LOCUS       XM_054350764            3596 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens tec protein tyrosine kinase (TEC),
            transcript variant X2, mRNA.
ACCESSION   XM_054350764
VERSION     XM_054350764.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060928) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..3596
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="tec protein tyrosine kinase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     ESTs, 83 long SRA reads, 2 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 7 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:7006"
                     /db_xref="HGNC:HGNC:11719"
                     /db_xref="MIM:600583"
     CDS             180..1967
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /codon_start=1
                     /product="tyrosine-protein kinase Tec isoform X2"
                     /protein_id="XP_054206739.1"
                     /db_xref="GeneID:7006"
                     /db_xref="HGNC:HGNC:11719"
                     /db_xref="MIM:600583"
                     /translation="

MKSGNSIHHQKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR"

     misc_feature    <210..515
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:450165"
     misc_feature    615..782
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Src Homology 3 domain of Tec (Tyrosine kinase
                     expressed in hepatocellular carcinoma); Region: SH3_Tec;
                     cd11905"
                     /db_xref="CDD:212838"
     misc_feature    order(633..635,639..641,648..650,660..662,714..719,
                     759..761,765..770)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212838"
     misc_feature    789..1109
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Src homology 2 (SH2) domain found in Tec protein,
                     IL2-inducible T-cell kinase (Itk); Region: SH2_Tec_Itk;
                     cd10396"
                     /db_xref="CDD:198259"
     misc_feature    order(831..833,888..890)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198259"
     misc_feature    order(1056..1058,1080..1085)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198259"
     misc_feature    1164..1943
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Tyrosine kinase expressed in hepatocellular carcinoma and
                     Resting lymphocyte kinase; Region: PTKc_Tec_Rlk; cd05114"
                     /db_xref="CDD:270685"
     misc_feature    order(1197..1202,1221..1223,1257..1259,1263..1265,
                     1320..1322,1389..1391,1395..1409,1413..1415,1536..1538,
                     1548..1550,1557..1559,1587..1592,1599..1601,1641..1655,
                     1680..1682,1782..1784)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="active site"
                     /db_xref="CDD:270685"
     misc_feature    order(1197..1202,1221..1223,1257..1259,1263..1265,
                     1320..1322,1389..1391,1395..1409,1413..1415,1548..1550,
                     1557..1559,1587..1592,1599..1601)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270685"
     misc_feature    order(1536..1538,1548..1550,1641..1655,1680..1682,
                     1782..1784)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270685"
     misc_feature    1587..1661
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270685"
ORIGIN      

ccttaaactacaaagagagactttttgtacttacaaagtccatgctaacctactatgagggtcgagcagagcttacacctgcctgaccatcgccctggcgccgggagcctgacttgatattccccccaggatccctgggaaagcatggcctgaggcagctgcagccactggttcttcagatgaaaagtggaaactcaatacatcaccagaagaaatacagaaaggggtttattgatgtttcaaaaatcaagtgtgtggaaatagtgaagaatgatgatggtgtcattccctgtcaaaataagtatccatttcaggttgttcatgatgctaacacactttacatttttgcacctagtccacaaagcagggacctgtgggtgaagaagttaaaagaagaaataaagaacaacaataatattatgattaaatatcatcctaaattctggacagatggaagttatcagtgttgtagacaaactgaaaaattagcacccggatgtgaaaaatacaatctttttgagagtagtataagaaaagcactacctccagcaccagaaacaaagaagcgaaggcctcccccaccaattccactagaagaagaagataatagtgaagaaatcgttgtagccatgtatgatttccaagcagcagaaggacatgatctcagattagagagaggccaagagtatctcattttagaaaagaatgatgttcattggtggagagcaagagataaatatgggaatgaaggatatatcccaagtaattacgtaacgggaaagaaatcaaacaacttagatcaatatgaatggtattgcagaaatatgaatagaagcaaggcagagcaactcctccgcagtgaagataaagaaggtggttttatggtaagggattccagtcaaccaggcttgtacacagtctccctttataccaagtttggaggagaaggttcatcgggttttaggcattatcatataaaggaaacaacaacatctccaaagaagtattacctagctgaaaaacatgcttttggctccattcctgagattattgaatatcataagcacaatgcagcaggacttgtcaccaggcttcggtacccagttagtgtgaaagggaagaatgcacccaccactgcaggattcagctatgagaaatgggagattaacccttcagaactgacctttatgagggaattgggaagtggactgtttggagtggtgaggcttggcaaatggcgagcccagtacaaagtcgcaatcaaagctattcgggaaggtgcaatgtgcgaggaggactttatagaagaagctaaagtgatgatgaaactgacacacccgaagttagtgcagctttatggtgtgtgcacccagcagaaaccaatatacattgttactgagttcatggaaaggggctgccttctgaatttcctccgacagagacaaggtcatttcagtagagacgtactgctgagcatgtgtcaggatgtgtgtgaagggatggagtatctggagagaaacagcttcatccacagagatctggctgccagaaattgtctagtaagtgaggcgggagttgtaaaagtatctgattttggaatggccaggtatgttctggatgatcagtacacaagttcttctggtgctaagtttcctgtgaagtggtgtccacctgaagtgtttaattacagccgcttcagcagcaaatcagatgtctggtcatttggtgttttaatgtgggaagtattcacggaaggcagaatgccttttgaaaaatacaccaattatgaagtggtaaccatggttactcgaggccaccgactctaccagccgaagttggcgtccaactatgtgtatgaggtgatgctgagatgttggcaggagaaaccagagggaaggccttctttcgaagatctgctgcgcacaatagatgaactagttgaatgtgaagaaacttttggaagataagtgatgtgtgaccagtggctcccagattcccaagcacaaggaaggatgggcattttgtggcttttaatttattgagcacttggacatgtagatcattttacttatacagtggaaacacataatttgcttctagaccagcctctgtctagacttgcttctagacagaatctcccagagtgtggaaatgttgccttagaaatggtgattaaaatcactcatttctattcattcctcaggcacttgagtgacagttgtttaccaggcactgtgtgtagccccagggtttggccattcaggggtgcacacatgggaccatgttagctgatgccagttgaaggccagggtatttgggaaggggaagggtattagagtcatgaccaagcaacccttctttttccctttgacttctacagaaatctgggcctgagacattgtctacaattgggttctagatacatcaggaacccatcttggataaataaatacctatcttttgttttgaaaacatctcagttttcaagactgctcttagtattacatgaacaatatttgtatgctgtatatattgtaaatatatataatatataaagttatatatttatgagaaacacgaattgtcttttaattgaaacttttaatcctgtagtataggagttcaccttcttaggactagagactgtgccttatagctgttaattcatttccccctgaacatcaaatatgcctgaagagaagaaagtctagattcttctatgagtaacgccccctcctcactcaggtaaatgtgtctggggatgcctgtccagcttaaccacgtgcatttggcctatgtaatcctgcccatggtggccgcagctaatcagaatcagatggaaaattaaaccgggtaatctgcttctaagccttaagaatattccctgggacacagacactataattggaagtgctgagctctggggcagaaggatcaggtgaccttcgcaacaaagtttgcccccacctcacataggacccggaagcagcctgagctgtggcggaggatccaggaagctacggagagaagcagccagcatggtgttccgtgcctcccggacgtttttcaggaggcctggttggacttgggttcctggatggtgggattgttgtacagcctctcaggagaccctgctgtcaagactgtgtgtgtggatttcccacccttagaagctctactaagacatcaacggaattagggccttcctttttgccttgtgagcgccaaggaaaagaaactatctcggtcacgtgagcgccagcgaaaagaaactgtatcagtcatccagagaccgtttattgcccaacacgttattcttgctgttggtggggtaactagccgaggaagacacagcgccttcccttcaggagttgcgtctcctctgcaggccacgatggtctgctctggagcattgggtgaacacacaggctggctgctctgggcagcgccttcactctgaccctggagaaccatttcatttcatcctggtcagtctagagtctgtgcaccaggcagtccatccactgaaggctgtgtttattcttttcctgtgcccctcataatggaagaaagtaaactgcttatcccgagcctta

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