LOCUS       NM_001002446            1530 bp    mRNA    linear   VRT 15-OCT-2021
DEFINITION  Danio rerio claudin 15-like b (cldn15lb), mRNA.
ACCESSION   NM_001002446 XM_694358
VERSION     NM_001002446.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1530)
  AUTHORS   Solis CJ, Hamilton MK, Caruffo M, Garcia-Lopez JP, Navarrete P,
            Guillemin K and Feijoo CG.
  TITLE     Intestinal Inflammation Induced by Soybean Meal Ingestion Increases
            Intestinal Permeability and Neutrophil Turnover Independently of
            Microbiota in Zebrafish
  JOURNAL   Front Immunol 11, 1330 (2020)
   PUBMED   32793187
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1530)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1530)
  AUTHORS   Baltzegar DA, Reading BJ, Brune ES and Borski RJ.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
REFERENCE   4  (bases 1 to 1530)
  AUTHORS   Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND,
            Mostov KE, Moens CB and Stainier DY.
  TITLE     Regulation of intrahepatic biliary duct morphogenesis by Claudin
            15-like b
  JOURNAL   Dev Biol 361 (1), 68-78 (2012)
   PUBMED   22020048
  REMARK    GeneRIF: Cldn15lb plays an important role in the remodeling process
            during biliary duct morphogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EH497153.1 and EH487007.1.
            
            On Sep 30, 2011 this sequence version replaced NM_001002446.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EH504874.1, BC076025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-890               EH497153.1         33-922
            891-1530            EH487007.1         1-640               c
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="15"
                     /map="15"
     gene            1..1530
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /note="claudin 15-like b"
                     /db_xref="GeneID:436719"
                     /db_xref="ZFIN:ZDB-GENE-040718-145"
     exon            1..125
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    112..114
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /note="upstream in-frame stop codon"
     exon            126..346
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..795
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /note="claudin 10-like 1b"
                     /codon_start=1
                     /product="claudin 15-like b precursor"
                     /protein_id="NP_001002446.2"
                     /db_xref="GeneID:436719"
                     /db_xref="ZFIN:ZDB-GENE-040718-145"
                     /translation="

MAVMVLQVLGLFLGIVGWCLESSSINSSVWKSSSHGEAVVTASSQFEGLWFSCASNSLGAIHCQRFKTTLGLPGYIQACRALMIIALILGLLSVVLASMGLKCTKLGSTSEEAKGKISLTAGIMFILSGLCVIVAVSWYAARVVQEFNDPFYGGTKYELGAGLYLGWAAAALCILGGGTLCTSFKGSSPAQTRGPGYNYSAAQPQKIYRSAPSDNSITKAYV"

     sig_peptide     127..183
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    136..657
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
     exon            347..511
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /inference="alignment:Splign:2.1.0"
     exon            512..593
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /inference="alignment:Splign:2.1.0"
     exon            594..704
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1530
                     /gene="cldn15lb"
                     /gene_synonym="cldn10l1b; zgc:92349"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gacattcggcccaccgctgcttccccactcacactgaaaacctgctcacagcacacactttctgaacaaaacgctaattattcttcattttcagcacacactccagtccactgagagacaaacaggatggcggtgatggtgctgcaggtgctgggcttgtttctggggatcgtgggctggtgtttggagtccagctctataaactcgtctgtgtggaagagcagcagtcatggggaagcggtggtgacggccagctcgcagttcgaaggcctctggttctcctgcgcctcaaactcactgggagccattcactgccagaggttcaagaccactctgggtctgccaggatatatccaggcttgtcgggctctgatgatcatcgctctgattctgggtctgctgtctgtggttctggcctcgatgggactcaagtgcactaaactgggcagcacgtctgaggaggccaagggcaaaatcagcctgactgcaggaatcatgttcatcctgtcaggtttgtgtgttatcgtggccgtgtcgtggtacgctgctcgagtcgtccaggaatttaatgacccgttttatggaggcacaaagtatgaactgggcgcgggtctgtatctgggatgggcggcagctgctctgtgtatattaggaggaggaactctctgcacttcctttaaaggttcatctcctgcacaaacacggggcccgggctacaactacagcgctgcacagcctcagaagatttacagatctgctccatcagacaacagcatcaccaaagcatatgtttaagactgactttattttgagctgtccttcatgtttttgtacatggaccccatgtaattgcatcttaaaagtcaacacacttaacctttgaaaaaaaaactgtggtattactcttatagtaatgcgtacatatgctaaaatttgttttatttgtatttttttctgtcaaagctgcatttaggcttaacttttaataaaaaaaaaaggttgaattcgttatattattttggttttgtgatttactacagcactataatacatttcctgtatttgtatatcattattatatgctctttttaatattaatgttctaactgttttaaatcacacgctttggccactcatgtgtcataaaattatgatacattttttagctctgttcttatttttgtttcatttttatatccactagaatttgatcaaaaatacattaaaattctaataattaaaaatattaattcagttctcactgcgttaatcttgcatcaattttatgtaacttcctcattgtcagcgaaatataattcagctttgtcttagataagaaacgcttatttcatcatcagttccctctgtttgtttctcattaaatctcaacttccgtattcatgtatattgtcatgttatatggatcctgtttagtgcgttatataaatgttacattgtctgttctgctcttttttttttttcttattttatgttttagccatttctgtaaataataaaaaaaatctgtgc

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