LOCUS       XM_054371921            4254 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens homeobox C8 (HOXC8), transcript variant X1,
            mRNA.
ACCESSION   XM_054371921
VERSION     XM_054371921.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4254
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..4254
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="homeobox C8; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 4 mRNAs, 3 ESTs, 101 long
                     SRA reads, 30 Proteins, and 98% coverage of the annotated
                     genomic feature by RNAseq alignments, including 2 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:3224"
                     /db_xref="HGNC:HGNC:5129"
                     /db_xref="MIM:142970"
     CDS             2136..2864
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /codon_start=1
                     /product="homeobox protein Hox-C8 isoform X1"
                     /protein_id="XP_054227896.1"
                     /db_xref="GeneID:3224"
                     /db_xref="HGNC:HGNC:5129"
                     /db_xref="MIM:142970"
                     /translation="

MSSYFVNPLFSKYKAGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD"

     misc_feature    order(2583..2597,2601..2603,2652..2654,2670..2672,
                     2709..2711,2715..2720,2727..2732,2736..2744,2748..2753)
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(2589..2591,2598..2600,2718..2720,2727..2732,
                     2739..2741)
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    2592..2750
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
ORIGIN      

agggaaggagggcgggcggcggcggccgtggtggccggggcttccctccccaggcgggagccgcctgtcctgtatctatggccgtggggagcgaaggaccaggtaacgaaggcgcttccgaagcgggattggaccaaaccagagggacagagtcttctgggtctctctgcctgaggccctggagggagagaagagctgggctccggatggggaaggaaaaggtctggttgcctaaccacctccttcctcatccaaccctgaaacccccaggatgtggaagaaaaacaggtagcattttgctttcataatgcaaagacctaaagatgcatctgtgtttgtcaggcatgtatgcatgtgtgcctgggtgtgcacatgtgcgtacagtgtctgtgaggtggcagggatgcttccaggcatgtgtgtgctagtttacactgagcatggacttgatgtgtctcagggtgaaaagtagcacgtacagtgtgtgtgtgtcctgagtgtgctctaggatttcctgggtgtaacagcctcacaccctggtgagggagaggactggaaaaataattcttactcatctttttcattcatatgcacacagcatgcatgtattctcaccttctccctttttctctctgtctgtgttaagcccaaatcactgtacacacttatggccagagaagggtgctgatggactaaggttctttaatccattagaattaacttgaacgtattcagtcttggggatgggggaaccctccagagaaagtgtggataaatatttaaagagtgtctgttgatagttcccatccacatcctggcctgggcagcctgcctggggaagagggagctgcagtgaagccaggggccccaccaggctgagctggcatttcctatggcatgggggtatgtggggacaagtaagaggcctgctccagtcccctccaactcagatgcaaatagtctcctaagaagaaatgtcctgaatcagcccagctagaaaccagggacacacagctgccctttccttttagtctccataagcagctttgctctcagagcccctagccaagcttgtggccattgcctgggtttcctgctccatgcaggggctcgtgtctgaaggggcagtgtggccctgactgggtatatggagttttccccagccccacctcctctgaccctctcctctacccatagcaggtagcaagagagtctcctggatctaaggaagaagacagaacagcttcggaccctggggaggggccaggggatggagggtctgatgcctgaagtatttgggagtatggtgtgcttgttcctcctcaaagtctccagacttagggaccccctaggaagcccatcttttgggttaggggccctgctctggcttgcaggtattcatccccttggaggtcttatacctgttgaggtaacctgggttgacctgctggctcaggtatctctctctctctgagaagaaggaaaagagaagcgaggctgggggcgagaggcaccttcacatctaaattcgtaccctggaaaactggccccagccattagctggggctggctcaccacccccctacacacaccacacacccccatccctccccctctcctcccctccccttcctccaggtccccccagccctgtacccctcaacccccgccatctctctctctctctctctctctctctctctctctctctctctctctctctctctctctctctctcgcctgtcttcatgtcgtggattgatgaacgcgaatcgcgtgtaagcgccgccaccgccgggagtctgaggaattcgcctgggctgttagaggaaagagctaagtgagagagcgcgagctctacctaccgacagtgaggagcgccgccgccgccgccgcccgctcgccgcccgccgccgccgccgcccgcgccccagccccgggagctctgctgatccggccgagctcagcaccgaggcgccccccaacctgcccagcccccagcccaccagcccagcccagtcccggggagccagctggcctggggttcggtcccggggggaggggagtttcgggggtactgggcggggtactcgtgagccagaggggagggggccgcgggttttcatgtacccagcatgagctcctacttcgtcaaccccctgttctccaaatacaaagccggcgagtccctggaaccggcctattacgactgccggttccctcagagcgtgggcaggagccatgcgctggtgtacgggcccggcggctcggcgcccggcttccagcacgcttcgcaccacgttcaagacttcttccaccacggcacctccggcatctccaactcaggctaccagcagaacccgtgctcgcttagctgccacggagacgcctccaaattctatggctacgaggcgctccccagacagtccctttatggggctcagcaagaggcgagcgtggtgcaatatcccgactgtaaatcctccgccaacactaacagtagcgaaggacaaggccacttaaatcaaaactcgtctcccagcctcatgtttccatggatgagaccccacgctccggggaggcgcagtggacggcaaacttacagccggtatcagaccttggaactagaaaaggagtttctctttaatccttatttgacacgaaaacgtcggattgaagtctctcatgccctgggactgaccgagagacaagtgaagatctggttccagaaccgaaggatgaagtggaaaaaggagaacaacaaggataaactgccgggagcccgagatgaggagaaggtggaggaagaaggaaatgaggaagaggagaaagaagaggaggaaaaggaagaaaacaaggactaagcaaaaaagaaagaccccccccccctttagcaactcccttgaagtttcgttttatggtagcagataaattgagaagtttacgactgtcatttgcttttatagagaatagaatgacactcacaactctaactacctgtcagatacttgcagctctggttttattacctttggacttcccccactctttatttgtttgggggctggaggggggagacggagaaacagtgaaaagttcggactctctgtctcactccttgccccacacacacttgtccctgcccccacccttctgagtccttcctggattttaaggtctgagacctggcctccgtgctcctcggtctgtctctcaccacactcccacctccctgcttctctggtatttattttagaggggagccccctcgaaatgcagaaaaggacttgtggttttgtttttatgctaaggctagtgtactagatgtactttttctaaaaaggaaaggacagaaaaaaatgaagaaaggaaaggaagacaaatgtaaagaaataaggaaaaaagcaaggaatatcccctccccctccccctccccctccccagggctccctgcttagaaaaacccccttgactttctctaggaacctgatggaaacctgaaggagatgtgggtctttcccctccccccatttccagaagggtagataggagcctgcagtcgcctctaaaatcctacctaaccatcccatggtcactcgggcccatgccttcctctccttcgctgtttgatttctattctgttgggcccgccttcctctgagctgcattagtgttagtgctcagaaatcaccataatcacgaaaataataataataaatctttaacatactacctaaagggaacctgcaataatcttgaaaaagaaaaagagaaaaattttaaaatcctgctataggagaaaaaaagagaaaaaaataaaaatcaaaaaaaaaaaaaaagaaagaaagaaacctccagcgtattttatcactacctatagaaagaaatcctgctttgagagtatttgtaatgcggttttgttgtcgtttgttgctgcttatttcactaagaaaacccaacaactgagactgcctagcccgccggtcctgtgcgcttttattgtgcttctaaccccagtagagtagaactaaattgcactgaatgtatagttaactctgtcttgaattctctgtttatgcaatgtgctcgaaagaaaaaaatgttaaaaatatatctataataataattttttgtcatttgtctttatgtccagctatgaatgtagattttgtgtcccgacagccctgttcctggtccaagtactttgtattgtatacgtgagtcataataataaaaagaagaagaaaaataata

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