LOCUS       NM_001007134            1764 bp    mRNA    linear   VRT 29-MAY-2023
DEFINITION  Danio rerio ladybird homeobox 2 (lbx2), mRNA.
ACCESSION   NM_001007134
VERSION     NM_001007134.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1764)
  AUTHORS   Juarez-Morales JL, Weierud F, England SJ, Demby C, Santos N, Grieb
            G, Mazan S and Lewis KE.
  TITLE     Evolution of lbx spinal cord expression and function
  JOURNAL   Evol Dev 23 (5), 404-422 (2021)
   PUBMED   34411410
REFERENCE   2  (bases 1 to 1764)
  AUTHORS   Sagarin KA, Redgrave AC, Mosimann C, Burke AC and Devoto SH.
  TITLE     Anterior trunk muscle shows mix of axial and appendicular
            developmental patterns
  JOURNAL   Dev Dyn 248 (10), 961-968 (2019)
   PUBMED   31386244
REFERENCE   3  (bases 1 to 1764)
  AUTHORS   Talbot JC, Teets EM, Ratnayake D, Duy PQ, Currie PD and Amacher SL.
  TITLE     Muscle precursor cell movements in zebrafish are dynamic and
            require Six family genes
  JOURNAL   Development 146 (10) (2019)
   PUBMED   31023879
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1764)
  AUTHORS   Wang J, Luo J, Chen Q, Wang X, He J, Zhang W, Yin Z, Zheng F, Pan
            H, Li T, Lou Q and Wang B.
  TITLE     Identification of LBX2 as a novel causal gene of atrial septal
            defect
  JOURNAL   Int J Cardiol 265, 188-194 (2018)
   PUBMED   29669692
REFERENCE   5  (bases 1 to 1764)
  AUTHORS   Masselink W, Masaki M, Sieiro D, Marcelle C and Currie PD.
  TITLE     Phosphorylation of Lbx1 controls lateral myoblast migration into
            the limb
  JOURNAL   Dev Biol 430 (2), 302-309 (2017)
   PUBMED   28843494
REFERENCE   6  (bases 1 to 1764)
  AUTHORS   Hinits Y, Osborn DP and Hughes SM.
  TITLE     Differential requirements for myogenic regulatory factors
            distinguish medial and lateral somitic, cranial and fin muscle
            fibre populations
  JOURNAL   Development 136 (3), 403-414 (2009)
   PUBMED   19141670
REFERENCE   7  (bases 1 to 1764)
  AUTHORS   Wotton KR, Weierud FK, Dietrich S and Lewis KE.
  TITLE     Comparative genomics of Lbx loci reveals conservation of identical
            Lbx ohnologs in bony vertebrates
  JOURNAL   BMC Evol Biol 8, 171 (2008)
   PUBMED   18541024
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1764)
  AUTHORS   Koudijs MJ, den Broeder MJ, Groot E and van Eeden FJ.
  TITLE     Genetic analysis of the two zebrafish patched homologues identifies
            novel roles for the hedgehog signaling pathway
  JOURNAL   BMC Dev Biol 8, 15 (2008)
   PUBMED   18284698
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1764)
  AUTHORS   Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly
            PD, Chu F, Postlethwait JH and Talbot WS.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   10 (bases 1 to 1764)
  AUTHORS   Haines L, Neyt C, Gautier P, Keenan DG, Bryson-Richardson RJ,
            Hollway GE, Cole NJ and Currie PD.
  TITLE     Met and Hgf signaling controls hypaxial muscle and lateral line
            development in the zebrafish
  JOURNAL   Development 131 (19), 4857-4869 (2004)
   PUBMED   15342468
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC075912.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075912.1, AJ295165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1764
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="14"
                     /map="14"
     gene            1..1764
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="ladybird homeobox 2"
                     /db_xref="GeneID:64276"
                     /db_xref="ZFIN:ZDB-GENE-001206-2"
     exon            1..637
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    292..294
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="upstream in-frame stop codon"
     CDS             310..1083
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="lady bird-like homeobox 1 homolog; ladybird
                     homeobox homolog 1; ladybird homeobox homolog 2; ladybird
                     homeobox protein homolog 2"
                     /codon_start=1
                     /product="transcription factor LBX2"
                     /protein_id="NP_001007135.1"
                     /db_xref="GeneID:64276"
                     /db_xref="ZFIN:ZDB-GENE-001206-2"
                     /translation="

MTSSSKDMKAGSVLQSSGEERRRGPLDQLPPPANSNKPLTPFSIEDILNKPSVKKSVGSLCPPRVLEKVTGSSASRNGISAPSSPLCALEELASKTFKGLEVSVIQAAEGREHINAFGQRQASKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESLKKIPPQALQKLVSMEDMEDAHGGSGPISPSLSPRAFPQSPSSSRGQTTDEFSEEDEEIEVDD"

     misc_feature    310..447
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="propagated from UniProtKB/Swiss-Prot (Q804R0.1);
                     Region: Required for convergent extension movement and
                     hypaxial myogenesis during gastrulation. Required for the
                     formation of thick and thin myofilaments. Required for
                     myod1 expression in the pectoral fin bud. Required for
                     continuous expression of cxcl12a in the posterior lateral
                     mesoderm at the tail bud stage and in adaxial cells at the
                     10-somite stage. /evidence=ECO:0000269|PubMed:19216761,
                     ECO:0000269|PubMed:22216300, ECO:0000269|PubMed:22406073"
     misc_feature    310..438
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="propagated from UniProtKB/Swiss-Prot (Q804R0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(688..702,706..708,757..759,775..777,814..816,
                     820..825,832..837,841..849,853..858)
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    694..855
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(694..696,703..705,823..825,832..837,844..846)
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    925..1080
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /note="propagated from UniProtKB/Swiss-Prot (Q804R0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            638..1738
                     /gene="lbx2"
                     /gene_synonym="fc26c12; homeobox; lbx; lbx1; lbx1h;
                     SI:zC207O21.2; wu:fc26c12; zgc:92170"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tgaacttcacaaaagcaatcaacaagaactcgttagcggttgcttgctgttttgaggctccttgagacactaaggctacacacggtgaagatcttcatggagcagctcagagaacaccgcgtatgaggactaaagttcgggtgccttcctgcatgtgacgcctgaagcatggtgcttttggagagcctcttcagagtgaggaacaacaacgattttttgtaaagaaaggaacagacaaggcttttgtatgtataaacaagtttgagcgagctaggtgacttctattcgaaatagtttcttgggactgagatgacctccagctctaaagacatgaaagcaggatccgttttgcagtccagcggcgaggagaggcggcggggtcccttggaccaactcccacctccggccaactccaacaagcctctcaccccgttcagcattgaggatatcttaaacaagccctccgttaagaagtccgtcggtagtttgtgccctccgcgggtgctggagaaagtaaccggctcgagcgcatctcggaacgggatcagcgccccgtcctcgccgttgtgcgcgctggaggagctggcgagcaaaacatttaagggtttggaagtcagcgttatacaagcagcagaaggtcgtgaacacatcaacgcctttggccaaagacaggcatccaaaaaacgacggaagtcccgcacagccttcaccaaccaccaaatctacgagctggaaaagaggtttttgtaccagaaatacctctcaccggctgacagagaccagatagcacagcagctggggctgaccaatgcgcaggtcatcacctggttccagaaccgacgggccaagctcaagagagatctggaggagatgaaggcggacgtagagtctctcaagaaaatcccaccacaggcattgcagaaactggtgtccatggaggacatggaagacgctcacggtggctcggggcccatttctcccagtctttccccaagagcctttccacagtccccatcctcgtccagaggccaaaccacagacgagttctcagaggaggacgaggaaatcgaggtggacgattaaacgcaggcccttgttttcagagaagggcatttttcacgactttttgcacggaagaacttgaaatgcaaggaacgttttctgtctcccttatttttaatttattgaaaggacctctacattctgacgtccagatggaagacacggttttaaggaatacgctttcataagaaacacttagagataaatggtacagtatcaagactgcaaaaagtgtatgtacattttaagctttatttctccatttcttttctcaaaggaaacctgtgcaattgtttacaccatttatgacacacatttatgaacgctgtagaaattcttaagccaaaagtgattttcaattcagttttcagctgagtagaattatatatttataaataatttcagaacacaagatgtcctcagaaaccttttttttcagtcttggttctgcactgtaatttcccaaagtttgacattatgtatcccagttcctgacacaattcctacaggcattatttacaaattattaaaaaaaaagatgtatgtccaaaacaatgcaagggcaaggttgtgtatatatataacaagttatgatgcatctaactcgttaaatttattgtaacattctatttaatcctcatttatgtaaataaagggtatatgtaatttcacaatgaaaaaaaaaaaaaaaaaaaaaaaaaa

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