LOCUS       XM_054350763            4261 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens tec protein tyrosine kinase (TEC),
            transcript variant X1, mRNA.
ACCESSION   XM_054350763
VERSION     XM_054350763.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060928) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..4261
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="tec protein tyrosine kinase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 4 ESTs, 83 long SRA reads, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7006"
                     /db_xref="HGNC:HGNC:11719"
                     /db_xref="MIM:600583"
     CDS             464..2632
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /codon_start=1
                     /product="tyrosine-protein kinase Tec isoform X1"
                     /protein_id="XP_054206738.1"
                     /db_xref="GeneID:7006"
                     /db_xref="HGNC:HGNC:11719"
                     /db_xref="MIM:600583"
                     /translation="

MGLFCWHLGKGELFLWDLTWSDVTWSYWWSFFPAPWRKPQYKRMGPCSEKQHCTVVRAHSALFEVQESAVPGLLDYNTGIFSGRRSNQKTEMNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR"

     misc_feature    755..1180
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Bruton's tyrosine kinase pleckstrin homology (PH)
                     domain; Region: PH_Btk; cd01238"
                     /db_xref="CDD:269944"
     misc_feature    order(761..766,818..826,863..865,1016..1018)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:269944"
     misc_feature    order(773..775,779..784,788..793,809..811,821..823,
                     887..889)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="phosphoinositide binding site [chemical binding];
                     other site"
                     /db_xref="CDD:269944"
     misc_feature    order(1097..1099,1130..1135,1163..1165)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:269944"
     misc_feature    1280..1447
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Src Homology 3 domain of Tec (Tyrosine kinase
                     expressed in hepatocellular carcinoma); Region: SH3_Tec;
                     cd11905"
                     /db_xref="CDD:212838"
     misc_feature    order(1298..1300,1304..1306,1313..1315,1325..1327,
                     1379..1384,1424..1426,1430..1435)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212838"
     misc_feature    1454..1774
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Src homology 2 (SH2) domain found in Tec protein,
                     IL2-inducible T-cell kinase (Itk); Region: SH2_Tec_Itk;
                     cd10396"
                     /db_xref="CDD:198259"
     misc_feature    order(1496..1498,1553..1555)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198259"
     misc_feature    order(1721..1723,1745..1750)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198259"
     misc_feature    1829..2608
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Tyrosine kinase expressed in hepatocellular carcinoma and
                     Resting lymphocyte kinase; Region: PTKc_Tec_Rlk; cd05114"
                     /db_xref="CDD:270685"
     misc_feature    order(1862..1867,1886..1888,1922..1924,1928..1930,
                     1985..1987,2054..2056,2060..2074,2078..2080,2201..2203,
                     2213..2215,2222..2224,2252..2257,2264..2266,2306..2320,
                     2345..2347,2447..2449)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="active site"
                     /db_xref="CDD:270685"
     misc_feature    order(1862..1867,1886..1888,1922..1924,1928..1930,
                     1985..1987,2054..2056,2060..2074,2078..2080,2213..2215,
                     2222..2224,2252..2257,2264..2266)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270685"
     misc_feature    order(2201..2203,2213..2215,2306..2320,2345..2347,
                     2447..2449)
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270685"
     misc_feature    2252..2326
                     /gene="TEC"
                     /gene_synonym="PSCTK4"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270685"
ORIGIN      

aatagctgccattgattgatcacttactttgtgtcaagcattgtgcttagcaatttatgtaaattatttcatttaatcctcccacaatatctataggaggtaggtactattttacaatgaggaacctgagttactgagaagttacattacttacctgaggtcatacagctagtaaatgtcaaagctgacctttaaaaccagttctgtctgacttcaaagctctctcaagtgcccttttggttatctggggccttcctgacaagtgactgtgctgtagtggactgattatttgtctgcccagactttcttcctttgggcagctactctgtccaattcatgtggtttgggtggagttgacactacccagggatgatcatgtgattcagccttggccaatccgagcagtccctccacttgaccaagggattggctcaggggttagcatgtgatccagtctggctcaatgggactcttctgctggcatttaggaaagggggagctcttcctctgggatttaacctggagcgatgtaacctggagctactggtggtcatttttccctgctccatggaggaagccgcaatacaagagaatgggaccgtgcagtgagaagcagcactgcacggtggtgagagcacactcagcattgtttgaagtgcaggagtcagctgtgccaggacttctcgattataatactgggatcttcagtggcaggaggagtaatcagaagacggagatgaattttaacactattttggaggagattcttattaaaaggtcacagcagaaaaagaagacatcgcccttaaactacaaagagagactttttgtacttacaaagtccatgctaacctactatgagggtcgagcagagaagaaatacagaaaggggtttattgatgtttcaaaaatcaagtgtgtggaaatagtgaagaatgatgatggtgtcattccctgtcaaaataagtatccatttcaggttgttcatgatgctaacacactttacatttttgcacctagtccacaaagcagggacctgtgggtgaagaagttaaaagaagaaataaagaacaacaataatattatgattaaatatcatcctaaattctggacagatggaagttatcagtgttgtagacaaactgaaaaattagcacccggatgtgaaaaatacaatctttttgagagtagtataagaaaagcactacctccagcaccagaaacaaagaagcgaaggcctcccccaccaattccactagaagaagaagataatagtgaagaaatcgttgtagccatgtatgatttccaagcagcagaaggacatgatctcagattagagagaggccaagagtatctcattttagaaaagaatgatgttcattggtggagagcaagagataaatatgggaatgaaggatatatcccaagtaattacgtaacgggaaagaaatcaaacaacttagatcaatatgaatggtattgcagaaatatgaatagaagcaaggcagagcaactcctccgcagtgaagataaagaaggtggttttatggtaagggattccagtcaaccaggcttgtacacagtctccctttataccaagtttggaggagaaggttcatcgggttttaggcattatcatataaaggaaacaacaacatctccaaagaagtattacctagctgaaaaacatgcttttggctccattcctgagattattgaatatcataagcacaatgcagcaggacttgtcaccaggcttcggtacccagttagtgtgaaagggaagaatgcacccaccactgcaggattcagctatgagaaatgggagattaacccttcagaactgacctttatgagggaattgggaagtggactgtttggagtggtgaggcttggcaaatggcgagcccagtacaaagtcgcaatcaaagctattcgggaaggtgcaatgtgcgaggaggactttatagaagaagctaaagtgatgatgaaactgacacacccgaagttagtgcagctttatggtgtgtgcacccagcagaaaccaatatacattgttactgagttcatggaaaggggctgccttctgaatttcctccgacagagacaaggtcatttcagtagagacgtactgctgagcatgtgtcaggatgtgtgtgaagggatggagtatctggagagaaacagcttcatccacagagatctggctgccagaaattgtctagtaagtgaggcgggagttgtaaaagtatctgattttggaatggccaggtatgttctggatgatcagtacacaagttcttctggtgctaagtttcctgtgaagtggtgtccacctgaagtgtttaattacagccgcttcagcagcaaatcagatgtctggtcatttggtgttttaatgtgggaagtattcacggaaggcagaatgccttttgaaaaatacaccaattatgaagtggtaaccatggttactcgaggccaccgactctaccagccgaagttggcgtccaactatgtgtatgaggtgatgctgagatgttggcaggagaaaccagagggaaggccttctttcgaagatctgctgcgcacaatagatgaactagttgaatgtgaagaaacttttggaagataagtgatgtgtgaccagtggctcccagattcccaagcacaaggaaggatgggcattttgtggcttttaatttattgagcacttggacatgtagatcattttacttatacagtggaaacacataatttgcttctagaccagcctctgtctagacttgcttctagacagaatctcccagagtgtggaaatgttgccttagaaatggtgattaaaatcactcatttctattcattcctcaggcacttgagtgacagttgtttaccaggcactgtgtgtagccccagggtttggccattcaggggtgcacacatgggaccatgttagctgatgccagttgaaggccagggtatttgggaaggggaagggtattagagtcatgaccaagcaacccttctttttccctttgacttctacagaaatctgggcctgagacattgtctacaattgggttctagatacatcaggaacccatcttggataaataaatacctatcttttgttttgaaaacatctcagttttcaagactgctcttagtattacatgaacaatatttgtatgctgtatatattgtaaatatatataatatataaagttatatatttatgagaaacacgaattgtcttttaattgaaacttttaatcctgtagtataggagttcaccttcttaggactagagactgtgccttatagctgttaattcatttccccctgaacatcaaatatgcctgaagagaagaaagtctagattcttctatgagtaacgccccctcctcactcaggtaaatgtgtctggggatgcctgtccagcttaaccacgtgcatttggcctatgtaatcctgcccatggtggccgcagctaatcagaatcagatggaaaattaaaccgggtaatctgcttctaagccttaagaatattccctgggacacagacactataattggaagtgctgagctctggggcagaaggatcaggtgaccttcgcaacaaagtttgcccccacctcacataggacccggaagcagcctgagctgtggcggaggatccaggaagctacggagagaagcagccagcatggtgttccgtgcctcccggacgtttttcaggaggcctggttggacttgggttcctggatggtgggattgttgtacagcctctcaggagaccctgctgtcaagactgtgtgtgtggatttcccacccttagaagctctactaagacatcaacggaattagggccttcctttttgccttgtgagcgccaaggaaaagaaactatctcggtcacgtgagcgccagcgaaaagaaactgtatcagtcatccagagaccgtttattgcccaacacgttattcttgctgttggtggggtaactagccgaggaagacacagcgccttcccttcaggagttgcgtctcctctgcaggccacgatggtctgctctggagcattgggtgaacacacaggctggctgctctgggcagcgccttcactctgaccctggagaaccatttcatttcatcctggtcagtctagagtctgtgcaccaggcagtccatccactgaaggctgtgtttattcttttcctgtgcccctcataatggaagaaagtaaactgcttatcccgagcctta

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