LOCUS       XM_054377955            2597 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens milk fat globule EGF and factor V/VIII
            domain containing (MFGE8), transcript variant X1, mRNA.
ACCESSION   XM_054377955
VERSION     XM_054377955.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060939) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..2597
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /note="milk fat globule EGF and factor V/VIII domain
                     containing; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 82 ESTs, 928 long SRA
                     reads, 4 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 11 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:4240"
                     /db_xref="HGNC:HGNC:7036"
                     /db_xref="MIM:602281"
     CDS             722..1885
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /codon_start=1
                     /product="lactadherin isoform X1"
                     /protein_id="XP_054233930.1"
                     /db_xref="GeneID:4240"
                     /db_xref="HGNC:HGNC:7036"
                     /db_xref="MIM:602281"
                     /translation="

MGLTEARVMWPFPEGGNTIPILHTDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC"

     misc_feature    803..922
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    935..1393
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; Region: FA58C;
                     cd00057"
                     /db_xref="CDD:238014"
     misc_feature    order(1073..1075,1157..1159,1178..1180)
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /note="sugar binding site [chemical binding]; other site"
                     /db_xref="CDD:238014"
     misc_feature    1415..1879
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; Region: FA58C;
                     cd00057"
                     /db_xref="CDD:238014"
     misc_feature    order(1556..1558,1640..1642,1661..1663)
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /note="sugar binding site [chemical binding]; other site"
                     /db_xref="CDD:238014"
ORIGIN      

acctccactgttgacaaacttagacaaagccccggggaccgggctgggcagaggggcggcttcttccgctgcgccctggcgggacagggggatgcggccctgctgtctctgcgctggggcttttgggctgggactcgggacatcgggtgacagccctgccgcccccagggatgcggcttacagataatgacaaaggaatccgctgtgtcgggcctctcttttccctggtgaaaaatgaggccagggaactgcgtttgactttcgaaccccttccacctgggagattctaggactctagtatggataagtcttgtctggataactttgtcctggccatctccctgccaactccagttggctggacagttcattggatttttgcgctcccaattgtccgtgcctggtcacataagggaagggccggggagtcggtgcaatggacgcaggccgtaagtggggcccgggaggggacccagaggcttcgaggagcttggaagagggctgcctgctgatgggagtctcctgactccctccctcccgcggccttggccggctgctgtatcttccccggtcctcctccgcctcccaggaggcctccggaggccagctgggccccttgcaggctggacttgcggatgccccgtgccattcaccgtggagcgctgggagggagtcagggccaggactctttaggtggcccctccatcattttctcatagaaatgggattgactgaagcaagggtgatgtggccttttccagaaggaggaaacaccatacctatcttacacacagatatctgttccaaaaacccctgccacaacggtggtttatgcgaggagatttcccaagaagtgcgaggagatgtcttcccctcgtacacctgcacgtgccttaagggctacgcgggcaaccactgtgagacgaaatgtgtcgagccactgggcctggagaatgggaacattgccaactcacagatcgccgcctcgtctgtgcgtgtgaccttcttgggtttgcagcattgggtcccggagctggcccgcctgaaccgcgcaggcatggtcaatgcctggacacccagcagcaatgacgataacccctggatccaggtgaacctgctgcggaggatgtgggtaacaggtgtggtgacgcagggtgccagccgcttggccagtcatgagtacctgaaggccttcaaggtggcctacagccttaatggacacgaattcgatttcatccatgatgttaataaaaaacacaaggagtttgtgggtaactggaacaaaaacgcggtgcatgtcaacctgtttgagacccctgtggaggctcagtacgtgagattgtaccccacgagctgccacacggcctgcactctgcgctttgagctactgggctgtgagctgaacggatgcgccaatcccctgggcctgaagaataacagcatccctgacaagcagatcacggcctccagcagctacaagacctggggcttgcatctcttcagctggaacccctcctatgcacggctggacaagcagggcaacttcaacgcctgggttgcggggagctacggtaacgatcagtggctgcaggtggacctgggctcctcgaaggaggtgacaggcatcatcacccagggggcccgtaactttggctctgtccagtttgtggcatcctacaaggttgcctacagtaatgacagtgcgaactggactgagtaccaggaccccaggactggcagcagtaagatcttccctggcaactgggacaaccactcccacaagaagaacttgtttgagacgcccatcctggctcgctatgtgcgcatcctgcctgtagcctggcacaaccgcatcgccctgcgcctggagctgctgggctgttagtggccacctgccacccccaggtcttcctgctttccatgggcccgctgcctcttggcttctcagcccctttaaatcaccatagggctggggactggggaaggggagggtgttcagaggcagcaccaccacacagtcacccctccctccctctttcccaccctccacctctcacgggccctgccccagcccctaagccccgtcccctaacccccagtcctcactgtcctgttttcttaggcactgagggatctgagtaggtctgggatggacaggaaagggcaaagtagggcgtgtggtttccctgcccctgtccggaccgccgatcccaggtgcgtgtgtctctgtctctcctagcccctctctcacacatcacattcccatggtggcctcaagaaaggcccggaagcgccaggctggagataacagcctcttgcccgtcggccctgcgtcggccctggggtaccatgtggccacaactgctgtggccccctgtccccaagacacttccccttgtctccctggttgcctctcttgccccttgtcctgaagcccagcgacacagaagggggtggggcgggtctatggggagaaagggagcgaggtcagaggagggcatgggttggcagggtgggcgtttggggccctctatgctggcttttcaccccagaggacacaggcagcttccaaaatatatttatcttcttcacgggaa

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