LOCUS       XM_054358836           22171 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens tensin 3 (TNS3), transcript variant X22,
            mRNA.
ACCESSION   XM_054358836
VERSION     XM_054358836.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060931) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..22171
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="tensin 3; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 4 mRNAs, 34 ESTs, 2384
                     long SRA reads, 3 Proteins, and 97% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     52 samples with support for all annotated introns"
                     /db_xref="GeneID:64759"
                     /db_xref="HGNC:HGNC:21616"
                     /db_xref="MIM:606825"
     CDS             16241..19249
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /codon_start=1
                     /product="tensin-3 isoform X10"
                     /protein_id="XP_054214811.1"
                     /db_xref="GeneID:64759"
                     /db_xref="HGNC:HGNC:21616"
                     /db_xref="MIM:606825"
                     /translation="

MTDARSKYSGTRHVVPAQVHVNGDAALKDRETDILDDEMPHHDLHSVDSLGTLSSSEGPQSAHLGPFTCHKSSQNSLLSDGFGSNVGEDPQGTLVPDLGLGMDGPYERERTFGSREPKQPQPLLRKPSVSAQMQAYGQSSYSTQTWVRQQQMVVAHQYSFAPDGEARLVSRCPADNPGLVQAQPRVPLTPTRGTSSRVAVQRGVGSGPHPPDTQQPSPSKAFKPRFPGDQVVNGAGPELSTGPSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHMNALGSQANGSVSPDSVGGGLRASSRLPDTGEGPSRATGRQGSSAEQPLGGRLRKLSLGQYDNDAGGQLPFSKCAWGKAGVDYAPNLPPFPSPADVKETMTPGYPQDLDIIDGRILSSKESMCSTPAFPVSPETPYVKTALRHPPFSPPEPPLSSPASQHKGGREPRSCPETLTHAVGMSESPIGPKSTMLRADASSTPSFQQAFASSCTISSNGPGQRRESSSSAERQWVESSPKPMVSLLGSGRPTGSPLSAEFSGTRKDSPVLSCFPPSELQAPFHSHELSLAEPPDSLAPPSSQAFLGFGTAPVGSGLPPEEDLGALLANSHGASPTPSIPLTATGAADNGFLSHNFLTVAPGHSSHHSPGLQGQGVTLPGQPPLPEKKRASEGDRSLGSVSPSSSGFSSPHSGSTISIPFPNVLPDFSKASEAASPLPDSPGDKLVIVKFVQDTSKFWYKADISREQAIAMLKDKEPGSFIVRDSHSFRGAYGLAMKVATPPPSVLQLNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGSLTALVCQHSITPLALPCKLLIPERDPLEEIAESSPQTAANSAAELLKQGAACNVWYLNSVEMESLTGHQAIQKALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFRRHYPVNSVIFCALDPQDRKWIKDGPSSKVFGFVARKQGSATDNVCHLFAEHDPEQPASAIVNFVSKVMIGSPKKV"

     misc_feature    <16781..18085
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    18413..18763
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="Src homology 2 domain found in Tensin-like
                     proteins; Region: SH2_Tensin_like; cd09927"
                     /db_xref="CDD:198181"
     misc_feature    order(18446..18448,18500..18502,18617..18619,18623..18625)
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198181"
     misc_feature    order(18620..18622,18710..18712)
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198181"
     misc_feature    18833..19228
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="Tensin Phosphotyrosine-binding (PTB) domain;
                     Region: PTB_tensin; cd01213"
                     /db_xref="CDD:269924"
     misc_feature    order(18851..18853,19103..19105,19166..19168)
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269924"
     misc_feature    order(19043..19060,19124..19126,19193..19195,19205..19207)
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269924"
ORIGIN      

tgtgcagttatggaggcaaagggcacagggaagacagcccactcaaatatctgaagtattttgcagtctgctaagaagaaaaaatttcccctgttttctcagaggtccagaatcacaccttcgtgtgacacagttgtgagttttgagggtcttcgtgagaataaggcatggtgagtttgggtcagggctttttgtgaagctgtaacgggtggatgagctgtcagtgaagttatatccaggagctccttggcctgaacttgtgtgtatgtataatgccagggaccgttcccccttcttccgtcccttccgttttgcatatggggatgccaagcgctggccacagccaaactagctactgttgtacggccccacatgcaacagacatcttgttttaatttctgtttgcttgttagtctagtgttcccgatttatggctgtatcatttaaatctctgttttcgtgaaaccgtctcacccaaacatgtcctctgttcacctgtgtaatatgcacattgggtcatagctaggagcgtgaaggaggaaaggaaggaaggggcagctgtgtgctggaatctccacaagacacaactggaggctgatttcaaaggaggggaattgaggcttttcctagcatgtcatgctgatcccttgtctttttcaaccaccgattgagaatcagacttgctttgggaaagaaattaaaacactttttgtcagattagttacatccagatgtaaaatagctaaaagcaagtgttgtggaaagaactgcagtagcgcctcatctttgtggatcgctgagcttcccatgactccaggaagggggtgtctgtggttagtgagaaaggacaccaattgtgtgtcccagggcagcacatggctcctctctgttgtcctggggaaaagcttgctccttcataggccttgtgggatggaatttcaactcaaggaattgttgcaacccaaatacacctagaccagaggtggagacccacagatggaatgttgatggtaaggacattaaaacacagatgaaatctggggctagtgggcaagttgtggacggggagagctttgctctggcctgtaaagtaaacagagtgttctttgctggtgtgaattattcagcacaccagtccttccagataaccagcacgttaaaagaaatgtagctgaaaactcttgcaaaatgatacattgtctttcaaaagatcacagtgcacactggaatcttaaagctgtgagaataatttcataagatttatcaaacaacagttatcaaactttttgatcacagagctctttttccagtaacgtctgtttgcatctgcatagctatattctgtccatcacatggtgatgttttccactggaggagagaagggtgaagcggtggctggtgaagtgtgtaaataatcatcgcaaggcaagatggggaaaggggctaatttggagagctggatggggactctgaggacagctgacttagcatcctaaattccaggctgaggcgagtggattttaccagagaggtcccttgctgcatgggagccagtgagcagcgctctgtcctgaggtgatgaatcagtggctgtgccgagtctcatggagaacagggaggcgagttgtggaaaggtcattctcgtgatgctgggaggttccttgcttgccaagggaggggcgagcctggagggttattgaccatgagggaggcaggggttctaaaacacaggtgggtgttctctgtgccaatgccgtaagaggggagcagtgaagtccggtggacagtgtggaggagccccagctcctgtgaggagcatgctctggagggcagctctgtgctcagtccctcattgggtgccccgctcttgtccccaagctggctcccagctaagcctgtgacctgcctgcggggcaggctttatccttcccatgtcacaaccagggaactgaaagctgggtgcctgcagcatgtcactcacaggtggtgaaggacctacgttgattttatgtagaaaacatatagacagaaaatcagttgagtgttcaccatcctttaggggttacatgaaactttacggagaatctgtggaattatgtgtgtgagcgtgtgtgtatagatccatacatgtggaggacttgccgttatcactgggtgaaatagacagaattcagtcttaaagactctcagccaccgcagtgtctcctgaagatgcagagggagatacttctttactttgaggccctctcagcccattcacgctgccttgacagatgaccataacctgggtgtcttaaacaacaagcgtgtatttctcctactttgagaggctgggaagtccaagatcaggcagccagcctggcggattctggtgagggctgtcatctggttgccaactcctgccttcttgtgtctccatgtggtggtgaggagagggagctccttggagcctcctttctgagggcatcaatcccacttataggggttccacccttatgctctgagcaccgccaaaggtcctgcctcctaataccatcactctggggattaggttttgacatatgaatcttaggggacacaaatattcagtccatagcagatactcaatgcgtgtttcttgaatgaatgattagagaagcaatttgaactttaaatatctaaggccctgacattacaaatcacaattcccattggtgtatttttcatgcagcatcttctgagccagtggtgtgagcaggtgggagactgctgtggattgtgtggttggaggtggtggagccatgcaggtgatggtctgggcatgcactcgggactctgtgtcaccgagagttgggtctaggggcgagtagagaaggtctggcattgccatgcaaaagatggagccagttgggagtgggtgcataggagttctggaaagaaactgagaaggacagggcagagtgggaaggacacccgggaaagagtggttcccagacaggagggtgaggagtcggatagggcgccaaggcagccaggtacactttgcagccagattcacagctttgtcattactgcttccaggcttcataaagcagcagagaccccctttatgggcagagtcatgcccagactcctcagggatatagtgggtgacagtgcagcctcctcccagtgcctggttcatcccttgcagcctcgatgatatctgaagcccatgagcacccccagggaggtggagtgacaggggaggactcagagcgagctcaggactggtatccggatgcttagcccagaacccgccacacagaatctgagtcctctcccaaaactggatctcagcaaccttcccttgaaccactgcctgagtattcttgagaattccagctcctgagttacagacaagcacggagcctttcctcaaatctgcatcccctcctcctgaccctccatccccacgtgctgtctggcgtgtctggggtacctgattcaatggaatgagttttatgcttttctttctttcttttacatacatttaagcttgtatcaatattttttgaagatgtaaattatcaaaaagaaggaataattaccgccatcttactgtctagagatgaagcactcgtcattggtgtatttttggcatgatttctaaatatcatgtaatttctcatagtaggatcagcctgtgcattgttttatagcctgagtttttcacttaacccacctccttgagcatctgtgcacatctttaaactttcttcccatgtccttctcactgagcacactggattcccttagaggggcttccaaagtgcgtttgatcttattgctgcactcctgcagggtttccaagttctccctgtgagacacgaggctgccatcaccacctctgccatcaaagttctgcagaatccccaggcttgggtccttttgagaaggtgttccccagaaagagtagtcacctttggatagaaaactcatccttgttgaatttccctcctctcttccactctgcagccctcctcagcccctctttggcatggaggccggtgtgctgcattggtgagctattactccaggcagtcttcgctcttgcctgcggtcagcagtgcctggctcaggtccctggactggacgccgcctggcgggtgaaaggctgagtcccagccgcattcccaccagggctttagtcttcagagctgtccagtgctttgaggagttaaggaaggtttggcagcctctgaaacattctcttttagctgggaaaatgatgtattgcggcactctcttttccacccctgcccctgccttttctatccccccgccgcctggttaaaaaaccccaaaaatgttgacttaagccgcatttatctctagcagtggttgccgtcctggaatggagccctccgcagctgccttcaatctgggcctgttaggggagcgctggctttgatgtgtgagcgcaacattctgcttctatactcagaaaggagccggccttgaatccgttccaatgtgggcaagtgattacaaacgccctgtcttcagcacagagaggagcacatggtcctggtctccccgtgggtctgtggtcctggcaggtgtggctgcgggggacggcagtcgtgtcagtgttccctggggtagttgctgtccctgaggagagggaagaatatctcgcggcacacagtgtggctgcctgccggaagcctcactatggtgttttaatcctcgagagagcctgtgagcccattttagagataaagagagcagatccaaagagaaatcaaaagctagtaactggccagggaccctggtagccttctggcgtacactgtcggcgatggcagctgtggctcagagtgtgtcttgtgctcgagaccgtgcaggacagggctcatacccttgactttcctctttgagactttgagactcagtgagactgggctgagtctcactgggtgccccacctcctcgtcacacaagagggctgtgggtggggggatttcttaccctagcag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