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Previous release (v1)
2025-04-03 20:09:02, GGRNA.v2 : RefSeq release 228 (Jan, 2025)
LOCUS NM_001266053 3577 bp mRNA linear PRI 22-FEB-2022
DEFINITION Macaca mulatta nuclear factor kappa B subunit 1 (NFKB1), mRNA.
ACCESSION NM_001266053 XM_001109277 XM_002804153
VERSION NM_001266053.1
KEYWORDS RefSeq.
SOURCE Macaca mulatta (Rhesus monkey)
ORGANISM Macaca mulatta
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE 1 (bases 1 to 3577)
AUTHORS Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S,
Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Marcais G,
Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA
and Norgren RB Jr.
TITLE A new rhesus macaque assembly and annotation for next-generation
sequencing analyses
JOURNAL Biol Direct 9 (1), 20 (2014)
PUBMED 25319552
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3577)
AUTHORS Gong J, Shen XH, Qiu H, Chen C and Yang RG.
TITLE Rhesus monkey TRIM5alpha represses HIV-1 LTR promoter activity by
negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated
NF-kappaB activation
JOURNAL Arch Virol 156 (11), 1997-2006 (2011)
PUBMED 21918865
REMARK GeneRIF: TRIM5alpha represses HIV-1 LTR promoter activity by
negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated
NF-kappaB activation.
REFERENCE 3 (bases 1 to 3577)
AUTHORS Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li
Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson
JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J,
Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N,
Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B,
Nielsen R, Yang H, Wang J, Wang X and Wang J.
TITLE Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques
JOURNAL Nat Biotechnol 29 (11), 1019-1023 (2011)
PUBMED 22002653
REMARK Publication Status: Online-Only
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from JV043229.1.
On or before May 25, 2012 this sequence version replaced
XM_002804153.1, XM_001109277.2.
##Evidence-Data-START##
Transcript exon combination :: JV043229.1, JU472947.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA4688317, SAMEA4688321
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..3577
/organism="Macaca mulatta"
/mol_type="mRNA"
/db_xref="taxon:9544"
/chromosome="5"
/map="5"
gene 1..3577
/gene="NFKB1"
/note="nuclear factor kappa B subunit 1"
/db_xref="GeneID:710324"
/db_xref="VGNC:VGNC:75339"
exon 1..122
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 123..168
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
CDS 130..3039
/gene="NFKB1"
/note="nuclear factor of kappa light polypeptide gene
enhancer in B-cells 1 (p105)"
/codon_start=1
/product="nuclear factor NF-kappa-B p105 subunit"
/protein_id="NP_001252982.1"
/db_xref="GeneID:710324"
/db_xref="VGNC:VGNC:75339"
/translation="
MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDSEGCDRSDDRNTVNLFGKVIETTEHNQEPSEATDGNGEVTLTYATRAKEESARVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAASWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGGSLLTLNKMPHDYGQEGPLEGKI"
misc_feature 256..861
/gene="NFKB1"
/note="N-terminal sub-domain of the Rel homology domain
(RHD) of nuclear factor of kappa B1 (NF-kappa B1); Region:
RHD-n_NFkB1; cd07935"
/db_xref="CDD:143651"
misc_feature order(298..300,304..309,313..318,325..336,559..561,
565..570,859..861)
/gene="NFKB1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:143651"
misc_feature 880..1185
/gene="NFKB1"
/note="IPT domain of the transcription factor NFkappaB and
related transcription factors. NFkappaB is considered a
central regulator of stress responses, activated by
different stressful conditions, including physical stress,
oxidative stress, and exposure to...; Region:
IPT_NFkappaB; cd01177"
/db_xref="CDD:238582"
misc_feature order(883..885,889..897,901..909,1027..1035,1072..1074,
1108..1110,1165..1167,1174..1176,1180..1182)
/gene="NFKB1"
/note="ankyrin protein binding site [polypeptide binding];
other site"
/db_xref="CDD:238582"
misc_feature order(889..894,898..900,937..939,943..945,949..951,
1048..1053,1060..1062,1066..1068)
/gene="NFKB1"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:238582"
misc_feature order(952..954,958..960,1051..1056)
/gene="NFKB1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:238582"
misc_feature 1624..2406
/gene="NFKB1"
/note="Ankyrin repeat [Signal transduction mechanisms];
Region: ANKYR; COG0666"
/db_xref="CDD:440430"
misc_feature order(1756..1758,1762..1764,1774..1779,1786..1794,
1798..1803,1813..1815,1822..1824,1867..1869,1873..1875,
1879..1881,1891..1896,1903..1911,1915..1920,1930..1932,
1939..1941,1966..1968,1972..1974,1978..1980,1990..1995,
2002..2010,2014..2019,2029..2031,2038..2040)
/gene="NFKB1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:293786"
misc_feature 1756..1869
/gene="NFKB1"
/note="ANK repeat [structural motif]; Region: ANK repeat"
/db_xref="CDD:293786"
misc_feature 1873..1968
/gene="NFKB1"
/note="ANK repeat [structural motif]; Region: ANK repeat"
/db_xref="CDD:293786"
misc_feature 2080..2172
/gene="NFKB1"
/note="ANK repeat [structural motif]; Region: ANK repeat"
/db_xref="CDD:293786"
misc_feature 2182..2280
/gene="NFKB1"
/note="ANK repeat [structural motif]; Region: ANK repeat"
/db_xref="CDD:293786"
misc_feature 2575..2802
/gene="NFKB1"
/note="Death domain of the Nuclear Factor-KappaB1
precursor protein p105; Region: Death_NFkB1_p105; cd08797"
/db_xref="CDD:260063"
exon 169..247
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 248..288
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 289..387
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 388..536
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 537..700
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 701..859
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 860..964
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 965..1056
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 1057..1195
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 1196..1339
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 1340..1429
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 1430..1624
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 1625..1766
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 1767..1881
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 1882..2083
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 2084..2253
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 2254..2356
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 2357..2481
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 2482..2548
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 2549..2721
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 2722..2878
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
exon 2879..3577
/gene="NFKB1"
/inference="alignment:Splign:2.1.0"
ORIGIN
ccgcacccgggcccgctcgggctccggccggccaccgcctcttccctctccagcccgcaggcccgcgccgcccaggagggagagacccgcgccaggaggccgaacgcggactcgccaccaggcttcagaatggcagaagatgatccatatttgggaaggcctgaacaaatgtttcatttggatccttctttgactcatacaatatttaacccagaagtatttcaaccacagatggcactgccaacagcagatggcccatatcttcaaatattagagcaacctaaacagagaggatttcgtttccgttatgtttgtgaaggcccatcccatggtggactacctggtgcctctagcgaaaagaacaagaagtcttaccctcaggtcaaaatctgcaactatgtgggaccagcaaaggttattgttcagttggtcacaaatggaaaaaatatccacctgcatgcccacagcctggtgggaaaacactgtgaggatgggatctgcactgtaactgctggacccaaggacatggtggtcggcttcgcaaacctgggtatacttcatgtaacaaagaaaaaagtatttgaaacactggaagcacgaatgacagaggcgtgtataaggggctataatcctggactcttggtgcaccctgaccttgcctatttgcaagcagaaggtggaggggaccggcagttgggagatcgggaaaaagagctaatccgccaagcagctctgcagcaaaccaaggagatggacctcagcgtggtgcggctcatgtttacagcttttcttccggatagcactggcagcttcacaaggcgcctggaacccgtggtatcagacgccatctatgacagtaaagcccccaacgcatccaacttgaaaattgtaagaatggacaggacagctggatgtgtgactggaggggaggaaatttatcttctctgtgacaaagttcagaaagatgacatccagattcgattttatgaagaggaggaaaatggtggagtctgggaaggatttggagatttttcccccacagatgttcatagacaatttgccatcgtcttcaaaactccaaagtataaagatgttaatattacgaaaccagcctctgtgttcgtccagcttcggaggaaatctgacttggaaactagtgaaccaaaacctttcctctactatcctgaaatcaaagataaagaagaagtacagaggaaacggcagaagctcatgcccaatttttcggatagtttcggcggtgggagtggcgctggagctggaggcggaggcatgtttggtagtggcgggggaggagggggcactggaagtacagggccagggtatagcttcccgcactatggatttcctacttatggtgggattaccttccatcctggaactactaaatctaatgctgggatgaagcatggaaccatggacactgaatctaaaaaggattctgaaggttgtgacagaagtgatgacagaaacactgtaaacctctttgggaaagtcattgaaaccacagagcacaatcaggagcccagcgaggccactgatgggaatggtgaggtcactctaacgtatgcaacaagagcaaaagaagagagtgctagggttcaggataacctctttctagagaaggctatgcagcttgcaaagaggcatgccaatgcccttttcgactacgcagtgacaggagacgtgaagatgctgctggccgtccagcgccatctcactgccgtgcaggatgagaatggggacagtgtcttacacttagcaatcatccaccttcattctcaacttgtgagggatctactagaagtcacatctggtttgatttctgatgacattatcaacatgagaaatgacctgtaccagacgcccttgcacttggcagtgatcactaagcaggaagatgtggtggaggatttgctgagggctggggccgacctgagccttctggaccgcttgggtaactctgttttgcacctagctgccaaagaaggacatgataaagttctcagtatcttactcaagcacaaaaaggcagcactacttcttgaccaccccaatggggacggtctgaatgccattcatctagccatgatgagcaatagcctgccatgtttgctgctgctggtggccgctggggccgacgtcaatgctcaggagcaaaagtccgggcgcacagcactgcacctggctgtggagcacgacaacatctcattggcaggctgcctgctcctggagggtgatgcccatgtggacagtactacctacgatggaaccacacccctgcatatagcagctgggagagggtccaccaggctggcagctcttctcaaagcagcaggagcagatcccctggtggagaactttgagcctctctatgacctggatgactcttgggaaaatgcaggagaggatgaaggagttgtgcctggaaccacgcctctagatatggccgccagctggcaggtatttgacatattaaatgggaaaccatatgaaccagagtttacatctgatgatttactagcacaaggagacatgaaacagctggctgaagatgtgaagctgcagctctataagttgctagaaattcctgatccagacaaaaactgggctactctggcacagaaattaggtctggggatacttaataatgccttccggctgagtcctgctccttccaaaacacttatggacaactatgaggtctctggggggacagtcagagagctggtggaggccctgagacaaatgggctacactgaagcgattgaagtgatccaggcagcctccagcccagtgaagaccacctctcaggcccactcgctgcctctctcgcctgcctccacaaggcagcaaatagatgagctccgagacagcgacagtgtctgcgacagcggcgtggagacctccttccgcaaactcagctttactgagtctctgaccagtggtggctcactgctaactctcaacaaaatgccccatgattatgggcaggaaggacctctagaaggcaaaatttagcctgcagacaatttcccacaccgtataaaccaaagccctaaaattctactgcattgtccacaaaacagaagctgaagcgcatccagaggtgctcagagagccggcctgcctgaatcattctcgatataactcgagaccttttcaacttggcttcctttcttggttcataaatgaattttagtttggttcacttacagatagtatctagcaatcacagcactggctgagcggatgcatctggggatgaggttgcttactaagctttgccggctgctgccggatcacagctgctttctgttgtcattgctattgtccctctgctacgttcctattgtcattaaaggtatcactgtccccacctggcattccttctgaccatccacagcatcgttttgcattcaaattaagggttaagaaaagggatattttaaaatgagagtcacttgacgtgccattttttaaaaaggcatattgctttttctaatgtggttatttctctgatttgaaaaaaaaaaaaagtactcgtcaatatttaaac
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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