LOCUS       XM_054376705            2576 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens tryptophanyl-tRNA synthetase 1 (WARS1),
            transcript variant X12, mRNA.
ACCESSION   XM_054376705
VERSION     XM_054376705.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060938) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..2576
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="tryptophanyl-tRNA synthetase 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 179 ESTs, 1690 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 35 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
     CDS             199..1491
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /codon_start=1
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X3"
                     /protein_id="XP_054232680.1"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
                     /translation="

MLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ"

     misc_feature    <202..267
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="S15/NS1/EPRS_RNA-binding domain. This short domain
                     consists of a helix-turn-helix structure, which can bind
                     to several types of RNA. It is found in the ribosomal
                     protein S15, the influenza A viral nonstructural protein
                     (NSA) and in several eukaryotic...; Region:
                     S15_NS1_EPRS_RNA-bind; cl00349"
                     /db_xref="CDD:444855"
     misc_feature    328..1473
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="aminoacyl-tRNA ligase; Region: PLN02486"
                     /db_xref="CDD:178104"
     misc_feature    order(550..564,583..585,589..594,601..603,655..657,
                     670..672,784..786,913..915,925..927,934..936,994..996,
                     1000..1005,1009..1014,1021..1023,1090..1092,1120..1125,
                     1129..1131)
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="active site"
                     /db_xref="CDD:173903"
     misc_feature    583..594
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="HIGH motif; other site"
                     /db_xref="CDD:173903"
     misc_feature    order(667..669,676..681,814..819,823..831,838..843,
                     847..858,862..867,901..903,907..912,919..924)
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:173903"
     misc_feature    1120..1134
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="KMSKS motif; other site"
                     /db_xref="CDD:173903"
ORIGIN      

actctcagcagctcaactgcccagcgtgaccagtggccacctctgcagtgtcttccacaacctgggtgaatctacttctcttaacaaagtctcaatgtcctatttgcaatttatgtggtaaacactgaagacaatggtccttaaccttttggcatctcagcctcctttcgaaaggatgaaattgattctgcagtaaagatgttggtgtcattaaaaatgagctacaaagctgccgcgggggaggattacaaggctgactgtcctccagggaacccagcacctaccagtaatcatggcccagatgccacagaagctgaagaggattttgtggacccatggacagtacagacaagcagtgcaaaaggcatagactacgataagctcattgttcggtttggaagtagtaaaattgacaaagagctaataaaccgaatagagagagccaccggccaaagaccacaccacttcctgcgcagaggcatcttcttctcacacagagatatgaatcaggttcttgatgcctatgaaaataagaagccattttatctgtacacgggccggggcccctcttctgaagcaatgcatgtaggtcacctcattccatttattttcacaaagtggctccaggatgtatttaacgtgcccttggtcatccagatgacggatgacgagaagtatctgtggaaggacctgaccctggaccaggcctatagctatgctgtggagaatgccaaggacatcatcgcctgtggctttgacatcaacaagactttcatattctctgacctggactacatggggatgagctcaggtttctacaaaaatgtggtgaagattcaaaagcatgttaccttcaaccaagtgaaaggcattttcggcttcactgacagcgactgcattgggaagatcagttttcctgccatccaggctgctccctccttcagcaactcattcccacagatcttccgagacaggacggatatccagtgccttatcccatgtgccattgaccaggatccttactttagaatgacaagggacgtcgcccccaggatcggctatcctaaaccagccctgttgcactccaccttcttcccagccctgcagggcgcccagaccaaaatgagtgccagcgaccccaactcctccatcttcctcaccgacacggccaagcagatcaaaaccaaggtcaataagcatgcgttttctggagggagagacaccatcgaggagcacaggcagtttgggggcaactgtgatgtggacgtgtctttcatgtacctgaccttcttcctcgaggacgacgacaagctcgagcagatcaggaaggattacaccagcggagccatgctcaccggtgagctcaagaaggcactcatagaggttctgcagcccttgatcgcagagcaccaggcccggcgcaaggaggtcacggatgagatagtgaaagagttcatgactccccggaagctgtccttcgactttcagtagcactcgttttacatatgcttataaaagaagtgatgtatcagtaatgtatcaataatcccagcccagtcaaagcaccgccacctgtaggcttctgtctcatggtaattactgggcctggcctctgtaagcctgtgtatgttatcaatactgtttcttcctgtgagttccattatttctatctcttatgggcaaagcattgtgggtaattggtgctggctaacattgcatggtcggatagagaagtccagctgtgagtctctccccaaagcagccccacagtggagcctttggctggaagtccatgggccaccctgttcttgtccatggaggactccgagggttccaagtatactcttaagacccactctgtttaaaaatatatattctatgtatgcgtatatggaattgaaatgtcattattgtaacctagaaagtgctttgaaatattgatgtggggaggtttattgagcacaagatgtatttcagcccatgccccctcccaaaaagaaattgataagtaaaagcttcgttatacatttgactaagaaatcacccagctttaaagctgcttttaacaatgaagattgaacagagttcagcaattttgattaaattaagacttgggggtgaaactttccagtttactgaactccagaccatgcatgtagtccactccagaaatcatgctcgcttcccttggcacaccagtgttctcctgccaaatgaccctagaccctctgtcctgcagagtcagggtggcttttcccctgactgtgtccgatgccaaggagtcctggcctccgcagatgcttcattttgacccttggctgcagtggaagtcagcacagagcagtgccctggctgtgtccctggacgggtggacttagctagggagaaagtcgaggcagcagccctcgaggccctcacagatgtctaggcaggcctcatttcatcacgcagcatgtgcaggcctggaagagcaaagccaaatctcagggaagtccttggttgatgtatctgggtctcctctggagcactctgccctcctgtcacccagtagagtaaataaacttccttggctcctg

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