LOCUS       XM_024646124            2871 bp    mRNA    linear   INV 10-APR-2018
DEFINITION  Strongyloides ratti Protein argonaute-4 (SRAE_0000025800), partial
            mRNA.
ACCESSION   XM_024646124
VERSION     XM_024646124.1
DBLINK      BioProject: PRJNA304930
            BioSample: SAMEA1682816
KEYWORDS    RefSeq.
SOURCE      Strongyloides ratti
  ORGANISM  Strongyloides ratti
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
            Strongyloides.
REFERENCE   1  (bases 1 to 2871)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-APR-2018) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   2
  AUTHORS   Aslett,A.Martin.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-SEP-2014) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
            Cambridgeshire. CB10 1SA, United Kingdom
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NW_020171519).
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Strongyloides ratti"
                     /mol_type="mRNA"
                     /strain="ED321 Heterogonic"
                     /db_xref="taxon:34506"
                     /chromosome="Unknown"
     gene            <1..>2871
                     /locus_tag="SRAE_0000025800"
                     /db_xref="GeneID:36373497"
     CDS             1..2871
                     /locus_tag="SRAE_0000025800"
                     /codon_start=1
                     /product="Protein argonaute-4"
                     /protein_id="XP_024500338.1"
                     /db_xref="GeneID:36373497"
                     /translation="

MAESNIDCPQLTDNNNDKINNIDENDKNNLLISLTNLLILQNTHNNCNNNFTNQFEELIMLNTGTQNSINNEGHEISNYPSFLNNVPIMNTKNNNELSLVQNKQIPFVFQIPKRPDHGTQGREIDLKANFFKIKIPYINIVWYYVEIFPENCPRKVNRQVMETLISTHPNIFGNLKIVYDGKKNMYSKEILSIGGDMIEFEVNIGVNPNEERLFTVTIIYQNTISLQLLDDVFNGLLSNVPSECIKALDIILRHLPSIEYTPVGRSFFSPPDNLIIERINYRPESAKLGGGREVWFGFHQSVRPSELRMMLNIDVSATAFYSKVSVLHFLCQVLEIPIPEPREKLSLSDAQRVKFCREIKGLKIEVTHLGQMRRKYRICNVTRRSAYSQTFPLDNGNGKSTECTVARYFSDKYNIKLRYPFLPCLQVGQENRHIYLPIEVCKIVLGQRCNKKLNDSQTSIMIKATARNAPDRESEITSLVRRANMIDDEWAKEFGISINDEMTEVKGRILPPPKLMYSRDTKSTVIPFQGVWDMRNKQFHTSFEVKTWAMACFAEQLHVRENDLREFTVHLRRISTDAGMPLIGNPCFCKYVGGVSQVEPMFQYLKTTYPTLQLIIVILPGKTPIYAEVKRVGDTILGIATQCIQAKNVIKTTSQNLSNLCLKINVKLGGVNTILLPSVRPPIFNEPVIFLGADITHPPAGDPKKPSIAAVVGSMDAHPSRYAATVRVQSTRQEIITDLAFMVRELLVQFYKSTHFKPTKIVLYRNGVTENNFLNVLQYELRAIREACMSLERGYQPGITFIVVQKRHHTRFFVCNKDERVGKAQNIPPGTIVDSGVTHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNKLNSDELQILTYQLCHTYVRCTRTISIPAPAYYAYLVAFRARYHLVDRERDSGEGSQPSETSEDTTMSNLTRAIRVHPNASKVMYFA"

     misc_feature    538..756
                     /locus_tag="SRAE_0000025800"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    784..963
                     /locus_tag="SRAE_0000025800"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    973..1332
                     /locus_tag="SRAE_0000025800"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1126..1128,1171..1173,1213..1215,1225..1227,
                     1279..1281,1300..1302,1306..1308)
                     /locus_tag="SRAE_0000025800"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1471..2742
                     /locus_tag="SRAE_0000025800"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1876..1878,1888..1890,1924..1935,1942..1944,
                     1966..1968,1975..1977,1987..1989,1999..2001)
                     /locus_tag="SRAE_0000025800"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2080..2082,2086..2088,2296..2298,2710..2712)
                     /locus_tag="SRAE_0000025800"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

atggctgaaagtaatattgattgccctcaattaacagataacaataatgataaaataaataatattgatgaaaatgataaaaataatcttttaatttctttaacaaatttattaatcttacaaaatactcataataattgtaataataattttactaatcaatttgaagaattaataatgttaaatactggaacacaaaattctataaataatgaaggacatgaaatttctaattatccatcttttttaaataatgtcccaataatgaatactaaaaataataatgaattatctttagtacaaaataagcaaataccatttgtatttcaaatcccaaaacgtcctgatcatggtactcaaggaagagaaattgatttaaaagcaaatttttttaaaataaaaattccatatataaatattgtatggtattatgtagaaatatttccagaaaattgtcctagaaaagttaatcgtcaagtaatggaaacattaatttctactcatccaaatatatttggtaatttaaaaatagtttatgatggtaaaaaaaatatgtattcaaaagaaattctttctataggaggtgatatgattgaatttgaagttaatattggagtaaatccaaatgaagaaagattatttacagtaacaataatttatcaaaatacaatttctttacaacttttagatgatgtttttaatggattactttcaaatgtaccatctgaatgtataaaagcattagatataattttaagacatcttccatctattgaatatacaccagttggaagatcatttttttcaccaccagataatttaattattgaaagaattaattatagaccagaatctgcaaaattaggaggtgggcgtgaggtatggtttggttttcatcaatcagttcgcccatcagaattacgtatgatgttaaatattgatgtttcagcaacagcattttacagtaaagtttcagttttacattttttatgtcaagtattagaaatacctattccagaacctagagaaaaattatcattatctgatgctcaaagagttaaattttgtagagaaataaaaggtttaaaaattgaagtaacacatttagggcaaatgcgtagaaaatatagaatttgtaatgtcacaagaagatcagcctattctcaaacatttccacttgataatggaaatggtaaaagtacagaatgtactgtcgcaagatatttttcagataaatataatattaaattacgatatccatttttaccatgtttacaagttggtcaagaaaatagacatatatatttaccaattgaagtatgtaaaattgttttaggacaaagatgtaataaaaaacttaatgatagtcaaacatctataatgattaaagcaacagcacgaaatgctcctgatagagaaagtgaaataacaagtttagttagaagagcaaatatgattgatgatgaatgggctaaagaatttggtatatcaataaatgatgaaatgactgaggtaaagggaagaattcttcctccaccaaaacttatgtatagtagagatacaaaatcaacagttataccatttcaaggtgtatgggatatgcgtaataaacaatttcatacaagttttgaagttaaaacatgggctatggcttgttttgctgaacaacttcatgttagagaaaatgatttacgtgaatttacagtacatcttagaagaatatcaacagatgctggtatgccattaattggtaatccatgtttttgtaaatatgtaggaggtgttagtcaagtagaaccaatgtttcaatatttaaaaactacatatcctactcttcaattaataattgtaattttaccaggaaaaacaccaatttatgctgaagtaaaaagagttggtgatactattttaggtattgcaacacaatgtattcaagctaaaaatgttatcaaaactacatcacaaaatctttctaatttatgtttaaaaataaatgttaaattaggaggtgttaatacaatattacttccatcagttagaccacctatatttaatgaaccagttatatttttaggtgctgatataactcatccacctgctggtgatccaaaaaaaccatcaattgctgctgttgttggttcaatggatgctcatccatcacgttatgctgctacagttcgtgtacaatcaacaagacaagaaataattactgatcttgcttttatggttagagaattattagtacaattttataaaagtacacattttaaaccaacaaaaattgtactttatcgtaatggtgttactgaaaataattttttaaatgttcttcaatatgaacttagagcaattagagaagcatgtatgtcattagaaagaggataccaacctggaattacatttattgttgttcaaaaacgtcatcatacaagattttttgtatgtaataaagatgaacgtgttggtaaggcacaaaatattccaccaggtactattgttgattctggagtaactcatccaactgaatttgatttttatctttgttctcatgctggtattcagggaacatctagaccatcacattatcatgttctttgggatgataataaacttaattcagatgaattacaaatattaacctatcaattatgtcatacttatgttcgttgtactagaactatatcaataccagcacctgcatattatgcatatcttgtagcatttcgtgctcgttaccatttagtagatcgtgaacgtgattctggtgaaggatcacaaccatctgaaacatcagaagatacaacaatgtcaaacttgactcgtgctattagggttcatcctaatgctagcaaagttatgtattttgcataa

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