LOCUS       XM_054328371            6459 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens lysine demethylase 5D (KDM5D), transcript
            variant X6, mRNA.
ACCESSION   XM_054328371
VERSION     XM_054328371.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060948) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="NA24385"
                     /bio_material="CORIELL:NA24385"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /sex="male"
                     /tissue_type="B-Lymphocyte"
     gene            1..6459
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="lysine demethylase 5D; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 37 ESTs, 428 long SRA reads, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 50 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:8284"
                     /db_xref="HGNC:HGNC:11115"
                     /db_xref="MIM:426000"
     CDS             76..4329
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /codon_start=1
                     /product="lysine-specific demethylase 5D isoform X6"
                     /protein_id="XP_054184346.1"
                     /db_xref="GeneID:8284"
                     /db_xref="HGNC:HGNC:11115"
                     /db_xref="MIM:426000"
                     /translation="

MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL"

     misc_feature    112..237
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="Small domain found in the jumonji family of
                     transcription factors; Region: JmjN; smart00545"
                     /db_xref="CDD:128818"
     misc_feature    310..585
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="ARID/BRIGHT DNA binding domain of lysine-specific
                     demethylase KDM5C and KDM5D; Region: ARID_KDM5C_5D;
                     cd16875"
                     /db_xref="CDD:350639"
     misc_feature    order(376..396,469..471,475..480,487..489,517..519,
                     523..531,535..537)
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350639"
     misc_feature    886..1023
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="PHD finger 1 found in Lysine-specific demethylase
                     5C (KDM5C) and 5D (KDM5D); Region: PHD1_KDM5C_5D; cd15604"
                     /db_xref="CDD:277077"
     misc_feature    order(886..888,922..936,946..948,1006..1008)
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277077"
     misc_feature    1411..1761
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="JmjC domain, hydroxylase; Region: JmjC; pfam02373"
                     /db_xref="CDD:396791"
     misc_feature    2029..2187
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="C5HC2 zinc finger; Region: zf-C5HC2; pfam02928"
                     /db_xref="CDD:427059"
     misc_feature    2224..2970
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="PLU-1-like protein; Region: PLU-1; pfam08429"
                     /db_xref="CDD:429992"
     misc_feature    3229..3411
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="PHD finger 2 found in Lysine-specific demethylase
                     5C (KDM5C) and 5D (KDM5D); Region: PHD2_KDM5C_5D; cd15608"
                     /db_xref="CDD:277081"
     misc_feature    order(3229..3231,3262..3276,3286..3288,3394..3396)
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277081"
ORIGIN      

actgcagggcccggaggtcaagatggtggctgtaaaactaggatccctgacgattgcttagcattaaggcccgacatggaaccggggtgtgacgagttcctgccgccaccggagtgcccggtttttgagcctagctgggctgaattccaagacccgcttggctacattgcgaaaataaggcccatagcagagaagtctggcatctgcaaaatccgcccacccgcggattggcagcctccttttgcagtagaagttgacaatttcagatttactcctcgcgtccaaaggctaaatgaactggaggcccaaactagagtgaaattgaactatttggatcagattgcaaaattctgggaaattcaaggctcctctttaaagattcccaatgtggagcggaagatcttggacctctacagccttagtaagattgtgattgaggaaggtggctatgaagccatctgcaaggatcgtcggtgggctcgagttgcccagcgtctccactacccaccaggcaaaaacattggctccctgctacgatcacattacgaacgcattatttacccctatgaaatgtttcagtctggagccaaccatgtgccagagcctacagaggaggacattgagaagcatccagagctaaagaagttacagatatatgggccaggtcccaaaatgatgggcttgggccttatggctaaggataaggataagactgtgcataagaaagtcacatgccccccaactgttacggtgaaggatgagcaaagtggaggtgggaacgtgtcatcaacattgctcaagcagcacttgagcctagagccctgcactaagacaaccatgcaacttcgaaagaatcacagcagtgcccagtttattgactcatatatttgccaagtatgctcccgtggggatgaagatgataagcttcttttctgtgatggctgtgatgacaattaccacatcttctgcttgttaccaccccttcctgaaatccccagaggcatctggaggtgcccaaaatgtatcttggcggagtgtaaacagcctcctgaagcttttggatttgaacaggctacccaggagtacagtttgcagagttttggtgaaatggctgattccttcaagtccgactacttcaacatgcctgtacatatggtgcctacagaacttgtagagaaggaattctggaggctggtgagcagcattgaggaagacgtgacagttgaatatggagctgatattcattccaaagaatttggcagtggctttcctgtcagcaatagcaaacaaaacttatctcctgaggagaaggagtatgcgaccagtggttggaacctgaatgtgatgccagtgctagatcagtctgttctctgtcacatcaatgcagacatctcaggcatgaaggtgccctggctgtacgtgggcatggttttctcagcattttgttggcatattgaggatcactggagttactctattaactatctgcattggggtgagccgaagacctggtatggtgtaccctccctggcagcagagcatttggaggaggtgatgaagatgctgacacctgagctgtttgatagccagcctgatctcctacaccagcttgtcactctcatgaatcccaacactttgatgtcccatggtgtgccagttgtccgcacaaaccagtgtgcaggggagtttgtcatcacttttcctcgtgcttaccacagtggttttaaccaaggctacaattttgctgaagctgtcaacttttgtactgctgactggctacctgctggacgccagtgcattgaacactaccgccggctccggcgctattgtgtcttctcccacgaggagctcatctgcaagatggctgccttcccagagacgttggatctcaatctagcagtagctgtgcacaaggagatgttcattatggttcaggaggagcgacgtctacgaaaggcccttttggagaagggcgtcacggaggctgagcgagaggcttttgagctgctcccagatgatgaacgccagtgcatcaagtgcaagaccacgtgcttcttgtcagccctggcctgctacgactgcccagatggccttgtatgcctttcccacatcaatgacctctgcaagtgctctagtagccgacagtacctccggtatcggtacaccttggatgagctccccaccatgctgcataaactgaagattcgggctgagtcttttgacacctgggccaacaaagtgcgagtggccttggaggtggaggatggccgtaaacgcagctttgaagagctaagggcactggagtctgaggctcgtgagaggaggtttcctaatagtgagctgcttcagcgactgaagaactgcctgagtgaggtggaggcttgtattgctcaagtcctggggctggtcagtggtcaggtggccaggatggacactccacagctgaccttgactgaactccgggtccttcttgagcagatgggcagcctgccctgtgccatgcatcagattggggatgtcaaggggcttttggttatgggtgccaagatagcctccagcccttctgtggacaaggcccgggctgagctgcaagaactactgaccattgcagagcgctgggaagaaaaggctcatttctgcctggaggccaggcagaagcatccaccagccacattggaagccataattcgtgagacagaaaacatccctgttcacctgcctaacatccaggctctcaaagaagctctgactaaggcacaagcttggattgctgatgtggatgagatccaaaatggtgaccactacccctgtctagatgacttggagggcctggtggctgtgggccgggacctgcctgtggggctggaagagctgagacagctagagctgcaggtattgacagcacattcctggagagagaaggcctccaagacctttctcaagaagaattcttgctacacactgcttgaggtgctttgcccgtgtgcagacgctggctcagacagcaccaagcgtagccggtggatggagaaggcgctggggttgtaccagtgtgacacagagctgctggggctgtctgcacaggacctcagagacccaggctctgtgattgtggccttcaaggaaggggaacagaaggagaaggagggtatcctgcagctgcgtcgcaccaactcagccaagcccagtccactggcaccatccctcatggcctcttctccgacttctatctgtgtgtgtgggcaggtgccagctggggtgggagttctgcagtgtgacctgtgtcaggactggttccatgggcagtgtgtgtcagtgccccatctcctcacctctccaaagcccagtctcacttcatctccactgctagcctggtgggaatgggacacaaaattcctgtgtccactgtgtatgcgctcacgacggccacgcctagagacaatcctagccttgctggttgccctgcagaggctgcccgtgcggctgcctgagggtgaggcccttcagtgtctcacagagagggccattggctggcaagaccgtgccagaaaggctctggcctctgaagatgtgactgctctgttgcgacagctggctgagcttcgccaacagctacaggccaaacccagaccagaggaggcctcagtctacacttcagccactgcctgtgaccctatcagagaaggcagtggcaacaatatttctaaggtccaagggctgctggagaatggagacagtgtgaccagtcctgagaacatggctccaggaaagggctctgacctggagctactgtcctcactgttgccgcagttgactggccctgtgttggagctgcctgaggcaatccgggctcccctggaggagctcatgatggaaggggacctgcttgaggtgaccctggatgagaaccacagcatctggcagctgctgcaggctggacagcctccagacctggacagaattcgcacacttctggagctggaaaaatttgaacatcaagggagtcggacaaggagccgggctctggagaggcgacggcggcggcagaaggtggatcagggtagaaacgttgagaatcttgttcaacaggagcttcagtcaaaaagggctcggagctcagggattatgtctcaggtgggccgagaagaagaacattatcaggagaaagcagaccgtgaaaatatgttcctgacaccttccacagaccacagccctttcttgaaaggaaaccaaaatagcttacaacacaaggattcaggctcttcagctgcttgtccttctttaatgcctttgctacaactctcctactctgatgagcaacagttgtgacagtggcaccaaaggtcatttgtggttgtttttgtttgtttgtttcttaaatcctactatctcctggcctggacctcagaaggagctttttgcctatctataatttttcactgccaatttttgatatcctctctcctagagttactgttaaaaggttggttcgtaaagtccacaccccgatgctcagaagtgtcttgccagcaacattcctgctagcatacaggagtgatttcctaaaccagtttcattctagtctgaatagggacaaacaaatcttgaggaagcccaagtgcgtacctttatttttgcccccaccaccctctttctgtacttcaatttttgtttgttttttgtttttttgtccctgtcataaaatattttggtgcttcaaaacttgtaccttcattgtacatccttttcttttctccccttgggtcttattataaaagaagacaatgtacgttgtaattaccaaaaagaatagggaaaaacaagaatttcatgactctacctgtggtctatctttaatttcatttcttttgttaaaaataaaacaatgagtatgtttggatactatgaatatgatttgaacttcttaaattgtacgagtgaaggactgaggttaggaaacaacagtagcatgggtcaacgtaatttttaatagtctttttcggggcagtggggaagggtaaattttacttagaaaacatacatgagacttaggccaaggttaatgttttctcaaaggatgtccagttgacccagcaccagcaatagaaaacttacctgtcctacacttaattgctttgtgctttttattgaaaatctgttggctggacttgcatgtgccaatatctgagttaacttgttgcattgcatcatttaactatgtgtctgtcccctgtggccagatcacaatgtcttggttacagtcgctttataataagtcttacatcagggtagacagattcatctcacttttttgtttttcagattgttttagcaagttaagtcaccagctctctttttcattatgtagtagcttttgtgtcctaaatctgattaagttgcactgacacaagttatctccctcaatattttctgttctttcaactggtgaatacaatagctaatctaaatcatttgttgtaagaattcagtaggattgatgtgtaaatatttcaggtaaaaccactctattagtataccactaattcaattcacggttcttgttttgtgtgtctctgggtgatctaataatacagactgtattatacttcttttaatccctttaaaggtgaacgcattctgtcatcctggattgaatctctcgcttttccacctactccttgctgacttgagtcagtgtagaacacgttattacccatagcatttctcatgcctataatcatacctaccttccttattgtctactcttttcacctctttctttctttgatactgtcatagggaactataattagctttcccagtaacaaagctatgcttggtgatgacctagtagagtagaaattgcttcacctgtccaagtacagtgtactttaccttaccacaccatagggaccaggtaaaatatatagaaaatcctgagataatttatctaaatctgagaattgtcttcgaaatttcttttttctcctcttccataaataggaggaaagtcatgattctcaagccattacagattctctgacacttgttaacggaaaattctgatgaggcatgatgagaacttctgcctataaaaatctcactaaagttctgagtcacaaattgttcacatacttcacagtaagcaggcaatccaatgtcaggacagttgtacacctttcttaggttgcctcccctaattggggctgtatttgacatgaggggccagttttgacactttttaaaaccatacacaaggatgcagcactaagtttttgcacataggcaagaatttatcttgtgattagaagttagttatatgttcattaagaaacatgacgaaatctgcagcaaaaattgaatttcataggccattcagtgttctctgcgataattctaattcagaaaaaaattgaatcttggtttaaaaaaattgtaataaaactttaccactggtaa

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