LOCUS       XM_054376698            2678 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens tryptophanyl-tRNA synthetase 1 (WARS1),
            transcript variant X3, mRNA.
ACCESSION   XM_054376698
VERSION     XM_054376698.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060938) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..2678
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="tryptophanyl-tRNA synthetase 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 5 mRNAs, 251 ESTs, 1921 long SRA reads, 7 Proteins,
                     and 100% coverage of the annotated genomic feature by
                     RNAseq alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
     CDS             178..1593
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /codon_start=1
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /protein_id="XP_054232673.1"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
                     /translation="

MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ"

     misc_feature    211..369
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="WHEP-TRS domain; Region: WHEP-TRS; pfam00458"
                     /db_xref="CDD:425693"
     misc_feature    order(232..234,238..240,247..249,262..264,277..279,
                     289..291,313..315,337..339)
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="tRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:238473"
     misc_feature    430..1575
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="aminoacyl-tRNA ligase; Region: PLN02486"
                     /db_xref="CDD:178104"
     misc_feature    order(652..666,685..687,691..696,703..705,757..759,
                     772..774,886..888,1015..1017,1027..1029,1036..1038,
                     1096..1098,1102..1107,1111..1116,1123..1125,1192..1194,
                     1222..1227,1231..1233)
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="active site"
                     /db_xref="CDD:173903"
     misc_feature    685..696
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="HIGH motif; other site"
                     /db_xref="CDD:173903"
     misc_feature    order(769..771,778..783,916..921,925..933,940..945,
                     949..960,964..969,1003..1005,1009..1014,1021..1026)
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:173903"
     misc_feature    1222..1236
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; IFI53; IFP53; NEDMSBA; WARS"
                     /note="KMSKS motif; other site"
                     /db_xref="CDD:173903"
ORIGIN      

gtttccacggacgcccaggagacagccggttgctgagccgggagcgctgactggcccggctgggcagggcaacccacccctgattggacagtctcatcaagaagtcttgactcgtctgctgaacaaatcctctgacctcaggccggctgtgaacgtagttcctgagagatagcaaacatgcccaacagtgagcccgcatctctgctggagctgttcaacagcatcgccacacaaggggagctcgtaaggtccctcaaagcgggaaatgcgtcaaaggatgaaattgattctgcagtaaagatgttggtgtcattaaaaatgagctacaaagctgccgcgggggaggattacaaggctgactgtcctccagggaacccagcacctaccagtaatcatggcccagatgccacagaagctgaagaggattttgtggacccatggacagtacagacaagcagtgcaaaaggcatagactacgataagctcattgttcggtttggaagtagtaaaattgacaaagagctaataaaccgaatagagagagccaccggccaaagaccacaccacttcctgcgcagaggcatcttcttctcacacagagatatgaatcaggttcttgatgcctatgaaaataagaagccattttatctgtacacgggccggggcccctcttctgaagcaatgcatgtaggtcacctcattccatttattttcacaaagtggctccaggatgtatttaacgtgcccttggtcatccagatgacggatgacgagaagtatctgtggaaggacctgaccctggaccaggcctatagctatgctgtggagaatgccaaggacatcatcgcctgtggctttgacatcaacaagactttcatattctctgacctggactacatggggatgagctcaggtttctacaaaaatgtggtgaagattcaaaagcatgttaccttcaaccaagtgaaaggcattttcggcttcactgacagcgactgcattgggaagatcagttttcctgccatccaggctgctccctccttcagcaactcattcccacagatcttccgagacaggacggatatccagtgccttatcccatgtgccattgaccaggatccttactttagaatgacaagggacgtcgcccccaggatcggctatcctaaaccagccctgttgcactccaccttcttcccagccctgcagggcgcccagaccaaaatgagtgccagcgaccccaactcctccatcttcctcaccgacacggccaagcagatcaaaaccaaggtcaataagcatgcgttttctggagggagagacaccatcgaggagcacaggcagtttgggggcaactgtgatgtggacgtgtctttcatgtacctgaccttcttcctcgaggacgacgacaagctcgagcagatcaggaaggattacaccagcggagccatgctcaccggtgagctcaagaaggcactcatagaggttctgcagcccttgatcgcagagcaccaggcccggcgcaaggaggtcacggatgagatagtgaaagagttcatgactccccggaagctgtccttcgactttcagtagcactcgttttacatatgcttataaaagaagtgatgtatcagtaatgtatcaataatcccagcccagtcaaagcaccgccacctgtaggcttctgtctcatggtaattactgggcctggcctctgtaagcctgtgtatgttatcaatactgtttcttcctgtgagttccattatttctatctcttatgggcaaagcattgtgggtaattggtgctggctaacattgcatggtcggatagagaagtccagctgtgagtctctccccaaagcagccccacagtggagcctttggctggaagtccatgggccaccctgttcttgtccatggaggactccgagggttccaagtatactcttaagacccactctgtttaaaaatatatattctatgtatgcgtatatggaattgaaatgtcattattgtaacctagaaagtgctttgaaatattgatgtggggaggtttattgagcacaagatgtatttcagcccatgccccctcccaaaaagaaattgataagtaaaagcttcgttatacatttgactaagaaatcacccagctttaaagctgcttttaacaatgaagattgaacagagttcagcaattttgattaaattaagacttgggggtgaaactttccagtttactgaactccagaccatgcatgtagtccactccagaaatcatgctcgcttcccttggcacaccagtgttctcctgccaaatgaccctagaccctctgtcctgcagagtcagggtggcttttcccctgactgtgtccgatgccaaggagtcctggcctccgcagatgcttcattttgacccttggctgcagtggaagtcagcacagagcagtgccctggctgtgtccctggacgggtggacttagctagggagaaagtcgaggcagcagccctcgaggccctcacagatgtctaggcaggcctcatttcatcacgcagcatgtgcaggcctggaagagcaaagccaaatctcagggaagtccttggttgatgtatctgggtctcctctggagcactctgccctcctgtcacccagtagagtaaataaacttccttggctcctg

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