LOCUS       NM_001020807             681 bp    mRNA    linear   MAM 19-DEC-2022
DEFINITION  Canis lupus familiaris PROP paired-like homeobox 1 (PROP1), mRNA.
ACCESSION   NM_001020807
VERSION     NM_001020807.1
KEYWORDS    RefSeq.
SOURCE      Canis lupus familiaris (dog)
  ORGANISM  Canis lupus familiaris
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
            Canis.
REFERENCE   1  (bases 1 to 681)
  AUTHORS   Lantinga-van Leeuwen IS, Kooistra HS, Mol JA, Renier C, Breen M and
            van Oost BA.
  TITLE     Cloning, characterization, and physical mapping of the canine
            Prop-1 gene (PROP1): exclusion as a candidate for combined
            pituitary hormone deficiency in German shepherd dogs
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 140-144 (2000)
   PUBMED   10773688
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF126157.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11526762
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Canis lupus familiaris"
                     /mol_type="mRNA"
                     /sub_species="familiaris"
                     /db_xref="taxon:9615"
                     /chromosome="11"
                     /map="11"
     gene            1..681
                     /gene="PROP1"
                     /note="PROP paired-like homeobox 1"
                     /db_xref="GeneID:474647"
                     /db_xref="VGNC:VGNC:45014"
     CDS             1..681
                     /gene="PROP1"
                     /note="prophet of Pit1, paired-like homeodomain
                     transcription factor; PROP-1; pituitary-specific
                     homeodomain factor"
                     /codon_start=1
                     /product="homeobox protein prophet of Pit-1"
                     /protein_id="NP_001018643.1"
                     /db_xref="GeneID:474647"
                     /db_xref="VGNC:VGNC:45014"
                     /translation="

MEAEGRSERGKQKKGRLCGSLWPDSYPAAGTLTSTVDVSPQPSKNLSGVGVRRPRLSPQGGQRGRLHSRRRHRTTFNPGQLEQLETAFGRNQYPDIWAREGLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPLAHLSPATFSGFLPESPACPYSYPTPPPPMTCFPHPYNHALPSQPSTGGSFARPHQSEDWYPTLHPPPTGHLPCPPPPTMLPLSLEPPKSWN"

     misc_feature    1..240
                     /gene="PROP1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9TTD8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(208..222,226..228,277..279,295..297,334..336,
                     340..345,352..357,361..369,373..378)
                     /gene="PROP1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    214..375
                     /gene="PROP1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(214..216,223..225,343..345,352..357,364..366)
                     /gene="PROP1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    523..678
                     /gene="PROP1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9TTD8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1..109
                     /gene="PROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..342
                     /gene="PROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..681
                     /gene="PROP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atggaagcggaagggaggagtgagcggggtaagcaaaagaaggggcgactttgcggcagcctctggcctgacagctaccccgctgctgggaccctgacctccacagtagatgtgagccctcagcccagcaagaacctttctggtgtaggcgtgcggagaccaaggctttccccccaaggaggacagaggggtcgcctgcactcccggcgccgccaccgcaccaccttcaacccagggcagttggaacagctggagacagcctttgggaggaatcagtaccccgacatttgggcccgagagggccttgcccgggacacaggcctcagcgaggccagaatccaggtctggttccagaaccgcagagctaagcagaggaagcaagaacggtcgctgctccagccactggcccatctgtctcctgccaccttctctggtttcttgcctgagtcccctgcatgcccctactcctacccaacaccacctccacccatgacctgcttccctcacccctacaaccatgcccttccttctcagccctccaccggtggttcctttgctcgaccccaccagtctgaagactggtaccccaccttgcacccaccccccactggtcatctgccctgtcccccacccccaaccatgcttcccctcagccttgagccaccaaagtcctggaactaa

//