcaatgccacttccaatagggagagataaacaggtggaattggaggtcactttgccaggagaagggaaggacagaatatttaaggtggccatcaagtggatgtcagttgtgagtctgcaggcgttgcatgatgctctctctggtcgtcttccaagtgttccttttgaaaccattcaggctcttgatgttgtgatgaggcatctgccctctatgagatatactccagtgggccgttccttttttactgcatcagaaggatgttctaatcctttgggaggtggcagagaagtttggtttggattccatcagtcagttaggccttcactgtggaaaatgatgctgaacattgatgtctctgcgacagcattttataaggcacagccagtaattgaatttgtatgtgaagttcttgatttcaaaagtattgaagaacaacagaaacctctgacagattcccaaagggttaagtttaccaaagaaattaaaggtcttaaggtggaaattactcattgtgggcaaatgaaaagaaaataccgagtatgcaacgttaccagaaggccagcaagtcaccaaacatttccccttcagcaggagagcggtcagactgttgaatgcaccgtagctcaatattttaaggacaggcacaaattagtattacgttatcctcatcttccatgtttacaagttggacaggagcagaaacacacataccttcccctagaggtatgcaatatagttgcaggacagagatgtattaagaagctgacagacaatcaaacttctactatgattagagcaacagcgagatcagccccagatcgtcaagaagagatcagcaaattgatgcgaagtgcaagttttaatactgaccctttcgttcgtgaatttggaattatggtcaaagatgaaatgacagatgtaacggggagagtgttacagccaccttcaattctctatggaggccggaacaaagcaattgctaccccagtacaaggggtttgggatatgaggaacaaacagtttcatactggaattgaaataaaggtctgggccattgcttgctttgctccccaacgtcagtgcactgaagtccatcttaagaccttcacggaacaactgaggaagatatcaagagatgcgggaatgcccatccagggtcagccttgtttctgtaaatatgcccagggagcagacagcgtggaaccgatgttccgccatctcaagaacacctatgctggcctgcagcttgtggttgtcattctgcctgggaaaactcctgtttatgcggaagtgaagcgtgttggtgataccgtgttgggaatggccacacagtgtgtgcagatgaaaaatgtgcaaaggaccaccccacaaacactttccaacttgtgcttaaagatcaatgtcaaactaggaggagtaaataacattttattgccacaaggaagacctccagtatttcagcagcctgtcatcttcctgggtgcagacgtcactcatccaccagccggagatgggaaaaaaccatctattgctgctgttgtaggcagcatggatgcccatccgaatcgctactgtgccactgtgagggtccagcagcatcgccaagaaataattcaagacttggctgccatggttagggagctgctgatccagttctacaaatcaacccgattcaagccaacacggattattttctatagggatggcgtttccgaggggcagttccagcaggttcttcatcatgaattgctggctatccgagaagcatgcattaagctagaaaaggattatcagccggggatcacgttcattgttgtgcagaaaagacatcacaccagactgttttgcacagacaaaaatgaaagagttgggaaaagtggaaacattccagcaggtacaaccgtggacacaaaaatcacccacccttcggagtttgacttctatctgtgtagtcatgctgggattcagggcacaagcagaccgtctcattaccatgttctctgggatgacaatcgcttctcttcagatgaacttcagatcctcacttaccaactgtgtcatacgtatgtgcgttgtactcgttctgtttcaatccctgcgccggcgtactatgcacacctggttgccttcagagccaggtatcatttggtggataaagagcatgacagtgctgaaggaagccacacttctgggcagagcaacggcagagaccatcaagccctcgcgaaagctgttcaggtccaccaggacacattgcgcaccatgtactttgcttgatgtggccgtgatttgaggaactcagttctgagttggattcacaggagaccagctgcacttagaccaacagttgcccaagctatagcgacagccagcaaggagtgatgcatctttatttttaattcggggggggggggatgatggtaatgatgatgattgtgattctgtttgcaagaacgcctttcatccagaatttcagacttgagtgtgaactgcagacctttacaaaattgcacagcttttagatgtgtggatttgccaaaatcaaaagctgcttgtcaggagaaaaggaaaaaaaaaaaaaatgaaaacccacgttttctaactaacttagagctgtgatctcagggctaaaaacaacacttctcgttttagttatgactttttcagatacacttctttgtaaaaatctgaaaaatatccaattaagatcagattgagcgggcctgggaaaaacgatgaatttgcttttattccttaaaaaaaacaaagcgctagttttgatgccattgaagtctttgatccttctggatgcatttgtaaaatgtttttgtactgatgtgcaacaggagtgagcgaatccgggtttgtcctttgctgtcttattgataagaagtctgtgaaggtctatgggcaaaaatgtatttttgaagttcgttcttgaatgtctttcattgtgctgtttaaattttttgtagggtgcgttatggaattatttcagttacaaaaagaagtttatctatactttttattaggtccactgaaagattagtgaagtgtgccactttttaaaagaagtttattttttcttaaaataatccattttgattactaatcatggagtttgtcctataggactgtgacacttaattttccaaagcttttctaaagaatacgggtctgtggtgatacagtacaatctctttcactgttatgtttgaattaatgtaaaatttatatatgtttcacagtattaacatgatagcatagatactatttatatttatttactaaagagtgctcaacatagttctgtttaacatatcacaaactgaagaatgctttggagttttaaagtgggaagcttatatgtggacaagagtgatttgggtcgaattcaccaactgtagcttcttgcaggttccctgttcattttaacgaggcttgtgtgggacacctcatcccggcctccttgaaatgaagcaaggaggaccggccctggtgtgttgtccctttaaagaacagggatatgcaactaccttgtatggcagaggggagacgtgcttggcgtttatatcattttttaaagctagtgtcttggaaggatttagaagaattcacaggctgtagtttagacaagagcatcaaaggaagtttcgtagttcattcaagcacataaattatttttttctgttggatcatctgagttacagaaatggaaggaaagagatctgtgtttatttggggagggaagtgatggcgtaatacgtaatgtggacaaaatgtgttaagtgggaagggcgttttctttggagaaggtgaacccctcagaggcctgctaaaaataaaagcttctcttactgtgcgcaagattcatccgaccaaatattcaaagctaccgttgcactaatgaggacaacaggaacactactaaaatactgtggattgggaagccttcttcctcttccgatcttctaggaattaaaaaaaaaaaaatactaaccgcatccaggc

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