LOCUS       XM_054376704            2772 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens tryptophanyl-tRNA synthetase 1 (WARS1),
            transcript variant X9, mRNA.
ACCESSION   XM_054376704
VERSION     XM_054376704.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060938) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..2772
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="tryptophanyl-tRNA synthetase 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 5 mRNAs, 192 ESTs, 1848 long SRA reads, 7 Proteins,
                     and 100% coverage of the annotated genomic feature by
                     RNAseq alignments, including 23 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
     CDS             272..1687
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /codon_start=1
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /protein_id="XP_054232679.1"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
                     /translation="

MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ"

     misc_feature    305..463
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="WHEP-TRS domain; Region: WHEP-TRS; pfam00458"
                     /db_xref="CDD:425693"
     misc_feature    order(326..328,332..334,341..343,356..358,371..373,
                     383..385,407..409,431..433)
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="tRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:238473"
     misc_feature    524..1669
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="aminoacyl-tRNA ligase; Region: PLN02486"
                     /db_xref="CDD:178104"
     misc_feature    order(746..760,779..781,785..790,797..799,851..853,
                     866..868,980..982,1109..1111,1121..1123,1130..1132,
                     1190..1192,1196..1201,1205..1210,1217..1219,1286..1288,
                     1316..1321,1325..1327)
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="active site"
                     /db_xref="CDD:173903"
     misc_feature    779..790
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="HIGH motif; other site"
                     /db_xref="CDD:173903"
     misc_feature    order(863..865,872..877,1010..1015,1019..1027,1034..1039,
                     1043..1054,1058..1063,1097..1099,1103..1108,1115..1120)
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:173903"
     misc_feature    1316..1330
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="KMSKS motif; other site"
                     /db_xref="CDD:173903"
ORIGIN      

gtttccacggacgcccaggagacagccggttgctgagccgggagcgctgactggcccggctgggcaggagtgtagtatttgttaaacaggtgaatctacttctcttaacaaagtctcaatgtcctatttgcaatttatgtggtaaacactgaagacaatggtccttaaccttttggcatctcagcctcctttcgaaagtcttgactcgtctgctgaacaaatcctctgacctcaggccggctgtgaacgtagttcctgagagatagcaaacatgcccaacagtgagcccgcatctctgctggagctgttcaacagcatcgccacacaaggggagctcgtaaggtccctcaaagcgggaaatgcgtcaaaggatgaaattgattctgcagtaaagatgttggtgtcattaaaaatgagctacaaagctgccgcgggggaggattacaaggctgactgtcctccagggaacccagcacctaccagtaatcatggcccagatgccacagaagctgaagaggattttgtggacccatggacagtacagacaagcagtgcaaaaggcatagactacgataagctcattgttcggtttggaagtagtaaaattgacaaagagctaataaaccgaatagagagagccaccggccaaagaccacaccacttcctgcgcagaggcatcttcttctcacacagagatatgaatcaggttcttgatgcctatgaaaataagaagccattttatctgtacacgggccggggcccctcttctgaagcaatgcatgtaggtcacctcattccatttattttcacaaagtggctccaggatgtatttaacgtgcccttggtcatccagatgacggatgacgagaagtatctgtggaaggacctgaccctggaccaggcctatagctatgctgtggagaatgccaaggacatcatcgcctgtggctttgacatcaacaagactttcatattctctgacctggactacatggggatgagctcaggtttctacaaaaatgtggtgaagattcaaaagcatgttaccttcaaccaagtgaaaggcattttcggcttcactgacagcgactgcattgggaagatcagttttcctgccatccaggctgctccctccttcagcaactcattcccacagatcttccgagacaggacggatatccagtgccttatcccatgtgccattgaccaggatccttactttagaatgacaagggacgtcgcccccaggatcggctatcctaaaccagccctgttgcactccaccttcttcccagccctgcagggcgcccagaccaaaatgagtgccagcgaccccaactcctccatcttcctcaccgacacggccaagcagatcaaaaccaaggtcaataagcatgcgttttctggagggagagacaccatcgaggagcacaggcagtttgggggcaactgtgatgtggacgtgtctttcatgtacctgaccttcttcctcgaggacgacgacaagctcgagcagatcaggaaggattacaccagcggagccatgctcaccggtgagctcaagaaggcactcatagaggttctgcagcccttgatcgcagagcaccaggcccggcgcaaggaggtcacggatgagatagtgaaagagttcatgactccccggaagctgtccttcgactttcagtagcactcgttttacatatgcttataaaagaagtgatgtatcagtaatgtatcaataatcccagcccagtcaaagcaccgccacctgtaggcttctgtctcatggtaattactgggcctggcctctgtaagcctgtgtatgttatcaatactgtttcttcctgtgagttccattatttctatctcttatgggcaaagcattgtgggtaattggtgctggctaacattgcatggtcggatagagaagtccagctgtgagtctctccccaaagcagccccacagtggagcctttggctggaagtccatgggccaccctgttcttgtccatggaggactccgagggttccaagtatactcttaagacccactctgtttaaaaatatatattctatgtatgcgtatatggaattgaaatgtcattattgtaacctagaaagtgctttgaaatattgatgtggggaggtttattgagcacaagatgtatttcagcccatgccccctcccaaaaagaaattgataagtaaaagcttcgttatacatttgactaagaaatcacccagctttaaagctgcttttaacaatgaagattgaacagagttcagcaattttgattaaattaagacttgggggtgaaactttccagtttactgaactccagaccatgcatgtagtccactccagaaatcatgctcgcttcccttggcacaccagtgttctcctgccaaatgaccctagaccctctgtcctgcagagtcagggtggcttttcccctgactgtgtccgatgccaaggagtcctggcctccgcagatgcttcattttgacccttggctgcagtggaagtcagcacagagcagtgccctggctgtgtccctggacgggtggacttagctagggagaaagtcgaggcagcagccctcgaggccctcacagatgtctaggcaggcctcatttcatcacgcagcatgtgcaggcctggaagagcaaagccaaatctcagggaagtccttggttgatgtatctgggtctcctctggagcactctgccctcctgtcacccagtagagtaaataaacttccttggctcctg

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