LOCUS       XM_014077232            2931 bp    mRNA    linear   PLN 29-DEC-2023
DEFINITION  Ogataea parapolymorpha DL-1 Pro-apoptotic serine protease NMA111
            (HPODL_02904), partial mRNA.
ACCESSION   XM_014077232
VERSION     XM_014077232.1
DBLINK      BioProject: PRJNA264114
            BioSample: SAMN02981294
KEYWORDS    RefSeq.
SOURCE      Ogataea parapolymorpha DL-1
  ORGANISM  Ogataea parapolymorpha DL-1
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Pichiales; Pichiaceae; Ogataea.
REFERENCE   1  (bases 1 to 2931)
  AUTHORS   Ravin,N.V., Mardanov,A.V., Eldarov,M.A., Kadnikov,V.V.,
            Beletsky,A.V., Zvereva,M.I., Smekalova,E.M., Dontsova,O.A. and
            Skryabin,K.G.
  TITLE     Genome sequence of the methylotrophic yeast Hansenula polymorpha
            DL1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2931)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 2931)
  AUTHORS   Mardanov,A.V., Kadnikov,V.V. and Beletsky,A.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-OCT-2013) Lab of Molecular Cloning, Centre
            'Bioengineering' RAS, Prosp. 60-let Oktyabrya, bld. 7-1, Moscow
            117312, Russia
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NC_027860).
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2931
                     /organism="Ogataea parapolymorpha DL-1"
                     /mol_type="mRNA"
                     /strain="DL-1"
                     /type_material="holotype of Candida parapolymorpha"
                     /db_xref="taxon:871575"
                     /chromosome="VII"
                     /geo_loc_name="Russia: Moscow"
     gene            <1..>2931
                     /locus_tag="HPODL_02904"
                     /db_xref="GeneID:25772351"
     CDS             1..2931
                     /locus_tag="HPODL_02904"
                     /EC_number="3.4.21.-"
                     /codon_start=1
                     /product="Pro-apoptotic serine protease NMA111"
                     /protein_id="XP_013932707.1"
                     /db_xref="GeneID:25772351"
                     /db_xref="GO:0004252"
                     /db_xref="GO:0005634"
                     /db_xref="GO:0006508"
                     /db_xref="GO:0006915"
                     /translation="

MFETEDYHPKRHGDPPSNGHAKKQKCDDISMDDVDSVLGSELGDFVKQDHSRWQHIVEKVVKSVVSIHFAQVVNFDTESALCSEATGFVVDAKLGIILTNRHVVGPGPFIGYAVFDNHEECEVKPIYRDPVHDFGFLRYNPADIKYMDVGELQLRPDLAKIGAEIMVIGNDSGEKLSILSGFISRLDRNAPDYGINSYNDFNTEYLQAAASASGGSSGSPVVNIDGHAVALQAGGNTETSTDFFLPVYRVLRALKCIQNNEPITRGSIQVQWLLEPFDKCRRLGLRAETEKLMREKFPSLNGLLVSAVTLPEGPADGLIREGDCLISINGELISTFITVDEILDTHVGKEIEIVIQRGGKDLTVRCTVGDLHSITPRRYVTVCGATFNDLSYQLARIYAVAVKGVHVSNAAGSFVFGNNVPNGWLLDSIDDKDVSNLDEFIEVMKSIPDSAFVTVKCRHLTDLHVPIIKIIQIDRHWHSSFRLAERNDTTGLWDFTTLQEKPLPPPALSPKNAKFVGLPIEFEGCKQLDRSLVMLKSTMPVPLDSFSGQSRKSYAVVIDATNGYLLASRYCVPHDLLDVTMTVAESIIVPAKVVFLHPTKGYAILKYDPKLILAPLQTPQFGEKPLGRGDKVVFIGHNRAQRVVVDETKVSDIGIIHLPNNVTSPRFKASNFEALLIDSNLGQQCGSGVLCDPSGLVRAFWLAFDADEDKTYSMGLDATDVLWELENLKTQQVPELKFIDAEFGNIPIVNARISGVPQEWITKIEEKSADQPRLLSVPKVSISLDNKPSCGLRHGDIVLSANNRVITQFRDIDHVIRDLEENKNEIAFKIVRNKQIMDINVPLVLSSSFVTKHMVYWAGAVLQEPHHGVRQVIKQLPSKVYCTAMAPGSPSRLYTIGVTNFITHVNEKPTPTLDEFVKVVKEIKDNSYCKLRIVSFDNVPFAQTLKVNYHYFETMEMKNEEGWHEYGELDSSSLHA"

     misc_feature    247..1113
                     /locus_tag="HPODL_02904"
                     /note="Periplasmic serine protease, S1-C subfamily,
                     contain C-terminal PDZ domain [Posttranslational
                     modification, protein turnover, chaperones]; Region: DegQ;
                     COG0265"
                     /db_xref="CDD:440035"
     misc_feature    838..1104
                     /locus_tag="HPODL_02904"
                     /note="circularly permuted first PDZ domain (PDZ1) of
                     Saccharomyces cerevisiae pro-apoptotic serine protease
                     Nma111p and related domains; Region: cpPDZ1_ScNma111-like;
                     cd06786"
                     /db_xref="CDD:467625"
     misc_feature    order(844..867,916..918,925..927,1015..1020,1027..1029)
                     /locus_tag="HPODL_02904"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467625"
     misc_feature    1117..1347
                     /locus_tag="HPODL_02904"
                     /note="PDZ-like domain; Region: PDZ_1; pfam12812"
                     /db_xref="CDD:372324"
     misc_feature    2251..2526
                     /locus_tag="HPODL_02904"
                     /note="permuted PDZ domain of Deg/high-temperature
                     requirement factor A (HtrA) family of housekeeping serine
                     proteases and related domains; Region:
                     cpPDZ_Deg_HtrA-like; cl49614"
                     /db_xref="CDD:483954"
     misc_feature    order(2257..2280,2323..2325,2332..2334,2434..2439,
                     2446..2448)
                     /locus_tag="HPODL_02904"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467528"
     misc_feature    2560..2796
                     /locus_tag="HPODL_02904"
                     /note="second and fourth PDZ domains (PDZ2 and 4) of
                     Saccharomyces cerevisiae pro-apoptotic serine protease
                     Nma111p and related domains; Region: PDZ2-4_Nma111p-like;
                     cd06719"
                     /db_xref="CDD:467617"
ORIGIN      

atgttcgagactgaggattatcaccctaagcgacatggagatcctccgtcaaatggccacgctaaaaaacaaaagtgtgatgatatatccatggatgatgtggattcagtgttgggatctgagctaggagactttgtaaagcaagatcattcgagatggcagcatatcgtggaaaaagttgtcaaatctgtggtttcgatccactttgctcaagtggtgaactttgatacggagagcgctctttgcagtgaggctacgggatttgttgttgacgcaaaactgggaataattctgactaatagacatgtcgttggaccagggcccttcatcggatatgctgtgtttgataaccatgaagaatgcgaggtcaaaccaatctacagggatcccgtgcacgactttggatttctcagatataacccagcagatataaaatacatggatgttggtgaattacagttaaggccagatcttgccaagatcggagcagaaataatggtcataggcaacgattcgggtgaaaaactttctatactctccggcttcatctcaagactcgacagaaatgccccagactatggaattaactcatacaacgacttcaacacagaatatttgcaagcagcagcttcggcttcgggagggtcctcgggttcccccgttgtcaatatagatggccatgcggtggctttacaagcaggaggtaatacagaaacctctacggacttttttctgcctgtgtatcgagttcttcgcgctctgaaatgcattcagaataacgagcctattacgagaggaagtattcaagttcaatggctattggaaccgttcgataaatgtcgccggctgggacttcgcgcagagacagaaaaactgatgagagaaaagtttccgagtctcaatggtcttctagtctctgctgtcacgttacctgaaggccctgctgatgggctgataagagaaggtgattgtttgatatcgatcaacggagagttgatatccacatttatcactgtggatgaaattctggacactcatgtcggtaaagagattgagatagtcattcagagaggaggcaaagatttaactgttcgctgtactgttggagatcttcactcaattacacctagacggtacgtcaccgtttgcggtgcaactttcaatgatctgagttaccaactcgctagaatttatgcagtggcagtgaaaggtgttcacgttagcaatgccgctggctcttttgtgtttggcaacaatgttcctaatggatggctcttagactcgatcgacgataaagatgtgtctaatctcgacgaattcatcgaggtcatgaaatcaatcccggactctgcttttgtgaccgtcaagtgccgccatcttacggaccttcatgtcccaattatcaaaatcatccaaatcgatcgccactggcactctagtttccgtttagcagaaagaaacgacacgactggtctttgggatttcacaactctgcaagagaaaccattaccaccaccggctctgtccccgaaaaatgccaagtttgtggggcttccgatcgaatttgaaggttgtaagcaactcgatcgttctttggtgatgttaaagagcaccatgcctgtcccgctggattcgttcagtggacaatctcgcaagtcgtacgcagttgtgattgatgctaccaacggatatcttcttgcttcgaggtactgtgtacctcatgacctcttggatgttactatgaccgttgcagaatcgatcatagtgccagctaaggttgtcttcttacacccaaccaagggatatgctattttgaaatacgatcccaaattaatattggctcctttgcaaactccccagttcggcgagaagcctttgggaagaggtgacaaagtggtgtttattggccacaacagagctcagagggtggttgttgacgaaacaaaagtcagtgacattggaatcatacatcttccgaataatgtcacctcccccagattcaaggcctccaatttcgaagccctactaattgactcaaacttaggccagcaatgtggttctggagttctttgtgaccccagtggactggtccgcgcgttttggcttgccttcgacgcggacgaggacaagacctattctatggggctggacgctacagatgtgctctgggaactcgaaaacctcaaaacccagcaggtcccggagctcaaattcattgatgctgaatttggtaacatccctatcgttaatgctagaatcagtggtgttccgcaggaatggatcacaaaaattgaagaaaagtctgcagatcaacccagactgctcagcgttcccaaggtaagcatttcactcgataacaagccctcttgtggtctcagacacggagatattgtgctgagtgcaaataatcgagtcatcacacaatttcgtgatattgaccatgttatcagagacctcgaagagaataaaaacgaaattgcgttcaaaatcgtcagaaacaagcaaatcatggacatcaatgttcctttggttttgagtagctcctttgtcactaagcacatggtctactgggccggtgctgtgttacaggagcctcatcatggtgtaagacaagtgatcaaacaactaccttccaaagtctattgtacggccatggcgccaggatctccctctagattatacaccattggcgtcacgaatttcatcacgcatgttaatgaaaagccaacaccaactttggacgagttcgttaaggtcgtgaaagaaatcaaagacaattcatattgcaagttaagaatcgtgtcttttgacaacgtcccatttgcacaaacgctcaaagtcaactaccactactttgagactatggagatgaaaaacgaggaggggtggcatgaatacggtgagctggactcctcctctttgcatgcatag

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