LOCUS       XM_002936732            7902 bp    mRNA    linear   VRT 18-DEC-2019
DEFINITION  PREDICTED: Xenopus tropicalis ATPase, Cu++ transporting, beta
            polypeptide (atp7b), mRNA.
ACCESSION   XM_002936732
VERSION     XM_002936732.5
DBLINK      BioProject: PRJNA205740
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_030678.2) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 18, 2019 this sequence version replaced XM_002936732.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Xenopus tropicalis Annotation
                                           Release 104
            Annotation Version          :: 104
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.3
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7902
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /strain="Nigerian"
                     /db_xref="taxon:8364"
                     /chromosome="2"
                     /sex="female"
                     /tissue_type="liver and blood"
                     /dev_stage="adult"
                     /note="F17 inbred"
     gene            1..7902
                     /gene="atp7b"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 EST, 4 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 33 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:100497797"
                     /db_xref="Xenbase:XB-GENE-6044681"
     CDS             394..4797
                     /gene="atp7b"
                     /codon_start=1
                     /product="copper-transporting ATPase 2"
                     /protein_id="XP_002936778.3"
                     /db_xref="GeneID:100497797"
                     /db_xref="Xenbase:XB-GENE-6044681"
                     /translation="

MFPKRILDEEEGVQLLSTENEKCSTKRRSSPQFCVNNTFSDSPVSVWKEAKKPSCAFDNRGYEGSPDDLCSLPDDVGSVVVAIQGMTCQSCVQSIEGRISKVSGVVGINVCLEQNNAIVNYLQTEITPHKICEEIEDMGFDASLSEQSGMPSSVKSSYYGDNVIKIRVEGMTCQSCVNTIEGKIGKIQGVQKIKVSLTGQEAVITYQSHIIQAEDLRKYIEDMGFEASIKNKPDPTKLGTIDIERLQNSIAENHSGHTNSNTVTLGIDGMRCKSCVHNIEGYVSGLAGIQSIRVSLKNKNAVVCLSQGSTSLLSLKESIENLPPGKFKVTLPVGVEKGQSLARNSTHSSHRDQSMGGNMAIISIGGMTCQSCVSSIENMISQRKGVLHILVSLDEGNGNIFYNPCETNAEELRAAIEDMGFHSTLVSDNSPSISCSEYNSKEEENKQTPPKATRQISGSRDYILDVLPKKSHPDFANEKYDTAPEKCFLQITGMTCASCVSNIERNLKKKDGIVSVLVALMSGKAEVKFYPDRIEPLEIAQLVEDLGFGASVMEDYTASDGNVELIITGMTCASCVHNIESRLMRTPGILQASVALATCKAQVKFDPEIVGPRDIIRIIEGIGFQASLAKRDPTAHKLDHKEEIKQWRNSFLFSLLFGIPVIILMIYMLAANKDHHNTMVLDRNIVPGLSIINLVFFILCTFVQTLGGRYFYVQAYKSLKHKATNMDVLIVLATTIAYIYSVVILTVAMVEKADKSPETFFDTPPMLFMFIALGRWLEHIAKSKTSEALAKLISLQATEAAVVTFGANQIILREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEGTSMADESLITGEPMPVRKKPGSMVIAGSINAHGTVLVEATHVGSETTLAQIVKLVEEAQMSKAPIQQLADKISGYFVPFIIIISVVTLVTWIIIGFVNFDIIIKYFPSYSKNISKTEVIIRVAFQTSITVLSIACPCALGLATPTAVMVGTGVAAQNGILIKGGEPLEMAHKIKAVMFDKTGTITHGVPKVMRVLLLGDVVKMPLKRMLAVVGTAEASSEHPLGMAVTKYCKEELGTELLGYCTDFQAVPGCGISCKVNNIESVLVQNEEGLNEQNSYRNSLIGTTDSSLIITPELLGAQAPLAHTVLIGNREWMRRNGLHISTDVDEAMSSHEMKGQTAVLVAIDGELCGMIAIADTVKQEAALAVHTLKSMGIDVVLITGDNRKTAKAIATQVGIKKVFAEVLPSHKVAKVQALQSDNKRVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADIVLIRNDLLDVVASIHLSKRTVRRIRLNFVFALIYNLLGIPIAAGVFMPAGLVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDSDRYEARAQGHMKPLTPSQISVHIGMDDRWRDLPKTKAWDQISYISQVSRASQKPKRHGSLVEQQDKWSLLINETHEDQMI"

     misc_feature    631..822
                     /gene="atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(649..657,664..666)
                     /gene="atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    886..1077
                     /gene="atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(904..912,919..921)
                     /gene="atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1183..1359
                     /gene="atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1201..1209,1216..1218)
                     /gene="atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1477..1665
                     /gene="atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1492..1500,1507..1509)
                     /gene="atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1858..2046
                     /gene="atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1873..1881,1888..1890)
                     /gene="atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2083..2274
                     /gene="atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2101..2109,2116..2118)
                     /gene="atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2338..4473
                     /gene="atp7b"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3331..3333,3337..3339,4402..4404)
                     /gene="atp7b"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3463..3471,3673..3675,3853..3861,3949..3951,
                     4069..4077,4135..4137,4144..4146,4153..4155,4210..4212,
                     4219..4221)
                     /gene="atp7b"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

tgcagaagtgcgcagcgcggcataaacagcgttcatgtcatataacctggctgtagcgtctagtatgggtttcacgtttatctgtaacttccaaaatgaaagttttaattaaaagttgttattggtggaagtggaacacgtgggtaaatgcattcaaatgcaaatacatgagtattccctgagtgacagtggttgggcgggttgcgcttgttttatttccccagcaacctggcgagtatcataaaggtcacgttggctgctgctgcttcctattgatcaaccggtttgtgggtccatagttcaaccccagagtaatgcacacatattctctcacatacagtcctgctgtgcggggaggcagagggacacagccaaacacctagggaaagaaagatgtttcctaaaaggattttagatgaagaggagggagtacagttgttaagcacagagaatgaaaaatgttcaaccaaaagaagatcctcaccacaattttgtgtgaacaataccttttccgactctccggtatctgtctggaaagaagcaaagaaacctagttgtgcttttgataacaggggctatgagggaagcccagacgacctctgctctttgcctgatgatgttggctcagtagtggtggcaattcaaggcatgacttgccagtcatgtgtgcagtccatcgaaggaagaatatctaaagtttcaggtgtagtaggcataaatgtatgcttggaacagaataatgccattgtcaactatttacagacagagataacgccacataaaatttgtgaagaaattgaagacatgggttttgatgcaagtttatcagaacagagtgggatgccgtcatctgtaaaatcctcatactatggtgacaatgtaataaaaattagggtagaaggcatgacgtgccagtcttgtgtcaacaccatagaaggcaaaataggcaaaattcagggtgtgcagaaaatcaaagtgtcgcttaccggtcaagaagcagtcatcacatatcagtcacacattattcaagcagaagacctgaggaaatacatagaagacatgggatttgaagcttcaattaaaaacaaaccagatccaacaaagcttgggacaattgacattgaacgcttgcagaacagcattgcagaaaaccattcaggtcatacaaacagcaacactgtgactctagggatagatggcatgcgctgtaaatcctgtgtgcacaacattgaaggatatgtatctggccttgccggtattcagagcatcagagtctccctcaagaacaaaaatgctgttgtgtgtctttcccaaggttctacctcactcttatccctaaaagaaagcatagaaaatctgcctccagggaaatttaaagtaacacttccagtgggagtagaaaagggccaatcattagcaaggaacagtacccattcttctcatagagaccagagtatgggtggaaatatggcaataatcagtattggggggatgacctgtcaatcttgtgtatcatcaattgaaaacatgatctcacaaagaaagggtgtactgcatatattggtgtctttagatgaggggaatgggaacattttctacaatccatgtgaaacaaacgcagaggagttacgagcagccatagaagatatgggatttcactccactcttgtgtctgataactcaccttctatcagctgtagtgagtataactccaaggaagaggaaaacaagcaaacccccccaaaggctacaaggcaaatcagtggcagtcgagattacatactggatgtgctgcccaagaaatctcacccggactttgctaatgagaaatatgacactgctcctgagaaatgtttcttgcagatcacaggaatgacgtgcgcatcgtgtgtttctaacattgagaggaacctgaaaaagaaagatggaattgtgtccgtgcttgtagcactgatgtctggtaaggcagaggtcaagttctacccagacagaattgagccactggaaatagcacaacttgttgaagacctgggatttggggcatcagtaatggaagattacacagccagcgatggcaacgtggagttaattattacaggaatgacatgcgcttcttgtgttcacaacattgagtccaggctaatgagaacccctggcattttgcaagcatcagtcgctctagctacgtgcaaagcccaggtcaagtttgatccagagattgttggtccacgagatataattagaattattgagggaattggctttcaagcatctttggccaaaagagatccaacagctcataaacttgaccacaaggaggaaataaagcagtggagaaattccttccttttcagtcttctatttgggatccctgttataattctcatgatttacatgttggctgctaacaaagatcatcacaacacaatggtgcttgacagaaatattgttcctggtttatcaataataaatcttgtcttcttcattctctgtaccttcgttcagacccttggaggcaggtatttttatgttcaagcctataaatctctgaagcacaaggcaactaatatggatgtgctgattgtcctggccaccacaattgcctacatttactctgtggtcattctgacagtggccatggtggagaaggccgacaaaagccctgagactttctttgatacccctcccatgctgttcatgtttattgccctgggaagatggctggagcatattgcaaagagtaaaacctccgaagctctcgccaagctgatatccttacaagctacagaggccgcagttgttacatttggtgcaaatcaaataattctaagagaggagcaggtagctgtagaattagttcaaagaggagatatcgtcaaggttgtccctgggggtaaattccctgttgatggaaaggttatagaaggaacctcaatggcagatgaatctctcattacaggtgagccgatgcccgtaaggaagaagcctggcagcatggttattgctggttccatcaacgcacatggcacagttcttgttgaagctacacatgttggatctgaaactactttggcacagattgtcaaacttgtggaggaagctcaaatgtccaaggcacctatccagcagctggcagataaaataagtggatactttgttccctttatcatcattatttctgttgtgactttggtgacttggataattattggctttgtaaattttgacatcataattaaatattttccgagttacagtaaaaatatttctaagacagaggttataatacgtgtggcatttcagacctccatcacggtgctgagcatcgcctgtccctgtgctttgggcctggcaacacccacagcagtaatggttggtacaggagtggcagctcagaatggcatccttattaaaggcggtgaaccactagagatggctcacaagataaaggcagtgatgtttgacaagaccggcaccataacacatggggtacctaaagtcatgcgagtgctgctgctaggcgacgtggtgaagatgcctctgaaaaggatgcttgctgtggtggggacggcggaagccagcagcgaacatcctctgggaatggcagtcacaaaatactgcaaggaggaacttggtacagaattgttaggatattgtacagatttccaggctgtccctggatgtggcatcagctgtaaagtgaataatatagagagtgttctagtgcagaatgaagaaggactaaatgaacagaattcttacagaaattctctcatcggaaccacagacagctctttgattatcactcctgaattattaggtgcccaagccccactagcccacactgttttaattggcaatcgagaatggatgagacgcaatgggctacacatctctactgatgttgatgaggccatgtccagccatgagatgaaaggacaaacagcagtactagtggcaatagatggtgagctgtgcgggatgattgccattgcagacacagtgaaacaggaggcagctctcgctgtacataccctgaaaagtatgggaatagacgtggttctaattacaggcgacaacagaaaaacagcgaaagctatcgctacccaggttggcatcaaaaaagtttttgcagaagttcttccctcccataaagttgccaaggttcaagctctccagagtgataacaagagggtggccatggtaggagatggagtgaatgactcgcccgcgcttgccagagctgatgtcggcattgctattggcactgggacggatgtggccattgaagctgctgatatagttcttatcaggaatgatttattagatgtggttgccagtatccacctctcaaagaggacagtgagacgaatacgactcaactttgtatttgctttgatatataatcttcttggcatacctattgctgcaggtgtgttcatgccagcgggacttgtgttacaaccttggatgggctccgctgcaatggcagcttcctctgtctctgtggttctgtcctcattgcagttaaaatgctaccggaaaccagactctgacaggtacgaagctcgtgcacagggacacatgaagccactcaccccatcacagattagtgttcacattgggatggatgaccggtggagggatctgccaaagacaaaagcctgggatcagatcagctacatcagccaagtgtccagagcatctcagaagccgaaacggcacggctctcttgtagagcaacaagacaagtggtcgctacttatcaatgaaacacatgaggaccagatgatctaaatccctgtgtaaagggaagtggcatcatattatgaaactgatcactctgaatctgccttgtgtgccatctggggttggattacccttgctttctgtctagtagtgaatagggaacagttgtgtatttttcattctatttacactgtagtggctttaaaggaagctttttaaaagcatataatagtgggtaaggaacagacaagggacagtgaggttgaaaagcagtagggcagcaaattgatgaaacaagggacggcaaagggacggaggcaaatagggaccataggggtaatagtgacatcacacagtgctgaaattatgtcattctgctagcaataggagttagtaaataatttcataggatatataaattatgggatagaaaggtagtagctatattgtttctttaacatttatgttgtttacatttaaacttgatcagtcagggactcacacaggatgctgggagtgattgtttataaacacaataagagacagtgtgtggctatccctgctctgtggagctgccaggttgccttacaattttggtatgtatgtgccttatgtgcacaaagaaaatgagtgagagaggttacatgagcatccactgatagacagaagggctcaggtgcaagtcaccatgttttgttacccacaatgcagagttttcccccattccagtgtcattcaggtgaaagtataaagggacaatcactggggttcttcacttgctttcctactacaaccctcagcacccgagcagttgatttggaagcattgattgacaaagcctgccactgtctggcataaaaaatataattcttgtaactattttaatacaaacaggagtataggtacaacagtagtataggtaagtcaaaaccaaagctgattaatggtgcatgctgggagatgtagtatagtagctaatcaaaatgatggtgggtggggttgaatgtatgctcaatgtactatgaatatcctgttactgaaaatacattaggggcttaactatatcaacccatgttaaccaatcagactcatgcaagcaataggctaattttacatttagctaattaagcatgagtataaggctctagtaccacgtgtattctgtccagtcctccttacagggctagccttgtttgatgttctattgttaaaacgggggcatcatgcggcccaaaacacacatattcatttcccccatgaaagtatcaatatcccgcaccctgtgtgatttgtagtgagcacaaacctttaggaattcaccaaaggaacaagtgataagagctctaccttgctgtaagccgaggatcttcactcagtcccaccaaatattgttagatgccaatacattatgtaaatgcaaagggaataaggctatccttcatgttacttgcactgtctttaactaaataatgatagtgtacctctaatgaactttttcagattggatcatgtaattactgatattgtctggtttgaatctaattatatttatttttctattcatttctttgcaagaagaatttcttctttattttttcattgtcttctagatatatttttgtggatgcaaggcagagattatttttaatgttttggattatatatatatatatatatatatatatatatataaatggctattttaggaatatatgaatttaaacatttcttggggggaaaaatccatttttatggtttacatattttccttcagcagactatacagtattaggggcctatttattatgctgtgtaaaatgaaatttgcccaaaaaaaagtgtaaaaagctgtgtaaaataaatggagaagttcaccgtctgaatggcagattttacgacattttatgtaagttcgcattaaaaaattacaccaattttacagcgttttttgtgagacgaagcctggtgatgatacgctgatgcaccgtgcactacataataaatctgcccctaagtgtacagtttattgtttgggaaacattttatctgcacatatttgcatttatagatgagtggaagctgaagtgctgttttcttcagcatagatattctccctaaaatcagtacagttatggggcctaattacagagaaaaaggaaatcatgtttaaaaaatagaattatttggttaaaatggactccatatgacgccatatgggagatggccttcctgtaattcagagcttaatggataatgggtttctggataggaggtccccaccatacctgaatagtatcagcttcttttctattgccacatgtactgtgttttatagaaatagcttttccaaggcacagaatgtgtatttgtgtgcaaagagattgtatgctctaggcatggtgtggccttatctttaattatctttaagggaaagtatatagaggataaatcataccccaaatacaggtccgtatctgtatgcatatgtgtacattttattgtttatacattttatatttaaatgtttatgtgctaataaaaatgagcagtatggtaatgcagtggttaatgtggctgcctataaaagcaggggtcccaggttaaaatcaagttagggcactatctgcaagggaattggatggtgtccctgtgcttgcatgggtttcagaggccgcccccgtcccacaccccaactcccccctccccaggatcacacacaatcacatccttttagctcacacacagagcactggggacaggacatgcagaaatctccctagaccccactgctctggatgtgagcaaagtctaggtgcggctgggcggctgggcggcattctgcccctaaatttgtgctgccctaggcccaggcctttgtggcattgccacaaatctgggcctctaattatacaggcaggttaattatctgtgtgtgttagggaccttagactgtaagctccactggggctggaactgatataaacaatgtagaattctgaaaagcaatgtgaaatatgttggcactttataaagaataaatacaactgggtgtattttgccttgtaatttctgttttactatgtagagctttttattagcagtaatatatatatatttgtgtgtgtatcattcaaataaaaacagtttttttta

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