LOCUS       NM_001424326            1712 bp    mRNA    linear   PRI 21-NOV-2024
DEFINITION  Homo sapiens cholesin (CHLSN), transcript variant 16, mRNA.
ACCESSION   NM_001424326 XM_011515583
VERSION     NM_001424326.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Ryk,A., Marcinkiewicz,A., Chrzanowski,J., Michalak,A.M., Drozdz,I.,
            Burzynski,J., Krejca,M. and Fendler,W.
  TITLE     Cholesin receptor signalling is active in cardiovascular
            system-associated adipose tissue and correlates with SGLT2i
            treatment in patients with diabetes
  JOURNAL   Cardiovasc Diabetol 23 (1), 211 (2024)
   PUBMED   38902687
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Hu,X., Chen,F., Jia,L., Long,A., Peng,Y., Li,X., Huang,J., Wei,X.,
            Fang,X., Gao,Z., Zhang,M., Liu,X., Chen,Y.G., Wang,Y., Zhang,H. and
            Wang,Y.
  TITLE     A gut-derived hormone regulates cholesterol metabolism
  JOURNAL   Cell 187 (7), 1685-1700 (2024)
   PUBMED   38503280
  REMARK    GeneRIF: A gut-derived hormone regulates cholesterol metabolism.
REFERENCE   3  (bases 1 to 1712)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1712)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1712)
  AUTHORS   Meeks,K.A.C., Henneman,P., Venema,A., Addo,J., Bahendeka,S.,
            Burr,T., Danquah,I., Galbete,C., Mannens,M.M.A.M.,
            Mockenhaupt,F.P., Owusu-Dabo,E., Rotimi,C.N., Schulze,M.B.,
            Smeeth,L., Spranger,J., Zafarmand,M.H., Adeyemo,A. and Agyemang,C.
  TITLE     Epigenome-wide association study in whole blood on type 2 diabetes
            among sub-Saharan African individuals: findings from the RODAM
            study
  JOURNAL   Int J Epidemiol 48 (1), 58-70 (2019)
   PUBMED   30107520
  REMARK    GeneRIF: Three ubiquitous methylation loci were consistently and
            strongly associated with type 2 diabetes in Ghanaians: TXNIP,
            C7orf50 and CPT1A
REFERENCE   6  (bases 1 to 1712)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   7  (bases 1 to 1712)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 1712)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
REFERENCE   9  (bases 1 to 1712)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   10 (bases 1 to 1712)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091729.4 and AC073957.7.
            
            On Sep 22, 2023 this sequence version replaced XM_011515583.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3104662.1,
                                           SRR14038193.3696447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC091729.4         65055-65103         c
            50-179              AC091729.4         54113-54242         c
            180-373             AC073957.7         131010-131203       c
            374-455             AC073957.7         121530-121611       c
            456-614             AC073957.7         118706-118864       c
            615-1712            AC073957.7         99024-100121        c
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..1712
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="cholesin"
                     /db_xref="GeneID:84310"
                     /db_xref="HGNC:HGNC:22421"
     exon            1..49
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /inference="alignment:Splign:2.1.0"
     exon            50..179
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..728
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="isoform e is encoded by transcript variant 16;
                     uncharacterized protein C7orf50; protein cholesin"
                     /codon_start=1
                     /product="protein cholesin isoform e"
                     /protein_id="NP_001411255.1"
                     /db_xref="GeneID:84310"
                     /db_xref="HGNC:HGNC:22421"
                     /translation="

MAKQKRKVPEVTEKKNKKLKKASAEGPLLGPEAAPSGEGAGSKGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHPPARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGRAQRIRQDTCAVDPAAMLWGSPAARRGAHVEGNPGPRNRGQAST"

     misc_feature    51..299
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BRJ6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    117..119
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9BRJ6.1); phosphorylation site"
     misc_feature    225..227
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q9BRJ6.1);
                     phosphorylation site"
     misc_feature    339..341
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q9BRJ6.1); phosphorylation site"
     misc_feature    573..575
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BRJ6.1); phosphorylation site"
     exon            180..373
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /inference="alignment:Splign:2.1.0"
     exon            374..455
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /inference="alignment:Splign:2.1.0"
     exon            456..614
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /inference="alignment:Splign:2.1.0"
     exon            615..1712
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="hexamer: AATAAA"
     polyA_site      1712
                     /gene="CHLSN"
                     /gene_synonym="C7orf50; YCR016W"
                     /note="major polyA site"
ORIGIN      

ggcgtccgcgacgcagctgttcacgcttaggtgggcgacgtgggcgcaggatggcaaaacagaagagaaaagttcctgaagtgacagagaaaaagaacaaaaagctgaagaaggcgtcagcagaggggccactgctgggccctgaggctgcaccaagtggcgaaggagccggctccaagggcgaagctgtgctcaggcccgggctggacgcagagccagagctgtccccagaggagcagagggtcctggaaaggaagctgaaaaaggaacggaagaaagaggagaggcagcgtctgcgggaggcaggccttgtggcccagcacccgcctgccaggcgctcgggggccgaactggccctggactacctctgcagatgggcccaaaagcacaagaactggaggtttcagaagacgaggcagacgtggctcctgctgcacatgtatgacagtgacaaggttcccgatgagcacttctccaccctgctggcctacctggaggggctgcagggccgggcccgagagctgacggtgcagaaggcggaagccctgatgcgggagctggatgaggagggctctgatccccccctgccggggagggcccagcgcatccgacaggacacctgtgccgtggacccagccgccatgctgtggggaagcccagcagctcgtagaggggcccatgtggaggggaacccaggcccacggaaccgtggccaggcttccacatgacactgagcccacctgcctgccagccacgtgtgccatcgtgagtggatcctccagtccgaagtggagctaacccggcccaggcctcgtggaatgtctccaccaagccctgcccaagtgcaagtgcaagttcacgggtaatgactgctgctaagcttggggtgctttgttatgcagcggcagataacgcgaacacggccacgtaagcttcagcaagggctgtgaccccttgagtctgtttctctgtgtcagatgaggataataagacctacttagctggattcattcatcttcgagctataaacggagcatgtccagcgtgccaggcactgctccaggctctggggatccgggtggaaatacctgcaataccttgattgctggggctcaaacaaggttcgttccctcctctgagcttttccttttttcttgtagacaaggtctcacttttttgcccaggctgcagtgcagtggtgcgatcttggttcactgcagcctcgacctcccagggctcagacgatcctcccacctcagcctctggggtagctgggaccacaggtgtgcgcccctacacctggctaatttttgtattttttatagacgtagggtttcagcatgttgccaaggctggtctcaaactcctgggctcaagtggtccgcccacctcggcttcccagagtgttgggattacaggtgtgagccaccgcccccagccccttccccactttttacaccggtgaactgctcataaaaattctttcctcttctctcccagctaaagatctcatataaagcaataatcatttgccaggtgacagtcaattaaaagccggttgtcacctccaggccacaggtccctcggggctcccagacagagaggcttagggcagccccaacggaggggctgtccttccactgctaagcggctgctgcagtcaagtgagtgagcgcttctttgctgggtaataaaagctcccattgttcaca

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