2024-03-30 00:57:23, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_017275 1619 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus pregnancy up-regulated nonubiquitous CaM kinase (Pnck), mRNA. ACCESSION NM_017275 VERSION NM_017275.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1619) AUTHORS Tokumitsu H, Iwabu M, Ishikawa Y and Kobayashi R. TITLE Differential regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms JOURNAL Biochemistry 40 (46), 13925-13932 (2001) PUBMED 11705382 REMARK GeneRIF: Residues 129-151 of recombinant CaM-KK beta participate in the release of the autoinhibitory domain from its catalytic core, resulting in generation of autonomous activity. REFERENCE 2 (bases 1 to 1619) AUTHORS Hook SS and Means AR. TITLE Ca(2+)/CaM-dependent kinases: from activation to function JOURNAL Annu Rev Pharmacol Toxicol 41, 471-505 (2001) PUBMED 11264466 REMARK Review article REFERENCE 3 (bases 1 to 1619) AUTHORS Naito Y, Watanabe Y, Yokokura H, Sugita R, Nishio M and Hidaka H. TITLE Isoform-specific activation and structural diversity of calmodulin kinase I JOURNAL J Biol Chem 272 (51), 32704-32708 (1997) PUBMED 9405489 REFERENCE 4 (bases 1 to 1619) AUTHORS Yokokura H, Terada O, Naito Y and Hidaka H. TITLE Isolation and comparison of rat cDNAs encoding Ca2+/calmodulin-dependent protein kinase I isoforms JOURNAL Biochim Biophys Acta 1338 (1), 8-12 (1997) PUBMED 9074610 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000491.1. On Nov 26, 2020 this sequence version replaced NM_017275.1. ##Evidence-Data-START## Transcript exon combination :: AB004267.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00132261, SAMD00132263 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-212 JACYVU010000491.1 439380-439591 c 213-282 JACYVU010000491.1 438852-438921 c 283-414 JACYVU010000491.1 438373-438504 c 415-489 JACYVU010000491.1 437956-438030 c 490-628 JACYVU010000491.1 437724-437862 c 629-752 JACYVU010000491.1 437422-437545 c 753-828 JACYVU010000491.1 437140-437215 c 829-941 JACYVU010000491.1 436933-437045 c 942-1020 JACYVU010000491.1 436775-436853 c 1021-1108 JACYVU010000491.1 436616-436703 c 1109-1253 JACYVU010000491.1 436343-436487 c 1254-1619 JACYVU010000491.1 435691-436056 c FEATURES Location/Qualifiers source 1..1619 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="X" /map="Xq37" gene 1..1619 /gene="Pnck" /gene_synonym="Camk1b" /note="pregnancy up-regulated nonubiquitous CaM kinase" /db_xref="GeneID:29660" /db_xref="RGD:69249" exon 1..212 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" misc_feature 185..187 /gene="Pnck" /gene_synonym="Camk1b" /note="upstream in-frame stop codon" exon 213..282 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" CDS 215..1246 /gene="Pnck" /gene_synonym="Camk1b" /EC_number="2.7.11.17" /note="calcium/calmodulin-dependent protein kinase 1, beta; caMKI-beta; caM-KI beta; caM kinase IB; caM kinase I beta; Protein Kinase-like; pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog; pregnancy upregulated non-ubiquitously expressed CaM kinase" /codon_start=1 /product="calcium/calmodulin-dependent protein kinase type 1B" /protein_id="NP_058971.1" /db_xref="GeneID:29660" /db_xref="RGD:69249" /translation="
MLLLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQHLWISGDAALDRDILGSVSEQIQKNFARTHWKRAFNATSFLRHIRKLGQSPEGEEASRQGMTRHSHPGLGTSQSPKW"
misc_feature 245..1075 /gene="Pnck" /gene_synonym="Camk1b" /note="Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; Region: STKc_CaMKI_beta; cd14169" /db_xref="CDD:271071" misc_feature order(275..289,299..301,338..340,344..346,434..436, 482..493,503..505,509..511,617..622,626..628,632..637, 641..643,680..685,692..694,731..745,749..751) /gene="Pnck" /gene_synonym="Camk1b" /note="active site" /db_xref="CDD:271071" misc_feature order(275..286,299..301,338..340,344..346,434..436, 482..493,503..505,632..637,641..643,680..685) /gene="Pnck" /gene_synonym="Camk1b" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:271071" misc_feature order(287..289,503..505,509..511,617..622,626..628, 632..634,692..694,731..745,749..751) /gene="Pnck" /gene_synonym="Camk1b" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:271071" misc_feature 680..745 /gene="Pnck" /gene_synonym="Camk1b" /note="activation loop (A-loop); other site" /db_xref="CDD:271071" misc_feature 1082..1147 /gene="Pnck" /gene_synonym="Camk1b" /note="propagated from UniProtKB/Swiss-Prot (O70150.1); Region: Calmodulin-binding. /evidence=ECO:0000250" misc_feature 1154..1243 /gene="Pnck" /gene_synonym="Camk1b" /note="propagated from UniProtKB/Swiss-Prot (O70150.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1226..1228 /gene="Pnck" /gene_synonym="Camk1b" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9QYK9; propagated from UniProtKB/Swiss-Prot (O70150.1); phosphorylation site" exon 283..414 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 415..489 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 490..628 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 629..752 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 753..828 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 829..941 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 942..1020 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 1021..1108 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 1109..1253 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" exon 1254..1619 /gene="Pnck" /gene_synonym="Camk1b" /inference="alignment:Splign:2.1.0" ORIGIN
aaggcatcttagctccgcagcccaccaccctcacacacacctgtgacgcccggcgcgcccccctgcccgcacgcgcacagcccacgcagctctggacacaggcggctgaggttgcggagtccccccacgctgaggcgccaggggccaagcagcgattagggggctgcgtgggtggctgtggtcgtgacaggtggctgcaagcagggtcgcagacatgctgctgctcaagaaacagacggaggacatcagcagtgtctatgagatccgggagaagctgggctcgggtgccttctctgaggtgatgctggcccaggaaaggggctctgctcatcttgtggccctcaagtgcattcccaagaaagcacttcggggcaaggaggccctggtggagaatgagatcgcagtactccgcaggattagccaccccaacattgtggctctggaggacgtccacgagagcccttcccatctctacttggccatggagctggtaacaggtggtgaactgtttgaccgaatcatggagcggggctcctacacagagaaggatgcgagccaccttgtagggcaggtccttggtgctgtctcctaccttcatagcctgggcatcgtgcaccgggacctcaagcctgaaaacctcctctatgccacaccttttgaggactccaagatcatggtctctgactttggcctgtccaaaattcaagctggcaacatgctaggcacagcctgtgggaccccaggatatgtggccccagagctcctggagcagaaaccctacgggaaggccgtagatgtgtgggccctgggtgtcatctcctacatcctgctgtgtgggtacccccccttctatgatgagagcgatcctgaactcttcagccagattctgagggccagctacgagtttgactctcccttttgggatgacatctcagaatcagccaaagacttcattcggcaccttctggaacgtgatccccagaagaggttcacctgccaacaggccttacagcatctctggatctctggggatgcagccttggacagggacatcctaggttctgtcagtgagcagatccagaagaattttgccaggacccactggaagcgtgcattcaatgccacatcattcctacgtcacatccgtaagctgggacagagcccagagggtgaggaggcctccaggcagggtatgacccgtcacagccacccaggccttgggactagccagtctcccaagtggtgacaaccaggtggatgccaaggaaggccaagtggactgactcctagcttttctttcctccagcccttttgatctccttccctgatccttgtcccccggactggcctctgttggaaagtccaagaccgtgggtgtgatgcatggcactggggtatggggcttcccaagtatgtccccagcctctgtcctttgttgctgccaccctctatggaaactgaggaggtattcaaaaatggatttgggggccatccttcctgcaccttgcacgcacatatgcattgcgtggctgttctgtgctttgctgactgtgggtggtcctgcttgtgttgtagccctttagttcctcctctttccaaccaataaagacaaacagaac
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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