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2024-03-28 20:25:57, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_031701               1442 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus claudin 5 (Cldn5), mRNA.
ACCESSION   NM_031701 XM_344058
VERSION     NM_031701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Hu Q, Wu C, Yu J, Luo J and Peng X.
  TITLE     Angelica sinensis polysaccharide improves rheumatoid arthritis by
            modifying the expression of intestinal Cldn5, Slit3 and Rgs18
            through gut microbiota
  JOURNAL   Int J Biol Macromol 209 (Pt A), 153-161 (2022)
   PUBMED   35318077
  REMARK    GeneRIF: Angelica sinensis polysaccharide improves rheumatoid
            arthritis by modifying the expression of intestinal Cldn5, Slit3
            and Rgs18 through gut microbiota.
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Andersson EA, Rocha-Ferreira E, Hagberg H, Mallard C and Ek CJ.
  TITLE     Function and Biomarkers of the Blood-Brain Barrier in a Neonatal
            Germinal Matrix Haemorrhage Model
  JOURNAL   Cells 10 (7), 1677 (2021)
   PUBMED   34359845
  REMARK    GeneRIF: Function and Biomarkers of the Blood-Brain Barrier in a
            Neonatal Germinal Matrix Haemorrhage Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Rosas-Martinez L, Rodriguez-Munoz R, Namorado-Tonix MDC, Missirlis
            F, Del Valle-Mondragon L, Sanchez-Mendoza A, Reyes-Sanchez JL and
            Cervantes-Perez LG.
  TITLE     Hyperglycemic levels in early stage of diabetic nephropathy affect
            differentially renal expression of claudins-2 and -5 by oxidative
            stress
  JOURNAL   Life Sci 268, 119003 (2021)
   PUBMED   33417957
  REMARK    GeneRIF: Hyperglycemic levels in early stage of diabetic
            nephropathy affect differentially renal expression of claudins-2
            and -5 by oxidative stress.
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   Shou J, Peng J, Zhao Z, Huang X, Li H, Li L, Gao X, Xing Y and Liu
            H.
  TITLE     CCL26 and CCR3 are associated with the acute inflammatory response
            in the CNS in experimental autoimmune encephalomyelitis
  JOURNAL   J Neuroimmunol 333, 576967 (2019)
   PUBMED   31151084
  REMARK    GeneRIF: The expression of claudin-5 in the EAE group was
            negatively correlated with the inflammation scores. Levels of CCL26
            in the serum and brain tissues and the number of CCR3-positive
            cells in the brain tissues were negatively correlated with the
            protein expression of claudin-5.
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer
            S, Rausch V, Blasig R, Richter M, Sporbert A, Wolburg H, Blasig IE
            and Haseloff RF.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Sun ZY, Wei J, Xie L, Shen Y, Liu SZ, Ju GZ, Shi JP, Yu YQ, Zhang
            X, Xu Q and Hemmings GP.
  TITLE     The CLDN5 locus may be involved in the vulnerability to
            schizophrenia
  JOURNAL   Eur Psychiatry 19 (6), 354-357 (2004)
   PUBMED   15363474
REFERENCE   7  (bases 1 to 1442)
  AUTHORS   Wolburg H, Wolburg-Buchholz K, Kraus J, Rascher-Eggstein G, Liebner
            S, Hamm S, Duffner F, Grote EH, Risau W and Engelhardt B.
  TITLE     Localization of claudin-3 in tight junctions of the blood-brain
            barrier is selectively lost during experimental autoimmune
            encephalomyelitis and human glioblastoma multiforme
  JOURNAL   Acta Neuropathol 105 (6), 586-592 (2003)
   PUBMED   12734665
REFERENCE   8  (bases 1 to 1442)
  AUTHORS   Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M
            and Tsukita S.
  TITLE     Size-selective loosening of the blood-brain barrier in
            claudin-5-deficient mice
  JOURNAL   J Cell Biol 161 (3), 653-660 (2003)
   PUBMED   12743111
REFERENCE   9  (bases 1 to 1442)
  AUTHORS   Poliak S, Matlis S, Ullmer C, Scherer SS and Peles E.
  TITLE     Distinct claudins and associated PDZ proteins form different
            autotypic tight junctions in myelinating Schwann cells
  JOURNAL   J Cell Biol 159 (2), 361-372 (2002)
   PUBMED   12403818
  REMARK    GeneRIF: MUPP1 and claudin-5 colocalized in the incisures, and the
            COOH-terminal region of claudin-5 interacts with MUPP1 in a
            PSD-95/Disc Large/zona occludens (ZO)-1 (PDZ)-dependent manner in
            tight junctions
REFERENCE   10 (bases 1 to 1442)
  AUTHORS   Morita K, Furuse M, Fujimoto K and Tsukita S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK479973.1, BC082073.1 and AI029697.1.
            
            On Nov 18, 2005 this sequence version replaced NM_031701.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: FQ212855.1, FQ213419.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CK479973.1         1-11
            12-1424             BC082073.1         10-1422
            1425-1442           AI029697.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1442
                     /gene="Cldn5"
                     /note="claudin 5"
                     /db_xref="GeneID:65131"
                     /db_xref="RGD:68431"
     exon            1..1427
                     /gene="Cldn5"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..799
                     /gene="Cldn5"
                     /codon_start=1
                     /product="claudin-5"
                     /protein_id="NP_113889.1"
                     /db_xref="GeneID:65131"
                     /db_xref="RGD:68431"
                     /translation="
MGSAALEILGLVLCLVGWVGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYESVLALSAEVQAARALTVGAVLLALVALFVTLTGAQCTTCVAPGPVKARVALTGGALYALCGLLALVPLCWFANIVVREFYDPTVPVSQKYELGAALYIGWAASALLMCGGGLVCCGAWVCTGRPEFSFPVKYSAPRRTTANGDYDKKNYV"
     misc_feature    155..682
                     /gene="Cldn5"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
     misc_feature    164..226
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     transmembrane region"
     misc_feature    386..448
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     transmembrane region"
     misc_feature    512..574
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     transmembrane region"
     misc_feature    623..685
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     transmembrane region"
     misc_feature    791..796
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     Region: Interactions with TJP1, TJP2 and TJP3.
                     /evidence=ECO:0000250"
ORIGIN      
tgtggttgaaacctctcttctgttccactgcaagaggctccggagcagaggcaccagaatcagcccccaacccacagcccacgcagcgcagagcgcacccggaggccccaagggccatcgggtgagcattcggtctttagccatggggtctgcagcgttggaaattctgggtctggtgctgtgtctggtaggctgggtgggcttgatcctggcgtgtgggctgcccatgtggcaggtgactgccttcctggaccacaatatcgtgacggcgcagacgacttggaaggggctgtggatgtcgtgcgtggtgcagagcaccgggcacatgcaatgcaaagtgtatgagtctgtgctggcgctgagcgcggaggtgcaggcagctcgggcactcaccgtgggcgctgtgctgctggcgcttgtggcactctttgttaccttgaccggcgctcagtgcaccacctgcgtggccccgggcccagttaaggcacgggtggcactcacgggaggagcgctttatgccctgtgtgggcttctggcactggtgccactctgctggttcgccaacatcgtagtccgggagttctatgatccaacggtgccggtgtctcagaagtacgagctgggcgcggcgctgtacatcggctgggcggcctccgcactgctcatgtgtggcggcggcctcgtgtgctgtggcgcctgggtttgcaccgggcgtccagagttcagttttccagtcaagtactcagcaccaaggcgaaccacggccaacggcgattacgacaagaagaactacgtctaagggcgggaggcacggcggggctcttcccgcagctaagcccgcgttcggaaagaccgatgtgggaagccgcgtgtggatgacgaccaccgctgaattgcgcagcgcagactccgaggcaagttaggttgggttcgggccagacttgcgcgctctcacagagaggggtcgttgatcaacgctagccaggccctgctcagaacagactacaggctcttgtgaggacttgaccgaccttttcttctatgcgcagttggccacgacatggtggaactctaagatttcatcggtgaagtagccaccaaactgccgctaacagttcctactgagtcctggggagtgctggatgctgccttaatgtccggtggtacctgctaacctgaaagggcagctggggaaaccctggggctgccagaggaatgcgttaaaaagggcatttttcttgttagtggagaggaacctactgaaccaaaggacttgccctggacctggtctcattccagcagtcccccaaggtgagggggcctgtaggtaccagagccttagaagggttgccttcctcctcgaagcttggggtttggggggtgggccgggtaagactttgcttagtaaatggtttgaacactttcaaaaaaaaaaaaaaaaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]