LOCUS       XM_018727279            3571 bp    mRNA    linear   VRT 18-JUN-2025
DEFINITION  PREDICTED: Scleropages formosus NRDE-2, necessary for RNA
            interference, domain containing (nrde2), transcript variant X2,
            mRNA.
ACCESSION   XM_018727279
VERSION     XM_018727279.1
DBLINK      BioProject: PRJNA540586
KEYWORDS    RefSeq.
SOURCE      Scleropages formosus (Asian bonytongue)
  ORGANISM  Scleropages formosus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
            Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_041820.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_900964775.1-RS_2025_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/18/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Scleropages formosus"
                     /mol_type="mRNA"
                     /db_xref="taxon:113540"
                     /chromosome="15"
     gene            1..3571
                     /gene="nrde2"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 3 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 3 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:108919351"
     CDS             40..3381
                     /gene="nrde2"
                     /codon_start=1
                     /product="protein NRDE2 homolog isoform X2"
                     /protein_id="XP_018582795.1"
                     /db_xref="GeneID:108919351"
                     /translation="

MALFPAFSSVSATSSASEKAKELDWLSNRSFCSDDALTIHQHVQDRILPERQEDSETGVPTLKKLKEDEENDYSHKKRRKKEKKKKHKKHKTKHGEHAEGSGSESDTVYPSDLVKQEADTASREEKVSTQGSFIWLDDLTAPTDRPFCIDKKADSANWEYKSLYRGDIPRYKRKGNSSLGLDPATQAVTWTDTKTSEKKRGDRTSERYFSRSCQQLLNTVDLSVVTGSRGSGPNLTAVRFIPVPQCLEEEGSADTPQVPSAVNPLGVYDSSTSLWLQGKGRQEPGLQKEEGSAVTSRGGSSSTALMAARVEDFNRRLRENPSDIPTWLEFVHFQDELTAGPSPFSGSEGDVDRCKKSLKMTLEKKMAILERALESNPGSVELKLARLDLGRELWDPAALLREWRQLVFLHPNNAELWRAYLLFIQGQFSTLTVSKVNGVYGKCLSTLASVQDGALVSHPALPGTEEAMLVIFLQQCHFLRQAGHSEKAIALFQAMLDFTFFKPDSVKEMHTKQQVEFFEPFWDSGEPRIGEKGARGWKAWMHQQERGGWVIPSEPDDDDDDDQDDGSEVKDKTWPKWRIWLDVEASREANHWLPWRPDKTKGQSEEDCEDPDQQVLFDDVGPSMILLSKPELRFQLLCSFLRFLGLPCDMDYPCGPSWSILLDNLALLVEELDADRPLSCSDLWQAGVSPLWPLLSASERSKLSLYWIQYEKIKVMRCVRSRNKRHMRSQGKRSKKVAKRLLKEAENRNDLALWREFGHLEWLLGNLEEARKVLDTALSLGLSRGLQDRALCDLCLLYAQLEVEQGVGPTAGTASPTLHILTRLAEGGTYSPFSGQVSPVSILKARRTFEQAQETNCRPGLVGCFALFQYLTVGVEAADKVYQQAMERLEERHTDHQEEILGEVNSELEALSVARASLLRHVASACPLSRLRDALTSALSHFPNNSHLWKLYLSAENRYHNAGRARRFLHTLTCRATSAIPRLFAISAEQKRKELVDTVQRSDRYGDVRATLPETGLKHRIRALFESAVATEHGSRCPLLWRMYIHFLVLEGNVDRGRGIFYRALQNIPWVKGLYMDAVLLFPDHVQEFLDLMQEKELRLRLPMEEVDILLED"

     misc_feature    475..771
                     /gene="nrde2"
                     /note="MTR4-interacting domain (MID) found in nuclear
                     exosome regulator NRDE2 and similar proteins; Region:
                     NRDE2_MID; cd22200"
                     /db_xref="CDD:412062"
     misc_feature    order(475..501,508..513,523..528,532..534,538..582,
                     589..597,601..609,634..642,652..657,661..666,673..693,
                     718..729,745..771)
                     /gene="nrde2"
                     /note="MTR4 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:412062"
     misc_feature    976..1974
                     /gene="nrde2"
                     /note="necessary for RNA interference; Region: NRDE-2;
                     pfam08424"
                     /db_xref="CDD:462472"
ORIGIN      

ttgctgcgactgtttacaggtggagacccggagcaaaggatggcgctttttccagctttttcgagtgtttcagcaacgagctcagccagcgaaaaagccaaagagctggactggctgagcaataggagtttctgctcagatgatgcccttactatccaccagcatgtccaggacaggattttgcctgagagacaagaggactcagagacaggtgttcccactttaaaaaagctaaaagaggacgaggagaatgactacagtcataagaaaaggagaaagaaggaaaagaagaagaagcacaaaaagcacaagacaaagcatggggagcatgcggagggcagcggctctgagtcagacaccgtgtatcctagtgatctcgtcaaacaggaagctgacactgcaagccgtgaagaaaaagtttcaacccagggttccttcatctggctcgatgacctaactgcccccacggaccgcccgttctgcatcgataagaaggctgattctgctaactgggagtacaagtcactgtaccgaggagacatccccaggtacaagcgcaagggaaattcctctttgggactagaccccgcgacccaggccgtgacctggaccgataccaagacctcagagaagaagcgaggggacaggacgtcagagcgttacttctcgcggagttgccagcagttgctgaacactgtggacctgtcggtggtgactggctcccgtggatcagggccaaacttgactgccgtccgtttcattcctgttcctcagtgcctggaggaggagggcagtgctgacaccccccaggtcccctctgcagtcaaccccttgggggtgtacgactcttctacctcattgtggctgcagggtaaaggtcggcaggagccaggcctgcagaaagaggagggctctgctgtcacgtcaaggggtggtagcagcagcacggctctgatggctgcaagagtggaagacttcaaccgcaggttgcgtgagaatccatctgacatacccacgtggttggagtttgtgcatttccaggatgagctgactgctggtccaagccccttctcaggttctgagggtgatgtagatagatgtaaaaagtccctgaagatgacactggaaaaaaagatggccatcctggagagggcgctggaaagcaacccgggcagtgtggaactgaagctggcacgattggacctgggtcgggagctgtgggatccagctgcactgcttcgcgagtggaggcagttggtcttcctgcaccccaacaacgcagagctctggagggcctatctgctcttcatccaaggccagttcagcacgctcactgtctccaaggtcaatggcgtctatggcaagtgcctaagcacgttggcgtccgtgcaggacggtgccttggtgtcccatcctgccctgcctggcaccgaggaagccatgctggtcatcttcctacaacagtgccacttcctcagacaggcgggacattcagagaaagcaatcgcgctcttccaggccatgcttgacttcaccttcttcaagcctgacagcgtaaaggagatgcacacaaagcagcaggtggagttcttcgagcccttctgggacagcggggagccacggattggcgagaagggcgcacggggctggaaggcctggatgcaccagcaagagagagggggctgggtcatccccagtgagccagatgatgatgacgatgatgaccaagacgacggatccgaggtgaaggataaaacctggcccaagtggcgaatctggcttgatgtcgaggcttctcgggaggccaaccactggctgccatggagacctgacaagaccaaaggccagtccgaggaggactgtgaggaccccgatcaacaggtcctgtttgatgatgtgggaccctctatgattcttctctcaaagcctgagctccgcttccagctgctctgctccttcctgcgtttcctagggcttccgtgtgacatggactatccctgcgggccctcttggagtatcctactggacaatctcgcactactggtggaggagctggatgcagacagacctctgagctgctctgacctctggcaggctggggtcagcccgctttggcccctgctgtctgcctcagagaggtccaagctctcactctactggatacagtatgagaagatcaaggtgatgcggtgtgtccgcagcaggaacaagcggcacatgagatcccaaggtaagcggagcaagaaggtggccaagcggctgttaaaggaagcggagaaccgcaatgacctggcactgtggagggagttcggccacctggagtggctgctggggaacctggaggaggcccggaaggtgttggacacagccttgtcactgggactatcccgtggcttacaggaccgtgccctgtgtgacctctgcctactctatgcccagctggaggtggagcagggggtggggccaacagctggaacagcttcccccacgcttcacatcctcacgcgtctggctgaaggtgggacgtactcccccttcagtggccaagtgtcccctgtgtccatcttgaaggcccggcggacctttgagcaggcccaagaaaccaactgccggcctgggcttgttggctgcttcgccctcttccagtacttgaccgtgggtgtggaggccgcagataaagtataccaacaggccatggagcggctggaggaaaggcacacagaccatcaggaggagatacttggcgaggtcaactcggagctggaggcactctctgtggcacgcgcctcgttgctacggcatgttgccagcgcgtgcccactgagccgccttcgcgatgccctcacctctgccctctcccatttccctaacaactcccacctgtggaagctgtacctgtcggcagagaacaggtaccacaacgctggccgcgcccgccgcttcctgcacaccctcacttgtcgtgccacaagtgccatccctcggttattcgccatcagcgctgagcagaaaaggaaggagctggtggacacagtgcagaggagtgatcgttacggggacgttcgggccactttaccggagactgggctgaaacaccgcattcgagcgctgttcgaaagtgcagtggccaccgagcacgggtcccgctgccccctcctctggaggatgtacatccacttcctggttctggaggggaatgtcgacaggggcagagggatcttttacagagctctgcagaacatcccttgggtaaagggcctctacatggatgccgttctgctgttccctgaccacgtgcaggagttcctcgacctcatgcaggagaaggaactgcggcttcgtctgcccatggaggaggtggacatcctactagaggactagccccccccccatccatcaaggctctgcacagtgggcccctaacccagagctacagtcaaagactgtatttatcatgccatgcccttgcaaaaaatcctctgtgcagaaaatgtgattgattgaaatatgaaacacattgctgttaatgagtgtatatagattgtatatatgttgaaactaattaaaaaga

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