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Previous release (v1)
2025-04-17 20:39:59, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_013114 3187 bp mRNA linear ROD 31-MAR-2024
DEFINITION Rattus norvegicus selectin P (Selp), mRNA.
ACCESSION NM_013114
VERSION NM_013114.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3187)
AUTHORS Horioka,K., Tanaka,H., Isozaki,S., Okuda,K., Asari,M., Shiono,H.,
Ogawa,K. and Shimizu,K.
TITLE Hypothermia-induced activation of the splenic platelet pool as a
risk factor for thrombotic disease in a mouse model
JOURNAL J Thromb Haemost 17 (10), 1762-1771 (2019)
PUBMED 31237986
REFERENCE 2 (bases 1 to 3187)
AUTHORS Jing,Y., Hu,Y., Li,H., Wang,J., Si,X., Zheng,H., Liu,J., Liao,W.,
Liao,Y. and Bin,J.
TITLE Assessment of Thrombotic Risk in Atrial Fibrillation with
Ultrasound Molecular Imaging of P-Selectin
JOURNAL Thromb Haemost 118 (2), 388-400 (2018)
PUBMED 29378361
REMARK GeneRIF: P-selectin may indicate thrombotic risk assessment in
atrial fibrillation
REFERENCE 3 (bases 1 to 3187)
AUTHORS Mehta-D'souza,P., Klopocki,A.G., Oganesyan,V., Terzyan,S.,
Mather,T., Li,Z., Panicker,S.R., Zhu,C. and McEver,R.P.
TITLE Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to
Stabilize the High Affinity State under Force
JOURNAL J Biol Chem 292 (6), 2510-2518 (2017)
PUBMED 28011641
REFERENCE 4 (bases 1 to 3187)
AUTHORS Vogel,K.U., Edelmann,S.L., Jeltsch,K.M., Bertossi,A., Heger,K.,
Heinz,G.A., Zoller,J., Warth,S.C., Hoefig,K.P., Lohs,C., Neff,F.,
Kremmer,E., Schick,J., Repsilber,D., Geerlof,A., Blum,H., Wurst,W.,
Heikenwalder,M., Schmidt-Supprian,M. and Heissmeyer,V.
TITLE Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40
costimulator mRNAs and control follicular helper T cell
differentiation
JOURNAL Immunity 38 (4), 655-668 (2013)
PUBMED 23583643
REFERENCE 5 (bases 1 to 3187)
AUTHORS Ehlers,P.I., Kivimaki,A.S., Siltari,A., Turpeinen,A.M., Korpela,R.
and Vapaatalo,H.
TITLE Plant sterols and casein-derived tripeptides attenuate blood
pressure increase in spontaneously hypertensive rats
JOURNAL Nutr Res 32 (4), 292-300 (2012)
PUBMED 22575043
REMARK GeneRIF: Aortic cyclooxygenase-2 and P-selectin were significantly
down-regulated in plant sterols and plant sterols + tripeptides
groups.
REFERENCE 6 (bases 1 to 3187)
AUTHORS Ruppert,M., Aigner,S., Hubbe,M., Yagita,H. and Altevogt,P.
TITLE The L1 adhesion molecule is a cellular ligand for VLA-5
JOURNAL J Cell Biol 131 (6 Pt 2), 1881-1891 (1995)
PUBMED 8557754
REFERENCE 7 (bases 1 to 3187)
AUTHORS Auchampach,J.A., Oliver,M.G., Anderson,D.C. and Manning,A.M.
TITLE Cloning, sequence comparison and in vivo expression of the gene
encoding rat P-selectin
JOURNAL Gene 145 (2), 251-255 (1994)
PUBMED 7520013
REFERENCE 8 (bases 1 to 3187)
AUTHORS Sammar,M., Aigner,S., Hubbe,M., Schirrmacher,V., Schachner,M.,
Vestweber,D. and Altevogt,P.
TITLE Heat-stable antigen (CD24) as ligand for mouse P-selectin
JOURNAL Int Immunol 6 (7), 1027-1036 (1994)
PUBMED 7524641
REFERENCE 9 (bases 1 to 3187)
AUTHORS Mayadas,T.N., Johnson,R.C., Rayburn,H., Hynes,R.O. and Wagner,D.D.
TITLE Leukocyte rolling and extravasation are severely compromised in P
selectin-deficient mice
JOURNAL Cell 74 (3), 541-554 (1993)
PUBMED 7688665
REFERENCE 10 (bases 1 to 3187)
AUTHORS Nelson,R.M., Dolich,S., Aruffo,A., Cecconi,O. and Bevilacqua,M.P.
TITLE Higher-affinity oligosaccharide ligands for E-selectin
JOURNAL J Clin Invest 91 (3), 1157-1166 (1993)
PUBMED 7680663
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from
JAXUCZ010000013.1.
On Nov 26, 2020 this sequence version replaced NM_013114.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: L23088.1, SRR26643297.41795.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN06621351, SAMN06680412
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-20 JAXUCZ010000013.1 79009511-79009530
21-111 JAXUCZ010000013.1 79018990-79019080
112-498 JAXUCZ010000013.1 79021440-79021826
499-606 JAXUCZ010000013.1 79023010-79023117
607-792 JAXUCZ010000013.1 79023793-79023978
793-978 JAXUCZ010000013.1 79025556-79025741
979-1164 JAXUCZ010000013.1 79027669-79027854
1165-1350 JAXUCZ010000013.1 79030252-79030437
1351-1536 JAXUCZ010000013.1 79033430-79033615
1537-1722 JAXUCZ010000013.1 79036616-79036801
1723-1932 JAXUCZ010000013.1 79037893-79038102
1933-2118 JAXUCZ010000013.1 79039116-79039301
2119-2238 JAXUCZ010000013.1 79040098-79040217
2239-2269 JAXUCZ010000013.1 79042272-79042302
2270-2325 JAXUCZ010000013.1 79043466-79043521
2326-3187 JAXUCZ010000013.1 79044132-79044993
FEATURES Location/Qualifiers
source 1..3187
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="13"
/map="13q23"
gene 1..3187
/gene="Selp"
/gene_synonym="PSELECT"
/note="selectin P"
/db_xref="GeneID:25651"
/db_xref="RGD:3656"
exon 1..20
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
CDS 18..2324
/gene="Selp"
/gene_synonym="PSELECT"
/note="P-selectin; LECAM3; PADGEM; GMP-140; granule
membrane protein 140; CD62 antigen-like family member P;
leukocyte-endothelial cell adhesion molecule 3; platelet
activation dependent granule-external membrane protein;
selectin, platelet"
/codon_start=1
/product="P-selectin precursor"
/protein_id="NP_037246.2"
/db_xref="GeneID:25651"
/db_xref="RGD:3656"
/translation="
MAGCPKGSWKPRLRSVVLGAAQLVWLSALISELVNQKEVAAWTYNYSTKAYSWNNSRAFCKRHFTDLVAIQNKNEIAHLNDVIPYVNSYYWIGIRKINNKWTWVGTNKTLTAEAENWADNEPNNKRNNQDCVEIYIKSNSAPGKWNDEPCFKRKRALCYTASCQDMSCNSQGECIETIGSYTCSCYPGFYGPECEYVQECGKFDIPQHVLMNCSHPLGDFSFSSQCTFSCPEGYDLNGPSEMQCLASGIWTNNPPQCKAVQCQSLEAPLHGTMDCTHPLAAFAYDSSCKFECQPGYRMRGSDILHCTDSGQWSEPLPTCEAIACEPLESPLHGSMDCFPSTGAFGYNSSCTFRCTEGFVLMGNDAIHCADLGQWTAPAPVCEALQCQEFPVPSKAQVSCSDPFGTLKYQSACSFSCDEGSLLVGASVIRCLATGHWSEAPPECQAVSCTPLLSPENGTMTCIQPLGHSNYKSTCQFMCDEGFYLSGPERLDCSPSGHWTGSPPMCEAIKCPEIFAPEQGSLDCSHVHGEFSVGSTCHFSCNEEFELLGSRNVECTVSGRWSAPPPTCKGVTSLPVPSVRCPALTTPGQGTMSCRHHLESFGPNTTCYFGCKTGFTLRGANSLRCGASGQWTAVTPVCRAVKCSELHMDTAVAMNCSNPWGNFSYGSTCAFHCPEGQSLNGSARTTCREDGHWSDAMPTCQAGTLTIQEALTYLGGALASTTGLAVGGTLLALLRKRLRKKDDGKCPLNPHSHLGTYGVFTNAAYDPTP"
sig_peptide 18..140
/gene="Selp"
/gene_synonym="PSELECT"
/note="/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1)"
mat_peptide 141..2321
/gene="Selp"
/gene_synonym="PSELECT"
/product="P-selectin. /id=PRO_0000017500"
/note="propagated from UniProtKB/Swiss-Prot (P98106.1)"
misc_feature 141..497
/gene="Selp"
/gene_synonym="PSELECT"
/note="C-type lectin-like domain (CTLD) of the type found
in the type 1 transmembrane proteins: P(platlet)-,
E(endothelial)-, and L(leukocyte)- selectins (sels);
Region: CLECT_selectins_like; cd03592"
/db_xref="CDD:153062"
misc_feature 150..152
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature 177..179
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature order(282..284,378..380,384..389,414..416,420..422,
453..461)
/gene="Selp"
/gene_synonym="PSELECT"
/note="carbohydrate binding site [chemical binding]; other
site"
/db_xref="CDD:153062"
misc_feature order(282..284,378..380,384..386,402..404,414..416,
420..422,453..461)
/gene="Selp"
/gene_synonym="PSELECT"
/note="PSGL-1 peptide binding surface; other site"
/db_xref="CDD:153062"
misc_feature 336..338
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature <519..602
/gene="Selp"
/gene_synonym="PSELECT"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:238011"
misc_feature 615..791
/gene="Selp"
/gene_synonym="PSELECT"
/note="Complement control protein (CCP) modules (aka short
consensus repeats SCRs or SUSHI repeats) have been
identified in several proteins of the complement system;
Region: CCP; cd00033"
/db_xref="CDD:153056"
misc_feature order(645..647,708..710)
/gene="Selp"
/gene_synonym="PSELECT"
/note="receptor-ligand interactions [active]"
/db_xref="CDD:153056"
misc_feature 651..653
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature 843..1532
/gene="Selp"
/gene_synonym="PSELECT"
/note="secreted complement-binding protein; Provisional;
Region: PHA02927"
/db_xref="CDD:222943"
misc_feature 1056..1058
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature 1344..2114
/gene="Selp"
/gene_synonym="PSELECT"
/note="secreted complement-binding protein; Provisional;
Region: PHA02927"
/db_xref="CDD:222943"
misc_feature 1383..1385
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature 1824..1826
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature 1977..1979
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature 1998..2000
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature 2052..2054
/gene="Selp"
/gene_synonym="PSELECT"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P98106.1); glycosylation site"
misc_feature 2145..2216
/gene="Selp"
/gene_synonym="PSELECT"
/note="propagated from UniProtKB/Swiss-Prot (P98106.1);
transmembrane region"
misc_feature 2283..2294
/gene="Selp"
/gene_synonym="PSELECT"
/note="propagated from UniProtKB/Swiss-Prot (P98106.1);
Region: Endocytosis signal. /evidence=ECO:0000305"
misc_feature 2292..2321
/gene="Selp"
/gene_synonym="PSELECT"
/note="propagated from UniProtKB/Swiss-Prot (P98106.1);
Region: Interaction with SNX17. /evidence=ECO:0000250"
exon 21..111
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 112..498
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 499..606
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 607..792
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 793..978
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 979..1164
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 1165..1350
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 1351..1536
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 1537..1722
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 1723..1932
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 1933..2118
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 2119..2238
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 2239..2269
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 2270..2325
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
exon 2326..3187
/gene="Selp"
/gene_synonym="PSELECT"
/inference="alignment:Splign:2.1.0"
ORIGIN
gacgggtcggagaggacatggccggctgcccaaaaggttcttggaagccaagactccggagtgtggtcctgggagccgctcagcttgtctggctcagtgctttgatctctgagcttgtaaatcagaaggaagtggccgcgtggacctataactacagcacgaaagcatactcatggaataactcacgggcattctgcaagaggcacttcacagacttagtggccatccagaacaagaatgaaatcgctcacctcaatgacgtcatcccatacgtcaactcttactactggattggtatccgaaagatcaacaataagtggacctgggtgggaaccaataagactctcacggcggaggctgagaactgggcagacaacgagcccaacaacaagaggaacaaccaggactgtgtggagatctacatcaagagtaattcggcccctggcaagtggaatgatgagccctgctttaaacgaaagcgggccctgtgctacacagcctcctgccaggacatgtcttgcaacagccaaggggagtgcatcgagaccattgggagctacacctgctcctgctacccgggcttctatgggccagagtgtgaatacgtccaagagtgtggaaaattcgacatcccgcaacacgttctcatgaactgcagccaccctctgggggacttctccttcagctcacagtgcaccttcagctgtcctgagggctatgacctgaacggacccagtgagatgcaatgtttggcctctggaatctggacaaataatcccccgcagtgtaaagctgtgcagtgccagagcctggaagcccctctccatggaaccatggactgtacacacccattggctgcctttgcctatgactccagctgtaaatttgagtgccagcctggatatcggatgaggggctctgacatactccactgcactgactctggtcagtggagtgaaccattgccaacctgtgaagccattgcatgcgaaccgctggagagccccctccatgggagcatggactgcttcccatccacaggagcattcgggtacaacagcagctgcacttttcgctgcacagagggattcgtgctgatgggaaatgatgccattcattgtgctgacttggggcagtggacagccccagccccagtctgtgaagcgttgcaatgtcaggagtttccggtcccaagtaaagcccaggtgagctgctcggaccccttcgggaccttgaagtaccagtcagcctgcagcttttcctgtgatgaaggctcactcttggtgggagcaagtgtgataagatgcttggctactggacactggagtgaggcccctcctgaatgtcaagctgtctcctgcacccctttgctcagccctgagaatggaaccatgacgtgtatccagcctcttgggcattccaactacaaatccacatgccagttcatgtgtgacgaaggattttatctatctggaccagaaagattggactgttctccatctggacactggacaggcagccctccaatgtgtgaagccatcaagtgcccagaaatctttgccccagaacaaggcagcttggactgctctcatgttcatggagaattcagtgtcggctccacctgtcacttctcctgcaacgaggagtttgagctcctgggatctcgaaatgtggagtgcacagtgtctggaagatggtcagcgcctccaccaacctgcaaaggtgtaacatcacttcctgtcccatcggttcgatgccccgccctcactactcctggacagggcacaatgtcctgtcgacaccacctggaaagctttggtccgaacaccacttgttactttgggtgcaaaactggatttacactcagaggagccaactctctccgctgcggggcttcaggacaatggacagcagtgacgcccgtgtgcagagccgtcaaatgctcagaattgcacatggacacagcagtcgcgatgaactgttccaacccctggggaaactttagctacggatcaacctgtgccttccactgtccagaggggcagtcactgaatggctctgccaggacaacctgccgagaggacggtcactggtcagatgccatgccaacctgccaagcagggacgctgacgatccaggaagctctgacttacttgggtggcgccttggcttctacaacaggcctggcagtgggcgggacgctactggctctgctaagaaagcgtctcagaaagaaagatgatggaaaatgccccctgaaccctcacagccacctaggaacatatggagtcttcacgaacgctgcatatgacccaaccccttaagaggcctggcctcccgatgtcaattggatctctcaggattccgcatgcagataacaagtttcctggtcgacttgactgtcactccccagcatttgctgcggttctttgtggtaaataattggacaggaaccaaacgaaaggacgatgtgctccgcccaccccttcctgctccgcccctcaccttcctcgggctcagccacagaaacaggagcaaatgtttctgctgtggtctgtggcttgatgttactttgctgttactgaaaacccgagttagtccaaggcactggagcatctgcctcaccaggtgaccaggctgtggaaaaccggaagtctgtctgctttctcttgggattgaagaatggcgatgttggtgggcaggcagacctctcgtttaagggaacgcctgctttaagatctcctgggtcttccgtgtttcttatctctgaggttgtttacacctctgctgctgagactttcagatggtactaggggacacagaagatcgggaacagagcatggacaccacatctgactgcagactttccgtccaccaaagcacccaaaggccattgtttgactgtagagttcaactcccccagctatcaagctcttcacgttttgttcagtgaggtctgtgtatctcactttgtctaccaccaatgtggtcacagttacactcctccaaatgacagctggaccctccagtgagcccacaaatatatgttgtatgtcgcctgtccacagagagaaaaatcagaggagcaggaaaggtcctcttttcgttattttgttctgcaggaaagaacagttatgttttatacgtaacttaattcacatatttaataaataagtcactgaaaatt
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]