LOCUS       XM_054324554            9640 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens PBX/knotted 1 homeobox 1 (PKNOX1),
            transcript variant X2, mRNA.
ACCESSION   XM_054324554
VERSION     XM_054324554.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060945) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9640
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..9640
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="PBX/knotted 1 homeobox 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 29 ESTs, 606 long SRA reads, 10 Proteins, and 72%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 13 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5316"
                     /db_xref="HGNC:HGNC:9022"
                     /db_xref="MIM:602100"
     CDS             4488..5798
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /codon_start=1
                     /product="homeobox protein PKNOX1 isoform X1"
                     /protein_id="XP_054180529.1"
                     /db_xref="GeneID:5316"
                     /db_xref="HGNC:HGNC:9022"
                     /db_xref="MIM:602100"
                     /translation="

MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALAPAHISGLVLENSDSLQ"

     misc_feature    4725..4982
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:435375"
     misc_feature    order(5265..5279,5283..5285,5343..5345,5361..5363,
                     5400..5402,5406..5411,5418..5423,5427..5435)
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(5271..5273,5280..5282,5409..5411,5418..5423,
                     5430..5432)
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    5319..5435
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
ORIGIN      

cctagatgctgagacttaaaaatggagtctcaccatggacagttctcataaagaattgtctcccaacaaagtggctgactgtgttgtggctgtattgttacagaccttctcagatgtgtttgctgcaagttttgtttatttggaactctttggaagctagcacaactacatagaaacccatataagttagccaccatgctcagctaatttttaaaaaaatttgttgtagagatggggtctcgttctgttgcccaggctggtcttgaactcctgggctcaagtgatccttccaccttggcctcccaaagtgctgggattacaggtgtgagcctctgtactcagctaatttagctagtttttgtatttgattttttttttttttaatagagtctctgtcatcccggctggagtgcagtggcatgatcttggctcactgcaacctttgcctcccaggttcaagtgattttcttgcctcagcctcccaagtagctgggactataggcatgtgccaccatgcccagctcatttttgtatttttagtagagatggggtttcgctattttggtcaggctggtttcgaattcctgacctcaggtgatcctcccacctcagcatcccaaagagctggaattacaggcatgagccataacgcctggccccatatgctgtttatttcatttttcccaagcaaactaggacttagagattgtttcacaaagccctgctgactcattttcaacacttctccacaggactagtgctatgcgtcagcagacgctgcctgtgtggggatggaggttggctcagacacagtgcgtggcctcgggagccttacgttccagcaaccacttgactaacagtcataaaaattaaaattgtaaaatattttgtcaactgtgcatcagccaaacaaaaaaaattaaaattgcctgaagtggaacaaggagatgtgggatgaagtcaagcaaattatgtgtccaaaaatgtataatgtcagtgattagcttcaggaagcatttgtatttagtgcctattgacatcagagacagcgctagtagttggggatgcagcaagacgggcccctggcccttaaggaacttgtagtccaaatgaacaactgaagtactgcggggctgagcagagggtgctgtgtgagggtccagcatggacaaacttaaccccagtgtgggtgagattcatcaggaaggctttctggagaaggtgatgtgggcgatgcatgttctccacctagccatgcccagagggaagtgtgtctgggcagaactatcaggctggggaggactcaggggtgggagagaacctggcatgctggggaagctaaatgtggcgattggtttgtttatacaacttggagtgcggaagggggtcagtaaggggatgctgatgcctgagggtgagggttgggcagaggcaattttaagcatgtgagtcacatgatcagatttccattttagaaagcttggagaatgggtctactcaggtagctcacaccttgtgttgtccattttcacactgctgataaagttgtacccaagactgggcaatttacaaaagaaagaggtttaattggacttacagttccatatggctggggaagcctcacaatcatggtgaaagacaaggaagagcaagtcatgtcttacatggatggcagcaggcaaagagaggagcatgtgtgcaggggagctcctctttttaaaaccatcagatcttgtgggacttattcgctatcatgagaacagcacagaaaagacttgcccccatgattcaactacctcccaccagctccctcccataacatgtgggaattcaagatgagatttgggtggggacacagccaaccatatcattgtgcccctgccccctcccaaatctcataatcatgtttcaaaaccaatcatgccttcccaacagtcccccaaagtcttaactcatttcagcattaacttaaaagtccacagtccaaagtctcatctgagataaggcaagtcccttccacgtatgagcctgtaaaatcaaaagcgggttagttacttcctaaatacagtgggggtacaggcattgggtaaatacagccatttcaaataggagaaattggccaaaacaaagaggctacaggctcccatgtaagtctgaaatccagcaggacagtcaaatcttaaagctcctaaatgatttcctttgactgcatgtctcacatctaggttatgctgatggaagaggtgggttcccatggtcctgggcatctccgcccctgtggctttgcaggatacagcctccctcccagctgctttcacgggctggcatttagtgtctgcagcttttccaggtgcatggtgcaagctgttggtagatctaccattctggggtctggaggacagtggccatcttctcacagctccactaggcagtgccccagtagggactctgtgtgaggcctccagtgccacatttcccttccatactgtcctagcagaggttctccatgagagccccacccttacagccaacatctgcctggacatccaggcacttctgtatattttctgaaatctaggcggaggttcccaaacctcaattcttgacttctgtgcactctcaggcccaatgccacgtggaagctgccaaggcttgaggtaccctctgaagccaaggcccgagttctgcattggcccttttcagccacggctggagcagctgggatgcagggcaccaagtccctatgctgcacacagaacaaggaccctgggcctggcccatgaaaccagtttttccttctaggcctctgggcctgtgatgggaggggctgccatgaggacttctgaaatgccctggagacattttccccattgtctgggggattaacattaggctcctcattacttatgcaaatttatgcagccagcttgaatttctcctcaggaaatgggattttcttttctttttttttcttttgaaatggagtctcactctgtcacccaggctggagtgtagtggcacaatcttggttcactgcaatctctgcctcctgggttcaaacaattctcctgcctcagcctcctgagtagctgggattacaggcgtgcaccaccaagcccggctaattttcgtatttttagtagagacggggtttctccatgttggtcaggctggtctcaaactcctgacctcatgatcctcctgcctcagactcccaaagtgctgggattacaggcatgagccattgctcccggctgggattttcttttctatcacattgtcaggctgcaaattttccaaactttcattctctgcttactttataaaaccgaatgctttcaatagcacccaagtcacctcttgaatgctttgctacttagaaatttcttccaccagataccctaaatcatctctcaagttcagagttccacaaatctctagggcaggggcaaaatgctgccagtctctttgctaaaacataacaagtcacctttgctccagttcccaacaagttccccacctccgagacctcctcagcctggactttactgttcatataattatcagcatttttgtcaaagccattcaacaagtctctaggaagttccaaactttcccacattttcctgtcttcttctgagccctccaaactgttgcaccctctgcctcttacccagttccaaagtcacttctacatttttgggtatcttttcagcaacaccccactcctggtaccaatttacagtgttagtccatattcatgctgctgataaagacatacccaagactgggcagttttcaaaagaaggaggtttaatggagttacagttccacatggctggggaagcctcacaatcatggcggaaggcaaggaaaagcaaattatgtcttacatggatggcagcaggcaaagagaggagagcatgtacaggggaattcctctttttaaaaccatcagatctcatgtgagacttattcactatcaggagaacaacatgggaaagacttgcccccatgattcaattacctcccactgggtccctcccacaacacgtgggaattcaagatgagatttgggtggggacacagctaaaccatatcacacctgtaatccagcactttgggaggctgaggcaggagaattgcttgagcccaggaattcaagaccagcctgagcaatatagcaagacttcatctctacaaaaaattaaaaagccagcatggtggtgtgggcctgtagttcctgctgtttagggggctgtggtgggagcatctcttgagttcaggaagtcggggccccagtgagctatgattgcaacattgcagtccagcctaggtgacagaacaagaacctgtctctaaaaaagggagaaaaaaagaaagcttggagaatggactggaagagggaagactggaggctcatacaaccagacaccattcgcttttcacccaagatgatttgatgtcttataaaactctgatgaaccatgatggctacacagacattaagtatagacagctatcaagatgggcaacagatgcaagtagtaacagagttaaagacagaacaagatccaaactgctctgaacccgatgcagaaggagtgagccctccccctgtggagtctcagaccccgatggatgtggacaagcaggccatttataggcatccactatttccattattagctttgttgtttgaaaaatgtgaacaatctacacagggctctgaaggcacaacttctgccagttttgatgtagacatcgaaaattttgtaagaaagcaagagaaggaagggaaacctttcttttgtgaagatccagaaaccgataatttaatggtaaaagcaatccaggttttgcgcattcatcttcttgagctggaaaaggttaacgaactctgcaaagatttctgcagtcgatacattgcttgtctgaaaacaaaaatgaacagtgaaactctgttgagtggagagcctggaagcccgtactcaccagtgcagtcccagcagattcaaagtgccatcacaggcaccatcagccctcagggaattgtggtgccggcgtccgcgctgcagcagggaaacgtagccatggcgacggtggcaggtggcacagtgtatcagcctgtcacggtcgtcactccccaaggccaagtggtcacacagacattgtcgcctgggacaattaggatccagaactcccagcttcagttacagttaaaccaagatctcagcatcttgcatcaagatgatggttcatctaagaacaagaggggcgtcctgccaaagcatgccacgaacgtgatgcggtcctggctcttccagcacatcgggcatccctacccaacagaggatgagaaaaaacagattgctgctcagacaaatttgacactactccaagtcaacaactggttcatcaatgccagaagacgaattcttcagccaatgttggattcaagttgttcagagacccccaaaacaaagaaaaaaactgctcagaaccggccagttcagaggttttggcctgattctattgcatcaggagtcgcacagccaccgccgagcgagctcaccatgtcggaaggagctgttgtcaccatcaccacgcccgtgaacatgaacgtggacagccttcagtctctgtcctcggacggggccaccctggcggtgcagcaggtcatgatggcagggcagagcgaggacgagtctgtggacagcacagaggaggatgcgggtgccctggcccctgcccacatcagcgggctggtcttggagaacagtgactccctgcagtaggggcaggagcagacgcacctgactttttggagtttgcacagcaaacattttacacagttttatttctaatatgttttatatgtagatatagaagagtgcacttttgtatttcatagtaagcttaaagcgcgtctttgccggtgcagcgacttctttcaagtgtgtgtgtgtgtgtgtgcgtgtgtgcgtgtgtgtggatttttaaagaaattctttaaaggtttaacgctagattgtgaggaatgacacaccactccctccccaccttgaatccctaattagattaaggaatagcgctgccattttctaaaccgtgatgcggttgtcacttagttctgtggttccagcagatctcagtgggctggttgatttgtgtggcccatggatttgaaagaagctgctgcacccgaaactgccagtgtgcggtgacaacggcacacgcctagactgagtgtggtttcgtcgtgagtggatggacggcaagcttagcaagcctaagtcccctcatgttcagtgagcctgtttcatttgctatatagaaaaagaaactcctatttttaccttgctggaattattggataaaaaagctatttttataaattcgttatgaattggatgatgactatattgaggataaaatttctagagaagaaacaatacatgcttgctattaatatttcaatttggaatgttctgaattgaccaaatttaacgaacctgcccaaagttagctaccgttccatggttctttgctctccccgggtagtgatgaacatttactactataaaagaaacagctatttaatgaaattttgatatctgcaaatttttgttgatatgtaatgctcagattgcattttacacttgatctaaacatatatcgaaagatatctgctaaacaggacttcaggtaagtgaggtgaaatggtagccagtgacccgttaggagctctcaccgtacatactccagtctaatttaaatctgaccacagttgcatggtcgctttaccatgttagctgtgtattgttttaaaagttttaacttcaaaatatgttatgcacagaatgtttattataaactaatataaaatgtgctctaccccattggctcagagctagggcaaacagcagatattcagactttattacttaactagcggacatccctggagtcccagcagcgagttggtctggcgagggcacctcggcagcccccacgggttggctcctacgtttgcgtttgtggctggtctcctggtgtcagtgttctcttgtacgttgttgctttcgacttttcagagccctcctgctcacttgaccacgtgagatttggaataactgtaggacttctgtttcctggtaacaagatgaaccgagagagtgggctgggttctgttttctttggttttgatttgttttcattgtttacttaggagtggtgctttttctcagaaaacaggccacggtgtttcatacagaatgtcttcatatcatctgaaatggtatggctgaagttcatttgtttacagggtcgggaatgtcttcagttcttgagagtcaacagtaatgattggttgtaagccaagggacattttaagctagtgaagagttttttctggaattgatttttcccaaaagaatatattaattaaggttaagaagtcagtgggaaacacacagaaatttattttaaaatctttcaggagctttaactgaaagacttggttatcaagtcttttggggagagaatgacattttttttttgagacagagttttgctcttgttgcccaggctggagggcaatggtgcaatctcagctcactgcaacctccacctcttatgttcaagcaattctccttccttagcctcctgagtagctgggattacaggcatgcgccaccacacccggctaattttgtatttttagtagagatgggtttctccatgttggtcgggctggtctcgaactcccgacctcaggtgatctgcctgcctcagcctcccaaagtgctgggattacaggtgtgagccaccgcgcccggccgagaatgacatcttaaagccaccattgcgttcctcatttgtgaactgtcttctcatattttaagtcaagtctataagatcatttttaacctaagttccaactttgttggactccttaaaataagcacccatgaaagccagccagcccttcctccttccctcaccaccctccgtctcttcgtccctcaccaccctccgtctcttcggctgcctgctctttagtgtagattagtggaagccattcacagaatgtagactcatgtataggtcaccgtttctttcccccactagaaatcacattcactaagcagtggattgaatttaagagtgctgcccctgcccggcgcagtagggcgtgcctctagttccagctactcgggagtctgaggcagaggatggcatgtgccaggagtttgaggctgcagtgcactatgcttgcacctgtgaatagccactgcactccatcttgggcaacacagtgagacccccatctataaaaagagagcactgcctgaaccttggtggcactgggaagctctggcctgagagttaaacacccatgctgaatggtacagtgtgcattctctccagctgaaaactttcttcaactttcctaaattcttactaaattcagaggaataggataaagatcacttagagaaagggtgcttatggacatagcctgagtttcctttaacctctctccaatgggtgcttttaactagcttctacatggcaagctgtttcagtttgcaaaatcactgcccagcatgtttgaggtcagttggcaccttaaaacacctgttctccagcccttggacagtggagagaatctgtaaaagtgtgaccccctctaagatttcgttttaaatgatcagattcggttccagttttattcttgttgagtttttccctatgaaggctccttttgaatgtgtcttgagacccaaattgagcatgttgctgttattcctgccctgcacctgtggagcaggagtggcagggctggctgtgctgggttccagctcgctcctgccgagggactagcttggcctttgcgctttgattccagatagtaagatgagtggaagtgtttatcgagcatgcaaaagaaaccctcacggctaacggctctgggagttgtgtctgtgtgacctgagagtgatccatctcctgcctgtgtgaggtagcagtgggcacttttcattgagacaaactccagggtgtccagagggggttctgccccttgtgaaggcccattcctggcacttagagacagaaagaactcagcaatctttcgttctagttatattcggtctttgaaactgacaatctttgaaatgtgaatactgtaacaatatgttttcttggattgttgtctttaaaaaggatttttgtgaagcaattgatttatcaaagcaaaaaaattaaaaatagaaacttgctttatggatgttttattttataaagctcatgtcaccaaaagctgcttctccattttatgtaaaacattgagaatgttttcatgttttctggtgacatgtagggtctgtagtcacccctgcatattgagaaactaggaccacactgcatcggactagtcaggtccatttacatgtccaagaatcttttcttaaattccttactttgttcattcattggctgttcaggcagaaaatggaaacaggtagcttttatgttttttattatagttttccacaaatctaattattttgatagttacaagaagataatgattcatcagtaagctaacataatccctttcatagttcatatt

//